Article
Infectious Diseases
Anna N. Chard, Francisco Nogareda, Annette K. Regan, Marta Fernanda Olivares Barraza, Rodrigo A. Fasce, Natalia Vergara, Marcela Avendano, Elena Penayo, Cynthia Vazquez, Marta Von Horoch, Fabiana Michel, Adriana Alfonso, Cristina Mogdasy, Hector Chiparelli, Natalia Goni, Miguel Alegretti, Sergio Loayza, Paula Couto, Angel Rodriguez, Daniel Salas, Ashley L. Fowlkes, Eduardo Azziz-Baumgartner
Summary: This study estimated the vaccine effectiveness (VE) against severe acute respiratory illness (SARI) hospitalization in Chile, Paraguay, and Uruguay during the 2022 influenza season. The results showed that the VE against any influenza-associated SARI hospitalization was 33.8%, and the VE against influenza A(H3N2)-associated SARI hospitalization was 30.4%. VE estimates were similar across target populations.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Krystal Lau, Ilaria Dorigatti, Marisa Miraldo, Katharina Hauck
Summary: This study estimated hospitalization rates, severity rates, mortality rates, and time lags between infections and hospitalizations of H1N1 pandemic patients in England during and after the pandemic period. Results showed increased severity in the post-pandemic flu season, highlighting the importance of continued vigilance by policymakers and researchers. Analysis of administrative hospital data and epidemiological modeling estimates can provide valuable insights for responding to COVID-19 and future pandemics.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Environmental Sciences
Nicolas Huneeus, Remy Lapere, Andrea Mazzeo, Cesar Ordonez, Nicolas Donoso, Ricardo Mun, Jose A. Rutllant
Summary: The transport of black carbon from the Santiago Metropolitan Area to the adjacent Andes Cordillera and its glaciers is a major concern due to its potential impact on melting snowpack and water supply stress. Wind patterns play a significant role in the transport of particulate matter, with easterly winds preventing deep intrusions into the Maipo canyon. This study highlights the importance of understanding atmospheric dynamics in the region to mitigate the impacts of urban pollution on the surrounding environment.
ENVIRONMENTAL POLLUTION
(2021)
Review
Virology
Gloria Perez-Rubio, Marco Antonio Ponce-Gallegos, Bruno Andre Dominguez-Mazzocco, Jaime Ponce-Gallegos, Roman Alejandro Garcia-Ramirez, Ramces Falfan-Valencia
Summary: Research has shown that genetic susceptibility to Influenza A virus infection is influenced by multiple pathways, including innate immune response, complement activation, and variants in inflammatory response genes. Specific gene polymorphisms such as SNPs play key roles in host immune responses, affecting viral replication and host response, representing important factors in genetic susceptibility to IAV infection.
Article
Multidisciplinary Sciences
Tamara Fukalova Fukalova, Maria Dolores Garcia Martinez, Maria Dolores Raigon
Summary: Wild edible herbs have diverse nutritional potential and high levels of bioactive components, especially antioxidants. Chenopodium album stands out for its higher concentration of nutritional compounds, while Diplotaxis erucoides is noted for its higher antioxidant capacity. The studied species could be relevant as healthy food ingredients with attractive flavors for the gourmet cuisine industry.
Article
Management
Emilio Gutierrez, Adrian Rubli
Summary: This study examines the impact of hospital congestion on in-hospital mortality using data from a large public hospital system in Mexico, leveraged the shock in hospitalizations induced by the 2009 H1N1 pandemic, and found that congestion led to an increase in non-ARI in-hospital mortality. The effects were nonlinear in the size of the local outbreak, and supply-side policies such as improving patient assignment and strategically increasing hospital capacity could mitigate some of the negative impacts.
