Article
Medicine, General & Internal
Seok Hui Kang, Gui Ok Kim, Bo Yeon Kim, Eun Jung Son, Jun Young Do
Summary: This retrospective study investigated the impact of proton pump inhibitors (PPIs) on the survival rate of patients undergoing hemodialysis (HD). The study found a significant association between long-term PPI usage and increased mortality among HD patients, especially in those without a high gastrointestinal burden or comorbidities.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Mariana Sant'Ana, Joana Gameiro, Claudia Costa, Carolina Branco, Bernardo Marques da Silva, Nadiesda Peres, Ana Cardoso, Ana Mafalda Abrantes, Jose Agapito Fonseca, Cristina Outerelo, Cristina Resina, Jose Antonio Lopes
Summary: This study aimed to determine the predictive value of the C-Reactive Protein to Albumin ratio (CAR) for six-month mortality in incident hemodialysis (HD) patients. The results demonstrated that higher CAR was significantly associated with a higher mortality risk in the first six months of HD, highlighting the prognostic importance of malnutrition and inflammation in these patients.
Article
Multidisciplinary Sciences
Shouliang Hu, Runjing Wang, Tean Ma, Qingfeng Lei, Fanli Yuan, Yong Zhang, Dan Wang, Junzhang Cheng
Summary: This study investigated the association between preoperative C-reactive protein to albumin ratio (CAR) and arteriovenous fistula (AVF) dysfunction in Chinese hemodialysis patients. The study found that higher CAR levels were associated with an increased risk of AVF dysfunction. The relationship between CAR and AVF dysfunction also varied by catheter placement site.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Urology & Nephrology
Tony Lopez, Debasish Banerjee
Summary: Fluid overload is a common and important complication in patients with end-stage kidney failure receiving hemodialysis, leading to adverse outcomes, necessitating the search for accurate methods for assessing fluid status.
KIDNEY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Seok-Hui Kang, Bo-Yeon Kim, Eun-Jung Son, Gui-Ok Kim, Jun-Young Do
Summary: The study aimed to evaluate the effect of different types of beta-blockers on patient survival in hemodialysis. The results showed no significant difference in patient survival based on the use or types of beta-blockers.
Article
Urology & Nephrology
Shun Yoshikoshi, Yuta Suzuki, Shohei Yamamoto, Keigo Imamura, Manae Harada, Shiwori Osada, Atsuhiko Matsunaga
Summary: This study investigated the association between changes in anthropometric indicators over one year and hospitalization and mortality rates in hemodialysis patients. The results showed that increases in body mass index, mid-upper arm circumference, triceps skinfold, and mid-arm muscle circumference were associated with lower risks of all-cause hospitalizations and death. However, changes in calf circumference were not associated with clinical events. Therefore, routinely assessing these simple measures in clinical practice may provide additional prognostic information.
JOURNAL OF NEPHROLOGY
(2023)
Article
Multidisciplinary Sciences
Georg Lorenz, Yuli Shen, Renate Ilona Hausinger, Caroline Scheid, Marie Eckermann, Sophia Hornung, Joana Cardoso, Maciej Lech, Andrea Ribeiro, Bernhard Haller, Christopher Holzmann-Littig, Dominik Steubl, Matthias C. Braunisch, Roman Guenthner, Andreas Poschenrieder, Britt Freitag, Mario Weber, Peter Luppa, Uwe Heemann, Christoph Schmaderer
Summary: Extended cut-off filtration using medium cut-off membranes is safe for maintenance hemodialysis, but does not reduce a broad range of inflammatory mediators. However, it does have lasting effects on activated CD4+ T cells and warrants further investigation.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Malgorzata Kaczkan, Sylwia Czaja-Stolc, Malgorzata Szczuko, Arleta Drozd, Przemyslaw Rutkowski, Alicja Debska-Slizien, Sylwia Malgorzewicz
Summary: The concentration of water-soluble vitamins is often not measured in hemodialysis patients, leading to undiagnosed deficiencies. This study compared the blood concentration of water-soluble vitamins in hemodialysis patients with healthy subjects and assessed the impact of diabetes mellitus on these vitamins. The study found significantly lower levels of vitamin B-1, B-6, and B-12 in the hemodialysis group.
