Article
Urology & Nephrology
Tadao Akizawa, Yu Sato, Kazuaki Ikejiri, Hironori Kanda, Masafumi Fukagawa
Summary: Tenapanor effectively controls phosphorus levels and reduces the number of phosphate binder tablets for hemodialysis patients, potentially improving treatment outcomes.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Materials Science, Ceramics
Fupo He, Jin Rao, Wenhao Fu, Jielin Zhou, Yuxuan Zhang, Tengyun Chen, Wenhao Huang, Yao Wang, Teliang Lu, Haishan Shi
Summary: This study successfully prepared gallium-containing magnesium/calcium phosphate ceramic scaffolds and investigated their performance at different sintering temperatures. The results showed that the compressive strength and porosity of the scaffolds could be controlled by varying the sintering temperature, and the release of ions stimulated cell growth and osteoblastic differentiation in vitro.
CERAMICS INTERNATIONAL
(2023)
Article
Urology & Nephrology
Ziad A. Massy, Thomas Merkling, Sandra Wagner, Nicolas Girerd, Marie Essig, Christoph Wanner, Bengt C. Fellstrom, Patrick Rossignol, Faiez Zannad
Summary: The study revealed that statins have limited treatment efficacy in patients on dialysis with hyperphosphatemia. Higher serum phosphate levels, both at baseline and during treatment, were associated with reduced protective effects of statins on major adverse cardiovascular events and all-cause death. This suggests that the presence of hyperphosphatemia may contribute to the resistance of dialysis patients to statins.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Hiroto Hiyamuta, Shunsuke Yamada, Masatomo Taniguchi, Masanori Tokumoto, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono
Summary: This study demonstrates a significant association between high serum phosphate levels and the risk of sudden death in patients undergoing hemodialysis.
Article
Construction & Building Technology
Jean Noel Yankwa Djobo, Dietmar Stephan
Summary: This study reports the role of calcium in the acidic aluminum phosphate-activation of metakaolin and the characteristics of the resulting binder. It was found that a replacement rate higher than 6 wt% hinders the subsequent dissolution of metakaolin, and highly soluble calcium hydroxide improves the compressive strength while sparsely soluble calcium silicate decreases it.
CEMENT AND CONCRETE RESEARCH
(2022)
Article
Chemistry, Physical
Magdalena Teresa Spicher, Sebastian Patrick Schwaminger, Daniela von der Haar-Leistl, Marco Reindl, Friedrich Ernst Wagner, Sonja Berensmeier
Summary: This study demonstrates different binding mechanisms of two similar phosphate-binding agents and reveals the significant influence of the composition of the organic shell on the interaction between iron(oxyhydr)oxide nanoparticles and phosphate. The experiments show that, at low concentrations, phosphate is bound through complexation reactions, while at high concentrations, iron phosphate species are formed. The ligands in the shell play a crucial role in the binding mechanism.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biophysics
Fupo He, Jin Rao, Jielin Zhou, Wenhao Fu, Yao Wang, Yihang Zhang, Fei Zuo, Haishan Shi
Summary: Magnesium calcium phosphate composite bioceramic scaffolds were fabricated using 3D printing technology with Mg3(PO4)2 and β-Ca3(PO4)2 as starting materials. The porosity and compressive strength of the scaffolds could be adjusted by altering the sintering temperature and the formula of starting materials. The Ca3Mg3(PO4)4-based bioceramic scaffolds, prepared from 60 wt% Mg3(PO4)2 and 40 wt% β-Ca3(PO4)2, showed the highest compressive strength and stimulated cellular growth and osteoblastic differentiation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Physical
Cedric Grauffel, Todor Dudev, Carmay Lim
Summary: The study reveals that monophosphate-containing ligands prefer monodentate coordination with Mg2+ rather than Ca2+, while larger Ca2+ prefers bidentate binding. In a low-dielectric environment, negatively charged monophosphate-containing ligands favor Mg2+ binding. By promoting Mg2+ over Ca2+ binding, signaling monophosphates do not interfere with cellular Ca2+ signaling processes.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2021)
Article
Chemistry, Multidisciplinary
Vetharaj HephzibahRajam Arkin, Uttamchand Narendrakumar, Harishkumar Madhyastha, Inderchand Manjubala
Summary: Injectable calcium phosphate cement is a promising biomaterial for hard tissue repair, with recent developments in magnesium and strontium-doped cements showing improved setting time, mechanical strength, and cell attachment. The research aims to develop suitable self-setting cements with good biocompatibility, utilizing synthesized hydroxyapatite and additives for enhanced properties.
