Article
Biotechnology & Applied Microbiology
Yilin Xiong, Cong Zhang, Wenting Gao, Yong Ma, Qingqing Zhang, Yuqiao Han, Shiyu Jiang, Zinan Zhao, Jia Wang, Yang Chen
Summary: This study investigated the prevalence of resistance genes in Klebsiella pneumoniae isolates causing nosocomial urinary tract infections in a Chinese hospital, finding that multiple resistance genes could be transmitted via plasmids. The emergence of plasmids carrying multiple resistance determinants exacerbating the resistance of K. pneumoniae causing UTIs in China was reported.
JOURNAL OF ANTIBIOTICS
(2021)
Article
Infectious Diseases
Marisa Haenni, Laetitia Du Fraysseix, Pauline Francois, Antoine Drapeau, Tristan Bralet, Jean-Yves Madec, Thierry Boulinier, Olivier Duriez
Summary: This study investigated whether griffon vultures (Gyps fulvus) from two populations in the French Alps carry antibiotic-resistant bacteria. Results showed that 11.8% of the bacteria exhibited resistance to extended-spectrum beta-lactamases (ESBL), with transmission primarily occurring within the same vulture population. These findings highlight the need for measures to mitigate the spread of multidrug-resistant bacteria through commensal species.
Article
Microbiology
Marita Vedovelli Cardozo, Apostolos Liakopoulos, Michael Brouwer, Arie Kant, Lucas Jose Luduverio Pizauro, Mariana Monezi Borzi, Dik Mevius, Fernando Antonio de Avila
Summary: This study in Sao Paolo, Brazil, investigated the phylogenetic diversity and epidemiology of ESBL-producing E. coli and K. pneumoniae from chicken, chicken meat, and human clinical isolates. The ESBL genes were characterized and their location determined on plasmids. The study found genetic diversity in isolates from chickens, chicken meat, and human feces, suggesting possible transmission of ESBL-producing pathogens from chickens to humans.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Pranita D. Tamma, Tiffeny T. Smith, Ayomikun Adebayo, Sara M. Karaba, Emily Jacobs, Teresa Wakefield, Kelly Nguyen, Natalie N. Whitfield, Patricia J. Simner
Summary: Understanding the prevalence of bla(CTX-M) genes in specific Gram-negative bacterial species is crucial for guiding antibiotic treatment. Carbapenemase genes were also identified in a small percentage of organisms, with specific prevalence varying among different species. Future molecular diagnostic panels could benefit from including additional ESBL targets beyond bla(CTX-M).
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Immunology
Kwang Gon Kim, Jin Jung, Ji Hyun Shin, Hye Jung Park, Min Ji Kim, Jin Jong Seo, Young Ok Kim, Su-Ya Lee, Chang-Yee Cho, Tae Sun Kim
Summary: Due to differences in perspectives on human rights and laws in various social strata in Asian countries, the development of human rights laws in the Asian region has been relatively slow. In some countries in Asia, reform in the field of human rights laws has been hindered by government restrictions and pressures. The importance of human rights in Asian countries has gradually been recognized, but still faces many challenges.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Microbiology
Elzbieta M. Stefaniuk, Aleksandra Kozinska, Izabela Wasko, Anna Baraniak, Stefan Tyski
Summary: A total of 65 colistin-resistant Enterobacterales isolates were analyzed in this study, with 45 identified as ESBL producers. CTX-M-1-like enzymes were the most common ESBLs. Additionally, one E. coli and seven Klebsiella pneumoniae strains produced carbapenemases.
POLISH JOURNAL OF MICROBIOLOGY
(2021)
Article
Infectious Diseases
Hadas Kon, Mor Lurie-Weinberger, Adi Cohen, Liat Metsamber, Alona Keren-Paz, David Schwartz, Yehuda Carmeli, Vered Schechner
Summary: Beta-lactam resistance can have negative impacts on mortality, healthcare expenses, and treatment options. This study found the presence of ESBL/AmpC-producing bacteria in vegetables, with ESBL producers mainly being Klebsiella pneumoniae and Escherichia coli, and AmpC producers mainly being Enterobacter cloacae complex. ESBL producers exhibited high genetic diversity, while AmpC producers were more commonly found in leafy greens. The presence of ESBL/AmpC-producing bacteria in raw vegetables may contribute to the spread of resistance genes in the community.
