期刊
CLINICAL INFECTIOUS DISEASES
卷 59, 期 -, 页码 S335-S339出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciu612
关键词
infections; neutropenia; carbapenem-resistant Enterobacteriaceae; Acinetobacter baumannii; Pseudomonas aeruginosa
资金
- Cleveland Department of Veterans Affairs [1I01BX001974]
- Geriatric Research Education and Clinical Center VISN [10]
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) [R01AI063517, R01AI10056]
- Antibiotic Resistance Leadership Group (NIH) [UM1AI104681]
- Clinical and Translational Science Collaborative of Cleveland from the National Center for Advancing Translational Sciences component of the NIH [UL1TR000439]
- Pfizer
- STERIS Corporation
- AstraZeneca
- Merck
- Rib-X Pharmaceuticals
Patients with cancer are at high risk for infections caused by antibiotic resistant gram-negative bacteria. In this review, we summarize trends among the major pathogens and clinical syndromes associated with antibiotic resistant gram-negative bacterial infection in patients with malignancy, with special attention to carbapenem and expanded-spectrum beta-lactam resistance in Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia-all major threats to our cancer patients. Optimal therapy for these antibiotic-resistant pathogens still remains to be determined.
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