Article
Medicine, General & Internal
Jose Manuel Munoz-Terol, Jose L. Rocha, Pablo Castro-de La Nuez, Emilio Garcia-Cabrera, Angel Vilches-Arenas
Summary: Chronic kidney disease is a non-communicable disease that is growing rapidly in terms of morbidity and mortality. Renal transplantation is the first choice for end-stage kidney disease patients, while dialysis is an alternative. This study aims to assess the potential years of life lost by patients on renal replacement therapy. The average potential years of life lost for dialysis patients is 9.0 years, while this figure decreases to 2.2 years for kidney transplant recipients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Deborah Kreher, Bero Luke Vincent Ernst, Dirk Ziebolz, Rainer Haak, Jonathan de Fallois, Thomas Ebert, Gerhard Schmalz
Summary: Patients on renal replacement therapy (RRT) often experience oral problems, such as dry mouth, periodontal disease, and dental caries. This systematic review aimed to assess the prevalence of caries in RRT patients. A comprehensive literature search was conducted in August 2022 using PubMed, Web of Science, and Scopus databases. Out of the 653 studies identified, 33 clinical investigations were included in the analysis. The majority of the studies focused on hemodialysis patients and used the decayed-(D), missing- and filled-teeth (DMF-T) index to assess caries burden.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Marta Calatroni, Gabriella Moroni, Claudio Ponticelli
Summary: Sarcoidosis is a systemic inflammatory disease of unknown cause that can affect the kidneys in up to 25-30% of cases. Early diagnosis and corticosteroid treatment can improve the prognosis, but in rare cases, renal sarcoidosis can lead to kidney failure requiring renal replacement therapy. Acute kidney injury in sarcoidosis can be caused by granulomatous interstitial nephritis or hypercalcemia. These conditions are often asymptomatic and can progress to end stage renal disease if not diagnosed or detected late. Dialysis and renal transplantation can be effective treatment options for patients with ESKD caused by sarcoidosis, with outcomes comparable to other causes of kidney failure.
FRONTIERS IN MEDICINE
(2023)
Review
Pediatrics
Johanna Lemke, Raphael Schild, Martin Konrad, Lars Pape, Jun Oh
Summary: With the increasing number of migrants, the pediatric nephrology community is dealing with challenges in managing ESKD in pediatric refugee population. Data on the care of these children on RRT is lacking, and they often face obstacles such as psychosocial issues, cultural differences, language barriers, and administrative problems. Treatment centers need to provide additional resources to address these challenges.
PEDIATRIC NEPHROLOGY
(2021)
Article
Critical Care Medicine
Matthew E. Cove, Graeme MacLaren, Daniel Brodie, John A. Kellum
Summary: The optimal timing of renal replacement therapy (RRT) in critically ill patients with acute kidney injury (AKI) has been debated, with high-quality evidence now supporting a deferred approach for up to 72 hours unless life-threatening indications develop. Physicians' judgment is still essential in identifying appropriate patients for expectant management.
Article
Critical Care Medicine
Thummaporn Naorungroj, Ary Serpa Neto, Amanda Wang, Martin Gallagher, Rinaldo Bellomo
Summary: This study investigated the impact of renal replacement therapy (RRT) modality and treatment protocol on RRT dependence in critically ill patients with acute kidney injury. The results showed that there was no difference in RRT dependence at day 28 between continuous RRT (CRRT) and intermittent hemodialysis (IHD). However, among survivors, CRRT-first was associated with decreased 28-day RRT dependence and more RRT-free days. Additionally, the ATN treatment protocol in CRRT-first patients was associated with increased RRT dependence and mortality.
Article
Medicine, General & Internal
Subin Hwang, Danbee Kang, Hyejeong Park, Youngha Kim, Eliseo Guallar, Junseok Jeon, Jung-Eun Lee, Wooseong Huh, Gee-Young Suh, Juhee Cho, Hye-Ryoun Jang
Summary: The impact of renal replacement therapy (RRT) type and pre-existing kidney disease on outcomes in patients with acute kidney injury (AKI) has been investigated. The study found that the continuous RRT (CRRT) group had a higher risk of in-hospital mortality, while the dialysis group had a lower risk, especially in patients with pre-existing kidney disease. Both the dialysis and CRRT groups had a higher risk of end-stage kidney disease (ESKD) compared to the control group, with the CRRT group having an even higher risk in patients without pre-existing kidney disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Fernando G. Zampieri, Bruno R. da Costa, Suvi T. Vaara, Francois Lamontagne, Bram Rochwerg, Alistair D. Nichol, Shay McGuinness, Danny F. McAuley, Marlies Ostermann, Ron Wald, Sean M. Bagshaw
Summary: The reanalysis using Bayesian framework of the STARRT-AKI trial found that an accelerated strategy of kidney-replacement therapy initiation did not offer clinically important benefits compared to a standard strategy. Patients receiving the accelerated strategy may have fewer days alive and free from kidney-replacement therapy.