Article
Pharmacology & Pharmacy
S. A. Hassoubah
Summary: This study examined a multidrug-resistant Citrobacter freundii recovered from a dog with kennel cough, and found that it harbored multiple antibiotic resistance genes, which could potentially lead to severe infections in humans.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Review
Chemistry, Medicinal
Manish Kaushik, Aditi Kaushik, Akash Jain, Jasmine Chaudhary, Vrinda Gupta
Summary: Multi-drug resistance and its transmission is a global health issue. The production of AmpC beta-lactamases by bacteria is hindering the development of new antibiotics. The lack of comprehensive data makes it difficult to choose appropriate beta-lactam antibiotics for treatment.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Article
Veterinary Sciences
Xiaoting Li, Haibin Liu, Sai Cao, Ping Cheng, Fulei Li, Muhammad Ishfaq, Jichao Sun, Xiuying Zhang
Summary: The isolated pathogenic E. coli were all multi-drug resistant, with O4 and O92 being the main serotypes. Beta-lactam resistance genes were prevalent in large-scale pig farms in East China, providing a theoretical basis for the prevention and control of pig-derived pathogenic E. coli in the future.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Khyati Bhardwaj, Suchitra M. Shenoy, Shrikala Baliga, B. Unnikrishnan, B. Shantharam Baliga, Vasanth Kumar Shetty
Summary: The study conducted in poultry farms of coastal Southern Karnataka, India, found high levels of antibiotic resistance in Escherichia coli and Klebsiella pneumoniae isolates, with a focus on resistance to fluoroquinolones and tetracycline. The most common resistance genes detected were qnrB, qnrS, and qnrA, with most isolates showing high MAR indices reflecting widespread antibiotic use.
Article
Infectious Diseases
Leah J. Toombs-Ruane, Jonathan C. Marshall, Jackie Benschop, Dragana Drinkovi, Anne C. Midwinter, Patrick J. Biggs, Zoe Grange, Michael G. Baker, Jeroen Douwes, Mick G. Roberts, Nigel P. French, Sara A. Burgess
Summary: This study aimed to assess whether having a pet in the home is a risk factor for community-acquired urinary tract infections associated with extended-spectrum β-lactamase (ESBL)-or AmpC β-lactamase (ACBL)-producing Enterobacterales. Through telephone questionnaire and logistic regression analysis, it was found that pet ownership was not associated with ESBL-or ACBL-producing Enterobacterales-related urinary tract infections, while the main risk factors included recent antimicrobial treatment, travel to Asia in the previous year, and a doctor's visit in the last 6 months.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Shambel Mekonnen, Tewodros Tesfa, Tadesse Shume, Fikru Tebeje, Kedir Urgesa, Fitsum Weldegebreal
Summary: This study aimed to assess the bacterial profile of urinary tract infections and their susceptibility to antimicrobial agents in under-five children at Hiwot Fana Specialized University Hospital, eastern Ethiopia. The results showed a high prevalence of bacterial UTIs, with most of the isolates exhibiting resistance to multiple drugs. Risk factors for bacterial infections included being a rural resident, uncircumcised male, indwelling catheterization, previous history of antibiotic usage and urinary tract infections, and urinary frequency. Regular monitoring of urinary tract infections and resistant bacterial pathogens is crucial.
