Article
Immunology
Satoshi Kamidani, Shikha Garg, Melissa A. Rolfes, Angela P. Campbell, Charisse N. Cummings, Julia C. Haston, Kyle P. Openo, Emily Fawcett, Shua J. Chai, Rachel Herlihy, Kimberly Yousey-Hindes, Maya L. Monroe, Sue Kim, Ruth Lynfield, Chad Smelser, Alison Muse, Christina B. Felsen, Laurie Billing, Ann Thomas, H. Keipp Talbot, William Schaffner, Ilene Risk, Evan J. Anderson
Summary: This study provides important population-based data on influenza-associated hospitalizations in US children. It highlights the higher rates of hospitalization and death among younger children, but also emphasizes the increased risk of severe outcomes among older children.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Virology
Gloria Perez-Rubio, Marco Antonio Ponce-Gallegos, Bruno Andre Dominguez-Mazzocco, Jaime Ponce-Gallegos, Roman Alejandro Garcia-Ramirez, Ramces Falfan-Valencia
Summary: Research has shown that genetic susceptibility to Influenza A virus infection is influenced by multiple pathways, including innate immune response, complement activation, and variants in inflammatory response genes. Specific gene polymorphisms such as SNPs play key roles in host immune responses, affecting viral replication and host response, representing important factors in genetic susceptibility to IAV infection.
Article
Microbiology
Alexey Markin, Giovana Ciacci Zanella, Zebulun W. Arendsee, Jianqiang Zhang, Karen M. Krueger, Phillip C. Gauger, Amy L. Vincent L. Baker, Tavis K. Anderson
Summary: Research reveals that the 2009 H1N1 influenza virus has the ability to cross species barriers and frequently spread between humans and swine. The virus undergoes genetic and antigenic changes in swine populations, posing a zoonotic threat to humans. The study confirms a correlation between human and swine cases of H1N1 influenza, and the burden of the virus in humans directly impacts its detection in pigs. Additionally, it was found that the persistence of the virus in swine is mainly due to spillovers from human-to-swine transmission. These findings underscore the risk of influenza transmission between humans and swine.
Article
Business, Finance
Di Gong, Tao Jiang, Liping Lu
Summary: This paper empirically analyzes the impact of pandemic on the contracting of bank loans. Using data on syndicated loans during the season of H1N1 Swine Flu, we find that more flu is associated with higher loan spreads and smaller loan size. The adverse impact of pandemic was alleviated by the approval of vaccines.
FINANCE RESEARCH LETTERS
(2021)
Article
Immunology
Krista Salo-Tuominen, Tamara Teros-Jaakkola, Laura Toivonen, Helena Ollila, Paivi Rautava, Minna Aromaa, Elina Lahti, Niina Junttila, Ville Peltola
Summary: The study investigated the association between parental socioeconomic and psychosocial factors and the uptake of the 2009 pandemic influenza vaccine in children. It found that children of younger and less educated mothers had a lower rate of vaccine uptake. However, the individual or relational psychosocial well-being of parents was not associated with children's vaccination.
Article
Microbiology
Dennis Maletich Junqueira, Caroline Tochetto, Tavis K. Anderson, Danielle Gava, Vanessa Haach, Mauricio E. Cantao, Amy L. Vincent Baker, Rejane Schaefer
Summary: This study analyzed a large number of H1N1pdm09 gene sequences from humans and swine globally between 2009 and 2022, and found that there was rapid transmission of the virus from humans to swine in Brazil during 2009-2011, but most of the infections in swine were self-limited with limited onward transmission. After 2012, there was a reduction in human-to-swine H1N1pdm09 transmissions in Brazil. The study highlights the dynamic interplay between human-to-swine transmission, antigenic drift, and the establishment of swine-to-swine transmission in shaping the evolution and persistence of H1N1pdm09 in swine populations.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Virology
Peter W. Cook, Thomas Stark, Joyce Jones, Rebecca Kondor, Natosha Zanders, Jeffrey Benfer, Samantha Scott, Yunho Jang, Alicia Janas-Martindale, Stephen Lindstrom, Lenee Blanton, John Schiltz, Rachel Tell, Richard Griesser, Peter Shult, Erik Reisdorf, Tonya Danz, Alicia Fry, John Barnes, Amy Vincent, David E. Wentworth, C. Todd Davis
Summary: The study discusses the transmission of seasonal influenza viruses between humans and pigs, leading to sustained circulation of human-like viruses in the U.S. swine population. Two cases of human infections with A(H1N1)pdm09 viruses originating from swine hosts are identified and classified as swine-origin variant influenza viruses. The study underscores the importance of developing techniques for distinguishing human-origin and swine-origin viruses for continued surveillance of influenza viruses.
