Article
Engineering, Biomedical
Shutao Zhang, Xinhua Qu, Juyang Jiao, Haozheng Tang, Minqi Wang, You Wang, Hongtao Yang, Weien Yuan, Bing Yue
Summary: Felodipine has antibacterial effects against MRSA, biofilm, and persisters. It can inhibit the expression of proteins associated with aminoglycoside resistance, eradicate formed biofilms and kill persisters. Felodipine also reduces MRSA virulence and modulates bacterial metabolism. It inhibits the growth of persisters by binding to a protease. In a mouse infection model, felodipine in combination with gentamicin alleviates bacterial burden and inflammation.
BIOACTIVE MATERIALS
(2022)
Review
Infectious Diseases
Sean N. Avedissian, Nathanial J. Rhodes, Christopher L. Shaffer, Lan Tran, John S. Bradley, Jennifer Le
Summary: MRSA remains a significant pathogen in children, with MRSA bacteremia closely associated with complications. Treatment options include vancomycin, oxazolidinones, semi-synthetic glycopeptides, daptomycin, tigecycline, novel cephalosporins, fosfomycin, and lefamulin, but limited data exist on usage in pediatric patients. Future studies are needed to ensure appropriate therapeutic treatment and outcomes, with phage therapy emerging as an investigational treatment option for deep-seated MRSA infections.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Rong Huang, Guang-Qing Cai, Jian Li, Xi-Sheng Li, Hai-Ting Liu, Xue-Ling Shang, Jian-Dang Zhou, Xin-Min Nie, Rong Gui
Summary: A novel nano-drug delivery system, PLT@Ag-MOF-Vanc, was constructed for the treatment of MRSA infections, showing good antibacterial activity, biocompatibility, and targeting capabilities. It killed MRSA through multiple approaches and demonstrated superior anti-infective effects in a mouse MRSA pneumonia model compared to free vancomycin.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shutao Zhang, Xinhua Qu, Haozheng Tang, You Wang, Hongtao Yang, Weien Yuan, Bing Yue
Summary: The study shows that high-dose diclofenac inhibits the growth of MRSA without inducing drug-resistant mutations easily, while low-dose diclofenac can resensitize bacteria to beta-lactams and inhibit biofilm formation. Transcriptomic and proteomic analyses indicate that diclofenac reduces the expression of genes and proteins associated with antibiotic resistance and biofilm formation. Murine implant infection models suggest that diclofenac combined with beta-lactams can substantially alleviate MRSA infections in vivo, offering promising applications for preventing perioperative infections.
Review
Infectious Diseases
Elham Zarenezhad, Hussein T. Abdulabbas, Mahrokh Marzi, Esraa Ghazy, Mohammad Ekrahi, Babak Pezeshki, Abdolmajid Ghasemian, Amira A. Moawad
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) has developed extensive antibiotic resistance and contains virulence factors for severe infections. Nickel nanoparticles (NiNPs) have shown potential as a cheap prognostic and therapeutic agent, exerting antibacterial effects through disrupting cell membranes, deforming proteins, and inhibiting DNA replication.
Article
Infectious Diseases
Md Saruar Bhuiyan, Jhih-Hang Jiang, Xenia Kostoulias, Ravali Theegala, Graham J. Lieschke, Anton Y. Peleg
Summary: The study investigated host innate immune responses against clinically derived, daptomycin-resistant and -susceptible Staphylococcus aureus isolates using a zebrafish infection model. Results showed that control of daptomycin-resistant S. aureus infections in vivo was compromised due to cross-resistance to host cationic antimicrobial peptides, shedding light on persistent infections caused by this troublesome pathogen.
Article
Microbiology
Jiun-Liang Chen, Tsung-Yu Huang, Wei-Bin Hsu, Chiang-Wen Lee, Yao-Chang Chiang, Pey-Jium Chang, Kuo-Ti Peng
Summary: This study investigated the genotypic and phenotypic characteristics of MRSA clones isolated from PJI patients in a hospital in Taiwan. The findings showed that ST239 MRSA isolates were highly resistant to multiple antibiotics, had a high biofilm formation ability, and infected patients typically exhibited fever and inflammation. Additionally, knee infections were mainly attributed to ST59 MRSA, and there was an increasing trend of infections caused by ST8 and other MRSA genotypes in PJI patients.
