Article
Immunology
Monika Bociaga-Jasik, Martyna Lara, Aleksandra Raczynska, Barbara Wizner, Stanislaw Polanski, Ewa Mlicka-Kowalczyk, Aleksander Garlicki, Marek Sanak
Summary: This study evaluated the immune response of 121 PLWH after receiving COVID-19 vaccines. The majority of patients who received mRNA vaccines developed an immune response, while a small number of patients did not. The mRNA-1273 vaccine showed the best immune response in this population.
Article
Multidisciplinary Sciences
Antonella Zizza, Federico Banchelli, Marcello Guido, Claudia Marotta, Francesco Di Gennaro, Walter Mazzucco, Vanna Pistotti, Roberto D'Amico
Summary: HPV vaccines are effective and safe in HIV-infected individuals, leading to high seroconversion rates and increased antibody levels without an increased risk of severe adverse events. However, there are no significant differences in CD4+ T-cell count and HIV viral load between the vaccine and placebo groups.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Jolynne Mokaya, Derick Kimathi, Teresa Lambe, George M. Warimwe
Summary: Yellow fever remains a global health threat, with efforts to eliminate it by vaccinating one billion people at risk by 2026. The current vaccine provides good protection, but production challenges limit its use, leading to exploration of alternative dosing strategies. Understanding immune responses to vaccination and exploring antibody characteristics and cell-mediated immunity are important for developing a comprehensive understanding of protective immunity.
Article
Immunology
Cornelia A. M. van de Weg, Mateus Thomazella, Mariana P. Marmorato, Carolina A. Correia, Juliana Z. C. Dias, Alvino Maestri, Luiz G. F. A. B. E. Zanella, Natalia B. Cerqueira, Alvina C. Felix, Carlos H. Moreira, Renata Buccheri, Priscilla R. Costa, Esper G. Kallas
Summary: In a large yellow fever outbreak in Sao Paulo, Brazil in 2018, it was found that angiopoietin 2, a marker related to endothelial damage, is strongly associated with mortality. This suggests that angiopoietin 2 could serve as a predictive marker for fatal outcomes in yellow fever cases.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Zhaozhen Liu, Can Pang, Yuchuan Deng, Caiping Guo, Jia Li, Yanping Li, Ruolei Xin, Xiyao Li, Conghui Xu, Chun Huang, Hongyan Lu, Jie Li
Summary: This study investigated the immunogenicity of the quadrivalent inactivated influenza vaccine in HIV-infected and uninfected individuals, and found that HIV-infected individuals had weaker immune responses, especially those with CD4+ T cell counts below 350 cells/mm3.
Article
Medicine, General & Internal
Houreratou Barry, Gaudensia Mutua, Hannah Kibuuka, Zacchaeus Anywaine, Sodiomon B. Sirima, Nicolas Meda, Omu Anzala, Serge Eholie, Christine Betard, Laura Richert, Christine Lacabaratz, M. Juliana McElrath, Stephen De Rosa, Kristen W. Cohen, Georgi Shukarev, Cynthia Robinson, Auguste Gaddah, Dirk Heerwegh, Viki Bockstal, Kerstin Luhn, Maarten Leyssen, Macaya Douoguih, Rodolphe Thiebaut
Summary: The study investigated the safety, tolerability, and immunogenicity of the heterologous 2-dose Ebola vaccination regimen in healthy and HIV-infected adults, with different intervals between vaccinations. The results showed that the vaccination was well tolerated and immunogenic in African adults, with increasing the interval between vaccinations improving the magnitude of humoral immune responses. Antibody levels persisted to at least 1 year, and a booster vaccination demonstrated the presence of vaccination-induced immune memory.
Article
Immunology
Ana Carolina dos Reis Albuquerque Cajaraville, Mariana Pierre de Barros Gomes, Tamiris Azamor, Renata Carvalho Pereira, Patricia Cristina da Costa Neves, Paula Mello De Luca, Sheila Maria Barbosa de Lima, Luciane Pinto Gaspar, Elena Caride, Marcos da Silva Freire, Marco Alberto Medeiros
Summary: The attenuated yellow fever (YF) vaccine is highly effective but can cause rare fatal adverse events and has contraindications. Therefore, developing a non-live vaccine is important.
Article
Public, Environmental & Occupational Health
Charlotte Martin, Eric Florence, Cristina Domingo, Marc Delforge, Stephane De Wit, Nicolas Dauby
Summary: This study aimed to determine the factors for seroconversion after yellow fever (YF) vaccine and the role of preexisting neutralizing antibodies (NAbs) in people living with HIV (PLWH). The results showed that PLWH with undetectable HIV viral load (VL) at baseline were more likely to seroconvert, and YF seropositivity before revaccination was associated with low rates of booster effect but a higher chance of long term persistent NAbs response. These findings suggest the potential benefit of revaccination in PLWH.
