Article
Pediatrics
Natalie Banniettis, Michael Horn, Manish M. Sadarangani, Shrita M. Patel, David Greenberg, Peninnah P. Oberdorfer, Nicola P. Klein, Richard Rupp, Ron Dagan, Peter Richmond, Jessie Lumley, Wei Zhou, Yaru Shi, Gretchen Tamms, Kristen Feemster, Robert Lupinacci, Luwy Musey, Kara Bickham
Summary: This study evaluated the safety and tolerability of V114 in infants. The results showed that the proportions of participants with adverse events were generally comparable between recipients of V114 and PCV13. Most adverse events were mild-to-moderate in intensity and lasted no more than 3 days. These study results support routine use of V114 in infants.
Article
Pediatrics
Julia G. Harris, Luke A. Harris, Liset Olarte, E. Claire Elson, Rachel Moran, Douglas L. Blowey, Rana E. El Feghaly
Summary: This project aimed to improve PPSV23 vaccination rates for pediatric patients at high risk for invasive pneumococcal disease (IPD) through several initiatives and practices. The results showed an increase in vaccination rate from approximately 20% to approximately 60%. This suggests that using quality improvement methodology can enhance vaccination rates and achieve sustained and comprehensive improvements across different divisions.
Article
Immunology
Juliette Romaru, Mathilde Bahuaud, Gauthier Lejeune, Maxime Hentzien, Jean-Luc Berger, Ailsa Robbins, Delphine Lebrun, Yohan N'Guyen, Firouze Bani-Sadr, Frederic Batteux, Amelie Servettaz
Summary: This study evaluated the immunological response and protection in HIV patients with a CD4 cell count above 200 cells/μL after receiving a single dose of PCV13. The results showed that PCV13 induced immune response and protection in these patients at one month, and over half of the patients remained immunologically protected at one year after vaccination.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rahul Ahuja, Asha Shelly, Jairam Meena, Amulya K. Panda
Summary: Protein-based vaccines are a safe and affordable strategy for combating pneumococcal disease. The study shows that using biodegradable polymer microparticles can improve the immunogenicity of the pneumococcal protein SP0845, resulting in higher antibody response and better temperature stability compared to traditional adjuvanted protein vaccines.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Immunology
Gail L. Rodgers, Cynthia G. Whitney, Keith P. Klugman
Summary: Pneumococcal conjugate vaccine has successfully reduced the burden of disease and provided herd protection for those who cannot be vaccinated. While widely rolled out in poor countries, there are still many unvaccinated children in middle income countries. Solutions being considered include reducing doses and supporting more affordable vaccine sources.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Marianna Riekkinen, Sari H. Pakkanen, Veronik Hutse, Inge Roukaerts, Jukka Ollgren, Helena Kayhty, Christian Herzog, Lars Rombo, Anu Kantele
Summary: This study examined the influence of coadministration of HepA and PCV13 on safety and immunogenicity. The results showed that coadministration of PCV13 significantly impaired antibody responses to HepA, but did not impact the response to PCV13. Overall, there were no major safety concerns.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Infectious Diseases
Hannah M. Garcia Garrido, Jenny L. Schnyder, Beheshta Haydari, Albert M. Vollaard, Michael W. T. Tanck, Godelieve J. de Bree, Bob Meek, Martin P. Grobusch, Abraham Goorhuis
Summary: The immunogenicity of the combined pneumococcal vaccination schedule in PLWH was investigated, showing low initial seroprotection rates and rapid decline, highlighting the need for further research into alternative strategies and higher-valent vaccine schedules.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Immunology
Kristina L. Bajema, Ryan Gierke, Monica M. Farley, William Schaffner, Ann Thomas, Arthur L. Reingold, Lee H. Harrison, Ruth Lynfield, Kari E. Burzlaff, Susan Petit, Meghan Barnes, Salina Torres, Paula M. Snippes Vagnone, Bernard Beall, Tamara Pilishvili
Summary: The incidence of antibiotic-nonsusceptible invasive pneumococcal disease (NS-IPD) has decreased in the United States after the introduction of 7- and 13-valent pneumococcal conjugate vaccines (PCVs). However, there has been an increase in nonvaccine type NS-IPD, particularly among older adults. The use of higher valency PCVs containing the common nonsusceptible serotypes could help further reduce NS-IPD.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Kevin Cannon, Charles Elder, Mariano Young, Daniel A. Scott, Ingrid L. Scully, Gary Baugher, Yahong Peng, Kathrin U. Jansen, William C. Gruber, Wendy Watson
Summary: The study demonstrated that PCV20 is well tolerated and immunogenic in adults over 65 years of age with a history of different pneumococcal vaccine regimens, showing robust immune responses to the 20 vaccine serotypes a month after vaccination.