Article
Medicine, General & Internal
Rita Afonso, Roberto Calcas Marques, Henrique Borges, Ana Cabrita, Ana Paula Silva
Summary: The calcium/magnesium ratio is an independent predictor for the early initiation of renal replacement therapy.
Article
Critical Care Medicine
Stephane Gaudry, Francois Grolleau, Saber Barbar, Laurent Martin-Lefevre, Bertrand Pons, Eric Boulet, Alexandre Boyer, Guillaume Chevrel, Florent Montini, Julien Bohe, Julio Badie, Jean-Philippe Rigaud, Christophe Vinsonneau, Raphael Porcher, Jean-Pierre Quenot, Didier Dreyfuss
Summary: This study reassessed the impact of choosing intermittent hemodialysis (IHD) or continuous renal replacement therapy (CRRT) as the first modality for patients with severe acute kidney injury (AKI), using secondary analysis of two multicenter randomized controlled trials. The results showed that CRRT as the first modality did not appear to provide a survival advantage or better kidney recovery compared to IHD, and may even be associated with a less favorable outcome in patients with lesser severity of disease.
Review
Anesthesiology
N. Boyer, K. Horne, N. M. Selby, L. G. Forni
Summary: Kidney disease is common in intensive care units and can greatly impact prescribing and therapeutic management due to the kidneys' role in maintaining whole body homeostasis. This review explores the pathophysiology of acute kidney injury and chronic kidney disease in critically ill patients. It covers various aspects of renal dysfunction management, including kidney replacement therapy, acute kidney injury management, and the use of novel biomarkers for identifying and stratifying patients. Early involvement of nephrology specialists can improve outcomes and provide valuable guidance for patients with end stage kidney disease or already known to nephrology services. Ongoing research questions within this field are also discussed.
Article
Biochemistry & Molecular Biology
Anna Maria Meyer, Lena Pickert, Annika Heess, Ingrid Becker, Christine Kurschat, Malte P. Bartram, Thomas Benzing, Maria Cristina Polidori
Summary: The negative impact of chronic kidney disease (CKD) on older patients' health and quality of life has been well documented. This study found that most older CKD inpatients were prefrail or frail, and a comprehensive geriatric assessment can accurately assess the frailty and long-term prognosis of these patients. Kidney transplant recipients and patients with hypoalbuminemia had a higher frailty and risk of mortality. Further research is needed to explore the prognostic and frailty-related signature of laboratory biomarkers in CKD.
Article
Urology & Nephrology
Samira Bell, Jacqueline Campbell, Emilie Lambourg, Chrissie Watters, Martin O'Neil, Alison Almond, Katharine Buck, Edward J. Carr, Laura Clark, Zoe Cousland, Mark Findlay, Nicola Joss, Wendy Metcalfe, Michaela Petrie, Elaine Spalding, Jamie P. Traynor, Vinod Sanu, Peter Thomson, Shona Methven, Patrick B. Mark
Summary: The study in Scotland found that 93% of KRT-treated patients had received two doses of an approved COVID-19 vaccine, but the effectiveness of the vaccine against infection and hospitalization was only 33% and 38%, respectively. Fully vaccinated patients had higher mortality rates and additional strategies are urgently needed to reduce the risk of COVID-19 infection and complications in this population.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Immunology
Xiaopeng Yang, Shasha Tian, Hui Guo
Summary: This meta-analysis examined the incidence of AKI and the use of RRT in COVID-19 patients, finding them to be significant public health concerns. Early and appropriate interventions are recommended to improve patient outcomes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Editorial Material
Urology & Nephrology
Sol Carriazo, Alberto Ortiz
Summary: The European Renal Association (ERA) Registry Annual Report 2019 focuses on the differences in primary renal disease, treatment modality, kidney donor type, and survival probabilities among different age categories. It also reveals the correlation between KRT incidence and the median age at the start of KRT, as well as the correlation between the median age at the start of KRT and per capita GDP.
CLINICAL KIDNEY JOURNAL
(2022)
