Article
Multidisciplinary Sciences
C. Sarai Racey, Robine Donken, Ellie Fox, Imogen Porter, Julie A. Bettinger, Jennifer Mark, Lizl Bonifacio, Meena Dawar, Mike Gagel, Rakel Kling, Silvina Mema, Hana Mitchell, Ian Roe, Gina Ogilvie, Manish Sadarangani
Summary: The study aims to characterize and identify sociodemographic factors associated with vaccine confidence and describe teachers' knowledge of and perceived role in the school-based immunization program, with the aim of informing public health policy and identifying opportunities for supporting teachers in their role in school-based immunization programs.
Article
Public, Environmental & Occupational Health
Jeffrey R. Brubacher, Herbert Chan, Shannon Erdelyi, Peter J. Zed, John A. Staples, Mahyar Etminan
Summary: The study found that drivers prescribed sedating antipsychotics, long-acting benzodiazepines, short-acting benzodiazepines, and high-potency opioids had an increased risk of collision responsibility. Among medications used for medical indications, the highest risk was seen in drivers prescribed neurological medications.
LANCET PUBLIC HEALTH
(2021)
Article
Clinical Neurology
Amir Khakban, Elisabet Rodriguez Llorian, Kristina D. Michaux, Scott B. Patten, Anthony Traboulsee, Jiwon Oh, Larry D. Lynd
Summary: The objective of this study was to quantify the excess health care costs of multiple sclerosis (MS) in British Columbia, Canada. The study found that the excess cost of MS was $6,881 per patient-year, with inpatient, outpatient, and medication costs accounting for 25%, 10%, and 65% of the excess costs, respectively. Patients receiving disease-modifying therapy (DMT) and those with a history of hospitalization had higher excess costs. The study suggests that early diagnosis and timely use of DMTs could help reduce costs and improve patients' quality of life.
Article
Oncology
Gillian E. Hanley, Paramdeep Kaur, Andrew Berchuck, Anne Chase, Bronwyn Grout, Cindy McKinnon Deurloo, Malcolm Pike, Jean Richardson, Kathryn L. Terry, Penelope M. Webb, C. Leigh Pearce
Summary: The study found that postdiagnosis statin use was associated with improved survival among people with ovarian cancer, particularly in women with serous cancers. However, there was no statistically significant association between beta-blocker use and survival.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Immunology
Guadalein Tanunliong, Aaron C. Liu, Samantha Kaweski, Mike Irvine, Romina C. Reyes, Dale Purych, Mel Krajden, Muhammad Morshed, Inna Sekirov, Soren Gantt, Danuta M. Skowronski, Agatha N. Jassem
Summary: Older adults have been disproportionately affected during the SARS-CoV-2 pandemic. This study found that prior exposure to endemic human coronaviruses (HCoV) may modulate the response to SARS-CoV-2 infection, and cross-reactive antibodies to HCoV are associated with age-related observations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Svetlana Popova, Danijela Dozet, Graham O'Hanlon, Valerie Temple, Juergen Rehm
Summary: The study estimated the prevalence of alcohol use during pregnancy as a risk factor in live births in British Columbia, Canada. It found that prenatal alcohol exposure was associated with younger maternal age, fewer antenatal visits, being primiparous, a history of mental illness, substance use, and smoking. Babies exposed to alcohol during pregnancy had higher odds of adverse neonatal outcomes like low birth weight, respiratory distress, breastfeeding difficulties, and feeding problems. More consistent screening and prevention efforts targeting alcohol use during pregnancy are urgently needed in Canada.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Medicine, General & Internal
C. Andrew Basham, Mohammad E. Karim, Victoria J. Cook, David M. Patrick, James C. Johnston
Summary: This study found that immigrants diagnosed with respiratory TB in a low-TB-incidence setting have a twofold higher risk of airway disease compared to non-TB controls. Unmeasured confounding is unlikely to explain this relationship, highlighting the need for post-TB care models.
Article
Multidisciplinary Sciences
Ana Michelle Avina-Galindo, Zahra A. Fazal, Shelby Marozoff, Jessie Kwan, Na Lu, Alison M. Hoens, Jacek Kopec, Diane Lacaille, Hui Xie, Jonathan M. Loree, J. Antonio Avina-Zubieta
Summary: This study aims to investigate the relationship between immunosuppression and the risk of COVID-19 infection through survey data and administrative health data, including a case-control study and a survey questionnaire.