JOURNAL OF TRAVEL MEDICINE
(2022)
Article
Medicine, General & Internal
Aitana Juan-Giner, Derick Kimathi, Kyra H. Grantz, Mainga Hamaluba, Patrick Kazooba, Patricia Njuguna, Gamou Fall, Moussa Dia, Ndeye S. Bob, Thomas P. Monath, Alan D. Barrett, Joachim Hombach, Edgar M. Mulogo, Immaculate Ampeire, Henry K. Karanja, Dan Nyehangane, Juliet Mwanga-Amumpaire, Derek A. T. Cummings, Philip Bejon, George M. Warimwe, Rebecca F. Grais
Summary: This study assessed the immunogenicity and safety of fractional doses of four yellow fever vaccines compared to standard doses. The results showed that fractional doses from all vaccines were non-inferior to the standard dose, with no major safety concerns. This supports the use of fractional dosage in the general adult population for outbreak response in situations of vaccine shortage.
Article
Immunology
Laura Gianserra, Maria Gabriella Dona, Eugenia Giuliani, Christof Stingone, Martina Pontone, Anna Rita Buonomini, Massimo Giuliani, Fulvia Pimpinelli, Aldo Morrone, Alessandra Latini
Summary: This study investigated the immunogenicity and safety of the BNT162b2 homologous boosting vaccination in people living with HIV (PLWH). The results showed that the booster dose greatly increased the immune response in PLWH and had a significantly higher antibody level compared to the primary vaccination. The study also found that the BNT162b2 booster vaccination was safe in PLWH, although there were some reported side effects.
Article
Rheumatology
Betina Soares dos Reis, Felipe Cintra Staub, Andrea Koishi, Camila Zanluca, Claudia Nunes Duarte dos Santos, Thelma L. Skare, Barbara Stadler Kahlow
Summary: The study found that fractionated dose of yellow fever vaccine is effective and safe in rheumatoid arthritis patients, with no clinical infection symptoms observed in the patients.
CLINICAL RHEUMATOLOGY
(2022)
Review
Oncology
Emanuela Romano, Steve Pascolo, Patrick Ott
Summary: The ongoing COVID-19 pandemic has affected millions worldwide, including vulnerable populations such as cancer patients. Currently approved mRNA vaccines appear suitable for cancer patients, but challenges exist in the vaccination process.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Gastroenterology & Hepatology
Jitao Wang, Zhiyun Hou, Jianxin Liu, Ye Gu, Yunhong Wu, Zhenhuai Chen, Jiansong Ji, Shiqi Diao, Yuanwang Qiu, Shengqiang Zou, Aiguo Zhang, Nina Zhang, Fengxian Wang, Xue Li, Yan Wang, Xing Liu, Cheng Lv, Shubo Chen, Dengxiang Liu, Xiaolin Ji, Chao Liu, Tao Ren, Jingwei Sun, Zhongwei Zhao, Fazong Wu, Fenxiang Li, Ruixu Wang, Yan Yan, Shiliang Zhang, Guohong Ge, Jiangbo Shao, Shiying Yang, Chuan Liu, Yifei Huang, Dan Xu, Xiaoguo Li, Jingwen Ai, Qing He, Ming-Hua Zheng, Liting Zhang, Qing Xie, Don C. Rockey, Jonathan A. Fallowfield, Wenhong Zhang, Xiaolong Qi
Summary: The study demonstrates that COVID-19 vaccination is safe and immunogenic in patients with non-alcoholic fatty liver disease (NAFLD). Most adverse reactions post-vaccination are mild and transient.
JOURNAL OF HEPATOLOGY
(2021)
Article
Immunology
Fabienne Piras-Douce, Franck Raynal, Alix Raquin, Yves Girerd-Chambaz, Sylviane Gautheron, Martha Erika Navarro Sanchez, Manuel Vangelisti, Nathalie Mantel
Summary: vYF-247, a live-attenuated yellow fever vaccine candidate, demonstrated low neurovirulence, neurotropism, viscerotropism, and comparable immunogenicity to Stamaril and YF-VAX in relevant animal models. In animal studies, vYF-247 provided protection against yellow fever virus and showed promising results as a potential vaccine candidate.