Article
Immunology
Donald Hurley, Carl Griffin, Mariano Young, Daniel A. Scott, Michael W. Pride, Ingrid L. Scully, John Ginis, Joseph Severs, Kathrin U. Jansen, William C. Gruber, Wendy Watson
Summary: This study evaluated the safety and immunogenicity of a 20-valent PCV in adults aged 60 to 64 without prior pneumococcal vaccination. Results showed that PCV20 was well tolerated and elicited robust immune responses against all serotypes in this age group, demonstrating its potential to expand pneumococcal disease protection.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Arabella S. Stuart, Robert H. Shaw, Xinxue Liu, Melanie Greenland, Parvinder K. Aley, Nick J. Andrews, J. C. Cameron, Sue Charlton, Elizabeth A. Clutterbuck, Andrea M. Collins, Tom Darton, Tanya Dinesh, Christopher J. A. Duncan, Anna England, Saul N. Faust, Daniela M. Ferreira, Adam Finn, Anna L. Goodman, Christopher A. Green, Bassam Hallis, Paul T. Heath, Helen Hill, Bryn M. Horsington, Teresa Lambe, Rajeka Lazarus, Vincenzo Libri, Patrick J. Lillie, Yama F. Mujadidi, Ruth Payne, Emma L. Plested, Samuel Provstgaard-Morys, Maheshi N. Ramasamy, Mary Ramsay, Robert C. Read, Hannah Robinson, Gavin R. Screaton, Nisha Singh, David P. J. Turner, Paul J. Turner, Iason Vichos, Rachel White, Jonathan S. Nguyen-Van-Tam, Matthew D. Snape
Summary: The study investigated the mixed use of different COVID-19 vaccines within the same schedule, showing that in certain conditions, heterologous vaccination can achieve similar immunogenicity to homologous vaccination, facilitating rapid global vaccine deployment.
Article
Biotechnology & Applied Microbiology
Randall Severance, Howard Schwartz, Ron Dagan, Laurie Connor, Jianing Li, Alison Pedley, Jonathan Hartzel, Tina M. Sterling, Katrina M. Nolan, Gretchen M. Tamms, Luwy K. Musey, Ulrike K. Buchwald
Summary: This study evaluated the safety and efficacy of concomitant administration of V114 pneumococcal conjugate vaccine and quadrivalent influenza vaccine in healthy adults aged 50 and older. The results showed that there was no difference in immunogenicity between the concomitant and non-concomitant groups, supporting the coadministration of these two vaccines.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Hyunjung Kim, Jigui Yu, Di Bai, Moon H. H. Nahm, Pengfei Wang
Summary: Both VSA-1 and QS-21 can enhance immune responses, particularly beneficial for breakthroughs related to PCV13. Due to its accessibility and lower toxicity, VSA-1 can be included in a new vaccine formulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Megan E. Peck, Lee M. Hampton, Sebastian Antoni, Ike Ogbuanu, Fatima Serhan, Tomoka Nakamura, Jenny A. Walldorf, Adam L. Cohen
Summary: The study found that countries participating in or conducting surveillance for invasive pneumococcal disease or rotavirus disease were more likely to introduce PCV or rotavirus vaccine. However, there is currently insufficient evidence to demonstrate whether countries with higher rotavirus positivity are more likely to introduce the vaccine.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Jeremy A. Duke, Fikri Y. Avci
Summary: The incidence of invasive pneumococcal disease (IPD) caused by infection with Streptococcus pneumoniae has been decreasing due to vaccination programs. However, the global burden of S. pneumoniae is still significant, emphasizing the need for new vaccination strategies. This review focuses on immune mechanisms triggered by existing pneumococcal vaccines and discusses challenges faced in selecting serotypes and using pneumococcal-derived proteins as vaccine antigens.