Article
Immunology
Alireza Dolatyar Dehkharghani, Setareh Haghighat, Marjan Rahnamaye Farzami, Mohammad Rahbar, Masoumeh Douraghi
Summary: The study focused on investigating resistant urinary AmpC-generating E. coli isolates and identifying their genetic variety. The most frequent gene determinant of AmpC beta-lactamase was bla(CIT) and may vary depending on time and geographical location.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Dariusz A. Hareza, Sara E. Cosgrove, Patricia J. Simner, Anthony D. Harris, Yehudit Bergman, Rick Conzemius, Emily Jacobs, Stephan Beisken, Pranita D. Tamma
Summary: This study investigated the clinical outcomes and optimal treatment methods for patients with ESBL-E bloodstream infections that do not produce CTX-M. The findings suggest that non-CTX-M and CTX-M ESBL-E infections are equally concerning and associated with similar clinical outcomes. Meropenem may be associated with improved survival in patients with non-CTX-M ESBL-E infections, highlighting the potential benefit of comprehensive molecular diagnostics for early antibiotic optimization in ESBL-E infections.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Biology
Beatriz Robredo, Rosa Fernandez-Fernandez, Carmen Torres
Summary: This study connects research and education through a service-learning methodology, the Small World Initiative project. It challenges young students to discover novel bioactive-producing microorganisms from environmental soil samples, promoting scientific vocations and communicating scientific culture.
JOURNAL OF BIOLOGICAL EDUCATION
(2023)
Article
Infectious Diseases
Maria Font-Font, Alba Belles-Belles, Rosa Fernandez-Fernandez, Carmen Torres
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2023)
Article
Infectious Diseases
Rosa Fernandez-Fernandez, Beatriz Robredo, Enrique Navajas, Carmen Torres
Summary: Antimicrobial resistance is a global problem, and soil is a promising resource for finding new antimicrobial agents. The MicroMundo project, part of the Tiny Earth citizen science project, has successfully raised awareness about antimicrobial resistance and contributed to the search for new alternatives. Through this project, 32 potentially antimicrobial-producing bacteria were isolated from 2600 isolates obtained from soil samples.
Article
Microbiology
Otavio Hallal Ferreira Raro, Patrice Nordmann, Manuel Dominguez Pino, Jacqueline Findlay, Laurent Poirel
Summary: There is an increasing occurrence of multidrug-resistant (MDR) and hypervirulent (hv) Klebsiella pneumoniae (MDR-hvKp) convergent clones. These strains can cause difficult-to-treat infections and have a higher mortality rate in healthy adults. This study in Switzerland identified a rate of 9.0% K. pneumoniae with a virulence genotype, producing carbapenemase and recovered from rectal swabs, urine, and blood. The presence of alarming MDR-hvKp and MDR nonhypervirulent K. pneumoniae (MDR-nhv-Kp) isolates highlights the need for surveillance networks to track and monitor their spread.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Public, Environmental & Occupational Health
Sara Quero, Marina Serras-Pujol, Noemi Parraga-Nino, Carmen Torres, Marian Navarro, Anna Vilamala, Emma Puigoriol, Javier Diez de los Rios, Elisenda Arque, Judit Serra-Pladevall, Alba Romero, Daniel Molina, Roger Paredes, Maria Luisa Pedro-Botet, Esteban Reynaga
Summary: This study investigated the prevalence of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) among workers in the pork production chain. The results showed that the prevalence of MRSA was high among workers in contact with live animals, especially in pig farms, livestock transporters, and slaughterhouses.
Article
Public, Environmental & Occupational Health
Idris Nasir Abdullahi, Carmen Lozano, Carmen Simon, Javier Latorre-Fernandez, Myriam Zarazaga, Carmen Torres
Summary: This study investigated the diversity and carriage rate of nasal Staphylococcus species, as well as the variability of antimicrobial resistance, virulence determinants, immune evasion cluster types, and genetic lineages of Staphylococcus aureus isolates. The study also examined the co-carriage rate of CoNS with S. aureus in the same nasal niche of healthy pigs and pig-farmers. The findings highlight the need for multiple samplings to understand the dynamics of AMR and control the transmission of S. aureus in pig-farms.
