Article
Anesthesiology
Donna L. Kennedy, Jan Vollert, Deborah Ridout, Caroline M. Alexander, Andrew S. C. Rice
Summary: The DFNS quantitative sensory testing method can effectively identify changes in sensory phenotype in patients with entrapment neuropathy, which are closely related to symptom changes after clinical interventions. In an entrapment neuropathy model, sensory phenotype is independent of disease severity and may reflect the underlying neuropathophysiology.
Article
Cell Biology
Huixing Wang, Xiaodong Huo, Chenyang Han, Jiang Ning, Hongguang Chen, Bo Li, Jingzhi Liu, Wenting Ma, Quanbo Li, Yonghao Yu, Kemei Shi
Summary: The study in rats indicated that ferroptosis is involved in the development of neuropathic pain by blocking neuron and astrocyte activation in the spinal dorsal horn.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Myrna Deciga-Campos, Rodrigo Villafan-Gutierrez, Josue Vidal Espinosa-Juarez, Osmar Antonio Jaramillo-Morales, Francisco Javier Lopez-Munoz
Summary: The study found that specific combinations of gabapentin and haloperidol can synergistically reduce nerve injury-induced allodynia and hyperalgesia, demonstrating an antiallodynic and antihyperalgesic effect.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Dermatology
Sara Moradi Tuchayi, Ying Wang, Alla Khodorova, Isaac J. Pence, Conor L. Evans, R. Rox Anderson, Ethan A. Lerner, Clifford J. Woolf, Lilit Garibyan
Summary: We developed a neural selective and injectable cryoneurolysis method using ice slurry, which effectively reduces cutaneous pain caused by skin disease. This method shows comparable effects on nerve structure and function compared to an FDA-approved cryoneurolysis device. The decrease in mechanical pain from slurry injection, although less profound than that of the FDA-approved device, lasts longer without inducing dysesthesia.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Immunology
Mohammad Mehdi Haghighat Lari, Hamid Reza Banafshe, Elahe Seyed Hosseini, Hamed Haddad Kashani
Summary: In this study, the chronic administration of risperidone was found to be effective in reducing heat hyperalgesia and allodynia in rats with neuropathic pain induced by the CCI model. However, acute administration of risperidone did not show any significant changes in behavioral tests. Gene expression analysis indicated an increase in IL-4 and IL-10 gene expression in the risperidone group compared to the sham group.
INFLAMMOPHARMACOLOGY
(2023)
Article
Anesthesiology
Julia Forstenpointner, Ruth Ruscheweyh, Nadine Attal, Ralf Baron, Didier Bouhassira, Elena K. Enax-Krumova, Nanna B. Finnerup, Rainer Freynhagen, Janne Gierthmuehlen, Per Hansson, Troels S. Jensen, Christoph Maier, Andrew S. C. Rice, Maerta Segerdahl, Thomas Toelle, Rolf-Detlef Treede, Jan Vollert
Summary: The study revealed that hypersensitivity symptoms, including hyperalgesia and allodynia, are present in patients with central and peripheral lesions of the somatosensory system, even if they do not report spontaneous pain. There was a difference in pain sensitivity between painful and painless neuropathic conditions, with hyperalgesia more common in painful mononeuropathy and hypoalgesia more pronounced in painful polyneuropathy.
Article
Dentistry, Oral Surgery & Medicine
Hye-Kyoung Kim, Mee-Eun Kim
Summary: Three heat and cold pain phenotypes were identified in patients with unilateral trigeminal nerve injury, with heat hypoalgesia being more common than heat hyperalgesia. Heat hypoalgesia was associated with subjective negative symptoms, while thermal hyperalgesia showed little relationship with negative and positive symptoms. The cold pain phenotypes differed between inferior alveolar nerve and lingual nerve injuries.
Article
Pharmacology & Pharmacy
Neha Munawar, Joelle Nader, Najat H. Khadadah, Ashraf Al Madhoun, Waleed Al-Ali, Linu A. Varghese, Willias Masocha, Fahd Al-Mulla, Milad S. Bitar
Summary: This study found that alpha-2A adrenoceptors (alpha 2-AR) in the nervous system of streptozotocin diabetic rats are upregulated, and the upregulation is associated with increased pain sensitivity. Chronic administration of the selective alpha 2-AR agonist guanfacine can downregulate the upregulation of alpha 2-AR and relieve hyperalgesia and allodynia in diabetic animals. These findings suggest that guanfacine may have potential as a potent analgesic for diabetic neuropathic pain.