Article
Infectious Diseases
Christian Ronn, Pradeesh Sivapalan, Josefin Eklof, Peter Kamstrup, Tor Biering-Sorensen, Barbara Bonnesen, Zitta Barrella Harboe, Andrea Browatzki, Jakob Lyngby Kjaergaard, Christian Niels Meyer, Torben Tranborg Jensen, Sofie Lock Johansson, Elisabeth Bendstrup, Charlotte Suppli Ulrik, Jens-Ulrik Staehr Jensen
Summary: This study aimed to determine the relationship between cumulative inhaled corticosteroid (ICS) doses and the risk of hospitalization for pneumonia in patients with chronic obstructive pulmonary disease (COPD). The results showed a positive correlation between ICS dose and the risk of hospitalization for pneumonia. Therefore, it is recommended to use the lowest possible dose of ICS in the treatment of COPD and only for patients who truly need it.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Immunology
Maarten van Wijhe, Kamille Fogh, Steen Ethelberg, Kasper Karmark Iversen, Henrik Nielsen, Lars Ostergaard, Berit Andersen, Henning Bundgaard, Charlotte S. Jorgensen, Bibi F. Ss Scharff, Svend Ellermann-Eriksen, Isik S. Johansen, Anders Fomsgaard, Tyra Grove Krause, Lothar Wiese, Thea K. Fischer, Kare Molbak, Thomas Benfield, Fredrik Folke, Freddy Lippert, Sisse R. Ostrowski, Anders Koch, Christian Erikstrup, Anne-Marie Vangsted, Anna Irene Vedel Sorensen, Henrik Ullum, Robert Leo Skov, Lone Simonsen, Susanne Dam Nielsen
Summary: This study assessed the burden of long COVID among nonhospitalized adults with PCR-confirmed SARS-CoV-2 infection. The results showed that 25 out of 100 cases reported at least one long-COVID symptom. Infected individuals had worse general health, higher odds of various symptoms, particularly loss of taste and smell, and significantly reduced physical and mental health. Female sex and severity of infection were identified as major risk factors for long COVID.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Microbiology
Kamille Fogh, Alexandra R. R. Eriksen, Tine Graakjaer Larsen, Rasmus B. Hasselbalch, Henning Bundgaard, Bibi F. S. S. Scharff, Susanne D. Nielsen, Charlotte S. Jorgensen, Christian Erikstrup, Lars ostergaard, Svend Ellermann-Eriksen, Berit Andersen, Henrik Nielsen, Isik S. Johansen, Lothar Wiese, Lotte Hindhede, Susan Mikkelsen, Susanne G. Saekmose, Bitten Aagaard, Dorte K. Holm, Lene Harritshoj, Lone Simonsen, Thea K. Fischer, Fredrik Folke, Freddy Lippert, Sisse R. Ostrowski, Thomas Benfield, Kare Molbak, Steen Ethelberg, Anders Koch, Anne-Marie Vangsted, Tyra Grove Krause, Anders Fomsgaard, Henrik Ullum, Robert Skov, Kasper Iversen
Summary: This study investigated the immunity against COVID-19, risk factors, and behavior among employees in day care facilities and preschools (DCS) in Denmark. The study found that DCS staff had a higher risk of exposure within their own household than at their workplace. The study also found that most employees expressed fear of contracting COVID-19 and there was limited use of personal protective equipment at work.
