Letter
Medicine, General & Internal
Brendon G. Neuen, Robert Fletcher, Hiddo J. L. Heerspink
Summary: The editorial suggests that the benefit of empagliflozin in slowing the progression of chronic kidney disease is less evident among patients who do not receive RAS blockade. This is because this subgroup only accounts for 15% of the overall trial population, resulting in less precise effect estimates and wider confidence intervals.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Leszek Kozlowski, Katarzyna Bielawska, Alena Zhymaila, Jolanta Malyszko
Summary: The prevalence of chronic kidney disease (CKD) in colorectal cancer (CRC) patients undergoing surgery is limited. Proper diagnosis and treatment of CKD in oncology patients is important for ensuring continuous therapy and preventing complications.
Article
Medicine, General & Internal
Sejun Park, Yunjin Yum, Jung-Joon Cha, Hyung Joon Joo, Jae Hyoung Park, Soon Jun Hong, Cheol Woong Yu, Do-Sun Lim
Summary: Chronic kidney disease (CKD) is a significant risk factor for cardiovascular disease, and electrocardiogram (ECG) can help predict future cerebrocardiovascular events in CKD patients. ECG abnormalities are closely associated with the incidence of major adverse cerebrocardiovascular events (MACCE) in CKD patients, and ECG diagnosis can be used in conjunction with traditional risk stratification models to improve cardiovascular risk assessment accuracy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Rohan Bir Singh, Erdem Yuksel, Shruti Sinha, Shudan Wang, Yukako Taketani, Zala Luznik, Jia Yin, Thomas H. Dohlman, Reza Dana
Summary: The prevalence, clinical characteristics, and risk factors of neurotrophic keratopathy (NK) in chronic ocular graft-versus-host disease (oGVHD) patients were investigated in this study. The results showed that patients with higher NIH oGVHD severity score and history of cataract surgery had a higher risk of developing NK.
Article
Dentistry, Oral Surgery & Medicine
Eduarda Palmeira, Flor de Liz Perez-Losada, Victor Diaz-Flores-Garcia, Juan J. Segura-Sampedro, Juan J. Segura-Egea, Jose Lopez-Lopez
Summary: The purpose of this study was to analyze the prevalence of apical periodontitis and periodontal disease in Chronic Kidney Disease (CKD) patients and their relation to the treatment phase. The results showed that oral infections are more prevalent in advanced stages of CKD. Therefore, the treatment of periodontal disease and apical periodontitis should be considered in the treatment planning for CKD patients.
Review
Pharmacology & Pharmacy
Lina Naseralallah, Malkan Khatib, Azhar Al-Khulaifi, Mohammed Danjuma
Summary: Polypharmacy is common in patients with chronic kidney disease (CKD) due to an ageing population and multimorbidity. This systematic review and meta-analysis found a high prevalence of polypharmacy in CKD patients, with higher rates in North America and Europe compared to Asia.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Magda Wisniewska, Natalia Serwin, Violetta Dziedziejko, Malgorzata Marchelek-Mysliwiec, Barbara Dolegowska, Leszek Domanski, Kazimierz Ciechanowski, Krzysztof Safranow, Andrzej Pawlik
Summary: Levels of renalase in serum and urine were significantly elevated in haemodialysis CKD patients, while levels in erythrocytes were lower. Plasma concentrations of dopamine, adrenaline, and noradrenaline were also decreased in CKD patients. These changes may be related to compensatory production in extrarenal organs and altered degradation by plasma renalase.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Urology & Nephrology
Ozdem Kavraz Tomar, Ayse Zeynep Bal, Semahat Karahisar Sirali, Murat Duranay, Berfu Korucu, Galip Guz, Seyit Ibrahim Akdag
Summary: Fabry disease is an X-linked lysosomal storage disease caused by a deficiency of alpha-galactosidase A enzyme, resulting in various clinical symptoms. The likelihood of developing nephropathy increases with age and the severity of the mutation in Fabry patients. Due to atypical or oligosymptomatic presentations, diagnosing Fabry disease is challenging.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Review
Pharmacology & Pharmacy
Cosimo Cosimato, Thomas Agoritsas, Thomas A. Mavrakanas
Summary: MRA can reduce cardiovascular morbidity and mortality in patients with heart failure and ischemic heart disease, and also have been used in patients with diabetic nephropathy to control proteinuria. Currently, guidelines recommend against the use of MRAs in patients with advanced CKD, but there is growing interest in their use in this population.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Aya Mizher, Heba Hammoudi, Farah Hamed, Abrar Sholi, Adham AbuTaha, Mazen A. Abdalla, Mohammad M. Jaber, Mohannad Hassan, Amer A. Koni, Sa'ed H. Zyoud
Summary: A cross-sectional study was conducted on hemodialysis patients, and the results showed that 47.1% of the patients reported chronic pain. Gender, social status, educational status, and number of chronic diseases were significantly related to pain severity. C-reactive protein and albumin were also significantly correlated with pain severity and interference.
