Article
Public, Environmental & Occupational Health
Feiteng Zhu, Hemu Zhuang, Shujuan Ji, Er Xu, Lingfang Di, Zhengan Wang, Shengnan Jiang, Haiping Wang, Lu Sun, Ping Shen, Yunsong Yu, Yan Chen
Summary: The study found that in households of CA-MRSA infected patients in China, most MRSA isolates belonged to epidemic CA-MRSA clones, while no MRSA was detected in the control group households. The research revealed that the home environment is an important reservoir for MRSA.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Infectious Diseases
Martyna Kasela, Mateusz Ossowski, Ewelina Dzikon, Katarzyna Ignatiuk, Lukasz Wlazlo, Anna Malm
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of infectious diseases in humans and animals, resulting in economic losses in human healthcare and the farming sector. The changing epidemiology of MRSA globally affects animal welfare and public health concerns. Livestock have high rates of MRSA colonization, raising questions about reservoirs and transmission, while companion animals vary in MRSA colonization and infection rates, impacting human health. This article highlights the circulation of animal-associated MRSA (AA-MRSA) in the environment and factors influencing its transmission, as well as successful strategies to limit its spread among animals and humans.
Article
Immunology
Tsai-Wen Wan, Lee-Jene Teng, Tatsuo Yamamoto
Summary: CA-MRSA/J is a unique community-associated strain of Staphylococcus aureus with surface structures associated with invasive infections.A local CA-MRSA/J strain has emerged in Japan, showing unique bacterial surface structures that could lead to more severe infections.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Review
Environmental Sciences
Ying Wang, Peihua Zhang, Jian Wu, Shuaiyin Chen, Yuefei Jin, Jinzhao Long, Guangcai Duan, Haiyan Yang
Summary: Staphylococcus aureus (S. aureus) is a dangerous bacterial pathogen that can infect both humans and animals. Methicillin-resistant S. aureus (MRSA) is classified into different types based on their sources, such as hospital-associated (HA-MRSA), community-associated (CA-MRSA), and livestock-associated MRSA (LA-MRSA). LA-MRSA, initially associated with livestock, has spread among humans, animals, and the environment due to factors like animal husbandry, globalization, and antibiotic use. This review provides an overview of the transmission characteristics of S. aureus and its clones in different hosts, as well as the changes in mobile genetic elements (MGEs) during host switching.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Cell Biology
Zhimin Bai, Min Chen, Qiaofa Lin, Ying Ye, Hongmei Fan, Kaizhen Wen, Jianxing Zeng, Donghong Huang, Wenfei Mo, Ying Lei, Zhijun Liao
Summary: By extracting feature vectors from protein sequences and using classification tools, MRSA and MSSA were successfully distinguished. MRSA showed high resistance to penicillin and high pathogenic risk. Cross-infection between different types of MRSA was found in Quanzhou, and MRSA in traditional hospitals exhibited increasingly blurred molecular characteristics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Muhammad Mubashar Idrees, Khadija Saeed, Muhammad Akbar Shahid, Muhammad Akhtar, Khadija Qammar, Javariya Hassan, Tayyaba Khaliq, Ali Saeed
Summary: This cross-sectional study aimed to determine the prevalence of mecA and mecC genes among phenotypically identified MRSA and evaluate their effectiveness against different antibiotics. The results showed a high prevalence of mecA and mecC in MRSA samples, and penicillin and amoxicillin/clavulanic acid were ineffective against MRSA, while vancomycin, teicoplanin, and linezolid were the most effective drugs.
Article
Chemistry, Multidisciplinary
Shutao Zhang, Xinhua Qu, Haozheng Tang, You Wang, Hongtao Yang, Weien Yuan, Bing Yue
Summary: The study shows that high-dose diclofenac inhibits the growth of MRSA without inducing drug-resistant mutations easily, while low-dose diclofenac can resensitize bacteria to beta-lactams and inhibit biofilm formation. Transcriptomic and proteomic analyses indicate that diclofenac reduces the expression of genes and proteins associated with antibiotic resistance and biofilm formation. Murine implant infection models suggest that diclofenac combined with beta-lactams can substantially alleviate MRSA infections in vivo, offering promising applications for preventing perioperative infections.