JOURNAL OF VIROLOGY
(2021)
Article
Infectious Diseases
Suzan C. M. Trienekens, Wendi Shepherd, Richard G. Pebody, Punam Mangtani, Paul Cleary
Summary: During the 2009 influenza A(H1N1)pdm09 pandemic in England, individuals of South Asian ethnic groups were disproportionately affected, with younger age, higher proportion of males, more from deprived areas, delayed healthcare seeking, lower antiviral treatment advice but higher compliance, and highest cumulative incidence in the West Midlands region, London, and East of England region. The study provides insights into demographic, socioeconomic, and ethnic factors of the outbreak to inform future influenza preparedness for appropriate prevention and care.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2021)
Article
Biology
Michael Lutz, Jordana Schmierer, Toru Takimoto
Summary: Avian species are the main source of pandemic influenza A viruses that can infect humans. This study found that avian influenza A virus genes, including PA, PB1, and PB2, need to undergo host-adaptive mutations in order to replicate and transmit in humans. It was discovered that the PA gene from the 2009 pH1N1 strain had host-adaptive mutations that enhanced viral replication by increasing translation efficiency. This was achieved through increased cytosolic accumulation of viral mRNA, which depended on the host RNA binding protein GRSF1. Mutations to the GRSF1 binding site and knockdown of GRSF1 reduced viral mRNA accumulation and translation efficiency. These findings reveal a previously unrecognized mechanism by which host-adaptive mutations in PA regulate viral replication and host adaptation.
COMMUNICATIONS BIOLOGY
(2022)
Article
Virology
Weixu Zhang, Hefeng Xu, Shuxuan Guan, Chengmin Wang, Guoying Dong
Summary: This study analyzed the available NA protein sequences of H1N1 influenza viruses worldwide and found that 3.76% of H1N1 viruses currently harbor oseltamivir resistance, with the most common mutation being H274Y. Oseltamivir resistance is mainly found in humans, swine, and avian, and the resistance level peaked in 2007-2008 and quickly decreased in 2009. The study highlights the importance of globally monitoring oseltamivir resistance.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Akeno Tsuneki-Tokunaga, Kyosuke Kanai, Asao Itagaki, Hideaki Tsuchie, Takayoshi Okada, Masaaki Kasagi, Kiyoshi Tanaka, Miho Aoki, Alfredo Jr A. Hinay, Seiji Kageyama
Summary: This study assessed the correlation between the growth capability of epidemic influenza A/H1N1, A/H3N2, and B viruses in cells and the viral load in nasopharyngeal swabs, revealing a positive correlation between growth capability and viral load. Additionally, a high positive correlation between growth capability and cell death was observed in the experiment. Therefore, the growth capability of viruses plays a significant role in disease prognosis.
