Review
Immunology
Arsheena Yassin, Mariya Huralska, Jason M. Pogue, Deepali Dixit, Robert G. Sawyer, Keith S. Kaye
Summary: The prevalence of multidrug-resistant gram-negative bacterial infections has significantly increased in the past decade, leading to higher rates of morbidity and mortality. Treating these infections presents challenges, particularly for critically ill patients with limited margin for error. The availability of new therapies has improved treatment options, but optimal clinical and therapeutic approaches for managing these infections still need to be established.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Pharmacology & Pharmacy
Chuanhai Wang, Deqing Yang, Yifan Wang, Wentao Ni
Summary: Cefiderocol is a promising powerful weapon for treating multidrug-resistant (MDR) infections, showing high in vitro and in vivo activity, especially against carbapenem-resistant isolates. Clinical trials have demonstrated its efficacy in treating complicated urinary tract infection and nosocomial pneumonia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Yuvaneswary Veloo, Syahidiah S. A. Thahir, Sakshaleni Rajendiran, Lim K. Hock, Norazah Ahmad, Vickneshwaran Muthu, Rafiza Shaharudin
Summary: The indiscriminate use of antibiotics in poultry farming has led to the emergence of antibiotic-resistant bacteria in poultry products and the surrounding environment. This study found high rates of multidrug-resistant Gram-negative bacteria in the environment of poultry farms, with some strains exhibiting resistance to multiple antibiotics. The presence of these bacteria poses a significant threat to the effectiveness of available antibiotics in treating infectious diseases. Efforts to regulate antibiotic use and conduct research on One Health issues are necessary to combat and prevent the spread of antibiotic-resistant bacteria.
MICROBIOLOGY SPECTRUM
(2022)
Article
Public, Environmental & Occupational Health
Z. Elnasser, R. Elsamarneh, H. Obeidat, Z. Amarin, S. Jaradat, N. Kaplan
Summary: The study identified multidrug-resistant Gram negative bacteria isolates with high resistance to various antibiotics, including approximately 21.4% resistance to tigecycline. These pathogens also carried resistance-related genes such as AcrB, RamR, and TetA.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Microbiology
Christine A. Pybus, Christina Felder-Scott, Victor Obuekwe, David E. Greenberg
Summary: The study compared the antimicrobial activity of Cefiderocol with seven commonly used antibiotics against multidrug-resistant pathogens, finding that Cefiderocol had potent inhibitory effects on biofilms of various pathogens, with consistently lower MIC90 values compared to other antibiotics.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Weijie Wang, Xiaoli Zhu, Huan Luo, Zheng Wang, Anjin Hong, Jie Zeng, Li Li, Dai Wang, Xianming Deng, Xilin Zhao
Summary: As the increase in antimicrobial resistance continues, the options for effectively treating multidrug-resistant (MDR) Gram-negative infections are decreasing. Finding ways to enhance the lethality of old agents with unique molecular targets is important, as new antimicrobial development is increasingly difficult. This study showed that the old antibiotic bicyclomycin has good bacteriostatic activity against multiple clinical isolates of MDR Gram-negative pathogens. Additionally, the combination of bicyclomycin with doxycycline showed enhanced efficacy in inhibiting bacterial growth and in vivo killing, suggesting the potential of bicyclomycin-containing regimens as new treatment options for MDR Gram-negative infections caused by specific pathogens.
MICROBIOLOGY SPECTRUM
(2023)
Article
Chemistry, Medicinal
Kenneth I. Onyedibe, Ansley M. Nemeth, Neetu Dayal, Richard D. Smith, Jones Lamptey, Robert K. Ernst, Roberta J. Melander, Christian Melander, Herman O. Sintim
Summary: Researchers have discovered a compound called HSD1624 that enhances the effectiveness of the antibiotic colistin against resistant bacteria in multiple strains.
ACS INFECTIOUS DISEASES
(2023)
Review
Infectious Diseases
Sisi Zhen, Hui Wang, Sizhou Feng
Summary: CAZ-AVI is a valuable therapeutic option for MDR-GNB infections, particularly for KPC or OXA-48 CRE infections. It shows significant benefits and improved clinical outcomes, even in immunocompromised patients. Early use of CAZ-AVI is associated with better efficacy. However, resistance development in CRE and MDR-PA against CAZ-AVI is a concern, and further investigations are needed.
