Review
Infectious Diseases
John C. Lam, Raynell Lang, William Stokes
Summary: Bacterial prostatitis is a common and complicated infection in men, with difficulties in diagnosis and treatment. The lack of high-quality evidence makes it challenging for clinicians to interpret patients' history, physical examination, and laboratory findings. Limited antimicrobials capable of prostate penetration, the emergence of antimicrobial resistance, and the high risk of recurrence further complicate treatment options.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Microbiology
Joaquin Burgos, Yannick Hoyos-Mallecot, Carles Ferre-Losa, Maider Arando, Arnau Monforte, Tomas Pumarola, Ibai Los-Arcos, Vicenc Falco
Summary: This study assessed the feasibility of oral fosfomycin-tromethamine (FT) for the management of multidrug-resistant (MDR) Enterobacterales-induced acute bacterial prostatitis (ABP). The results showed that all patients achieved clinical cure and 11 out of 12 patients achieved microbiological cure. Two patients relapsed during the follow-up period. The availability of oral treatment with FT could have important benefits in terms of patient's quality of life, health costs, and ecological impact.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Joaquin Burgos, Yannick Hoyos-Mallecot, Carles Ferre-Losa, Maider Arando, Arnau Monforte, Tomas Pumarola, Ibai Los-Arcos, Vicenc Falco
Summary: The study assessed the feasibility of using oral fosfomycin-tromethamine for the treatment of acute bacterial prostatitis caused by multidrug-resistant Enterobacterales. The results showed that all patients achieved clinical cure and only two patients reported diarrhea as a side effect.
MICROBIOLOGY SPECTRUM
(2023)
Review
Infectious Diseases
Sander G. Kuiper, Maarten Ploeger, Erik B. Wilms, Marleen M. van Dijk, Emiel Leegwater, Robert A. G. Huis in't Veld, Cees van Nieuwkoop
Summary: In this case series, 11 men with chronic bacterial prostatitis caused by multi-resistant E. coli were treated with once-daily ceftriaxone intravenously. Nine patients were clinically cured at 3 months follow up, suggesting that ceftriaxone can be considered an appropriate treatment option for chronic bacterial prostatitis.
Article
Immunology
Wei-Jie Song, Jun Gao, Ji-Wei Huang, Yuan Liu, Zhi Long, Le-Ye He
Summary: By detecting the composition and function of microorganisms in expressed prostatic secretion (EPS) of patients with chronic prostatitis (CP) and healthy people, this study explored whether type III prostatitis is related to bacterial infection. The results showed that there were many microorganisms in EPS in both CP patients and healthy populations, but the relative abundance of specific bacteria in CP patients, including Pseudomonas, Haemophilus, Sneathia, Allobaculum, and Enterococcus, was significantly different. Metagenomics sequencing also revealed that different bacteria in the type III prostatitis group had certain biological functions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Roy H. Stevens, Hongming Zhang, Michal Kajsik, Rafal Ploski, Malgorzata Rydzanicz, Peter Sabaka, Stanislav Sutovsky
Summary: Chronic prostatitis (CP) is a common inflammatory condition of the prostate that affects 2%-10% of the world's male population. This study reports the successful use of a bacteriophage-derived muralytic enzyme to treat and resolve chronic bacterial prostatitis (CBP) in a 39 years-old patient.
FRONTIERS IN MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Ester Marquez-Algaba, Joaquin Burgos, Benito Almirante
Summary: Bacterial prostatitis, both acute and chronic, is a common urogenital infection in men. Gram-negative bacilli are the most frequent causative agents, and an increase in multiresistant bacteria has been observed. Optimal antimicrobial treatment should include drugs with proven in vitro activity and good penetration into the prostatic tissue.
EXPERT OPINION ON PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Apurva Virmani Johri, Pranav Johri, Naomi Hoyle, Lia Nadareishvili, Levan Pipia, Dea Nizharadze
Summary: This case presents a patient with Chronic Bacterial Prostatitis (CBP) who did not respond to long-term antibiotic treatment. Phage therapy resulted in significant symptomatic improvement and complete resolution of symptoms, indicating the potential efficacy of bacteriophages in treating drug-resistant and chronic infections.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Jiangtao Qiao, Xingying Xiao, Kai Wang, Eric Haubruge, Jie Dong, Hongcheng Zhang
Summary: This study found that rapeseed bee pollen can effectively alleviate chronic non-bacterial prostatitis by selectively regulating gut microbiota, with higher doses and wall-disrupted pollen showing greater efficacy. Rapeseed bee pollen can inhibit the growth of pathogenic bacteria and enhance the abundance of beneficial bacteria, particularly in the Firmicutes-to-Bacteroidetes (F/B) ratio and the abundance of Prevotella (genus).
