Review
Biochemistry & Molecular Biology
Steven Char, Max Y. Jin, Vinicius Tieppo Francio, Nasir Hussain, Eric J. Wang, Mahmoud Morsi, Vwaire Orhurhu, Larry J. Prokop, Adam Fink, Ryan S. D'Souza
Summary: This review synthesized data from prospective studies on the efficacy of peripheral nerve stimulation (PNS) for neuropathic pain. The results showed that there is limited and low-quality evidence supporting the effectiveness of PNS for peripheral neuropathic pain, with modest improvement in pain and neurological function. Only PNS for phantom limb pain had moderate level evidence.
Review
Biochemistry & Molecular Biology
Lady Christine Ong Sio, Brian Hom, Shuchita Garg, Alaa Abd-Elsayed
Summary: Peripheral nerve stimulation (PNS) has been widely used for treating chronic pain, although its mechanism of action remains largely unknown. The gate control theory proposed by Melzack and Wall in the 1960s has been the mainstay for understanding its mechanism. This review article discusses the mechanism of action, safety, and effectiveness of PNS in treating chronic pain, as well as current PNS devices available in the market.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Alaa Abd-Elsayed, Mitchell K. Keith, Nancy N. Cao, Kenneth J. Fiala, Joshua M. Martens
Summary: This study suggests the potential role of PNS therapy in improving pain levels in patients with various neuropathies. However, further research is needed to evaluate the efficacy of PNS therapy for pain management and complications associated with PNS device placements.
Article
Biotechnology & Applied Microbiology
Haocheng Zhou, Rui Han, Li Chen, Zhen Zhang, Xiaobo Zhang, Jianlong Wang, Zuoliang Liu, Dong Huang
Summary: This study found that both spinal cord stimulation (SCS) and peripheral nerve stimulation (PNS) can induce cortical alpha oscillation changes in patients with zoster-related pain, which may partly mediate the analgesic effect of implantable electrical nerve stimulation (ENS).
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vincent Yaccarino, Max Y. Jin, Alaa Abd-Elsayed, Jacob M. Kraemer, Nalini Sehgal
Summary: This article briefly introduces the evolution, mechanisms, applications, and complications of peripheral nerve stimulation. The latest technology provides new treatment options for chronic neuropathic pain of the upper extremity.
Review
Clinical Neurology
Standiford Helm, Nikita Shirsat, Aaron Calodney, Alaa Abd-Elsayed, David Kloth, Amol Soin, Shalini Shah, Andrea Trescot
Summary: PNS shows level II evidence for treating refractory peripheral nerve injury and level III evidence for certain other pain conditions. The risk of adverse events with PNS is generally low compared to spinal cord stimulation. However, there is a lack of literature on certain indications for PNS treatment.
Review
Automation & Control Systems
Christine Beauchene, Claire A. Zurn, Wanru Duan, Yun Guan, Sridevi Sarma
Summary: This research has constructed linear phenomenological models of spinal cord activity in chronic pain and healthy conditions, and applied closed-loop control techniques to drive the dynamics of the chronic pain model into normal ranges of physiological pain. This proof-of-concept computational framework is expected to guide the development of new closed-loop PNS therapies for chronic pain.
ANNUAL REVIEWS IN CONTROL
(2022)
Review
Biochemistry & Molecular Biology
Clayton Busch, Olivia Smith, Tristan Weaver, Jayesh Vallabh, Alaa Abd-Elsayed
Summary: Peripheral nerve stimulation (PNS) is a widely used interventional pain treatment modality for chronic lower extremity pain. Despite the lack of large prospective evidence, PNS has shown potential for improving pain scores, functionality, and opioid consumption, making it a viable option for patients with chronic lower extremity pain.
Review
Anesthesiology
Jijun Xu, Zhuo Sun, Jiang Wu, Maunak Rana, Joshua Garza, Alyssa C. Zhu, Krishnan Chakravarthy, Alaa Abd-Elsayed, Ellen Rosenquist, Hersimren Basi, Paul Christo, Jianguo Cheng
Summary: PNS may be effective in managing chronic headaches, postamputation pain, chronic pelvic pain, and chronic low back and lower extremity pain.
Article
Medicine, Research & Experimental
Selina Johnson, Anne Marshall, Dyfrig Hughes, Emily Holmes, Florian Henrich, Turo Nurmikko, Manohar Sharma, Bernhard Frank, Paul Bassett, Andrew Marshall, Walter Magerl, Andreas Goebel
Summary: Two interlinked studies examined the therapeutic LTD for chronic peripheral nerve injury pain, with the clinical trial showing non-significant results and the mechanistic study indicating improvement in mechanical hyperalgesia.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Anesthesiology
Alice Huai-Yu Li, Anuj Bhatia, Amit Gulati, Einar Ottestad
Summary: The use of peripheral nerve stimulation (PNS) in interventional pain management (IPM) for refractory neuropathic pain (NP) has increased in recent years. However, there is a lack of high-quality evidence and guidelines on this topic. A survey was conducted to understand the perception of physicians with expertise in treating NP regarding IPM and the role of PNS. The survey results showed that the distal common peroneal, tibial, and sural nerves were most frequently targeted with PNS, and persistent postsurgical pain was the most common indication for PNS.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Ryan S. D'Souza, Yeng F. Her, Max Y. Jin, Mahmoud Morsi, Alaa Abd-Elsayed
Summary: This study conducted a systematic review to assess the impact of neuromodulation therapy on pain intensity and neurological function in patients with chemotherapy-induced peripheral neuropathy (CIPN). The results suggest that dorsal column spinal cord stimulation (SCS), dorsal root ganglion stimulation (DRG-S), and peripheral nerve stimulation (PNS) may reduce pain severity in CIPN patients, but the effects on neurological function remain uncertain.
Review
Medicine, General & Internal
Agustin Garcia-Collado, Juan A. Valera-Calero, Cesar Fernandez-de-las-Penas, Jose L. Arias-Buria
Summary: This paper assesses the effects of percutaneous electrical nerve stimulation (PENS) on pain- and function-related outcomes. The study found that PENS had positive effects on nerve tissue, but due to heterogeneity in populations, interventions, and follow-up periods, pooling analyses were not possible. Further research is needed to determine the application of PENS in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Fei Jin, Tong Li, Tao Yuan, Lijuan Du, Chengteng Lai, Qi Wu, Ying Zhao, Fengyu Sun, Long Gu, Ting Wang, Zhang-Qi Feng
Summary: A fully implantable neural electrical stimulation (FI-NES) system has been developed, providing a physiologically adaptive function for promoting the recovery of peripheral nerve injury (PNI) with highly self-responsive parameters derived from the body itself. The system shows significant results in accelerating PNI recovery and is also suitable for other tissue injuries or neurodegenerative diseases.
ADVANCED MATERIALS
(2021)
Article
Anesthesiology
Meghan McCullough, Deborah Kenney, Catherine Curtin, Einar Ottestad
Summary: Treatment of saphenous neuralgia has always been challenging. Our case series demonstrates the potential of peripheral nerve stimulation as a treatment for saphenous neuralgia. Comparative effectiveness studies are needed to assess whether our results are clinically significant.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)