Article
Oncology
Wei Zhang, Daphne P. Guh, Tima Mohammadi, Reka E. Pataky, Alexander C. T. Tam, Larry D. Lynd, Annalijn I. Conklin
Summary: This study aimed to estimate the total health care costs associated with prostate cancer (PCa) in British Columbia (BC), Canada, by age, cancer stage, tumor grade, and primary treatment. Data from linked administrative health records were used to follow a cohort of men aged 50 years and older diagnosed with PCa between 2010 and 2017. The mean age of the cohort was 69.9 years, and the median follow-up time was 5.2 years. The highest PCa attributable costs were observed in the first year after diagnosis and the year before death. Radiation therapy had higher costs each year after diagnosis compared to radical prostatectomy or other surgeries in advanced-stage PCa, while androgen deprivation therapy had the highest costs for high-grade and early-stage cancer during the three years after diagnosis. Up-to-date cost estimates are important for economic evaluations and decision-making.
Article
Public, Environmental & Occupational Health
Melissa C. MacKinnon, Scott A. McEwen, David L. Pearl, Elizabeth C. Parfitt, Kelsey Pasquill, Lisa Steele, Kevin B. Laupland
Summary: This population-based study aimed to describe characteristics and outcomes of Escherichia coli bloodstream infections and identify factors associated with outcomes. The study found that healthcare-associated or nosocomial cases of E. coli BSIs had higher 30-day mortality rates, while older patients, non-urogenital foci infections, and patients with higher Charlson comorbidity index scores were more likely to have higher 30-day mortality rates. Patients who survived to discharge with extended-spectrum beta-lactamase (ESBL)-producing E. coli BSIs, nosocomial BSIs, and higher Charlson comorbidity index scores had higher odds of long post-infection length of hospital stay compared to patients with non-ESBL-producing, community-acquired, and lower Charlson comorbidity index scores.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Fisheries
Joao F. Romero, Ian A. Gardner, Sonja Saksida, Peter McKenzie, Kyle Garver, Derek Price, Krishna Thakur
Summary: The study developed a model to simulate the spread of IHN virus in BC coast and evaluated the effectiveness of the viral disease management plan (VDMP) in limiting epidemic spread, with results indicating the need for comprehensive use of multiple control measures.
Article
Public, Environmental & Occupational Health
Mahmood R. Gohari, Marsha Taylor, Melissa C. MacKinnon, Dimitra Panagiotoglou, Eleni Galanis, Gilaad G. Kaplan, Richard J. Cook, David M. Patrick, Steen Ethelberg, Shannon E. Majowicz
Summary: This study assessed the patterns and impacts of enteric infections in British Columbia, Canada from 2005 to 2014. The majority of individuals experienced only one infection, but some had multiple concurrent infections or unreported infections. The study highlights the need to consider the impacts of multiple infections and to estimate the risk for individuals with potentially unreported infections in sequelae risk analysis.
EPIDEMIOLOGY AND INFECTION
(2022)
Article
Medicine, General & Internal
Ni Gusti Ayu Nanditha, Adrianna Paiero, Hiwot M. Tafessu, Martin St-Jean, Taylor McLinden, Amy C. Justice, Jacek Kopec, Julio S. G. Montaner, Robert S. Hogg, Viviane D. Lima
Summary: This study compared the prevalence trends and age at diagnosis of nine chronic age-associated comorbidities between individuals living with and without HIV. It found that PLWH had higher prevalence and earlier age at diagnosis of non-AIDS comorbidities than their HIV-negative controls, emphasizing the need for optimized screening and comprehensive care for chronic age-associated conditions among PLWH. The methodology developed in this study for using administrative health data to measure prevalence and incidence is reproducible in other settings.
Article
Virology
Shannon L. Russell, Braeden R. A. Klaver, Sean P. Harrigan, Kimia Kamelian, John Tyson, Linda Hoang, Marsha Taylor, Beate Sander, Sharmistha Mishra, Natalie Prystajecky, Naveed Z. Janjua, James E. A. Zlosnik, Hind Sbihi
Summary: This study reports a severity analysis of the SARS-CoV-2 variant Omicron, showing that BA.2 subvariant is associated with a lower risk of hospitalization and intensive care unit admission compared to BA.1, while BA.5 is associated with a higher risk of hospitalization.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Public, Environmental & Occupational Health
C. Andrew Basham, Mohammad Ehsanul Karim, Victoria J. Cook, David M. Patrick, James C. Johnston
Summary: The study aimed to estimate the risk of depression among TB patients and found that TB patients had a higher risk of developing depression, with 50% of the risk being mediated by hospital LOS. Screening for depression among TB patients is recommended.
ANNALS OF EPIDEMIOLOGY
(2021)
Article
Infectious Diseases
Anna Gottschlich, Laurie W. Smith, Hannah Caird, Mark Gilbert, Troy Grennan, Gina Ogilvie
Summary: This study investigated willingness to use non-clinic-based self-collection for STI testing among STI clinic attendees in British Columbia, Canada. The results showed a high willingness among participants to use non-clinic-based self-collection methods for STI testing. Those aged 35 to 54 years were more likely to be willing, while those identifying as straight/mostly straight were less likely to be willing.
