Article
Biochemistry & Molecular Biology
Laura Tijerina-Rodriguez, Elvira Garza-Gonzalez, Adrian Martinez-Melendez, Rayo Morfin-Otero, Adrian Camacho-Ortiz, Esteban Gonzalez-Diaz, Hector Raul Perez-Gomez, Licet Villarreal-Trevino, Hector Maldonado-Garza, Sergio Esparza-Ahumada, Eduardo Rodriguez-Noriega
Summary: This study evaluated risk factors associated with severe-complicated and recurrent outcomes in different age groups of Clostridium difficile infection (CDI) patients. Female gender and lymphoma were identified as risk factors for severe-complicated CDI, while mature adulthood, previous rifampicin use, and neoplasm were risk factors for recurrent infection. Autoimmune disorders, leukemia, lymphoma, and previous colistin treatment were found to be risk factors for 30-day mortality.
BIOMEDICAL JOURNAL
(2022)
Article
Infectious Diseases
Annelies Boven, Erika Vlieghe, Lars Engstrand, Fredrik L. Andersson, Steven Callens, Johanna Simin, Nele Brusselaers
Summary: This study found an association between CDI and increased mortality rates, both in all-cause mortality and cause-specific mortality. The elevated mortality rates were consistent across different genders, age groups, and comorbidity groups.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Pediatrics
Danilo Buonsenso, Rosalia Graffeo, Davide Pata, Piero Valentini, Carla Palumbo, Luca Masucci, Antonio Ruggiero, Giorgio Attina, Manuela Onori, Laura Lancella, Barbara Lucignano, Martina Di Giuseppe, Paola Bernaschi, Laura Cursi
Summary: This study provides important clinical and epidemiological analysis of children with CDI, revealing that CDI children had higher hospital admission rates and chronic comorbidity occurrence. The use of antibiotics and fluoroquinolones were significantly associated with CDI.
FRONTIERS IN PEDIATRICS
(2022)
Article
Immunology
Silvia Vazquez-Cuesta, Laura Villar, Nuria Lozano Garcia, Ana I. Fernandez, Maria Olmedo, Luis Alcala, Mercedes Marin, Patricia Munoz, Emilio Bouza, Elena Reigadas
Summary: This study aimed to explore the role of the microbiome as a predictive biomarker of CDI. The researchers found differences in microbiome patterns between CDI patients, C. difficile carriers, healthy individuals, and patients with diarrhea of other causes, and identified potential microbiome biomarkers that could aid in the diagnosis of true CDI infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Infectious Diseases
Daniel J. Adams, Josephine B. Barone, Cade M. Nylund
Summary: Clostridioides difficile infection in children is more often acquired in the community than in the hospital, with exposure to various factors playing a role. Most cases are mild and managed on an outpatient basis, but a small subset can be severe and may require hospitalization, with a risk of recurrence. Measures to prevent community spread of C. difficile are needed.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2021)
Article
Immunology
Liqian Wang, Danyang Li, Zixi Chen, Liuqing He, Xianjun Wang, Liang Tao
Summary: An unusual case of monomicrobial Clostridioides difficile septicemia was reported in a patient without overt gastrointestinal symptoms. The strain isolated from the blood sample was different from the one in the stool, suggesting a potential invasion through the root canal after a recent tooth extraction. Oral C. difficile colonization may be a risk factor for severe C. difficile septicemia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Michael Y. Lin, Brian D. Stein, Sonya M. Kothadia, Samantha Blank, Michael E. Schoeny, Alexander Tomich, Mary K. Hayden, John Segreti
Summary: Inappropriate Clostridioides difficile testing is common in hospitals, resulting in potential overdiagnosis of infection. The potential role of infectious diseases specialists in enforcing appropriate testing is unclear. A retrospective study at an academic hospital found that mandatory approval from infectious diseases specialists led to a significant decrease in hospital-onset C. difficile infections.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Anada Silva, Tim Du, Kelly B. Choi, Linda Pelude, George R. Golding, Romeo Hizon, Bonita E. Lee, Blanda Chow, Jocelyn A. Srigley, Susy S. Hota, Jeannette L. Comeau, Nisha Thampi, CNISP C Difficile Working Grp
Summary: Pediatric healthcare-associated and community-associated Clostridioides difficile infection rates have decreased or stabilized in Canadian acute care hospitals from 2015 to 2020. Ribotype 106 remains predominant while recurrence remains low. Continued surveillance is vital to assess the changing epidemiological trends of pediatric CDI in Canada.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2023)
Article
Immunology
Noah D. Budi, Jared J. Godfrey, Nasia Safdar, Sanjay K. Shukla, Warren E. Rose
Summary: This study found that omadacycline was more effective than vancomycin at treating severe Clostridioides difficile infection. The combination of germinants and antibiotics was more effective at preventing infection recurrence.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Infectious Diseases
Guido Granata, Francesco Schiavone, Giuseppe Pipitone
Summary: Bezlotoxumab administration during a first CDI episode is effective and safe in reducing the rate of rCDI. Despite its high cost, evidence suggests considering bezlotoxumab in patients with a primary CDI episode. Further studies are needed to assess the benefit in specific subgroups of primary CDI patients and to define the risk factors to guide bezlotoxumab use.