Article
Medicine, Research & Experimental
Chen Wang, Peng Chen, Dongsheng Lin, Yi Chen, Baojiang Lv, Kenan Zheng, Xingdong Lin, Zhibing Wu
Summary: This study examined the ligature tightness in the CCI model, finding that the surrounding muscles briefly twitched when the diameter of the sciatic nerves was constricted by approximately 14-15%. This may serve as a reference for other researchers in establishing CCI models.
Article
Anesthesiology
Rui Li, Amy L. Holley, Tonya M. Palermo, Olivia Ohls, Robert R. Edwards, Jennifer A. Rabbitts
Summary: This study assessed the feasibility, reliability, and sources of variability of a brief QST protocol in youth with acute MSK pain. The results showed high completion rates and reliability of the protocol, and indicated that age and ethnicity had some influence on QST parameters.
Review
Clinical Neurology
Zhen-Rong Zhang, Yao Wu, Wen-Jing Wang, Fang-Yong Wang
Summary: The role of GABAergic cell transplantation in improving neuropathic pain is significant, showing statistically significant improvements in allodynia and hyperalgesia. Differentiated GABAergic cells and avoiding the use of antibiotics may have a better effect in improving neuropathic pain.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Mikhail Nemenov, Harutyun Alaverdyan, Carrie Burk, Kristen Roles, Karen Frey, Yan Yan, Gene Kazinets, Simon Haroutounian
Summary: Chemotherapy induced peripheral neuropathy (CIPN) is a common complication of chemotherapy and lacks early detection methods and specific biomarkers. This study compared DLss and QST in identifying differences between patients with painful CIPN and a control group.
Article
Biochemistry & Molecular Biology
Neha Munawar, Milad S. Bitar, Willias Masocha
Summary: This study investigates the role of serotoninergic nervous system in diabetic neuropathic pain (DNP) and suggests that treatment with 8-OH-DPAT, a selective 5-HT1AR agonist, could be effective in alleviating DNP symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anesthesiology
James C. Eisenach, Regina S. Curry, Timothy T. Houle
Summary: This study compared the effects of intrathecal oxytocin and placebo on neuropathic pain and mechanical hyperalgesia. The results showed that oxytocin reduced pain intensity more than placebo, but also increased the hyperalgesic area. Although limited by the small sample size, further research on spinal oxytocin in this population is warranted.
Article
Multidisciplinary Sciences
Ozgur Gunduz, Zekiye Gulfem Yurtgezen, Ruhan Deniz Topuz, Melike Sapmaz-Metin, Oktay Kaya, Abdullah Erkan Orhan, Ahmet Ulugol
Summary: This study investigated the effect of RIPCs transfusion by different routes on neuropathic pain symptoms and found that intravenous administration of RIPCs remarkably improved neuropathic pain symptoms, thermal hyperalgesia, and mechanical allodynia.