Article
Multidisciplinary Sciences
Lucia Visiedo, Laura Rey, Francisco Rivas, Francisca Lopez, Begona Tortajada, Rafael Gimenez, Jimena Abiles
Summary: Malnutrition is common in hemodialysis patients and can negatively impact quality of life. A nutritional intervention program can improve quality of life by addressing malnutrition in its early stages.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Luona Wen, Chunrong Tang, Yun Liu, Jie Jiang, Dee Zou, Wenxuan Chen, Shilin Xu, Yuqi Wang, Jingxian Qiu, Xiaoshi Zhong, Yan Liu, Rongshao Tan
Summary: This study found that non-protein calorie supplements may improve the nutritional status of MHD patients with PEW, including increasing subjective global assessment scores, reducing the proportion of PEW patients, improving body mass index, nutrition risk screening 2002 scores, mid-upper arm circumference, and mid-arm muscle circumference.
Article
Medicine, General & Internal
T. Ebert, A. R. Qureshi, C. Lamina, J. Fotheringham, M. Froissart, K. -U. Eckardt, D. C. Wheeler, J. Floege, F. Kronenberg, P. Stenvinkel
Summary: In patients with end-stage kidney disease, there is an inverse relationship between lipid profile and mortality in European haemodialysis patients, which is not affected by inflammation/malnutrition.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Ting-Yun Lin, Ping-Hsun Wu, Yi-Ting Lin, Szu-Chun Hung
Summary: The relationship between gut dysbiosis, inflammation, and adverse outcomes in chronic kidney disease patients is still unclear. Higher microbial diversity in hemodialysis patients is associated with a 74% lower risk of death. Nonsurvivors have lower microbial diversity and higher proinflammatory cytokine levels, with reduced abundance of certain beneficial bacteria like Succinivibrio and Anaerostipes.
NPJ BIOFILMS AND MICROBIOMES
(2021)
Article
Medicine, General & Internal
Marijana Mikacic, Marko Kumric, Martina Baricevic, Daria Tokic, Sanda Stojanovic Stipic, Ivan Cvitkovic, Daniela Supe Domic, Tina Ticinovic Kurir, Josko Bozic
Summary: This study aims to explore the dynamic changes of serum TWEAK levels in critically-ill COVID-19 patients, and found that serum TWEAK can predict in-hospital mortality and is associated with impaired testosterone levels observed in severe COVID-19.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Dorde Pojatic, Dajana Nikic, Ivana Tolj, Davorin Pezerovic, Andrijana Santic, Dunja Degmecic
Summary: This study found that Alexithymia in hemodialysis patients is associated with increased leukocyte counts, lower predialysis phosphorus values, and more pronounced daytime sleepiness. Alexithymia is an independent predictor of high daytime sleepiness in hemodialysis patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Lucyna Kozlowska, Jolanta Gromadzinska, Rafal Zwiech, Zbigniew Zbrog, Wojciech Wasowicz
Summary: The aim of this project was to evaluate the effectiveness of two types of nutritional interventions on hemodialysis patients. The results showed that providing a meal before dialysis had a positive impact on nutritional status and inflammatory markers. Further research and discussions are needed to improve the daily diet and dietary adjustments for hemodialysis patients.
Review
Urology & Nephrology
Mehmet Kanbay, Sidar Copur, Dimitrie Siriopol, Abdullah Burak Yildiz, Metehan Berkkan, Raluca Popa, Nuri Baris Hasbal, Alberto Ortiz, Mark A. Perazella
Summary: The development of acute kidney injury (AKI) in cancer patients receiving immune checkpoint inhibitors is associated with an increased risk of mortality.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Gregorio Romero-Gonzalez, Joaquin Manrique, Maria F. Slon-Roblero, Faeq Husain-Syed, Rafael De la Espriella, Fiorenza Ferrari, Jordi Bover, Alberto Ortiz, Claudio Ronco
Summary: Point-of-Care Ultrasonography (PoCUS) is a method that adds sonographic imaging to the classical physical examination to help clinicians answer specific questions at the bedside. In recent years, PoCUS has become a valuable tool in clinical practice, improving the accuracy of diagnosis and assessment of renal diseases.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Jose Portoles, Paula Lopez-Sanchez, Leyre Martin-Rodriguez, Maria Luisa Serrano-Salazar, Maria Valdenebro-Recio, Antonio Ramos, Rosa Maria Malo, Felipe Zalamea, Juan Manuel Martin-Giner, Maria Marques, Alberto Ortiz