MANAGEMENT SCIENCE
(2021)
Article
Microbiology
Dennis Maletich Junqueira, Caroline Tochetto, Tavis K. Anderson, Danielle Gava, Vanessa Haach, Mauricio E. Cantao, Amy L. Vincent Baker, Rejane Schaefer
Summary: This study analyzed a large number of H1N1pdm09 gene sequences from humans and swine globally between 2009 and 2022, and found that there was rapid transmission of the virus from humans to swine in Brazil during 2009-2011, but most of the infections in swine were self-limited with limited onward transmission. After 2012, there was a reduction in human-to-swine H1N1pdm09 transmissions in Brazil. The study highlights the dynamic interplay between human-to-swine transmission, antigenic drift, and the establishment of swine-to-swine transmission in shaping the evolution and persistence of H1N1pdm09 in swine populations.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Virology
Nima Ghalekhani, Saied Bokaie, Sana Eybpoosh, Hesameddin Akbarein, Hamid Sharifi
Summary: Using Bayesian phylogeography analysis, this study investigates the time and path of transmission of H1N1 serotype influenza A viruses in Iran and neighboring countries. The study finds that the age of emergence of H1N1 virus in Iran is older compared to neighboring countries, and Tehran seems to have played a key role in its transmission within Iran. Continuous monitoring and screening of H1N1 virus, along with addressing gaps and shortages in virus control, are important measures to be taken.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Respiratory System
Ary Serpa Neto, Aidan J. C. Burrell, Michael Bailey, Tessa Broadley, D. Jamie Cooper, Craig J. French, David Pilcher, Mark P. Plummer, Tony Trapani, Steve A. Webb, Rinaldo Bellomo, Andrew Udy
Summary: Compared to 2009 H1N1 influenza, ICU admissions for COVID-19 during the winter in Australia resulted in fewer patients admitted and lower bed-day occupancy. Crude in-hospital mortality rates were similar, but demographic differences in affected patients led to a significant increase in PYLL in critically ill patients with 2009 H1N1 influenza.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Virology
Oksana Zolotarova, Anna Fesenko, Olga Holubka, Larysa Radchenko, Eric Bortz, Iryna Budzanivska, Alla Mironenko
Summary: The 2015/16 influenza epidemic season in Ukraine was characterized by a severe outbreak caused by the A(H1N1)pdm09 viruses, leading to a high incidence of acute respiratory infections and a significant number of fatalities. Genetic analysis revealed a diverse spectrum of mutations in the viral genomes, affecting antigenicity, virulence, and immune evasion mechanisms. The circulation of multiple lineages of A(H1N1)pdm09 viruses in Ukraine, a country with low vaccination coverage, posed challenges for public health measures against influenza.
Article
Virology
Peter W. Cook, Thomas Stark, Joyce Jones, Rebecca Kondor, Natosha Zanders, Jeffrey Benfer, Samantha Scott, Yunho Jang, Alicia Janas-Martindale, Stephen Lindstrom, Lenee Blanton, John Schiltz, Rachel Tell, Richard Griesser, Peter Shult, Erik Reisdorf, Tonya Danz, Alicia Fry, John Barnes, Amy Vincent, David E. Wentworth, C. Todd Davis
Summary: The study discusses the transmission of seasonal influenza viruses between humans and pigs, leading to sustained circulation of human-like viruses in the U.S. swine population. Two cases of human infections with A(H1N1)pdm09 viruses originating from swine hosts are identified and classified as swine-origin variant influenza viruses. The study underscores the importance of developing techniques for distinguishing human-origin and swine-origin viruses for continued surveillance of influenza viruses.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Krista Salo-Tuominen, Tamara Teros-Jaakkola, Laura Toivonen, Helena Ollila, Paivi Rautava, Minna Aromaa, Elina Lahti, Niina Junttila, Ville Peltola
Summary: The study investigated the association between parental socioeconomic and psychosocial factors and the uptake of the 2009 pandemic influenza vaccine in children. It found that children of younger and less educated mothers had a lower rate of vaccine uptake. However, the individual or relational psychosocial well-being of parents was not associated with children's vaccination.
Article
Entomology
Fabiola Altimira, Nathalia de la Barra, Paulo Godoy, Juan Roa, Sebastian Godoy, Nancy Vitta, Eduardo Tapia
Summary: Lobesia botrana, the European grapevine moth, is a major pest that affects grapes in Chile. This study explored the use of entomopathogenic fungi to control this pest, with promising results. Two selected strains, RGM 2184 and RGM 678, showed maximum efficacies of 80% and 88% respectively. The use of these fungi can reduce the population of the pest and decrease the reliance on chemical pesticides.