Article
Anesthesiology
Stuart L. Silverman, Miroslav Backonja, Lynne Pauer, Jaren Landen, Pritha Bhadra Brown, Joseph M. Scavone, Richard Vissing, Andrew Clair
Article
Health Care Sciences & Services
Charles R. Jonassaint, Nema Rao, Alex Sciuto, Galen E. Switzer, Laura De Castro, Gregory J. Kato, Jude C. Jonassaint, Zakia Hammal, Nirmish Shah, Ajay Wasan
JOURNAL OF MEDICAL INTERNET RESEARCH
(2018)
Article
Clinical Neurology
Randy L. Gollub, Irving Kirsch, Nasim Maleki, Ajay D. Wasan, Robert R. Edwards, Yiheng Tu, Ted J. Kaptchuk, Jian Kong
Article
Biochemistry & Molecular Biology
Eric P. Hoffman, Valerie Riddle, Maxime A. Siegler, Daniel Dickerson, Miroslav Backonja, William G. Kramer, Kanneboyina Nagaraju, Heather Gordish-Dressman, Jesse M. Damsker, John M. McCall
Article
Anesthesiology
Jeungchan Lee, Ishtiaq Mawla, Jieun Kim, Marco L. Loggia, Ana Ortiz, Changjin Jung, Suk-Tak Chan, Jessica Gerber, Vincent J. Schmithorst, Robert R. Edwards, Ajay D. Wasan, Chantal Berna, Jian Kong, Ted J. Kaptchuk, Randy L. Gollub, Bruce R. Rosen, Vitaly Napadow
Article
Anesthesiology
Samantha M. Meints, Ishtlaq Mawla, Vitaly Napadow, Jian Kong, Jessica Gerber, Suk-Tak Chan, Ajay D. Wasan, Ted J. Kaptchuk, Christina McDonnell, Junie Carriere, Bruce Rosen, Randy L. Gollub, Robert R. Edwards
Article
Clinical Neurology
Hayden E. Hundley, Mark E. Hudson, Ajay D. Wasan, Trent D. Emerick
JOURNAL OF PAIN RESEARCH
(2019)
Article
Anesthesiology
Jieun Kim, Ishtiaq Mawla, Jian Kong, Jeungchan Lee, Jessica Gerber, Ana Ortiz, Hyungjun Kim, Suk-Tak Chan, Marco L. Loggia, Ajay D. Wasan, Robert R. Edwards, Randy L. Gollub, Bruce R. Rosen, Vitaly Napadow
Review
Clinical Neurology
Alex M. Dressler, Andrea G. Gillman, Ajay D. Wasan
JOURNAL OF PAIN RESEARCH
(2019)
Article
Anesthesiology
Binlong Zhang, Minyoung Jung, Yiheng Tu, Randy Gollub, Courtney Lang, Ana Ortiz, Joel Park, Georgia Wilson, Jessica Gerber, Ishtiaq Mawla, Suk-Tak Chan, Ajay Wasan, Robert Edwards, Jeungchan Lee, Vitaly Napadow, Ted Kaptchuk, Bruce Rosen, Jian Kong
BRITISH JOURNAL OF ANAESTHESIA
(2019)
Article
Neurosciences
Hyungjun Kim, Ishtiaq Mawla, Jeungchan Lee, Jessica Gerber, Kathryn Walker, Jieun Kim, Ana Ortiz, Suk-Tak Chan, Marco L. Loggia, Ajay D. Wasan, Robert R. Edwards, Jian Kong, Ted J. Kaptchuk, Randy L. Gollub, Bruce R. Rosen, Vitaly Napadow
Article
Multidisciplinary Sciences
Benedict J. Alter, Nathan P. Anderson, Andrea G. Gillman, Qing Yin, Jong-Hyeon Jeong, Ajay D. Wasan
Summary: This study utilized an algorithmic approach to group patients by pain distribution, finding that pain distribution subgroups were significantly associated with differences in pain intensity, impact, and clinically relevant outcomes.
Editorial Material
Anesthesiology
Connor Richardson, Harry Burke, Zach Frabitore, Ruth Segall, Malcolm Moses-Hampton, Raj Kubendran, Kevin Woeppel, Ajay D. Wasan, Trent Emerick
Article
Anesthesiology
Ajay D. Wasan, Robert R. Edwards, Kevin L. Kraemer, Jong Jeong, Megan Kenney, Kevin Luong, Marise C. Cornelius, Caitlin Mickles, Bhagya Dharmaraj, Essa Sharif, Anita Stoltenberg, Trent Emerick, Jordan F. Karp, Matt J. Bair, Steven Z. George, William M. Hooten
Summary: The study aims to investigate the prevalence of comorbid depression or anxiety disorders in patients with chronic low back pain (CLBP). The presence of negative affect (NA) in CLBP patients is associated with increased pain, worse treatment outcomes, and higher rates of prescription opioid misuse. The SYNNAPTIC protocol is designed to evaluate the effectiveness of antidepressants, fear-avoidance rehabilitation, or their combination in treating CLBP patients with high NA.
Article
Neuroimaging
Wei Shen, Yiheng Tu, Randy L. Gollob, Ana Ortiz, Vitaly Napadow, Siyi Yu, Georgia Wilson, Joel Park, Courtney Lang, Minyoung Jung, Jessica Gerber, Ishtiaq Mawla, Suk-Tak Chan, Ajay D. Wasan, Robert R. Edwards, Ted Kaptchuk, Shasha Li, Bruce Rosen, Jian Kong
NEUROIMAGE-CLINICAL
(2019)