MICROBIOLOGY SPECTRUM
(2023)
Article
Endocrinology & Metabolism
Anton Lund Andersen, Sigrid Bjerge Gribsholt, Lars Pedersen, Reimar Wernich Thomsen, Thomas Lars Benfield, Ole Sogaard, Stig Lonberg Nielsen, Lars Haukali Omland, Birgitte Lindegaard, Bjorn Richelsen, Jacob Bodilsen, Jens Meldgaard Bruun
Summary: This study examines the association between obesity and severity of infection in a Danish cohort hospitalized with COVID-19. The results show that compared to non-obese patients, obese patients have a slightly increased risk of ICU admission, invasive mechanical ventilation, and death, although these relationships are not statistically significant. In addition, COVID-19 patients who are both obese and under the age of 60 have an almost doubled risk of ICU admission and invasive mechanical ventilation.
OBESITY SCIENCE & PRACTICE
(2023)
Article
Medicine, Research & Experimental
Maria Lange Pedersen, Dennis Vestergaard Pedersen, Mikael Becher Lykkegaard Winkler, Heidi Gytz Olesen, Ole Schmeltz Sogaard, Lars Ostergaard, Nick Stub Laursen, Anna Halling Folkmar Rahimic, Martin Tolstrup
Summary: The complement system, an important part of the innate immune response, can be utilized to eliminate HIV-1-infected cells. Researchers developed a new therapeutic approach, a bispecific complement engager (BiCE), which can direct complement activity to the surface of HIV-1-infected cells. This BiCE has shown the ability to increase complement deposition and mediate complement-dependent cytotoxicity (CDC) of HIV-1-infected cells.
EMBO MOLECULAR MEDICINE
(2023)
Article
Psychiatry
Valdemar Romer, Pradeesh Sivapalan, Josefin Ekloef, Susanne D. Nielsen, Zitta B. Harboe, Tor Biering-Sorensen, Theis Itenov, Jens-Ulrik S. Jensen
Summary: This study found that SARS-CoV-2 infection was not associated with an increased risk of psychiatric admissions in the general population of Denmark. However, there was an increased risk of de novo prescription of psychoactive medication among infected individuals.
EUROPEAN PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Zitta Barrella Harboe, Casper Roed, Jon G. Holler, Fahim Iqbal Khan, Aya Nihad Abdulrahman Abdulrahman, Stefan Lundby Mulverstedt, Betina Lindgaard-Jensen, Barbara Bonnesen Bertelsen, Christian Soborg, Thyge Lynghoj Nielsen, Line Vinum Hansen, Birgitte Lindegaard Madsen, Andrea Browatzki, Mads Eiberg, Peter Haahr Bernhard, Emilie Marie Juelstorp Pedersen, Gertrud Baunbaek Egelund, Arnold Matovu Dungu, Adin Sejdic, Inger Hee Mabuza Mathiesen, Naja Z. Jespersen, Pelle Trier Petersen, Lars Nielsen, Micha Phill Gronholm Jepsen, Thomas Ingemann Pedersen, Robert Eriksson, Hans Eric Sebastian Seitz-Rasmussen, Morten Bestle, Henrik Andersen, Ulrik Skram, Mads Romer Skott, Sarah Altaraihi, Pradeesh Sivapalan, Jens-Ulrik Staehr Jensen, Kristian Bagge, Kristina Melbardis Jorgensen, Maja Johanne Sondergaard Knudsen, Thomas Leineweber, Uffe Vest Schneider, Magnus Glindvad Ahlstrom, Sofie Rytter, Nina le Dous, Pernille Ravn, Nanna Reiter, Daria Podlekareva, Andreas Knudsen, Stine Johnsen, Lars-Erik Kristensen, Caecilie Leding, Bastian Bryan Hertz, Thomas Benfield, Ole Kirk, Jon Gitz Holler, Sisse Rye Ostrowski, Sigurdur Thor Sigurdsson, Anders Perner, Nikolai Kirkby, Martin Schou Pedersen, Maarten van Wijhe, Lone Simonsen, Peter Michael Bager, Tyra Grove Krause, Marianne Voldstedlund, Lasse Engbo Christiansen, Marc Stegger, Arieh Cohen, Jannik Fonager, Anders Fomsgaard, Rebecca Legarth, Morten Rasmussen, Sophie Gubbels, Jan Wohlfahrt, Troels Lillebaek, Caroline Klint Johannesen, Maarten van Wijhe, Thea K. Fischer
Summary: This study compared the intrinsic virulence of the SARS-CoV-2 omicron variant and the delta variant in hospitalized adults with COVID-19. The results showed that patients with the omicron variant had milder hypoxemia and higher 30- and 60-day survival rates compared to those with the delta variant, mainly due to a higher proportion of omicron patients vaccinated with three doses of an mRNA vaccine.