ARCHIVES OF VIROLOGY
(2021)
Article
Obstetrics & Gynecology
Nicola Vousden, Marian Knight
Summary: Influenza during pregnancy is associated with an increased risk of hospital admission, and there is variability in policies and uptake of immunization globally. Immunization is cost-effective and safe in preventing influenza in pregnant women and their infants.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Infectious Diseases
Krystal Lau, Ilaria Dorigatti, Marisa Miraldo, Katharina Hauck
Summary: This study estimated hospitalization rates, severity rates, mortality rates, and time lags between infections and hospitalizations of H1N1 pandemic patients in England during and after the pandemic period. Results showed increased severity in the post-pandemic flu season, highlighting the importance of continued vigilance by policymakers and researchers. Analysis of administrative hospital data and epidemiological modeling estimates can provide valuable insights for responding to COVID-19 and future pandemics.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Nanoscience & Nanotechnology
Seong Uk Son, Eun-Kyung Lim, Soojin Jang, Jaewoo Lim, Seung Beom Seo, Taejoon Kang, Juyeon Jung, Seo Yeong Oh, Sun-Woo Yoon, Dongeun Yong, Jaejong Lee
Summary: The study developed a conductive thread-based immunosensor to easily detect airborne viruses, which is important in preventing the spread of infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Clinical Neurology
Xiling Wang, Fulong Xiao, Yiping Wang, Xiaowei Deng, Zhiyuan Chen, Xiaosong Dong, Wei Wang, Chenyang Li, Zhifei Xu, Huijuan Wu, Huan Yu, Changjun Su, Zan Wang, Xiangdong Tang, Yunhui Lv, Yun Li, Shuchen Sun, Junying Huang, Lijuan Hao, Xuan Wei, Liying Deng, Yu-Shu Huang, Jihui Zhang, Yun-Kwok Wing, Jun Zhang, Emmanuel Mignot, Fang Han, Hongjie Yu
Summary: The incidence of narcolepsy increased during the 2009 H1N1 pandemic, possibly due to the circulation of the A(H1N1) pdm09 virus. This observation should be considered for future influenza pandemic preparedness plans.
Article
Infectious Diseases
Matthew Biggerstaff, David Alper, Mark Dredze, Spencer Fox, Isaac Chun-Hai Fung, Kyle S. Hickmann, Bryan Lewis, Roni Rosenfeld, Jeffrey Shaman, Ming-Hsiang Tsou, Paola Velardi, Alessandro Vespignani, Lyn Finelli
BMC INFECTIOUS DISEASES
(2016)
Article
Public, Environmental & Occupational Health
R. J. Stewart, J. Rossow, J. T. Conover, E. E. Lobelo, S. Eckel, K. Signs, M. G. Stobierski, S. C. Trock, A. M. Fry, S. J. Olsen, M. Biggerstaff
ZOONOSES AND PUBLIC HEALTH
(2018)
Article
Infectious Diseases
Matthew Biggerstaff, Michael Johansson, David Alper, Logan C. Brooks, Prithwish Chakraborty, David C. Farrow, Sangwon Hyun, Sasikiran Kandula, Craig McGowan, Naren Ramakrishnan, Roni Rosenfeld, Jeffrey Shaman, Rob Tibshirani, Ryan J. Tibshirani, Alessandro Vespignani, Wan Yang, Qian Zhang, Carrie Reed
Article
Multidisciplinary Sciences
Nicholas G. Reich, Logan C. Brooks, Spencer J. Fox, Sasikiran Kandula, Craig J. McGowan, Evan Moore, Dave Osthus, Evan L. Ray, Abhinav Tushar, Teresa K. Yamana, Matthew Biggerstaff, Michael A. Johansson, Roni Rosenfeld, Jeffrey Shaman
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Review
Immunology
Andrew J. Leidner, Neil Murthy, Harrell W. Chesson, Matthew Biggerstaff, Charles Stoecker, Aaron M. Harris, Anna Acosta, Kathleen Dooling, Carolyn B. Bridges
Article
Multidisciplinary Sciences
Fred S. Lu, Mohammad W. Hattab, Cesar Leonardo Clemente, Matthew Biggerstaff, Mauricio Santillana
NATURE COMMUNICATIONS
(2019)
Article
Public, Environmental & Occupational Health