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Engineering, Biomedical
Jun Zheng, Ruimin Hu, Yang Yang, Yu Wang, Qianmei Wang, Senlin Xu, Pu Yao, Zhiyong Liu, Jiangling Zhou, Jing Yang, Ying Bao, Dinglin Zhang, Wenhao Shen, Zhansong Zhou
Summary: The study fabricated cefpodoxime proxetil (CPD)-loaded nanoparticles for targeted treatment of chronic bacterial prostatitis, which demonstrated efficient eradication of bacteria, relief of pain, and reduction of proinflammatory cytokine expression in prostate tissues.
ACTA BIOMATERIALIA
(2022)
Article
Medicine, General & Internal
Biagio Barone, Benito Fabio Mirto, Alfonso Falcone, Francesco Del Giudice, Achille Aveta, Luigi Napolitano, Dario Del Biondo, Matteo Ferro, Gian Maria Busetto, Celeste Manfredi, Daniela Terracciano, Raffaele Gambardella, Savio Domenico Pandolfo, Francesco Trama, Ciro De Luca, Raffaele Martino, Federico Capone, Gaetano Giampaglia, Enrico Sicignano, Octavian Sabin Tataru, Giuseppe Lucarelli, Felice Crocetto
Summary: Bacterial prostatitis is a common prostatic infection that significantly affects quality of life. The combination of appropriate antibiotics and nutraceutical products can enhance treatment efficacy. This study found that the combination therapy of Flogofilm (R) and fluoroquinolones demonstrated significant improvement in pain, urinary symptoms, and quality of life in patients with chronic bacterial prostatitis, as indicated by IPSS and NIH-CPSI scores, compared to fluoroquinolones alone.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Microbiology
Ester Marquez-Algaba, Carles Pigrau, Pau Bosch-Nicolau, Belen Vinado, Judit Serra-Pladevall, Benito Almirante, Joaquin Burgos
Summary: The study aimed to analyze risk factors for relapse in patients with acute bacterial prostatitis and found inadequate antibiotic therapy to be the only independent risk factor for relapse. Adjusting antibiotic therapy based on susceptibility pattern reduced relapse rates, with quinolones and intravenous beta-lactams showing lower rates compared to other antibiotics. Choosing an appropriate antibiotic based on microbiological isolation results is crucial for definitive treatment of acute bacterial prostatitis.
MICROBIOLOGY SPECTRUM
(2021)
Article
Pharmacology & Pharmacy
Apurva Virmani Johri, Pranav Johri, Naomi Hoyle, Levan Pipia, Lia Nadareishvili, Dea Nizharadze
Summary: Chronic Bacterial Prostatitis is a long-lasting inflammatory condition primarily affecting men under 50, with limited effectiveness of antibiotic treatment and bacteriophage therapy emerging as a promising alternative. The use of lytic bacterial viruses has shown significant improvements in controlling chronic infections caused by antibiotic-resistant bacteria in the male pelvic region.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Alberto Trinchieri, Khalid Mohammed Abdelrahman, Kamran Hassan Bhatti, Jibril O. Bello, Krishanu Das, Ognyan Gatsev, Ivanka Gergova, Vittorio Magri, Nikos Mourmouras, Panagiotis Mourmouris, Soni Murdeshwar, Gianpaolo Perletti, Iliya Saltirov, Idrissa Sissoko, Konstantinos Stamatiou, Noor Buchholz
Summary: This study evaluated spectrum and resistance rates to antibacterial agents in causative pathogens of bacterial prostatitis in patients from Southern Europe, the Middle East, and Africa. The findings showed significant differences in resistance rates to various antibiotics, highlighting the importance of local guidelines for treatment.
Article
Pharmacology & Pharmacy
Catalin Pricop, Daniel Andone, Silviu Latcu, George Daniel Radavoi, Ioan Cordos, Viorel Jinga, Tudor Proca, Alin Cumpanas, Dragos Puia
Summary: The study found that fluoroquinolones and cephalosporins are equally effective and tolerated in treating patients with acute bacterial prostatitis, and both groups showed similar rates of side effects and positive urine culture.