Article
Multidisciplinary Sciences
Martin Munthe Thomsen, Lea Munthe-Fog, Pelle Trier Petersen, Thore Hillig, Lennart Jan Friis-Hansen, Casper Roed, Zitta Barrella Harboe, Christian Thomas Brandt
Summary: The study investigates the diagnostic and prognostic abilities of Cerebrospinal fluid (CSF) Pentraxin 3 (PTX3) in central nervous system (CNS) infections. CSF PTX3 levels were measured retrospectively from 174 patients suspected with CNS infection. The results showed that CSF PTX3 was significantly higher in CNS infections, especially bacterial meningitis, compared to viral and Lyme infections. However, no association was found between CSF PTX3 and Glasgow Outcome Score, indicating no prognostic abilities.
Article
Respiratory System
Christian Kjer Heerfordt, Josefin Eklof, Pradeesh Sivapalan, Truls Sylvan Ingebrigtsen, Tor Biering-Sorensen, Zitta Barrella Harboe, Jesper Koefod Petersen, Christian Ostergaard Andersen, Jonas Bredtoft Boel, Anne Kathrine Bock, Alexander G. Mathioudakis, John R. Hurst, Shailesh Kolekar, Sofie Lock Johansson, Jette Marie Bangsborg, Jens Otto Jarlov, Ram Benny Dessau, Christian Borbjerg Laursen, Michael Perch, Jens-Ulrik Staehr Jensen
Summary: This study found that the use of inhaled corticosteroids (ICS) in patients with chronic obstructive pulmonary disease (COPD) is associated with an increased risk of pneumonia. Furthermore, the risk of pneumonia is dose-dependent, with higher doses of ICS associated with higher risk. Caution should be exercised when administering high doses of ICS to patients with COPD, as low doses do not seem to carry this risk.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Article
Immunology
Wendy P. Bannister, Dorthe Raben, Palle Valentiner-Branth, Martin Tolstrup, Lykke Larsen, Britta Tarp, Mette Brouw Iversen, Ole Schmeltz Sogaard, Sisse Rye Ostrowski, Nina Breinholt Staerke, Marie Louise Jakobsen, Susan Olaf Lindvig, Maria Ruwald Juhl, Isik Somuncu Johansen, Ahmed B. Mustafa, Lars Ostergaard, Fredrikke Dam Larsen, Lene Surland Knudsen, Vibeke Klastrup, Lothar Wiese, Thomas Benfield, Kristine Toft Petersen, Kasper K. Iversen, Henrik Nielsen, Joanne Reekie, Jens Lundgren
Summary: Concerns about side effects may contribute to vaccine hesitancy, but knowing that SARS-CoV-2 vaccines can lead to a stronger immune response may encourage more individuals to get vaccinated. Severe adverse reactions were associated with a stronger antibody response after the second vaccine dose, but not after the first. Regardless of side effects, most people experienced an effective immune response following vaccination.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Jesper D. Gunst, Jesper F. Hojen, Marie H. Pahus, Miriam Rosas-Umbert, Birgitte Stiksrud, James H. Mcmahon, Paul W. Denton, Henrik Nielsen, Isik S. Johansen, Thomas Benfield, Steffen Leth, Jan Gerstoft, Lars Ostergaard, Mariane H. Schleimann, Rikke Olesen, Henrik Stovring, Line Vibholm, Nina Weis, Anne M. Dyrhol-Riise, Karen B. H. Pedersen, Jillian S. Y. Lau, Dennis C. Copertino, Noemi Linden, Tan T. Huynh, Victor Ramos, R. Brad Jones, Sharon R. Lewin, Martin Tolstrup, Thomas A. Rasmussen, Michel C. Nussenzweig, Marina Caskey, Dag Henrik Reikvam, Ole S. Sogaard
Summary: In people with HIV-1 undergoing antiretroviral treatment interruption, combining lefitolimod with broadly neutralizing antibodies (bNAbs) did not delay viral rebound beyond that achieved with bNAbs alone, raising the question of how to optimize combination immunotherapy to control HIV-1.