SCIENTIFIC REPORTS
(2023)
Article
Geriatrics & Gerontology
Jing Chang, Wenwen Hou, Yanchun Li, Shujuan Li, Kai Zhao, Yanfei Wang, Yuanping Hou, Qianmei Sun
Summary: Cognitive frailty is more prevalent in older adults with chronic kidney disease (CKD). Advanced age, comorbidity, depression, low social support, eGFR, and albuminuria are independent risk factors for cognitive frailty in older CKD patients.
Article
Medicine, Research & Experimental
Miguel A. Villasis-Keever, Jessie N. Zurita-Cruz, Juana Serret-Montoya, Andrea Ponce de Leon-Herrera, Penelope Galvan-Heredia, Claudia del Carmen Zepeda-Martinez, Gabriela Alegria-Torres, Carolina Hernandez-Hernandez, Sara Alonso-Flores, Lourdes Barbosa-Cortes, Luis Antonio Arenas-Aguayo
Summary: Although the frequency of cardiometabolic factors in patients with chronic diseases is lower than in obese and overweight children, hypertriglyceridemia, hypoalphalipoproteinemia, and systemic arterial hypertension are still common.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Hilmi Alnsasra, Gal Tsaban, Adam Solomon, Fouad Khalil, Enis Aboalhasan, Abed N. Azab, Joseph Azuri, Ariel Hammerman, Ronen Arbel
Summary: This study compared the cost-effectiveness of dapagliflozin and empagliflozin for preventing renal and cardiovascular events in CKD patients. The results showed that empagliflozin had better cost-effectiveness in diabetic patients, while dapagliflozin had better cost-effectiveness in non-diabetic patients. Additionally, dapagliflozin had better cost-effectiveness for preventing cardiovascular death, while empagliflozin was more cost-effective for preventing CKD progression.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Urology & Nephrology
Emilie Lambourg, Lesley Colvin, Greg Guthrie, Kiruthikka Murugan, Michelle Lim, Heather Walker, Georgia Boon, Samira Bell
Summary: The study showed that pain prevalence is high among patients with chronic kidney disease, with musculoskeletal pain being the most common type. Kidney transplant recipients have lower pain prevalence compared to patients undergoing dialysis and those with nondialysis CKD. The burden of pain is significant across all subgroups of CKD patients.
KIDNEY INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Geraldo Jose De Amorim, Cinthia Katiane Martins Calado, Bruno Carlos Souza de Oliveira, Renata Patricia Oliveira Araujo, Tayrine Ordonio Filgueira, Matheus Santos De Sousa Fernandes, Angela Castoldi, Gisele Vajgel, Lucila Maria Valente, Jose Luiz De Lima-Filho, Paulo Roberto Cavalcanti Carvalho, Fabricio Oliveira Souto
Summary: This study investigated the prevalence and factors associated with sarcopenia in ND-CKD individuals. The results showed that sarcopenia was common in this population and was associated with age, body mass index, phase angle, gait speed, and serum markers.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Juan E. Grunwald, Maxwell Pistilli, Gui-Shuang Ying, Maureen Maguire, Ebenezer Daniel, Revell Whittock-Martin, Candace Parker-Ostroff, Emile Mohler, Joan C. Lo, Raymond R. Townsend, Crystal Ann Gadegbeku, James Phillip Lash, Jeffrey Craig Fink, Mahboob Rahman, Harold Feldman, John W. Kusek, Dawei Xie
AMERICAN JOURNAL OF CARDIOLOGY
(2015)
Article
Urology & Nephrology
Kailin L. Hsu, Jeffrey C. Fink, Jennifer S. Ginsberg, Marni Yoffe, Min Zhan, Wanda Fink, Corinne M. Woods, Clarissa J. Diamantidis
AMERICAN JOURNAL OF KIDNEY DISEASES
(2015)
Editorial Material
Urology & Nephrology
Lee-Ann Wagner, Asha L. Tata, Jeffrey C. Fink
AMERICAN JOURNAL OF KIDNEY DISEASES
(2015)
Article
Urology & Nephrology
Ana C. Ricardo, Cheryl A. Anderson, Wei Yang, Xiaoming Zhang, Michael J. Fischer, Laura M. Dember, Jeffrey C. Fink, Anne Frydrych, Nancy G. Jensvold, Eva Lustigova, Lisa C. Nessel, Anna C. Porter, Mahboob Rahman, Julie A. Wright Nunes, Martha L. Daviglus, James P. Lash