Article
Virology
Akeno Tsuneki-Tokunaga, Kyosuke Kanai, Asao Itagaki, Hideaki Tsuchie, Takayoshi Okada, Masaaki Kasagi, Kiyoshi Tanaka, Miho Aoki, Alfredo Jr A. Hinay, Seiji Kageyama
Summary: This study assessed the correlation between the growth capability of epidemic influenza A/H1N1, A/H3N2, and B viruses in cells and the viral load in nasopharyngeal swabs, revealing a positive correlation between growth capability and viral load. Additionally, a high positive correlation between growth capability and cell death was observed in the experiment. Therefore, the growth capability of viruses plays a significant role in disease prognosis.
ARCHIVES OF VIROLOGY
(2021)
Article
Virology
D. Collins Owuor, Zaydah R. de Laurent, Gilbert K. Kikwai, Lillian M. Mayieka, Melvin Ochieng, Nicola F. Muller, Nancy A. Otieno, Gideon O. Emukule, Elizabeth A. Hunsperger, Rebecca Garten, John R. Barnes, Sandra S. Chaves, D. James Nokes, Charles N. Agoti
Summary: This study investigated the spatiotemporal spread of influenza A(H1N1)pdm09 viruses in Kenya from 2009 to 2018, revealing multiple virus introductions, seasonal fluctuations in effective reproduction number and genetic diversity, as well as a wide spread of the virus across the country. It also highlighted the diversity of influenza viruses circulating within Kenya, including unique viral lineages that may have global implications.
Article
Health Care Sciences & Services
Ignacio Olivera, Carlos Grau, Hugo Dibarboure, Juan Pablo Torres, Gustavo Mieres, Luis Lazarov, Fabian P. Alvarez, Juan Guillermo Lopez Yescas
BMC HEALTH SERVICES RESEARCH
(2020)
Article
Immunology
Juan Pablo Torres, Cecilia Pinera, Veronica De La Maza, Anne J. Lagomarcino, Daniela Simian, Barbara Torres, Cinthya Urquidi, Maria Teresa Valenzuela, Miguel O'Ryan
Summary: A study on a SARS-CoV-2 outbreak in a large school community in Santiago, Chile found that teachers were more affected and younger children were at higher risk for infection. Self-administered antibody testing was proven to be a suitable and rapid tool for assessment.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Oncology
Veronica De la Maza, Macarena Manriquez, Magdalena Castro, Paola Viveros, Maria Fernandez, Evelyn Vogel, Erica Pena, Maria Elena Santolaya, Milena Villarroel, Juan Pablo Torres
EUROPEAN JOURNAL OF CANCER CARE
(2020)
Article
Infectious Diseases
Yalda Lucero, Anne J. Lagomarcino, Juan P. Torres, Patricia Roessler, Nora Mamani, Sergio George, Nicole Huerta, Monica Gonzalez, Miguel O'Ryan
Summary: In apparently healthy school-aged children, persistent H. pylori infection was associated with increased clinical symptoms and higher levels of the biomarker pepsinogen II, indicating early gastric involvement.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Lorena Tapia, Mauricio Olivares, Juan P. Torres, Veronica De la Maza, Romina Valenzuela, Veronica Contardo, Juan Tordecilla, Ana M. Alvarez, Monica Varas, Marcela Zubieta, Carmen Salgado, Marcela Venegas, Valentina Gutierrez, Ximena Claverie, Milena Villarroel, Maria E. Santolaya
Summary: A prospective, multicenter study in Santiago, Chile included 110 children with cancer and persistent high-risk febrile neutropenia (HRFN). The study found that measuring serum concentrations of specific cytokines and chemokines can predict the presence of infectious agents and differentiate between infections and episodes of unknown origin in these children.
Article
Gastroenterology & Hepatology
Yalda Lucero, Anne J. Lagomarcino, Juan P. Torres, Patricia Roessler, Nora Mamani, Sergio A. George, Nicole Huerta, Monica Gonzalez, Miguel G. O'Ryan
Summary: The study included 61 school-aged children undergoing H. pylori eradication therapy, with a high eradication rate and good tolerance observed in the treatment group. Significant reductions in serum markers PGI and PGII levels were noted post-eradication. Despite a small percentage experiencing reinfection, no significant difference in symptoms was observed between the treated and control groups.