Article
Immunology
Zitta Barrella Harboe, Annemette Hald, Christina Ekenberg, Neval Ete Wareham, Lene Fogt Lundbo, Jon Gitz Holler, Tavs Qvist, Sebastian Rask Hamm, Stephanie Bjerrum, Omid Rezahosseini, Paul Suno Krohn, Finn Gustafsson, Michael Perch, Allan Rasmussen, Susanne Dam Nielsen
Summary: This study describes the experience of implementing a vaccination clinic targeting different organ transplantation in a transplantation center in Denmark. The study found a low proportion of documented recommended vaccinations before transplantation, with higher serological protection against measles, mumps, or rubella. Most candidates required multiple vaccinations, including some needing live attenuated vaccines.
Article
Medicine, General & Internal
Christina V. Konrad, Emma F. Iversen, Jesper D. Gunst, Ida Monrad, Andreas Holleufer, Rune Hartmann, Lars J. Ostergaard, Ole S. Sogaard, Mariane H. Schleimann, Martin Tolstrup
Summary: In this study, we have developed an immunotherapy technology that utilizes vaccination-induced CTLs to be redirected and kill antigen-expressing target cells through RoVER. This technology is highly specific and eliminates the need for adoptive transfer of CTLs.
Article
Multidisciplinary Sciences
Eva A. M. Baerends, Astrid K. Hvidt, Joanne Reekie, Ole S. Sogaard, Nina B. Staerke, Dorthe Raben, Henrik Nielsen, Kristine T. Petersen, Maria R. Juhl, Isik S. Johansen, Susan O. Lindvig, Lone W. Madsen, Lothar Wiese, Lene S. Knudsen, Mette B. Iversen, Thomas Benfield, Kasper K. Iversen, Sidsel D. Andersen, Anna K. Juhl, Lisa L. Dietz, Signe R. Andreasen, Thea K. Fischer, Christian Erikstrup, Palle Valentiner-Branth, Jens Lundgren, Lars Ostergaard, Martin Tolstrup
Summary: SARS-CoV-2 Omicron is rapidly spreading globally, even in regions with high vaccination coverage. A study found that high levels of vaccine-induced antibodies provide partial protection against Omicron breakthrough infections. This is important knowledge to further understand the threshold for protection against new variants and to determine the necessity and timing of booster vaccination.
Article
Medicine, Research & Experimental
Lisa Lokso Dietz, Anna Karina Juhl, Ole Schmeltz Sogaard, Joanne Reekie, Henrik Nielsen, Isik Somuncu Johansen, Thomas Benfield, Lothar Wiese, Nina Breinholt Staerke, Tomas Ostergaard Jensen, Stine Finne Jakobsen, Rikke Olesen, Kasper Iversen, Kamille Fogh, Jacob Bodilsen, Kristine Toft Petersen, Lykke Larsen, Lone Wulff Madsen, Susan Olaf Lindvig, Inge Kristine Holden, Dorthe Raben, Sidsel Dahl Andersen, Astrid Korning Hvidt, Signe Rode Andreasen, Eva Anna Marianne Baerends, Jens Lundgren, Lars Ostergaard, Martin Tolstrup
Summary: This study examines the immune response to SARS-CoV-2 vaccination in older Danish citizens and finds that age and disease burden can impact the vaccine-induced T cell immunity. These findings contribute to the understanding of immune responses in individuals at increased risk of severe COVID-19.
COMMUNICATIONS MEDICINE
(2023)