Summary: This study analyzed the epidemiological characteristics of chronic kidney disease (CKD) and acute kidney injury (AKI) in 2878 hospitalized COVID-19 patients in Madrid, and found that CKD and AKI were independent risk factors for in-hospital mortality.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Luis M. Ruilope, Alberto Ortiz, Alejandro Lucia, Blanca Miranda, Gloria Alvarez-Llamas, Maria G. Barderas, Massimo Volpe, Gema Ruiz-Hurtado, Bertram Pitt
Summary: Chronic kidney disease (CKD) is a leading cause of death that requires early detection for effective management. The current diagnostic criteria for CKD only identify advanced stages, leaving a 'blind spot' in detection where kidney injury is present but undetectable. Elevated urinary albumin-excretion rate can predict future cardiovascular events. Implementing opportunistic or systematic albuminuria screening and therapy has the potential to improve cardiorenal outcomes and mitigate the projected burden of CKD and cardiovascular diseases in the future.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Jose Luis Morgado-Pascual, Beatriz Suarez-Alvarez, Vanessa Marchant, Pamela Basantes, Pierre-Louis Tharaux, Alberto Ortiz, Carlos Lopez-Larrea, Marta Ruiz-Ortega, Sandra Rayego-Mateos
Summary: This study found that the use of iBET drugs can reduce collagen accumulation in experimental glomerulosclerosis by inhibiting the accumulation and overexpression of collagen IV. The study also found that SOX9 plays an important role in kidney fibrosis, and iBET drugs can prevent the translocation of SOX9 into the nucleus. These findings provide further research evidence for the application of iBET drugs in the treatment of glomerulosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jonas Laget, Sam Hobson, Karen Muyor, Flore Duranton, Irene Cortijo, Piotr Bartochowski, Bernard Jover, Anne-Dominique Lajoix, Magnus Soderberg, Thomas Ebert, Peter Stenvinkel, Angel Argiles, Karolina Kublickiene, Nathalie Gayrard
Summary: Increased senescent cell burden and dysregulation of the NRF2 pathway play a role in vascular calcification. In vivo and in vitro studies showed increased senescence markers in calcified tissues and VSMCs exposed to uremic serum. NRF2 expression correlated with calcification in vivo but was depleted in vitro. These findings highlight the therapeutic potential of targeting senescence and the NRF2 pathway in the treatment of VC in CKD.
Article
Transplantation
Jorge E. Rojas-Rivera, Sevcan A. Bakkaloglu, Davide Bolignano, Ionut Nistor, Pantelis A. Sarafidis, Sokratis Stoumpos, Mario Gennaro Cozzolino, Alberto Ortiz, ERA ERBP
Summary: Chronic kidney disease (CKD) is diagnosed based on glomerular filtration rate (GFR) and urinary albumin:creatinine ratio (UACR). High cardiovascular risk is associated with moderate or severe CKD. The management recommendations for lupus nephritis (LN) and cardiovascular risk in rheumatic and musculoskeletal diseases do not consider albuminuria or CKD. The authors propose a change in the conceptual framework to treat LN as a cause of CKD and apply evidence from large CKD trials.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Food Science & Technology
Denise Mafra, Julie A. Kemp, Natalia A. Borges, Michelle Wong, Peter Stenvinkel
Summary: Residual kidney function is associated with better quality of life and outcome for patients with chronic kidney disease (CKD), and strategies should be implemented to preserve kidney function. Gut dysbiosis due to increased uremic toxin production and endotoxemia is a major cause of kidney damage, and various strategies, including diet, medications, and faecal transplantation, have been proposed to modulate the gut microbiota in these patients. Modifying gut microbiota composition may mitigate chronic kidney damage and preserve residual kidney function, but the effects of diet on residual kidney function remain limited.
Review
Urology & Nephrology
Pantelis Sarafidis, Fotini Iatridi, Charles Ferro, Maria-Eleni Alexandrou, Beatriz Fernandez-Fernandez, Mehmet Kanbay, Francesca Mallamaci, Ionut Nistor, Patrick Rossignol, Christoph Wanner, Mario Cozzolino, Alberto Ortiz, ERBP Board
Summary: Chronic kidney disease (CKD) in individuals with type 2 diabetes is a major public health issue. Renin-angiotensin system (RAS) blockers have been the standard treatment, but their effectiveness in reducing cardiovascular events and mortality is limited. Non-steroidal mineralocorticoid receptor antagonists (MRAs) have gained interest due to their better pharmacologic profile. Finerenone, the first compound of this class, has shown promise in reducing kidney disease progression and cardiovascular outcomes in patients with type 2 diabetes.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Alberto Ortiz