Article
Microbiology
Yuwen Lu, Yifei Lu, Baobao Li, Jiazhen Liu, Lixin Wang, Lianyang Zhang, Yang Li, Qiu Zhong
Summary: StAP1 phage is a MRSA phage isolated from a Chinese hospital, exhibiting broad-spectrum characteristics and strong lytic effects on various MRSA strains, indicating its potential application in MRSA infection treatment.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Kuan-Yi Lu, Nikki J. Wagner, Amanda Z. Velez, Agathe Ceppe, Brian P. Conlon, Marianne S. Muhlebach
Summary: MRSA infections are common and chronic in cystic fibrosis patients but are often resistant to antibiotic therapy. This study investigated whether bacterial phenotypes could predict the clinical outcomes of MRSA infections. The results showed no associations between these phenotypes and MRSA clearance, suggesting that additional factors may be relevant for predicting the clearance of MRSA.
MICROBIOLOGY SPECTRUM
(2023)
Article
Dermatology
Mariko Sugawara-Mikami, Hiroshi Kaneko, Hiroaki Sasaki, Nobuko Sagawa, Takeshi Kambara, Hidemasa Nakaminami
Summary: Skin infections caused by PVL-positive MRSA, specifically the USA300 clone, have been increasing in Japan. This study reports 10 cases of PVL-positive MRSA skin infections over a two-year period, with 90% of the infections being caused by the USA300 clone. Atopic dermatitis (AD) was found to be a common underlying disease, and longer durations of antimicrobial therapy were required for AD patients compared to non-AD patients. However, all cases improved with long-term treatment using fosfomycin, minocycline, doxycycline, and/or rifampicin.
JOURNAL OF DERMATOLOGY
(2022)
Article
Immunology
Sarah C. J. Jorgensen, Brad Spellberg, Andrew F. Shorr, William F. Wright
Summary: In this analysis, the methodological weaknesses and inconsistencies in the data surrounding therapeutic drug monitoring based on vancomycin 24-hour area under the concentration-time curve are highlighted. It is suggested that alternative strategies, such as antibiotic stewardship and achieving earlier and more complete source control, may be more effective with superior safety and efficacy outcomes. The implementation of AUC(24)-based therapeutic drug monitoring may divert resources away from these more promising alternative solutions, as the supporting data for vancomycin AUC(24) monitoring are insufficient and lack convincing evidence of benefit.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Engineering, Biomedical
J. J. Aguilera-Correa, M. Gisbert-Garzaran, A. Mediero, M. J. Fernandez-Acenero, D. de-Pablo-Velasco, D. Lozano, J. Esteban, M. Vallet-Regi
Summary: This study proposes the use of bone-targeted mesoporous silica nanoparticles for the treatment of Staphylococcus aureus-caused osteomyelitis, providing synergistic therapeutic effects through multidrug delivery. The nanoparticles are engineered with a functional coating that can disaggregate bacterial biofilms, inhibit premature antibiotic release, and protect the intact bone. They effectively target bone tissue both in vitro and in vivo, demonstrating high biocompatibility and significant antibacterial effects.
ACTA BIOMATERIALIA
(2022)
Article
Dermatology
Torstein Gronseth, Kirill Ovchinnikov, Harald Carlsen, Jurate Saltyte Benth, Dzung B. Diep, Magnus von Unge, Juha T. Silvola
Summary: This study evaluated the antibacterial efficacy of Lugol's solution and Gentian violet against MRSA biofilm in vivo, and found that these two agents effectively eradicated MRSA biofilm, suggesting their potential as alternatives or adjuncts to topical antibiotics.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Infectious Diseases
Hyemin Chung, Eunsil Kim, Eunmi Yang, Yun Woo Lee, Joung Ha Park, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim
Summary: This study investigated the clinical and microbiological characteristics of persistent bacteremia caused by the major CA-MRSA strain in Korea. Recurrent bacteremia within 12 weeks was significantly more common in persistent bacteremia group, and risk factors included liver cirrhosis, high initial CRP, infective endocarditis, and bone and joint infections.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Microbiology
Jian Wei, Yinxian Wen, Kai Tong, Hui Wang, Liaobin Chen
Summary: In a rat model, intraarticular injection of vancomycin showed better effectiveness and safety in controlling MRSA periprosthetic joint infection compared to systemic administration, providing potential eradication of the infection with a 2-week treatment course.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