Article
Microbiology
Jimmy Zhang, Ling Chen, Angela Gomez-Simmonds, Michael T. T. Yin, Daniel E. Freedberg
Summary: This retrospective cohort study explored the association between antibiotic exposure and community-acquired Clostridioides difficile infection (CA-CDI). The study found that the relative risks associated with different antibiotics may vary over time, and the absolute risks have not been clearly established. Clindamycin, cefdinir, cefuroxime, and fluoroquinolones had the highest risks for CA-CDI compared to doxycycline. Nitrofurantoin was also associated with CA-CDI in older patients with elevated baseline risk. These findings can guide antibiotic selection and future stewardship efforts.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Public, Environmental & Occupational Health
Daniel De-la-Rosa-Martinez, Frida Rivera-Buendia, Patricia Cornejo-Juarez, Bertha Garcia-Pineda, Carolina Nevarez-Lujan, Diana Vilar-Compte
Summary: CDI is recognized as the leading cause of nosocomial diarrhea. This study describes the clinical characteristics, risk factors, and outcomes of CDI in cancer patients. The CDI rate was lower compared to other series, and the incidence of CO-HCFA-CDI episodes increased. Risk factors for acquisition and severe infection were similar to those reported in non-cancer populations.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Immunology
Tanner M. Johnson, Kyle C. Molina, Amanda H. Howard, Kerry Schwarz, Lorna Allen, Misha Huang, Valida Bajrovic, Matthew A. Miller
Summary: The study demonstrates that bezlotoxumab (BEZ) is effective in preventing recurrent Clostridioides difficile infection (rCDI) and reducing all-cause hospital readmission, supporting current guideline recommendations for high-risk patients. Bezlotoxumab was significantly associated with reduced odds of rCDI and all-cause readmission at 90 days on both unadjusted and adjusted analysis. Bezlotoxumab was well tolerated with low frequency of adverse events observed.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Clinical Neurology
Mairead Skally, Maeve Leonard, Philip J. O'Halloran, Ben Husien, Kathleen Bennett, Karen Burns, Binu Dinesh, Hilary Humphreys, Fidelma Fitzpatrick
Summary: CDI in neurosurgery patients differs from the wider hospital, with greater awareness of CDI testing. Longer LOS impacted bed utilization with limited capacity. Robust surveillance supports proactive antimicrobial stewardship programs in this vulnerable population.
ACTA NEUROCHIRURGICA
(2023)
Article
Microbiology
Nicholas A. Lesniak, Alyxandria M. Schubert, Kaitlin J. Flynn, Jhansi L. Leslie, Hamide Sinani, Ingrid L. Bergin, Vincent B. Young, Patrick D. Schloss
Summary: Clostridioides difficile colonization can lead to a range of infection severities, from mild diarrhea to life-threatening conditions. While factors such as patient age, blood cell count, and C. difficile characteristics have been associated with disease severity, the role of specific gut bacteria in influencing severity is unclear. This study demonstrates that different gut bacterial communities can contribute to variations in Clostridioides difficile infection outcomes. Certain bacterial groups were associated with more severe outcomes, while others were associated with milder outcomes. Incorporating gut bacterial community data into severity models may aid in identifying at-risk patients and improving interventions.