Correction
Infectious Diseases
Y. Lucero, A. J. Lagomarcino, J. P. Torres, P. Roessler, N. Mamani, S. George, N. Huerta, M. Gonzalez, M. O'Ryan
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Denis Saure, Miguel O'Ryan, Juan Pablo Torres, Marcela Zuniga, Emilio Santelices, Leonardo J. Basso
Summary: The study in Chile found that individuals who received the CoronaVac vaccine had a lower IgG seropositivity compared to those who received the BNT162b2 vaccine. Over time, the IgG seropositivity for CoronaVac recipients declined, while those who received BNT162b2 maintained high levels of IgG positivity. Further monitoring of IgG levels will help in evaluating vaccine effectiveness and exploring potential adjustments to vaccination strategies in the future.
LANCET INFECTIOUS DISEASES
(2022)
Article
Pharmacology & Pharmacy
Brenda Zylbersztajn, Suzanne Parker, Daniel Navea, Giannina Izquierdo, Paula Ortiz, Juan Pablo Torres, Cristian Fajardo, Rodrigo Diaz, Cristian Valverde, Jason Roberts
Summary: This study aimed to describe the primary pharmacokinetic/pharmacodynamic parameters of vancomycin and meropenem in pediatric patients undergoing ECMO, and analyze the dosing utilized to reach the PK/PD target. The study found that conventional doses of vancomycin partially achieved the PK/PD objectives, while higher dosing with extended infusion was needed for meropenem to reach the PK/PD target.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Virology
Yalda Lucero, David O. Matson, Shai Ashkenazi, Sergio George, Miguel O'Ryan
Summary: Research on Human Norovirus continues to deepen our understanding of its biological and disease spectrum, but limitations in effectively replicating and propagating the virus hinder progress in several areas. Current areas of interest include clinical and molecular epidemiology, viral-host interactions, antiviral drugs, and vaccine development. The impact of the COVID-19 pandemic on Norovirus infection and disease is also a subject of reflection.
Article
Infectious Diseases
Juan P. Torres, Denis Saure, Leonardo J. Basso, Marcela Zuniga, Andre Cazor, Miguel O'Ryan
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Denis Saure, Ignasi Neira, Marcel Goic, Miguel O'Ryan, Juan P. Torres, Alejandro Bruhn, Marcela Ferres, Jenniffer Angulo, Magdalena Vera, Leonardo J. Basso
Summary: The 2021 wave of SARS-CoV-2 infection in Chile saw a significant increase in ICU admissions, particularly among individuals younger than 60 years. This wave was accompanied by a surge in Gamma (P.1) variant detections and a mass vaccination campaign. By using a queueing model that incorporates various factors, including genomic surveillance and vaccine effectiveness, researchers discovered that infection with the Gamma variant led to a 3.5-4.7-fold increase in ICU admissions for people under 60. Importantly, the vaccines used in Chile were found to effectively reduce the risk of Gamma variant-related ICU admissions.
Article
Infectious Diseases
Carolina Ibanez Guelfenbein, Juan Pablo Torres Torretti, Maria Elena Santolaya de Pablo
Summary: The COVID-19 pandemic has led to an accelerated vaccine development process, studying various aspects simultaneously. Currently, there are four types of vaccines in Phase III studies, aiming to provide safe, effective, and immunogenic options to help restore normalcy to the world.
REVISTA CHILENA DE INFECTOLOGIA
(2021)
Article
Pediatrics
Orkun Tolunay, Umit Celik, Ilknur Arslan, Ali Orgun, Husnu Demir, Oguzhan Demir, Erdi Cagri Dagdelen
Summary: This study evaluated the clinical characteristics and treatment outcomes of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19. Analysis of 52 pediatric patients revealed common presenting symptoms like fever, abdominal pain, rash, and vomiting, with most patients showing abnormal biochemical markers upon admission. Comprehensive research is needed to understand the pathogenesis and treatment of this disease.
JOURNAL OF TROPICAL PEDIATRICS
(2021)