Editorial Material
Endocrinology & Metabolism
Luigi Uccioli, Laura Giurato, Marco Meloni, Valentina Izzo, Valeria Ruotolo, Roberto Gandini, Benjamin Lipsky
Letter
Dermatology
Karel Bakker, Jan Apelqvist, Ben A. Lipsky, Jaap J. Van Netten, Nicolaas C. Schaper
INTERNATIONAL WOUND JOURNAL
(2016)
Article
Surgery
Kheeldass Jugun, Jean-Christophe Richard, Benjamin A. Lipsky, Benjamin Kressmann, Brigitte Pittet-Cuenod, Domizio Suva, Ali Modarressi, Ilker Uckay
Review
Infectious Diseases
Ilker Uckay, Karim Gariani, Victor Dubois-Ferriere, Domizio Suva, Benjamin A. Lipsky
CURRENT OPINION IN INFECTIOUS DISEASES
(2016)
Article
Endocrinology & Metabolism
Benjamin A. Lipsky
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2016)
Article
Endocrinology & Metabolism
E. J. Peters, B. A. Lipsky, J. Aragon-Sanchez, E. J. Boyko, M. Diggle, J. M. Embil, S. Kono, L. A. Lavery, E. Senneville, V. Urbancic-Rovan, S. A. Van Asten, W. J. Jeffcoate
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2016)
Article
Endocrinology & Metabolism
K. Bakker, J. Apelqvist, B. A. Lipsky, J. J. Van Netten, N. C. Schaper
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2016)
Article
Endocrinology & Metabolism
N. C. Schaper, J. J. Van Netten, J. Apelqvist, B. A. Lipsky, K. Bakker
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2016)
Article
Endocrinology & Metabolism
Benjamin A. Lipsky, Javier Aragon-Sanchez, Mathew Diggle, John Embil, Shigeo Kono, Lawrence Lavery, Eric Senneville, Vilma Urbancic-Rovan, Suzanne Van Asten, Edgar J. G. Peters
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2016)
Article
Endocrinology & Metabolism
Mustafa Hatipoglu, Mesut Mutluoglu, Vedat Turhan, Gunalp Uzun, Benjamin A. Lipsky, Erol Sevim, Hayati Demiraslan, Esma Eryilmaz, Cem Ozuguz, Ali Memis, Hakan Ay, Bilgin Arda, Serhat Uysal, Vicdan Koksaldi Motor, Cigdem Kader, Ayse Erturk, Omer Coskun, Fazilet Duygu, Selma Guler, Fatma Aybala Altay, Aziz Ogutlu, Sibel Bolukcu, Senol Yildiz, Ozlem Kandemir, Halide Aslaner, Arife Polat, Mustafa K. Karahocagil, Kadriye Kart Yasar, Emine Sehmen, Sirri Kilic, Mustafa Sunbul, Serap Gencer, Fatma Bozkurt, Tugba Yanik, Nefise Oztoprak, Ayse Batirel, Hamdi Sozen, Inci Kilic, Ilhami Celik, Bengisu Ay, Selma Tosun, Ayten Kadanali, Senol Comoglu, Affan Denk, Salih Hosoglu, Ozlem Aydin, Nazif Elaldi, Serife Akalin, Bahar Kandemir, Ayhan Akbulut, Tuna Demirdal, Recep Balik, Emel Azak, Gonul Sengoz
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2016)
Article
Dermatology
Christian Willy, Animesh Agarwal, Charles A. Andersen, Giorgio De Santis, Allen Gabriel, Onnen Grauhan, Omar M. Guerra, Benjamin A. Lipsky, Mahmoud B. Malas, Lars L. Mathiesen, Devinder P. Singh, V. Sreenath Reddy
INTERNATIONAL WOUND JOURNAL
(2017)
Article
Infectious Diseases
Helene Chaussade, Ilker Uckay, Albert Vuagnat, Jerome Druon, Guillaume Gras, Philippe Rosset, Benjamin A. Lipsky, Louis Bernard
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2017)
Article
Health Care Sciences & Services
Matthew Scarborough, Ho Kwonn Li, Ines Rombach, Rhea Zambellas, A. Sarah Walker, Martin McNally, Bridget Atkins, Michelle Kumin, Benjamin A. Lipsky, Harriet Hughes, Deepa Bose, Simon Warren, Damien Mack, Jonathan Folb, Elinor Moore, Neil Jenkins, Susan Hopkins, R. Andrew Seaton, Carolyn Hemsley, Jonathan Sandoe, Ila Aggarwal, Simon Ellis, Rebecca Sutherland, Claudia Geue, Nicola McMeekin, Claire Scarburough, John Paul, Graham Cooke, Jennifer Bostock, Elham Khatamzas, Nick Wong, Andrew Brent, Jose Lomas, Philippa Matthews, Tri Wangrangsimakul, Roger Gundle, Mark Rogers, Adrian Taylor, Guy E. Thwaites, Philip Bejon
HEALTH TECHNOLOGY ASSESSMENT
(2019)
Article
Endocrinology & Metabolism
Benjamin A. Lipsky, Eric Senneville, Zulfiqarali G. Abbas, Javier Aragon-Sanchez, Mathew Diggle, John M. Embil, Shigeo Kono, Lawrence A. Lavery, Matthew Malone, Suzanne A. van Asten, Vilma Urbancic-Rovan, Edgar J. G. Peters
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2020)
Article
Endocrinology & Metabolism
Ilker Uckay, Vinoth Yogarasa, Felix W. A. Waibel, Annette Seiler-Banziger, Maja Kuhn, Margrit Sahli, Martin C. Berli, Benjamin A. Lipsky, Madlaina Schoni
Summary: This study found that DFI episodes with low Nutritional Risk Status-Scores were associated with lower failure rates after treatment, while nutritional interventions improved the outcome of DFI.
JOURNAL OF DIABETES RESEARCH
(2022)