Article
Public, Environmental & Occupational Health
Leigh Smith, Sara Pau, Susan Fallon, Sara E. Cosgrove, Melanie S. Curless, Valeria Fabre, Sara M. Karaba, Lisa L. Maragakis, Aaron M. Milstone, Anna C. Sick-Samuels, Polly Trexler, Clare Rock
Summary: This study analyzed the impact of a 7-day recurring asymptomatic SARS-CoV-2 testing protocol for all hospitalized patients in a large academic center. The results showed that 40 new cases were identified, with 1 out of 3 cases occurring after 14 days of hospitalization. Recurring testing can effectively identify unrecognized infections, especially during periods of high community transmission.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Leigh Smith, C. Paul Morris, Morgan H. Jibowu, Susan Fallon, Stuart C. Ray, Sara E. Cosgrove, Melanie S. Curless, Valeria Fabre, Sara M. Karaba, Lisa L. Maragakis, Aaron M. Milstone, Anna C. Sick-Samuels, Polly Trexler, Heba H. Mostafa, Clare Rock
Summary: This passage discusses the challenges of confirming the transmission of SARS-CoV-2 among healthcare workers and hospitalized patients, as well as the potential risk factors identified through investigation.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Microbiology
Michael Biggel, Sophia Johler, Tim Roloff, Sarah Tschudin-Sutter, Stefano Bassetti, Martin Siegemund, Adrian Egli, Roger Stephan, Helena M. B. Seth-Smith
Summary: This study developed a bioinformatic tool called PorinPredict to predict defects in the outer membrane porin OprD of Pseudomonas aeruginosa, which are strongly associated with reduced carbapenem susceptibility. PorinPredict relies on a database of OprD variants and can identify inactivating mutations in the coding or promoter region. The tool was validated against P. aeruginosa genomes and showed a high correlation between OprD loss and meropenem nonsusceptibility, regardless of the presence of carbapenemases.
MICROBIOLOGY SPECTRUM
(2023)
Editorial Material
Public, Environmental & Occupational Health
Erica C. Prochaska, Tania Maria Caballero, Valeria Fabre, Aaron M. Milstone
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
K. C. Coffey, Sara C. Keller, Deverick J. Anderson, Valerie M. Deloney, Anthony D. Harris, David Henderson, Aaron M. Milstone, Daniel J. Morgan, Clare Rock, Marin Schweizer, Kathleen Chiotos
Summary: In 2021, a survey involving 50 healthcare facilities was conducted to examine changes in infection prevention, control, and antibiotic stewardship practices. The findings revealed continued surveillance for multidrug-resistant organisms, but a decline in the utilization of human resource-intensive interventions compared to previous surveys conducted in 2013 and 2018 prior to the COVID-19 pandemic.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Microbiology
Elena Gomez-Sanz, Claudia Bagutti, Jan A. Roth, Monica Alt Hug, Ana B. Garcia-Martin, Laura Maurer Pekerman, Ruth Schindler, Reto Furger, Lucas Eichenberger, Ingrid Steffen, Adrian Egli, Philipp Huebner, Tanja Stadler, Lisandra Aguilar-Bultet, Sarah Tschudin-Sutter
Summary: This study investigated the spatiotemporal distribution of ESBL-PE in municipal wastewater in Basel, Switzerland. The results showed that ESBL-PE are widely spread in the wastewater, with higher proportions of Klebsiella pneumoniae in mixed sites and higher proportions of Escherichia coli in urban sites.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Matthias von Rotz, Richard Kuehl, Ana Durovic, Sandra Zingg, Anett Apitz, Fanny Wegner, Helena M. B. Seth-Smith, Tim Roloff, Karoline Leuzinger, Hans H. Hirsch, Sabine Kuster, Manuel Battegay, Luigi Mariani, Stefan Schaeren, Stefano Bassetti, Florian Banderet-Uglioni, Adrian Egli, Sarah Tschudin-Sutter
Summary: We investigated the transmission pathways of SARS-CoV-2 in healthcare-associated infections using epidemiological work-up and whole genome sequencing. We identified four major clusters of transmission during the second wave of the pandemic. Phylogenetic analysis revealed that less than 50% of the suspected transmissions were confirmed, indicating a higher percentage of community-acquired infections.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Public, Environmental & Occupational Health
