Article
Multidisciplinary Sciences
Macarena Silva, Carmen G. Montes, Andrea Canals, Maria J. Mackenna, Marcelo Wolff
Summary: The study investigated the effects of zinc supplementation on patients with immunovirological discordance (IVD). Results showed that there was no significant difference in CD4 cell count between the treated group and the control group after 12 months of supplementation. Further studies with a larger sample size are needed to confirm these findings.
Article
Health Care Sciences & Services
Wei Cao, Xiaosheng Liu, Yang Han, Xiaojing Song, Lianfeng Lu, Xiaodi Li, Ling Lin, Lijun Sun, An Liu, Hongxin Zhao, Ning Han, Hongxia Wei, Jian Cheng, Biao Zhu, Min Wang, Ying Li, Ping Ma, Liying Gao, Xicheng Wang, Jianhua Yu, Ting Zhu, Jean-Pierre Routy, Min Zuo, Taisheng Li
Summary: This study evaluated the efficacy of the Chinese herbal derivative LLDT-8 in HIV-suppressed immunological non-responders. The results showed that LLDT-8 was well-tolerated and effective in inhibiting viral replication and improving CD4 T cell counts. It provides a potential therapeutic option for long-term suppressed INRs.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Biology
Eva Liliane Ujeneza, Wilfred Ndifon, Shobna Sawry, Geoffrey Fatti, Julien Riou, Mary-Ann Davies, Martin Nieuwoudt
Summary: This study introduces a novel 'ratio' model to explore the long-term effects of the growing population of HIV-treated individuals in Southern Africa on both individuals and the public health sector. Results show that children were closer to healthy CD4+ counts compared to adults, and adults had a higher CD4+ growth rate post-ART initiation.
Review
Food Science & Technology
Alireza Jafari, Zeinab Noormohammadi, Mohammadreza Askari, Elnaz Daneshzad
Summary: This study provides a systematic review and meta-analysis on the effect of zinc supplementation on immune factors. The results show that zinc supplementation can significantly reduce inflammation markers and neutrophil levels, as well as increase certain immune cell levels.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Cell Biology
Lesley R. de Armas, Suresh Pallikkuth, Li Pan, Stefano Rinaldi, Rajendra Pahwa, Savita Pahwa
Summary: The study found that people living with HIV who received anti-retroviral therapy experienced accelerated immune aging compared to healthy controls, and immune biomarkers in blood samples could be used as an indicator of "immunological age" during HIV infection treated with ART.
Article
Urology & Nephrology
Luigi Morrone, Suetonia C. Palmer, Valeria M. Saglimbene, Annalisa Perna, Giuseppe Cianciolo, Domenico Russo, Loreto Gesualdo, Patrizia Natale, Antonio Santoro, Sandro Mazzaferro, Mario Cozzolino, Adamasco Cupisti, Marina Di Luca, Biagio Di Iorio, Giovanni F. M. Strippoli
Summary: This study found that calcifediol supplementation for patients undergoing hemodialysis with vitamin D insufficiency did not have definitive effects on reducing mortality and cardiovascular outcomes.