Article
Urology & Nephrology
Akiko Hashimoto, Jiaqi Gao, Yuki Kanome, Yukihiro Ogawa, Masaharu Nakatsu, Masahiro Kohno, Koji Fukui
Summary: This study evaluated cerium oxide as a potential phosphate binder, showing that it can adsorb phosphate at both acidic and neutral pH levels. Cerium oxide reduced serum phosphate concentrations in 5/6 nephrectomy model rats without causing hepatotoxicity, and it maintained serum creatinine and blood urea nitrogen levels.
Review
Chemistry, Medicinal
Robert Gosik, Krzysztof Danel
Summary: Research suggests that Chronic Kidney Disease will be the 5th main cause of global deaths by 2040, with hyperphosphatemia being a significant contributing factor. Various Phosphate Binders have been evaluated for their effectiveness and potential side effects, with different outcomes for each. Development of new Phosphate Binders should consider their ability to act as protective modifiers.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jeffrey Paulo H. Perez, Dominique J. Tobler, Helen M. Freeman, Andy P. Brown, Nicole S. Hondow, Case M. van Genuchten, Liane G. Benning
Summary: The study quantified the influence of As(iii) and As(v) on the crystallization of GR sulfate (GRSO4) and found that As(iii) had a stronger inhibitory effect than As(v), reducing structural coherence and ordering in As(iii)-bearing GRSO4 crystals. Mineral-bound As(iii) significantly increased the stability of GRSO4 phase and fully prevented its transformation to magnetite even after 720 hours.
ENVIRONMENTAL SCIENCE-NANO
(2021)
Article
Engineering, Multidisciplinary
Pengzhen Zhuang, Yue Yao, Xiaoxuan Su, Yanan Zhao, Kun Liu, Xiaopei Wu, Honglian Dai
Summary: MCPC has the ability to stimulate migration of vascular endothelial cells and up-regulate the expression of genes related to blood vessel formation, leading to improved wound healing and blood vessel formation. Additionally, MCPC can accelerate nerve regeneration, contributing to wound healing.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Materials Science, Ceramics
Teliang Lu, Yali Miao, Xinyuan Yuan, Yu Zhang, Jiandong Ye
Summary: In this study, the effects of Mg doping on the physicochemical and biological properties of BCP scaffold were systematically studied. The results showed that Mg doping improved the sintering of BCP scaffold and reduced the degradation rate at the initial soaking period, but damaged the lattice stability of BCP and increased the degradation rate at the later soaking period. BCP scaffolds with Mg doping content ≥3 mol.% could achieve long-term sustained release of Mg and promote osteogenic differentiation and angiogenic activity.