Article
Public, Environmental & Occupational Health
Frieder Schaumburg, Franziska Schuler, Martin P. Grobusch
Summary: The Permanent Vaccination Commission in Germany has updated its recommendations for yellow fever vaccination, conflicting with WHO recommendations. The article presents arguments supporting adherence to the WHO recommendations, including the complexity of booster vaccinations and the importance of T-cell driven immune response.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Public, Environmental & Occupational Health
Fabio Mauri, Sara Cottler-Casanova, Matthias Cavassini, Marcel Stoeckle, Gilles Wandeler, Patrick Schmid, Dominique L. Braun, Alexandra Scherrer, Enos Bernasconi, Alexandra Calmy, Jasmine Abdulcadir
Summary: FGM/C is a harmful practice that involves injury to the female genitalia without medical purpose, and it is prevalent worldwide. There is a lack of knowledge on how to care for women with FGM/C, and improvements in care and prevention are needed.
JOURNAL OF IMMIGRANT AND MINORITY HEALTH
(2023)
Article
Immunology
Isabella C. Schoepf, Christian W. Thorball, Helen Kovari, Bruno Ledergerber, Ronny R. Buechel, Alexandra Calmy, Rainer Weber, Philipp A. Kaufmann, Rene Nkoulou, Johannes M. Schwenke, Dominique L. Braun, Jacques Fellay, Philip E. Tarr
Summary: In Swiss HIV-infected individuals, subclinical coronary artery disease is independently associated with an individual polygenic risk score for coronary artery disease. Combining non-genetic and genetic cardiovascular risk factors provides the most powerful prediction for subclinical coronary artery disease.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Marco Labarile, Tom Loosli, Marius Zeeb, Katharina Kusejko, Michael Huber, Hans H. Hirsch, Matthieu Perreau, Alban Ramette, Sabine Yerly, Matthias Cavassini, Manuel Battegay, Andri Rauch, Alexandra Calmy, Julia Notter, Enos Bernasconi, Christoph Fux, Huldrych F. Gunthard, Chloe Pasin, Roger D. Kouyos
Summary: This study investigated and predicted the dynamics of HIV transmission in Switzerland using a network-based clustering method and statistical learning approaches. The study found that network characteristics can capture major heterogeneities in transmission and that cluster structure has the potential for real-time prediction of ongoing transmission.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Dina Bigler, Bernard Surial, Christoph Victor Hauser, Torsten Konrad, Hansjakob Furrer, Andri Rauch, Karoline Aebi-Popp
Summary: Access to affordable STI testing for asymptomatic individuals is important to reduce STI transmission. Our study examines the prevalence of STIs and the factors motivating people to attend our easily accessible and affordable testing site.
SEXUALLY TRANSMITTED INFECTIONS
(2023)
Article
Multidisciplinary Sciences
Julien Riou, Anthony Hauser, Anna Fesser, Christian L. Althaus, Matthias Egger, Garyfallos Konstantinoudis
Summary: The study estimates that after accounting for deaths directly related to COVID-19, mortality in Switzerland was lower than expected, suggesting a positive impact of control measures.
NATURE COMMUNICATIONS
(2023)
Article
Biochemical Research Methods
Migle J. Gabrielaite, Marc Bennedbaek, Malthe Sebro J. Rasmussen, Virginia Kan, Hansjakob J. Furrer, Robert Flisiak, Marcelo J. Losso, Jens D. Lundgren, INSIGHT START Study Group, Rasmus L. Marvig
Summary: After HIV transmission, the viral population becomes more diverse due to recombination and acquired mutations, and this diversity is associated with viral load (VL), a key progression marker. Understanding the relationship between intrahost genetic diversity and VL could help improve HIV monitoring and treatment strategies.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Catia Marzolini, Matthias L. Cavassini, Dominique L. Braun, Anna Hachfeld, Enos Bernasconi, Alexandra Calmy, Patrick Schmid, Manuel Battegay, Luigia Elzi
Summary: This study aimed to investigate whether a common single polymorphism could explain the phenomenon of some HIV patients not achieving their lipid targets despite elevated statin concentrations. The study found that individuals carrying the SLCO1B1 c.521T>C polymorphism had smaller changes in lipid levels after statin initiation compared to those without this polymorphism.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Immunology
Suzanne M. Ingle, Jose M. Miro, Margaret T. May, Lauren E. Cain, Christine Schwimmer, Robert Zangerle, Helen Sambatakou, Charles Cazanave, Peter Reiss, Vanessa Brandes, Heiner C. Bucher, Caroline Sabin, Francesc Vidal, Niels Obel, Amanda Mocroft, Linda Wittkop, Antonella d'Arminio Monforte, Carlo Torti, Cristina Mussini, Hansjakob Furrer, Deborah Konopnicki, Ramon Teira, Michael S. Saag, Heidi M. Crane, Richard D. Moore, Jeffrey M. Jacobson, W. Chris Mathews, Elvin Geng, Joseph J. Eron, Keri N. Althoff, Abigail Kroch, Raynell Lang, M. John Gill, Jonathan A. C. Sterne
Summary: This study aimed to investigate the impact of the timing of antiretroviral therapy (ART) initiation on mortality rates among patients with HIV and cryptococcal meningitis in high-income settings. The study found little evidence to suggest that early ART was associated with higher mortality rates in high-income settings.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Paul Thoueille, Susana Alves Saldanha, Vincent Desfontaine, Katharina Kusejko, Perrine Courlet, Pascal Andre, Matthias Cavassini, Laurent A. Decosterd, Thierry Buclin, Monia Guidi
Summary: This study investigated the pharmacokinetics of tenofovir alafenamide (TAF) in people living with HIV (PLWH), and found that renal function significantly affects TAF exposure. The study suggests cautious adjustment of TAF dosage intervals in case of moderate or severe chronic kidney disease (CKD).