Michelle M. Hughes, Joshua D. Doyle, Keegan McCaffrey, Melissa McMahon, Melanie Spencer, Karen Martin, Gregg M. Reed, Anna E. Carmack, Shikha Garg, Melissa Rolfes, Carrie Reed, Matthew Biggerstaff
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2019)
Article
Immunology
Matthew Biggerstaff, Cheryl Cohen, Carrie Reed, Stefano Tempia, Meredith L. McMorrow, Sibongile Walaza, Jocelyn Moyes, Florette K. Treurnicht, Adam L. Cohen, Paul Hutchinson, Charles Stoecker, Joni Steinberg
Review
Infectious Diseases
Pei-Ying Kobres, Jean-Paul Chretien, Michael A. Johansson, Jeffrey J. Morgan, Pai-Yei Whung, Harshini Mukundan, Sara Y. Del Valle, Brett M. Forshey, Talia M. Quandelacy, Matthew Biggerstaff, Cecile Viboud, Simon Pollett
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Infectious Diseases
Matthew Biggerstaff, Fredrick Scott Dahlgren, Julia Fitzner, Dylan George, Aspen Hammond, Ian Hall, David Haw, Natsuko Imai, Michael A. Johansson, Sarah Kramer, James M. McCaw, Robert Moss, Richard Pebody, Jonathan M. Read, Carrie Reed, Nicholas G. Reich, Steven Riley, Katelijn Vandemaele, Cecile Viboud, Joseph T. Wu
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2020)
Article
Economics
Evan L. Ray, Logan C. Brooks, Jacob Bien, Matthew Biggerstaff, Nikos I. Bosse, Johannes Bracher, Estee Y. Cramer, Sebastian Funk, Aaron Gerding, Michael A. Johansson, Aaron Rumack, Yijin Wang, Martha Zorn, Ryan J. Tibshirani, Nicholas G. Reich
Summary: The U.S. COVID-19 Forecast Hub collects forecasts from multiple teams to provide short-term burden predictions for COVID-19 in the United States. Through experiments, they found that an untrained and robust approach of equally weighted median is a good choice for ensemble forecasting, especially when component forecasts occasionally misalign with reported data or show instability in performance over time. However, trained ensembles that give higher weight to reliable forecasters can also be valuable in certain settings.
INTERNATIONAL JOURNAL OF FORECASTING
(2023)
Article
Health Care Sciences & Services
Raymond Soto, Litty Paul, Christina A. Porucznik, Heng Xie, Rita Czako Stinnett, Benjamin Briggs, Matthew Biggerstaff, Joseph Stanford, Robert Schlaberg
Summary: This study compared self-collected nasal swabs to swabs collected by trained staff. The results showed that self-collection was feasible and yielded consistent results with staff-collected samples. This method has potential importance for identifying respiratory viruses and implementing testing during pandemics.
JMIR FORMATIVE RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Rebecca Garten, Lenee Blanton, Anwar Isa Abd Elal, Noreen Alabi, John Barnes, Matthew Biggerstaff, Lynnette Brammer, Alicia P. Budd, Erin Burns, Charisse N. Cummings, Todd Davis, Shikha Garg, Larisa Gubareva, Yunho Jang, Krista Kniss, Natalie Kramer, Stephen Lindstrom, Desiree Mustaquim, Alissa O'Halloran, Wendy Sessions, Calli Taylor, Xiyan Xu, Vivien G. Dugan, Alicia M. Fry, David E. Wentworth, Jacqueline Katz, Daniel Jernigan
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2018)
Article
Public, Environmental & Occupational Health
Matthew Biggerstaff, Krista Kniss, Daniel B. Jernigan, Lynnette Brammer, Joseph Bresee, Shikha Garg, Erin Burns, Carrie Reed
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2018)
Article
Public, Environmental & Occupational Health
Noreen Qualls, Alexandra Levitt, Neha Kanade, Narue Wright-Jegede, Stephanie Dopson, Matthew Biggerstaff, Carrie Reed, Amra Uzicanin
MMWR RECOMMENDATIONS AND REPORTS
(2017)