Article
Infectious Diseases
Maxime Bouvier, Auriane Kerbol, Jacqueline Findlay, Samanta Freire, Laurent Poirel, Patrice Nordmann
Summary: Resist Acineto is a novel immunochromatographic test for detecting the major acquired carbapenemases (OXA-23, OXA-40, OXA-58, and NDM) in Acinetobacter spp. This test is rapid and easy to perform, and it has shown excellent specificity and sensitivity with 100% positive and negative predictive values in both cases.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2023)
Article
Infectious Diseases
Jacqueline Findlay, Patrice Nordmann, Maxime Bouvier, Auriane Kerbol, Laurent Poirel
Summary: This study investigated the spread and emergence of A. baumannii clones co-producing OXA-23 and ArmA in Switzerland. The majority of the isolates were obtained from infections and belonged to the high-risk GC-2 clone. Monitoring and control of these MDR A. baumannii strains are crucial to prevent further spread.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Otavio Hallal Ferreira Raro, Maxime Bouvier, Auriane Kerbol, Jean-Winoc Decousser, Laurent Poirel, Patrice Nordmann
Summary: The study developed a rapid test for the detection of Acinetobacter baumannii susceptibility to the antibiotic cefiderocol. The test showed high sensitivity and specificity and significantly reduced the time required compared to current methods.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Microbiology
Sara Garcia-Vela, Agusti Martinez-Sancho, Laila Ben Said, Carmen Torres, Ismail Fliss
Summary: This study characterized a collection of 20 C. perfringens isolates from poultry affected by necrotic enteritis (NE) at the genomic level, focusing on resistance mechanisms and bacteriocin production. Antimicrobial resistance genes, especially tet genes associated with tetracycline resistance, were found to be prevalent. Interestingly, two isolates carried the erm(T) gene associated with erythromycin resistance, which is rarely reported in other Gram-positive bacteria. The study also revealed a high variability of sequence types and identified unique characteristics in one isolate (C. perfringens MLG7307) that made it impossible to toxinotype.
Article
Infectious Diseases
Carolina Sabenca, Eliana Costa, Sara Sousa, Lillian Barros, Ana Oliveira, Sonia Ramos, Gilberto Igrejas, Carmen Torres, Patricia Poeta
Summary: The emergence of Klebsiella pneumoniae strains producing ESBL and KPC has become a major public health concern. The ability of these strains to form biofilms is worrisome as it can facilitate the spread of antibiotic resistance and prolong infections in healthcare facilities.
Article
Infectious Diseases
Idris Nasir Abdullahi, Carmen Lozano, Carmen Simon, Myriam Zarazaga, Carmen Torres
Summary: This study characterizes the antimicrobial resistance mechanisms, intra-host species diversity, and intra-species AMR diversity in coagulase-negative staphylococci (CoNS) recovered from the nasal cavities of healthy pigs and pig farmers. The study finds a high level of multidrug resistance, diversity of species within hosts, and diversity of resistance profiles within species, indicating the potential for CoNS to be reservoirs of AMR genes. The study also detects various antimicrobial resistance genes in pigs and pig farmers.
Article
Microbiology
Beatriz Robredo, Rosa Fernandez-Fernandez, Carmen Torres, Ruben Ladrera
Summary: MicroMundo contributes to improving knowledge about antimicrobial resistance and its consequences at all educational levels. Questionnaires and satisfaction surveys were conducted to evaluate the impact of MicroMundo and the optimal age of participants. The results showed significant improvement in knowledge about antimicrobial resistance and increased interest in scientific research.
FEMS MICROBIOLOGY LETTERS
(2023)
Article
Infectious Diseases
Valentina Dona, Patrice Nordmann, Sonja Kittl, Simone Schuller, Maxime Bouvier, Laurent Poirel, Andrea Endimiani, Vincent Perreten
Summary: A study in Switzerland found that Enterobacter hormaechei producing the carbapenemase OXA-48 was identified in companion animals and human patients. The study analyzed the genetic relatedness of these strains and their mobile genetic elements and found a connection between antimicrobial resistance in E. hormaechei and animals and humans in the same environment.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Meriam B. Said, Lamia Thabet, Sarah Cheriet, Amen A. Messadi, Paula Gomez, Laura Ruiz-Ripa, Senda Sghaier, Bilel Hassen, Abdennaceur Hassen, Carmen Torres, Mohamed S. Abbassi
Summary: The study characterized 25 MRSA clinical isolates collected in a Tunisian hospital, revealing a predominance of the ST239-CC8 lineage and high levels of drug resistance. The findings highlight the urgent need for strict hygiene control measures in the hospital.
LETTERS IN APPLIED MICROBIOLOGY
(2023)