JOURNAL OF NEPHROLOGY
(2022)
Article
Immunology
Shi-Tao Geng, Jian-Bo Zhang, Yue-Xin Wang, Yu Xu, Danfeng Lu, Zunyue Zhang, Ju Gao, Kun-Hua Wang, Yi-Qun Kuang
Summary: The study found that oral supplementation of a pre-digested enteral nutritional supplement significantly increased CD4(+) T cell and CD8(+) T cell counts. Among pro-inflammatory cytokines in the serum, only IL-1 beta level decreased significantly, while TNF-beta increased. Levels of intestinal mucosal damage markers decreased significantly, and body weight, body mass index, albumin, and hemoglobin significantly increased.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Amir Hossein Faghfouri, Behzad Baradaran, Alireza Khabbazi, Mahdi Abdoli Shadbad, Shahab Papi, Elnaz Faghfuri, Yaser Khajebishak, Shima Rahmani, Parastoo Tolou Hayat, Beitullah Alipour
Summary: Supplementation of zinc gluconate can be considered as an adjuvant therapy in alleviating inflammation and genital ulcer among Behcet's disease patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Kehinde S. Okunade, Olusola F. Olowoselu, Sarah John-Olabode, Basirat O. Hassan, Oluwatosin J. Akinsola, Chidinma M. Nwogu, Aloy O. Ugwu, Olusanjo E. Moses, Kabiru A. Rabiu, Adegbenga Ajepe, Muisi A. Adenekan, Adebola A. Adejimi, Sulaimon A. Akanmu, Phyllis J. Kanki
Summary: Selenium supplementation has positive effects on pregnancy outcomes among HIV-infected women, reducing the risk of preterm delivery.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Nutrition & Dietetics
Danfeng Lu, Yue-Xin Wang, Shi-Tao Geng, Zunyue Zhang, Yu Xu, Qing-Yan Peng, Shao-You Li, Jian-Bo Zhang, Kun-Hua Wang, Yi-Qun Kuang
Summary: People living with human immunodeficiency virus (PLWH) often suffer from malnutrition, intestinal barrier dysfunction, and gut microbial imbalance. A 3-month pilot study was conducted on HIV-infected immunological nonresponders (INRs) who failed to reach normal CD4+ T-cell counts. The study found that supplementation with whole-protein enteral nutrition formula significantly increased CD4+ T-cell counts, improved intestinal barrier function and nutritional status, and increased gut microbiota diversity in HIV-infected INRs.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Razieh Hosseini, Gordon A. Ferns, Amirhossein Sahebkar, Mohammad Ali Mirshekar, Mohammad Jalali
Summary: This study found that zinc supplements can significantly reduce serum concentrations of inflammation and oxidation markers, including CRP, TNF-alpha, and MDA. The duration of treatment was identified as the source of inter-study heterogeneity.
Review
Biochemistry & Molecular Biology
Hamed Mohammadi, Sepide Talebi, Abed Ghavami, Masoumeh Rafiei, Shima Sharifi, Zahra Faghihimani, Golnaz Ranjbar, Maryam Miraghajani, Gholamreza Askari
Summary: This study found through systematic review and meta-analysis that zinc supplementation may have beneficial anti-inflammatory and antioxidative effects in adults.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Medicine, General & Internal
L. Corey, P. B. Gilbert, M. Juraska, D. C. Montefiori, L. Morris, S. T. Karuna, S. Edupuganti, N. M. Mgodi, A. C. deCamp, E. Rudnicki, Y. Huang, P. Gonzales, R. Cabello, C. Orrell, J. R. Lama, F. Laher, E. M. Lazarus, J. Sanchez, I. Frank, J. Hinojosa, M. E. Sobieszczyk, K. E. Marshall, P. G. Mukwekwerere, J. Makhema, L. R. Baden, J. I. Mullins, C. Williamson, J. Hural, M. J. McElrath, C. Bentley, S. Takuva, M. M. Gomez Lorenzo, D. N. Burns, N. Espy, A. K. Randhawa, N. Kochar, E. Piwowar-Manning, D. J. Donnell, N. Sista, P. Andrew, J. G. Kublin, G. Gray, J. E. Ledgerwood, J. R. Mascola, M. S. Cohen
Summary: The study found that broadly neutralizing antibodies did not prevent HIV-1 acquisition more effectively than placebo, but analyses of VRC01-sensitive HIV-1 isolates indicated that prophylaxis with broadly neutralizing antibodies may be effective.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Nutrition & Dietetics
Yoonjung Park, Young-Mi Ah, Yun Mi Yu
Summary: This study conducted a meta-analysis of randomized controlled trials to investigate the effects of vitamin D supplementation on depressive symptom improvement in individuals aged ≥60 years with or without a diagnosis of depression or depressive symptoms. The results showed that vitamin D supplementation was not significantly associated with an improvement in depressive symptoms.
FRONTIERS IN NUTRITION
(2023)
Review
Nutrition & Dietetics
Dominika Guzek, Aleksandra Kolota, Katarzyna Lachowicz, Dominika Skolmowska, Malgorzata Stachon, Dominika Glabska
Summary: This study conducted a systematic review of randomized controlled trials to assess the influence of vitamin D supplementation on depression. Eight studies were included, and most of them supported the positive effect of vitamin D supplementation on psychological measures of depression. However, there were also three studies that did not support this conclusion. Overall, the effectiveness of vitamin D supplementation in the treatment of depression remains uncertain.