Summary: Diabetes is the leading cause of chronic kidney disease (CKD) and more research is needed to understand its distinct phenotypes in patients with CKD. Routine kidney biopsy may be overused in CKD patients with diabetes, and expanding the biopsy criteria may result in more complications. Limited resources should be allocated optimally for early diagnosis and preventive treatment.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Jose M. Valdivielso, Sol Carriazo, Marisa Martin, Beatriz Fernandez-Fernandez, Marcelino Bermudez-Lopez, Alberto Ortiz, Aladren Regidor, Jaume Almirall, Esther Ponz, Arteaga Coloma, Bajo Rubio, Diaz M Auxiliadora, Montserrat Belart Rodriguez, Antonio Gascon, Jordi Bover Sanjuan, Josep Bronsoms Artero, Juan B. Cabezuelo Romero, Salome Muray Cases, Jesus Calvino Varela, Pilar Caro Acevedo, Jordi Carreras Bassa, Aleix Cases Amenos, Elisabet Masso Jimenez, Rosario Moreno Lopez, Secundino Cigarran Guldris, Saray Lopez Prieto, Lourdes Comas Mongay, Isabel Comerma, M. Teresa Compte Jove, Marta Cuberes Izquierdo, Fernando de alvaro, Covadonga Hevia Ojanguren, Gabriel de Arriba de la Fuente, M. Dolores Pino, Rafael Diaz-Tejeiro Izquierdo, Marta Dotori, Veronica Duarte, Sara Estupinan Torres, M. Jose Fernandez Reyes, M. Loreto Fernandez Rodriguez, Guillermina Fernandez, Antonio Galan Serrano, Cesar Garcia Canton, Antonio L. Garcia Herrera, Mercedes Garcia Mena, Luis Gil Sacaluga, Maria Aguilar, Jose Luis Gorriz, Emma Huarte Loza, Jose Luis Lerma, Antonio Liebana Canada, Jesus Pedro Marin alvarez, Nadia Martin Alemany, Jesus Martin Garcia, Alberto Martinez Castelao, Maria Martinez Villaescusa, Isabel Martinez, Inigo Moina Eguren, Silvia Moreno Los Huertos, Ricardo Mouzo Mirco, Antonia Munar Vila, Ana Beatriz Munoz Diaz, Juan F. Navarro Gonzalez, Javier Nieto, Agustin Carreno, Enrique Novoa Fernandez, Alberto Ortiz, Beatriz Fernandez, Vicente Paraiso, Miguel Perez Fontan, Ana Peris Domingo, Celestino Pinera Haces, M. Dolores Prados Garrido, Mario Prieto Velasco, Carmina Puig Mari, Maite Rivera Gorrin, Esther Rubio, Pilar Ruiz, Mercedes Salgueira Lazo, Ana Isabel Martinez Puerto, Jose Antonio Sanchez Tomero, Jose Emilio Sanchez, Ramon Sans Lorman, Ramon Saracho, Maria Sarrias, Daniel Seron, Maria Jose Soler, Clara Barrios, Fernando Sousa, Daniel Toran, Fernando Tornero Molina, Jose Javier Uson Carrasco, Ildefonso Valera Cortes, M. Merce Vilaprinyo del Perugia, Rafael C. Virto Ruiz
Summary: Hyperkalemia is common among patients with chronic kidney disease, but differential risk factors and outcomes exist between men and women. Smoking is identified as a risk factor for hyperkalemia in men, while hyperkalemia is associated with an increased risk of cardiovascular events in men. Additionally, women are more likely to stop using RAASi.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Xiejia Li, Abdul Rashid Qureshi, Mohamed E. Suliman, Olof Heimburger, Peter Barany, Peter Stenvinkel, Bengt Lindholm
Summary: This study examined the association of interleukin-6 (IL-6) and albumin levels with outcomes in chronic kidney disease (CKD) patients, using the IL-6 to albumin ratio (IAR) as a predictor of death risk in incident dialysis patients. The results showed that IAR had a higher discrimination for predicting all-cause mortality compared to IL-6 and albumin alone. Additionally, high and middle IAR tertiles were significantly associated with an increased risk of all-cause mortality.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Correction
Urology & Nephrology
Carla Maria Avesani, Peter Stenvinkel, Alice Sabatino, Claudia D'Alessandro, Giorgina Barbara Piccoli
JOURNAL OF NEPHROLOGY
(2023)
Review
Urology & Nephrology
Laiis de Souza Gouveia Moreira, Isabela de Souza da Costa Brum, Drielly C. M. de Vargas Reis, Liana Trugilho, Tuany R. Chermut, Marta Esgalhado, Ludmila F. M. F. Cardozo, Peter Stenvinkel, Paul G. Shiels, Denise Mafra
Summary: Cinnamon, a widely used spice and traditional herbal medicine, may have beneficial effects on cardiovascular disease, obesity, and diabetes. However, its effectiveness for chronic kidney disease (CKD) remains uncertain. Bioactive compounds in cinnamon can mitigate common complications in CKD patients, such as oxidative stress, inflammation, hyperglycemia, gut dysbiosis, and dyslipidemia. This narrative review explores the mechanisms by which cinnamon may alleviate CKD complications and its potential role as an additional nutritional strategy for this patient group.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2023)