CERAMICS INTERNATIONAL
(2023)
Article
Urology & Nephrology
Xiaoling Ye, Jeroen P. Kooman, Frank M. van der Sande, Jochen G. Raimann, Len A. Usvyat, Yuedong Wang, Franklin W. Maddux, Peter Kotanko
Summary: The study found that both low and high phosphate levels were associated with higher risk of mortality across all age strata. Additionally, U-shaped relationships between phosphate levels and outcome persisted even for patients with low or high levels of nutritional and inflammatory markers.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Sharon M. Moe, Glenn M. Chertow, Patrick S. Parfrey, Yumi Kubo, Geoffrey A. Block, Ricardo Correa-Rotter, Tilman B. Drueeke, Charles A. Herzog, Gerard M. London, Kenneth W. Mahaffey, David C. Wheeler, Maria Stolina, Bastian Dehmel, William G. Goodman, Juergen Floege
Article
Urology & Nephrology
Patrick S. Parfrey, Tilman B. Drueeke, Geoffrey A. Block, Ricardo Correa-Rotter, Juergen Floege, Charles A. Herzog, Gerard M. London, Kenneth W. Mahaffey, Sharon M. Moe, David C. Wheeler, Yumi Kubo, Bastian Dehmel, William G. Goodman, Glenn M. Chertow
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2015)
Review
Urology & Nephrology
Alastair J. Hutchison, Rosamund J. Wilson, Svetlana Garafola, John Brian Copley
Article
Urology & Nephrology
Ramya Bhargava, Philip A. Kalra, Mark Hann, Paul Brenchley, Helen Hurst, Alastair J. Hutchison
Review
Urology & Nephrology
Alastair J. Hutchison, Ron Wald, Thomas F. Hiemstra
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2019)
Article
Urology & Nephrology
Tamara Glavinovic, Helen Hurst, Alastair Hutchison, Lina Johansson, Nicola Ruddock, Jeffrey Perl
PERITONEAL DIALYSIS INTERNATIONAL
(2020)
Article
Urology & Nephrology
Helen Eddington, Rajkumar Chinnadurai, Helen Alderson, Sara T. Ibrahim, Constantina Chrysochou, Darren Green, Ibi Erekosima, Alastair Hutchison, Abdalla Bubtana, Janet Hegarty, Philip A. Kalra
Summary: An open-label prospective randomized controlled trial was conducted on 36 hemodialysis patients to compare the effects of cinacalcet alongside standard therapy versus standard therapy alone on cardiovascular and CKD-MBD parameters over a 12-month period. The results showed that there was no significant benefit in bone and cardiovascular markers with the addition of cinacalcet to standard therapy. However, tight control of hyperphosphatemia and secondary hyperparathyroidism may lead to reductions in LVMI and CIMT, as observed in the study.
Article
Medicine, General & Internal
Katherine Wade, Beatrice Robertson-Jones, Alastair Hutchison
Article
Urology & Nephrology
Iain C. Macdougall, Andreas H. Bock, Fernando Carrera, Kai-Uwe Eckardt, Carlo Gaillard, David Van Wyck, Yvonne Meier, Sylvain Larroque, Amandine Perrin, Simon D. Roger
CLINICAL NEPHROLOGY
(2017)
Meeting Abstract
Transplantation
Alastair Hutchison, Ravi Thadhani, Gillian Hall, Andrew Whelton, Heinrich Achenbach, Jingyang Wu
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2017)
Article
Surgery
Sean Rezvani, Bachar Zelhof, Alastair Hutchison, Peter Selby, Michael Picton, Ben R. Grey
JOURNAL OF SURGICAL CASE REPORTS
(2016)
Article
Urology & Nephrology
Milind D. Nikam, James Ritchie, Anu Jayanti, Ondina A. Bernstein, Leonard Ebah, Paul Brenchley, Alastair Hutchison, Nicholas Chalmers, Sandip Mitra
Article
Urology & Nephrology
Ramya Bhargava, Philip A. Kalra, Paul Brenchley, Helen Hurst, Alastair Hutchison
INTERNATIONAL JOURNAL OF NEPHROLOGY
(2015)
Article
Public, Environmental & Occupational Health
Angel M. Chater, Rhian Parham, Steve Riley, Alastair J. Hutchison, Rob Horne
PSYCHOLOGY & HEALTH
(2014)
Article
Urology & Nephrology
Alastair Hutchison, Andrew Whelton, Ravi Thadhani, Heinrich Achenbach, Andrea Vergani, Jingyang Wu, Gillian Hall