Article
Substance Abuse
Marianna K. Baum, Javier A. Tamargo, Janet Diaz-Martinez, Ivan Delgado-Enciso, Christina S. Meade, Gregory D. Kirk, Shruti H. Mehta, Richard Moore, Michele D. Kipke, Steven J. Shoptaw, Brian Mustanski, Raul N. Mandler, Jag H. Khalsa, Suzanne Siminski, Marjan Javanbakht, Pamina M. Gorbach
Summary: The study aimed to analyze the impact of the COVID-19 pandemic on mental health and substance misuse, finding that PLWH had higher resilience and that high resilience was associated with lower risk of anxiety and substance misuse.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Substance Abuse
Catherine R. Lesko, Jeanne C. Keruly, Richard D. Moore, Nicola M. Shen, Jarratt D. Pytell, Bryan Lau, Anthony T. Fojo, Shruti H. Mehta, Michele Kipke, Marianna K. Baum, Steven Shoptaw, Pamina M. Gorbach, Brian Mustanski, Marjan Javanbakht, Suzanne Siminski, Geetanjali Chander
Summary: Social determinants of health, substance use, and disruptions to mental health and substance use treatment were associated with poorer engagement in HIV care.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Review
Biochemistry & Molecular Biology
Sabrina Sales Martinez, Yongjun Huang, Leonardo Acuna, Eduardo Laverde, David Trujillo, Manuel A. Barbieri, Javier Tamargo, Adriana Campa, Marianna K. Baum
Summary: Viral infections continue to impact human health despite advancements in scientific knowledge, and the COVID-19 pandemic has highlighted the importance of nutritional strategies to maintain a healthy immune system. Selenium, an essential trace element, has been found to reduce the occurrence and severity of viral infections. Its benefits are mainly attributed to its incorporation into selenocysteine, a crucial component of proteins. Studies suggest that selenium deficiency alters immune response and increases oxidative stress, leading to higher pathogenicity and damage in viral infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Akemi T. Wijayabahu, Angela M. Mickle, Volker Mai, Cynthia Garvan, Toni L. Glover, Robert L. Cook, Jinying Zhao, Marianna K. Baum, Roger B. Fillingim, Kimberly T. Sibille
Summary: The study found that shorter leukocyte telomere length (LTL), a measure of cellular aging, is associated with elevated inflammatory cytokines and chronic pain. Micronutrients such as vitamin D and omega 3, which have anti-inflammatory properties, are also found to be associated with LTL and chronic pain. The complex relationships between anti-inflammatory micronutrients, inflammation, cellular aging, and chronic pain are highlighted in this study.
Article
Substance Abuse
Jarratt D. Pytell, Nicola M. Shen, Jeanne C. Keruly, Catherine R. Lesko, Bryan Lau, Anthony T. Fojo, Marianna K. Baum, Pamina M. Gorbach, Marjan Javanbakht, Michele Kipke, Gregory D. Kirk, Brian Mustanski, Steven Shoptaw, Susanne Siminski, Richard D. Moore, Geetanjali Chander
Summary: Alcohol use increased during the COVID-19 pandemic, especially among people living with HIV or at risk for HIV acquisition. Cannabis and stimulant use were associated with low-risk alcohol use, while tobacco, stimulant, cannabis use, and recent overdose were associated with hazardous alcohol use. Substance use treatment and living with HIV were associated with a lower prevalence of low-risk or hazardous alcohol use.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Substance Abuse
Javier A. Tamargo, Kenneth E. Sherman, Rafick-Pierre Sekaly, Rebeka Bordi, Daniela Schlatzer, Shenghan Lai, Jag H. Khalsa, Raul N. Mandler, Richard L. Ehman, Marianna K. Baum
Summary: The simultaneous use of cocaine and alcohol leads to the production of a highly toxic metabolite called cocaethylene (CE), which increases the risk of liver fibrosis. This study found that CE cocaine users had higher levels of cocaine in their blood, engaged in hazardous drinking, and had a greater risk of liver fibrosis. The impact of CE on liver fibrosis was greater than that of cocaine or alcohol alone.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Substance Abuse