SEXUALLY TRANSMITTED DISEASES
(2022)
Article
Immunology
Sarai Racey, Robine Donken, Imogen Porter, Arianne Albert, Julie A. Bettinger, Jennifer Mark, Lizl Bonifacio, Meena Dawar, Mike Gagel, Rakel Kling, Silvina Mema, Hana Mitchell, Ian Roe, Gina Ogilvie, Manish Sadarangani
Summary: In British Columbia, a high proportion of public school teachers have expressed intentions to receive a COVID-19 vaccine. Factors influencing their intention include sociodemographic factors, vaccine hesitancy, general vaccine knowledge, and perception of the severity of COVID-19. Continued monitoring of vaccine intentions will be crucial for informing public health vaccine implementation.
Review
Obstetrics & Gynecology
Winnie Fu, Brintha Sivajohan, Elisabeth McClymont, Arianne Albert, Chelsea Elwood, Gina Ogilvie, Deborah Money
Summary: Vaccination with COVID-19 vaccines during pregnancy and lactation is safe, immunogenic, and effective in preventing COVID-19 disease.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Infectious Diseases
Mark Gilbert, Hsiu-Ju Chang, Aidan Ablona, Travis Salway, Gina Suzanne Ogilvie, Jason Wong, Devon Haag, Heather Nicole Pedersen, Sophie Bannar-Martin, Laurence Campeau, Geoffrey Ford, Catherine Worthington, Daniel Grace, Troy Grennan
Summary: The study found that many sexual health service clients in British Columbia, Canada, had unmet needs during the COVID-19 pandemic, with the main reasons being public messaging against seeking non-urgent healthcare and concerns about COVID-19 transmission in clinics or labs. Offering alternative service delivery methods, such as home self-collection kits or receiving test kits at home, may help improve access to sexual health services.
SEXUALLY TRANSMITTED INFECTIONS
(2022)
Article
Public, Environmental & Occupational Health
Angela Kaida, Lori A. Brotto, Melanie C. M. Murray, Helene C. F. Cote, Arianne Y. Albert, Valerie Nicholson, Rebecca Gormley, Shanlea Gordon, Amy Booth, Laurie W. Smith, Ally Baaske, Liisa A. M. Galea, Manish Sadarangani, Gina S. Ogilvie
Summary: This study investigated COVID-19 vaccine intention and its predictors among people living with HIV. The findings showed that the intention to vaccinate was lower among PLWH compared to those without HIV, but this difference was not significant after adjusting for certain factors. Among PLWH, those with higher vaccine confidence, positive attitudes, and stronger influence of social norms had a higher intention to vaccinate.
Article
Oncology
Anna Gottschlich, Lovedeep Gondara, Laurie W. Smith, Darrel Cook, Ruth Elwood Martin, Marette Lee, Stuart Peacock, Lily Proctor, Gavin Stuart, Mel Krajden, Eduardo L. Franco, Dirk van Niekerk, Gina Ogilvie
Summary: Cervix screening using cytology may miss more precancerous lesions compared to HPV-based screening, even at shorter intervals. Transitioning from cytology to HPV-based screening could improve detection rates and reduce missed diagnoses.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Angeli Rawat, Nadia Mithani, Catherine Sanders, Ruth Namugosa, Beth Payne, Sheona Mitchell-Foster, Jackson Orem, Gina Ogilvie, Carolyn Nakisige
Summary: Uganda has a high incidence of cervical cancer due to limited screening access. Men's knowledge and involvement in community-based cervical cancer screening programs are crucial for improving screening rates for women.
JOURNAL OF CANCER EDUCATION
(2023)
Article
Immunology
Catharine Chambers, Shelley L. Deeks, Rinku Sutradhar, Joseph Cox, Alexandra de Pokomandy, Troy Grennan, Trevor A. Hart, Gilles Lambert, David M. Moore, Francois Coutlee, Daniel Grace, Ramandip Grewal, Jody Jollimore, Nathan Lachowsky, Rosane Nisenbaum, Gina Ogilvie, Chantal Sauvageau, Darrell H. S. Tan, Ann N. Burchell
Summary: Most Canadian provinces implemented publicly-funded HPV vaccination programs for gay, bisexual, and other men who have sex with men (GBM) aged <= 26 years starting from 2015/16. Within 5 years, significant progress was made in HPV vaccine coverage among young GBM. However, gaps remain, particularly among older men who are ineligible for publicly-funded programs. Expanded public funding or insurance coverage for HPV vaccines is needed.