Selina Ehrenzeller, Richard Kuehl, Ana Durovic, Aurelien Emmanuel Martinez, Manuel Battegay, Matthias von Rotz, Andre Fringer, Sarah Tschudin-Sutter
Summary: We conducted a qualitative interview-based study to examine the perception of infection prevention and control measures among healthcare workers without patient contact during the COVID-19 pandemic. The study identified four main themes, including the importance of transparent communication for employees' sense of security, the need for stratified information on personal protective equipment usage, the positive perception of consistent IPC measures, and the preference for digital training resources among HCWs without patient contact.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Public, Environmental & Occupational Health
Kyle J. J. Popovich, Kathy Aureden, D. Cal Ham, Anthony D. D. Harris, Amanda J. J. Hessels, Susan S. S. Huang, Lisa L. L. Maragakis, Aaron M. M. Milstone, Julia Moody, Deborah Yokoe, David P. P. Calfee
Summary: This document aims to provide practical recommendations in a concise format to assist acute-care hospitals in preventing methicillin-resistant Staphylococcus aureus (MRSA) transmission and infection.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Isabelle Vock, Lisandra Aguilar-Bultet, Daniel Goldenberger, Silvio Ragozzino, Sabine Kuster, Sarah Tschudin-Sutter
Summary: This study evaluated the epidemiology of carbapenemase-producing bacteria (CPB) in Switzerland and compared the risk factors between patients colonized with CPB and patients colonized with extended-spectrum β-lactamase-producing Enterobacterales (ESBL-PE). The results showed that hospitalization abroad and prior antibiotic therapy were independently associated with CPB colonization. Frequent evaluation of CPB epidemiology is required to improve detection of patients at risk of CPB carriage.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Obstetrics & Gynecology
Anushree Aneja, Julia Johnson, Erica C. Prochaska, Aaron M. Milstone
Summary: Dysbiosis is a major concern for neonates, but strategies such as microbiota transplantation can prevent infections and correct dysbiosis.
JOURNAL OF PERINATOLOGY
(2023)
Editorial Material
Infectious Diseases
Rebecca Grant, Daniel Benamouzig, Howard Catton, Vincent Chi-Chung Cheng, Neelam Dhingra, Ramanan Laxminarayan, Helena Legido-Quigley, Susanna Lorenzo Martinez, Kadar Marikar, Marc Mendelson, Pierre Parneix, Eli Perencevich, Hardeep Singh, Sarah Tschudin-Sutter, Shin Ushiro, Evelyn Wesangula, Celine Gardiol, Gerald Dziekan, Stephan Harbarth, Didier Pittet
LANCET INFECTIOUS DISEASES
(2023)
Article
Biotechnology & Applied Microbiology
Marius Muller, Andrea Wiencierz, Christian Gehringer, Veronika Muigg, Stefano Bassetti, Martin Siegemund, Vladimira Hinic, Sarah Tschudin-Sutter, Adrian Egli
Summary: This study aims to identify risk factors for and the clinical impact of infections caused by non-beta-lactamase mediated carbapenem-resistant bacteria. The duration of prior carbapenem treatment was found to be a strong risk factor for the development of carbapenem resistance, but there was no strong evidence for the clinical implications of resistance or increased mortality.
INTERNATIONAL MICROBIOLOGY
(2023)
Letter
Clinical Neurology
Florian Ebel, Sarah Tschudin-Sutter, Maja Weisser, Michel Roethlisberger
JOURNAL OF NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Janne Estill, Plamenna Venkova-Marchevska, Huldrych F. Gunthard, Sara Botero-Mesa, Amaury Thiabaud, Maroussia Roelens, Laure Vancauwenberghe, Lauro Damonti, Ulrich Heininger, Anne Iten, Peter W. Schreiber, Rami Sommerstein, Sarah Tschudin-Sutter, Nicolas Troillet, Danielle Vuichard-Gysin, Andreas Widmer, Torsten Hothorn, Olivia Keiser
Summary: This study aims to investigate the effectiveness of remdesivir in COVID-19 patients. The results show that certain subgroups, such as individuals with oncological comorbidities or elderly males, may benefit from remdesivir.
SWISS MEDICAL WEEKLY
(2023)