Article
Medicine, General & Internal
Ching Hoong Chew, Chew Chieng Yeo, Ainal Mardziah Che Hamzah, Esra'a I. Al-Trad, Sherry Usun Jones, Kek Heng Chua, Suat Moi Puah
Summary: Multidrug resistance (MDR) poses a significant challenge in healthcare management, and a comprehensive approach is needed to address this issue. In this study, a combination of phenotypic and genotypic methods, including whole genome sequencing (WGS), was used to investigate hospital-associated MDR methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from newborn infants. The findings revealed different levels of resistance to antimicrobial classes among the MDR-MRSA strains, along with the presence of slime and biofilms, SCCmec type IV, and various types of microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) and virulence genes. The WGS data for specific strains showed the presence of antimicrobial resistance genes in the chromosomes, with one gene found in a small plasmid. The presence of MDR-MRSA strains in neonates raises public concern, and multifaceted interventions are recommended to address this issue. Furthermore, there is a need for metadata to improve the investigation of antimicrobial resistance genes in MDR isolates.
Article
Food Science & Technology
Martina Florianova, Kristyna Korena, Helena Juricova
Summary: This study evaluated the prevalence of Staphylococcus aureus in dry-fermented salami and found multidrug-resistant and virulent strains. The source of contamination was identified as raw pork and human carriers. Therefore, maintaining high standards of hygiene and manufacturing practices in food processing is crucial.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Immunology
Stephanie N. Thiede, Evan S. Snitkin, William Trick, Darjai Payne, Alla Aroutcheva, Robert A. Weinstein, Kyle J. Popovich
Summary: This study used genomic epidemiology and statewide data to infer the origins of methicillin-resistant Staphylococcus aureus (MRSA). Among individuals with hospital-onset and healthcare-associated community-onset MRSA, community exposures associated with infection were identified, but there was little evidence of shared exposure in healthcare settings.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Infectious Diseases
Joshua. B. Parsons, Annette. C. Westgeest, Brian. P. B. Conlon, Vance. G. Fowler
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a deadly pathogen that can persist in the bloodstream for days despite appropriate antibiotics. Persistent MRSA bacteremia is common and associated with poor clinical outcomes. This review explores the factors related to host-pathogen interaction and discusses the clinical relevance of each element. Treatment options and diagnostic approaches for managing persistent MRSA bacteremia are also discussed.
Article
Medicine, General & Internal
Ming-Han Tsai, Chih-Yung Chiu, Kuan-Wen Su, Sui-Ling Liao, Hsiang-Ju Shih, Man-Chin Hua, Tsung-Chieh Yao, Shen-Hao Lai, Kuo-Wei Yeh, Li-Chen Chen, Jing-Long Huang
Summary: The study found that infants had the highest incidence of S. aureus colonization at 1 month of age, which decreased to a nadir at 12 months. Maternal smoking may increase the risk of infant S. aureus colonization. Horizontal transmission between mothers and infants may be the primary source of MRSA acquisition in early infancy.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Kazuhiko Ikeuchi, Eisuke Adachi, Takashi Sasaki, Masato Suzuki, Lay Ahyoung Lim, Makoto Saito, Michiko Koga, Takeya Tsutsumi, Yasutoshi Kido, Yuki Uehara, Hiroshi Yotsuyanagi
Summary: An outbreak of USA300 has been identified among people with HIV in Tokyo, with individuals who have a history of sexually transmitted infections showing a higher risk of colonization by this strain. Genomic analysis revealed close relatedness and specific genetic variations related to carbohydrate metabolism and antimicrobial resistance in the isolated strains.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Nanoscience & Nanotechnology
Maricely Ramirez-Hernandez, Javiera Norambuena, Hongnan Hu, Belvin Thomas, Chaoyun Tang, Jeffrey M. Boyd, Tewodros Asefa
Summary: The urgent need for materials that can more efficiently deliver antimicrobial agents has arisen due to the increase in microbial resistance to traditional antibiotics. This study presents the synthesis of amine-functionalized SBA-15 mesoporous silica nanomaterials loaded with rafoxanide and anchored Cu(II) ions, which exhibit enhanced antimicrobial efficacy against pathogenic Staphylococcus aureus. The structurally characterized nanomaterials demonstrate 10 times the bactericidal action compared to nanomaterials loaded with rafoxanide only, and the synthetic sequence used in the production significantly impacts their bactericidal efficacy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Microbiology
Melissa J. Karau, Suzannah M. Schmidt-Malan, Scott A. Cunningham, Jayawant N. Mandrekar, Bobbi S. Pritt, Tiffany R. Keepers, Alisa W. Serio, Surya Chitra, Robin Patel
Summary: Omadacycline, vancomycin, and rifampin, as well as rifampin combination therapies, were evaluated in an experimental rat model of MRSA osteomyelitis. The results showed that rifampin combination therapy was effective in reducing MRSA recovery without developing resistance. The combination of omadacycline and rifampin yielded negative MRSA detection, suggesting its potential as a treatment for osteomyelitis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)