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Medicine, General & Internal
Nicolas Banholzer, Kathrin Zuercher, Philipp Jent, Pascal Bittel, Lavinia Furrer, Matthias Egger, Tina Hascher, Lukas Fenner
Summary: The study assessed the transmission of respiratory infections in schools and the association with infection control measures. The findings showed that mask mandates were more effective than air cleaners in reducing aerosol concentrations and the transmission risk of SARS-CoV-2. The multiple-measurement approach used in this study could be applied to continuously monitor the transmission risk of respiratory infections and the effectiveness of infection control measures in schools and other congregate settings.
Article
Infectious Diseases
Bashkim Jaha, Corinne D. Schenkel, Lisa Jorimann, Michael Huber, Maryam Zaheri, Kathrin Neumann, Christine Leemann, Alexandra Calmy, Matthias Cavassini, Roger D. Kouyos, Huldrych F. Gunthard, Karin J. Metzner, Swiss HIV Cohort Study
Summary: A new method was used to analyze HIV-1 DNA, including the detection of drug resistance. The results showed varying levels of drug resistance mutations, which were associated with the duration of antiretroviral therapy.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Oncology
Carole Metekoua, Yann Ruffieux, Victor Olago, Tafadzwa Dhokotera, Matthias Egger, Julia Bohlius, Eliane Rohner, Mazvita Muchengeti
Summary: The main risk factors for squamous cell carcinoma of the conjunctiva (SCCC) among people with HIV (PWH) in South Africa are immunodeficiency and exposure to ultraviolet radiation. The incidence rate of SCCC decreased between 2004 and 2014, and PWH residing within latitudes 30°S to 34°S had a lower SCCC risk. Other risk factors for SCCC were lower CD4 counts and middle age, while there was no evidence for an association of sex or settlement type with SCCC risk.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Gastroenterology & Hepatology
Lukas Baumann, Dominique L. Braun, Matthias Cavassini, Marcel Stoeckle, Enos Bernasconi, Patrick Schmid, Alexandra Calmy, David Haerry, Charles Beguelin, Christoph A. Fux, Gilles Wandeler, Bernard Surial, Andri Rauch
Summary: The study assessed the changes in the prevalence of replicating HCV infection, treatment uptake, and liver-related morbidity and mortality in persons with HIV and hepatitis C. The introduction of direct-acting antiviral therapy was associated with a significant reduction in the prevalence of replicating HCV infection, as well as a decrease in overall mortality and incidence of liver-related events in this population.
LIVER INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Anna Severin, Michaela Strinzel, Matthias Egger, Tiago Barros, Alexander Sokolov, Julia Vilstrup Mouatt, Stefan Mueller
Summary: This study analyzed 10,000 peer review reports from 1,644 biomedical journals and found that peer review in higher impact factor journals tends to be more thorough in addressing study methods but gives relatively less emphasis to presentation and suggesting solutions. This indicates that the Journal Impact Factor is a poor predictor of the quality of peer review.
Article
Geriatrics & Gerontology
Isabella C. Schoepf, Andres Esteban-Cantos, Christian W. Thorball, Berta Rodes, Peter Reiss, Javier Rodriguez-Centeno, Carlotta Riebensahm, Dominique L. Braun, Catia Marzolini, Marco Seneghini, Enos Bernasconi, Matthias Cavassini, Helene Buvelot, Maria Christine Thurnheer, Roger D. Kouyos, Jacques Fellay, Huldrych F. Gunthard, Jose R. Arribas, Bruno Ledergerber, Philip E. Tarr
Summary: In this long-term study, accelerated epigenetic ageing was observed in untreated HIV infection and partial reversal was achieved with effective antiretroviral therapy. It underscores the significance of limiting the duration of untreated HIV infection.
LANCET HEALTHY LONGEVITY
(2023)