Article
Microbiology
Aidan M. Nikiforuk, Brynn McMillan, Sofia R. Bartlett, Ana Citlali Marquez, Tamara Pidduck, Jesse Kustra, David M. Goldfarb, Vilte Barakauskas, Graham Sinclair, David M. Patrick, Manish Sadarangani, Gina S. Ogilvie, Mel Krajden, Muhammad Morshed, Inna Sekirov, Agatha N. Jassem
Summary: Quantitative multiplex anti-IgG assay tested on finger prick capillary dried blood spot (DBS) samples is accurate in detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies after infection or vaccination. It has high sensitivity and specificity in unvaccinated individuals and even higher sensitivity in COVID-19 vaccine recipients. Modeling analysis showed that DBS testing has a high positive predictive value in a population with high seroprevalence.
MICROBIOLOGY SPECTRUM
(2022)
Article
Public, Environmental & Occupational Health
Anna de Waal, C. Sarai Racey, Robine Donken, Kara Plotnikoff, Simon Dobson, Laurie Smith, Troy Grennan, Manish Sadarangani, Gina Ogilvie
Summary: This study explored the acceptability of bacterial STI vaccines among young HPV-vaccinated Canadian women and found that over 80% of respondents expressed interest in receiving future STI vaccines.
CANADIAN JOURNAL OF PUBLIC HEALTH-REVUE CANADIENNE DE SANTE PUBLIQUE
(2022)
Article
Health Care Sciences & Services
Gabrielle Griffin-Mathieu, Ben Haward, Ovidiu Tatar, Patricia Zhu, Samara Perez, Gilla K. Shapiro, Emily McBride, Erika L. Thompson, Laurie W. Smith, Aisha K. Lofters, Ellen M. Daley, Juliet R. Guichon, Jo Waller, Marc Steben, Kathleen M. Decker, Marie-Helene Mayrand, Julia M. L. Brotherton, Gina S. Ogilvie, Gregory D. Zimet, Teresa Norris, Zeev Rosberger
Summary: This study aims to develop valid psychometric measures for assessing knowledge, attitudes, and beliefs related to cervical cancer screening and to examine psychosocial factors influencing women's intentions to undergo HPV-based screening. A web-based survey was conducted to assess Canadian women's acceptance and feasibility of a questionnaire, and the validated scales will be used in a national survey. The results of this study will provide guidance for public health authorities in Canada to address women's concerns and optimize the acceptance and uptake of HPV-based primary screening.
JMIR RESEARCH PROTOCOLS
(2022)
Review
Primary Health Care
Evelyne Marie Piret, Beth A. Payne, Laurie W. Smith, Jessica Trawin, Jackson Orem, Gina Ogilvie, Carolyn Nakisige
Summary: This study reviewed the side effects and acceptability of thermal ablation (TA) treatment in women living in low-income and middle-income countries (LMICs), finding that while TA results in common side effects, satisfaction with treatment remains high among women in LMICs.
FAMILY MEDICINE AND COMMUNITY HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Kalysha Closson, Campion Zharima, Michelle Kuchena, Janan J. Dietrich, Anne Gadermann, Gina Ogilvie, Mags Beksinska, Angela Kaida
Summary: This study examines the validity, comprehensiveness, and contemporary relevance of the Sexual Relationship Power Scale (SRPS) for young South African women and men. The results reveal comprehension issues, applicability issues, and logical problems with the scale. South African youth provided recommendations for scale adaptations, including revisions to make the scale more inclusive, contemporary, context-specific, relational, and strength-based.
Article
Oncology
Anne Lesack, Laurie W. Smith, C. Sarai Racey, Lovedeep Gondara, Mel Krajden, Marette Lee, Ruth Elwood Martin, Gavin Stuart, Stuart Peacock, Eduardo L. Franco, Dirk van Niekerk, Gina S. Ogilvie
Summary: Self-collection provides an innovative opportunity for population-based HPV cervical cancer screening programs. The survey found that 52.1% of participants were willing to self-collect an HPV sample, and factors such as acceptance of HPV testing and higher education level influenced willingness.
Review
Criminology & Penology
Kalysha Closson, Jane Ndungu, Mags Beksinska, Gina Ogilvie, Janan J. Dietrich, Anne Gadermann, Andrew Gibbs, Mzikazi Nduna, Jenni Smit, Glenda Gray, Angela Kaida
Summary: Gender inequity, including low sexual relationship power, is an important determinant of young people's lives in sub-Saharan Africa. However, there is a lack of detailed research on the psychometric properties of measures of sexual relationship power in this region.
TRAUMA VIOLENCE & ABUSE
(2022)