Article
Immunology
Sharon Ong'uti, Mary Czech, Elizabeth Robilotti, Marisa Holubar
Summary: Cefiderocol, a novel injectable siderophore cephalosporin, is effective against multidrug-resistant gram-negative bacteria by hijacking the bacterial iron transport system. It has broad-spectrum antibacterial activity, including against carbapenem-resistant and Acinetobacter baumannii strains.
CLINICAL INFECTIOUS DISEASES
(2022)
Letter
Immunology
Ashka Patel, Michele Emerick, Marie K. Cabunoc, Michelle H. Williams, Michael Anne Preas, Gregory Schrank, Ronald Rabinowitz, Paul Luethy, J. Kristie Johnson, Surbhi Leekha
Summary: The rapid spread of multidrug-resistant gram-negative bacteria among patients in a dedicated coronavirus disease care unit in a Maryland hospital was attributed to factors such as critical illness, high antibiotic use, double occupancy of single rooms, and modified infection prevention practices. Surveillance culturing played a key role in identifying and controlling the outbreak.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Microbiology
Yuhang Wang, Junfeng Su, Ziyan Zhou, Jie Yang, Wenjuan Liu, Yafen Zhang, Pengyu Zhang, Tingting Guo, Guocai Li
Summary: As multidrug-resistant pathogens emerge and spread rapidly, novel antibiotics are urgently needed. Traditional Chinese medicine, such as baicalein, can be used as an adjuvant to enhance the efficacy of antibiotics. Baicalein was found to potentiate doxycycline against multidrug-resistant Gram-negative pathogens by disrupting the bacterial membrane and enhancing antibiotic entry. It can also increase the production of reactive oxygen species and inhibit multidrug efflux pumps and biofilm formation to potentiate antibiotic efficacy.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Arianne Lovey, Mila Krel, Allen Borchardt, Thomas Brady, Jason N. Cole, Quyen-Quyen Do, Joanne Fortier, Grayson Hough, Wanlong Jiang, Alain Noncovich, Les Tari, Qiping Zhao, James M. Balkovec, Yanan Zhao, David S. Perlin
Summary: ADCs have the potential to bind strongly to drug-resistant G- pathogens, regardless of lipopolysaccharide modifications, indicating a promising treatment alternative in infections caused by drug-resistant G- bacteria.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Su Min Son, Joonbeom Kim, Sangryeol Ryu
Summary: The study introduces a potential biocontrol agent, a fusion endolysin called Lys1S-L9P, which shows high bactericidal effects and biofilm eradication capabilities against MDR Gram-negative bacteria. It also demonstrates stability at various storage temperatures and no cytotoxicity against human cells, making it a promising candidate for clinical use.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Chemistry, Medicinal
Elnaz Harifi Mood, Lise Goltermann, Camilla Brolin, Lina M. Cavaco, Alireza Japoni Nejad, Niloofar Yavari, Nicki Frederiksen, Henrik Franzyk, Peter E. Nielsen
Summary: The peptidomimetic CEP-136 significantly potentiates the antibacterial activity of clinically important antibiotics against several human pathogens, showing strong synergy with some combinations resulting in over 50-fold reduction in antibiotic concentration. Mechanistic studies suggest the potentiation effect arises from permeabilization of the Gram-negative bacteria's outer membrane lipopolysaccharide layer. Additionally, CEP-136 exhibits low toxicity to mammalian cells and mice, making it a promising compound for developing adjuvants to combat infections by multidrug-resistant Gram-negative bacteria.
ACS INFECTIOUS DISEASES
(2021)
Article
Chemistry, Medicinal
Wenhui Guo, Yan Liu, Zhuocheng Yao, Huijing Zhou, Xiuxiu Wang, Zeyu Huang, Xiaotuan Zhang, Qing Wu, Tieli Zhou
Summary: This study found that bithionol (BT), an FDA-approved anthelminthic drug, exhibited a synergistic antibacterial effect with colistin (COL) against colistin-resistant Gram-negative bacteria (COL-R GNB). In addition to reversing the sensitivity of COL-R GNB to COL, BT also reduced bacterial biofilm formation and showed a scavenging effect on mature biofilm. The BT/COL combination demonstrated a synergistic antibacterial effect both in vitro and in vivo, and BT was considered safe at the concentrations used.