AMERICAN JOURNAL OF KIDNEY DISEASES
(2015)
Article
Immunology
Lindsay D. Croft, Anthony D. Harris, Lisa Pineles, Patricia Langenberg, Michelle Shardell, Jeffrey C. Fink, Linda Simoni-Wastila, Daniel J. Morgan
CLINICAL INFECTIOUS DISEASES
(2015)
Article
Urology & Nephrology
Clarissa J. Diamantidis, Jennifer S. Ginsberg, Marni Yoffe, Lisa Lucas, Divya Prakash, Saurabh Aggarwal, Wanda Fink, Stefan Becker, Jeffrey C. Fink
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2015)
Article
Health Care Sciences & Services
Ana C. Ricardo, Jason A. Roy, Kaixiang Tao, Arnold Alper, Jing Chen, Paul E. Drawz, Jeffrey C. Fink, Chi-yuan Hsu, John W. Kusek, Akinlolu Ojo, Martin Schreiber, Michael J. Fischer
JOURNAL OF GENERAL INTERNAL MEDICINE
(2016)
Article
Health Care Sciences & Services
Jeffrey C. Fink, Rebecca M. Doerfler, Marni R. Yoffe, Clarissa J. Diamantidis, Jacob B. Blumenthal, Tariq Siddiqui, James F. Gardner, Soren Snitker, Min Zhan
JOURNAL OF MEDICAL INTERNET RESEARCH
(2016)
Article
Multidisciplinary Sciences
Jayanta Gupta, Elizabeth A. Dominic, Jeffrey C. Fink, Akinlolu O. Ojo, Ian R. Barrows, Muredach P. Reilly, Raymond R. Townsend, Marshall M. Joffe, Sylvia E. Rosas, Melanie Wolman, Samir S. Patel, Martin G. Keane, Harold I. Feldman, John W. Kusek, Dominic S. Raj
Article
Medicine, General & Internal
Sarah J. Schrauben, Hsiang-Yu Chen, Eugene Lin, Christopher Jepson, Wei Yang, Julia J. Scialla, Michael J. Fischer, James P. Lash, Jeffrey C. Fink, L. Lee Hamm, Radhika Kanthety, Mahboob Rahman, Harold I. Feldman, Amanda H. Anderson
Editorial Material
Urology & Nephrology
Lee-Ann Wagner, Jeffrey C. Fink
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Engineering, Industrial
Benjamin M. Knisely, Camille Levine, Monifa Vaughn-Cooke, Lee-Ann Wagner, Jeffrey C. Fink
Summary: Heterogeneous product user populations are common in safety-critical domains, but designing for variable user needs is often approached with a one-size-fits-all mindset. Quantifying the risk of use error can help justify design decisions for maximizing system performance and safety. Introducing expert elicitation as an alternative to traditional human factors design validation efforts, this study focuses on the diabetes population to demonstrate how performance distributions for task-user group pairs can help identify human error risks in design validation efforts.
Article
Computer Science, Cybernetics
Benjamin M. Knisely, Monifa Vaughn-Cooke, Lee-Ann Wagner, Jeffrey C. Fink
Summary: Interaction with patient-facing medical devices involves complex physical and cognitive tasks that are highly dependent on user characteristics. Quantifying product use variability early in design is challenging due to patient population differences, user heterogeneity, and resource constraints, but modeling prevalent patient sub-populations using NHANES dataset can help personalize device features and improve health outcomes.
USER MODELING AND USER-ADAPTED INTERACTION
(2021)
Article
Urology & Nephrology
Mitchell D. Belkin, Rebecca M. Doerfler, Lee-Ann Wagner, Min Zhan, Jeffrey C. Fink
Summary: This study found that as performance-based functional assessment scores decreased, the risk of death and adverse outcomes in CKD patients increased. Specifically, low SPPB performers had the highest risk. This suggests that various performance-based functional assessments may have significant implications for the prognosis of CKD patients.
Article
Health Care Sciences & Services
Cassandra Bowman, Joseph Lunyera, Aviel Alkon, L. Ebony Boulware, Jennifer St Clair Russell, Jennie Riley, Jeffrey C. Fink, Clarissa Diamantidis
JMIR FORMATIVE RESEARCH
(2020)