Kenneth A. Feder, JinCheol Choi, Catherine G. Schluth, Kanna Hayashi, Kora DeBeck, Michael -John Milloy, Gregory D. Kirk, Shruti H. Mehta, Michele Kipke, Richard D. Moore, Marianna K. Baum, Steven Shoptaw, Pamina M. Gorbach, Brian Mustanski, Marjan Javanbakht, Suzanne Siminski, Becky L. Genberg
Summary: This study found significant differences between cities in the prevalence of avoiding picking up medications for opioid use disorder during the first year of the COVID-19 pandemic, with individual factors not significantly associated with avoidance. The only factor significantly associated with avoiding syringe service programs was higher levels of self-reported worry about COVID-19.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Substance Abuse
Soroush Moallef, Becky L. Genberg, Kanna Hayashi, Shruti H. Mehta, Gregory D. Kirk, JinCheol Choi, Kora DeBeck, Michele Kipke, Richard D. Moore, Marianna K. Baum, Steven Shoptaw, Pamina M. Gorbach, Brian Mustanski, Marjan Javanbakht, Susanne Siminski, M-J Milloy
Summary: The COVID-19 pandemic has worsened the longstanding drug poisoning crisis in Canada and the United States. This study aimed to estimate the prevalence of nonfatal overdose and identify associated factors among people who use unregulated drugs. The findings suggest that women, those who are unstably housed/homeless, and those experiencing significant impacts from the pandemic are more vulnerable to nonfatal overdose.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Biochemistry & Molecular Biology
Haley R. Martin, Sabrina Sales Martinez, Vitalii Stebliankin, Javier A. Tamargo, Adriana Campa, Giri Narasimhan, Jacqueline Hernandez, Jose A. Bastida Rodriguez, Colby Teeman, Angelique Johnson, Kenneth E. Sherman, Marianna K. Baum
Summary: This study explored the associations between dietary quality, fecal microbiome, metabolome, and liver health in people living with HIV. The results suggest that dietary components are associated with the fecal microbiome, metabolome, and liver health in people living with HIV. Future studies should investigate whether targeting specific dietary components may reduce liver-related morbidity and mortality in people living with HIV.
Article
Environmental Sciences
Rachel D. Clarke, Nana Aisha Garba, Manuel A. Barbieri, Leonardo Acuna, Marianna Baum, Maribel Saad Rodriguez, Hansel Frias, Paulina Saldarriaga, Troy Stefano, Kalai Mathee, Giri Narasimhan, David R. Brown
Summary: This study investigates the presence of SARS-CoV-2 in public spaces and examines the effectiveness of inexpensive air purifiers with HEPA filters for viral detection. The results show the potential for airborne transmission of SARS-CoV-2 in indoor air, especially in child daycare centers. Additionally, the study demonstrates the efficacy of readily available HEPA filters in detecting the virus. Improving indoor ventilation and implementing air filtration systems are crucial in reducing COVID-19 transmission.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2023)
Article
Environmental Sciences
Alicia Sneij, Adriana Campa, Fatma Huffman, Florence George, Mary Jo Trepka, Sabrina Sales Martinez, Marianna Baum
Summary: This study aimed to assess the effectiveness of an intervention for low-income people living with HIV and prediabetes. The results showed that nutrition intervention was effective in promoting positive health behavior by improving the stages of behavioral change, nutrition knowledge, and self-efficacy.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Immunology
Sabrina Sales Martinez, Vitalii Stebliankin, Jacqueline Hernandez, Haley Martin, Javier Tamargo, Jose Bastida Rodriguez, Colby Teeman, Angelique Johnson, Leslie Seminario, Adriana Campa, Giri Narasimhan, Marianna K. Baum
Summary: This study aims to compare the characteristics of gut microbiota and plasma metabolites between HIV-infected individuals who use cocaine and those who do not.
Meeting Abstract
Urology & Nephrology
Janet Diaz Martinez, Javier Tamargo, Carlos Bejar, Ivan Delgado Enciso, Marianna Baum
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)