ACS INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Erika M. C. D'Agata, Daniel Habtemariam, Susan Mitchell
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2015)
Article
Immunology
Erica M. C. D'Agata, Glenn F. Webb, Mary Ann Horn, Robert C. Moellering, Shigui Ruan
CLINICAL INFECTIOUS DISEASES
(2009)
Article
Immunology
Erin O'Fallon, Shiva Gautam, Erika M. C. D'Agata
CLINICAL INFECTIOUS DISEASES
(2009)
Article
Public, Environmental & Occupational Health
Erin O'Fallon, Robert Schreiber, Ruth Kandel, Erika M. C. D'Agata
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2009)
Article
Public, Environmental & Occupational Health
Aurora Pop-Vicas, E. Tacconelli, Stefan Gravenstein, Bing Lu, Erika M. C. D'Agata
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2009)
Article
Microbiology
A. Y. Peleg, Y. Tilahun, M. J. Fiandaca, E. M. C. D'Agata, L. Venkataraman, R. C. Moellering, G. M. Eliopoulos
JOURNAL OF CLINICAL MICROBIOLOGY
(2009)
Article
Geriatrics & Gerontology
Aurora Pop-Vicas, Susan L. Mitchell, Ruth Kandel, Robert Schreiber, Erika M. C. D'Agata
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2008)
Article
Immunology
L. E. Johnson, E. M. C. D'Agata, D. L. Paterson, L. Clarke, Z. A. Qureshi, B. A. Potoski, A. Y. Peleg
TRANSPLANT INFECTIOUS DISEASE
(2009)
Review
Public, Environmental & Occupational Health
R. Araos, Erika M. C. D'Agata
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2019)
Review
Public, Environmental & Occupational Health
Erika M. C. D'Agata, Sara F. Geffert, Rebecca McTavish, Florence Wilson, Chris Cameron
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2019)
Article
Medicine, General & Internal
Susan L. Mitchell, Erika M. C. D'Agata, Laura C. Hanson, Andrea J. Loizeau, Daniel A. Habtemariam, Timothy Tsai, Ruth A. Anderson, Michele L. Shaffer
Summary: The study aimed to test the effectiveness of a multicomponent intervention in improving the management of suspected UTIs and LRIs in nursing home residents with advanced dementia. Despite high adherence to the training, the intervention did not significantly reduce antimicrobial use, particularly in cases of LRIs.
JAMA INTERNAL MEDICINE
(2021)
Review
Public, Environmental & Occupational Health
Yousef M. Elfanagely, Joshua Ray Tanzer, Anuoluwapo Shobayo, Mouhand F. H. Mohamed, Jonathan J. C. Ho, Douglas Shemin, Laura Pavlech, Erika M. C. D'Agata
Summary: Patients requiring maintenance hemodialysis have a higher risk of CDI compared to those not requiring hemodialysis, and the rates of CDI are increasing in both groups.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Medicine, Research & Experimental
Meghan Hendricksen, Andrea J. Loizeau, Daniel A. Habtemariam, Ruth A. Anderson, Laura C. Hanson, Erika M. C. D'Agata, Susan L. Mitchell
Summary: This study examined facility and provider characteristics associated with adherence to the TRAIN-AD program. The results showed that being a nurse was associated with higher likelihood of attending training seminars, while providers who were in facilities when implementation began and in facilities with better quality ratings were more likely to complete the online course. Prevalent participation and higher facility quality were also significantly associated with greater adherence to either seminar or online course.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Aislinn D. Rowan-Nash, Rafael Araos, Erika M. C. D'Agata, Peter Belenky
Letter
Urology & Nephrology
Qadeer Farhan, Douglas Shemin, Fizza S. Gillani, Erika M. C. D'Agata