Editorial Material
Medicine, General & Internal
Thomas D. Sequist
Summary: This viewpoint reviews the evidence of poor health outcomes experienced by American Indian/Alaska Native persons due to structural disadvantage, and proposes an aggressive agenda to improve their health and well-being by addressing social determinants of health, improving access to and quality of care, and improving data availability and transparency.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Infectious Diseases
Michael G. Bruce, Sara S. Bressler, Andria Apostolou, Rosalyn J. Singleton
Summary: The study revealed a 26% increase in LRTI rates among adult AI/AN residing in AK compared to a 38% decrease in rates among AI/AN residing in non-AK, likely due to factors such as tobacco use and crowding. Strategies to reduce LRTI in AI/AN adults are necessary.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Eili Y. Klein, Xianming Zhu, Molly Petersen, Eshan U. Patel, Sara E. Cosgrove, Aaron A. R. Tobian
Summary: According to the National Inpatient Sample data, hospitalization rates for methicillin-resistant Staphylococcus aureus (MRSA)-related septicemia have increased between 2016 and 2019. The rates of methicillin-sensitive Staphylococcus aureus (MSSA)-related septicemia and pneumonia hospitalizations have also significantly increased during this period.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Microbiology
Chih-Jung Chen, Tsai-Ling Yang Lauderdale, Yhu-Chering Huang
Summary: The global MRSA strains were dominated by few genetic lineages, with ST59, ST239/241, and ST5 MRSA estimated to emerge in Taiwan in 1974, 1979, and 1995 respectively. ST59 and ST239/241 evolved drastically during 1980 and 1995, resulting in successful subclones prevailing in Taiwan, while ST5 did not show significant genetic drift during 20 years of evolution. Each lineage harbored specific toxome, resistome, and plasmids, with genes mediating immune evasion, leukocidins, enterotoxins, and aminoglycosides resistance being frequently identified between subclones.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Surgery
Kevin N. Harrell, Tyler Koestner, Jacob Lloyd, Breanna L. Carter, Darren Hunt, Benjamin Dart, Robert Maxwell
Summary: MRSA nasal swab screening was not sensitive enough to withhold empiric antibiotic MRSA coverage in trauma patients with suspected pneumonia, as it had a low sensitivity and a significant percentage of patients with negative swabs had positive MRSA pneumonia. Inadequate antibiotic coverage in these patients was associated with longer hospital and ICU stays, more ventilator days, and higher rates of unplanned intubation.
JOURNAL OF SURGICAL RESEARCH
(2023)
Review
Materials Science, Multidisciplinary
Shreya Kanth, Akshatha Nagaraja, Yashoda Malgar Puttaiahgowda
Summary: The current global death rate is threatened by deadly unknown infections and the emergence of multidrug-resistant bacteria. Combatting drug-resistant bacteria, such as MRSA, has become a daunting challenge globally, with polymer synthesis being explored as a significant approach in preventing the spread of infections.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Cell Biology
Zhimin Bai, Min Chen, Qiaofa Lin, Ying Ye, Hongmei Fan, Kaizhen Wen, Jianxing Zeng, Donghong Huang, Wenfei Mo, Ying Lei, Zhijun Liao
Summary: By extracting feature vectors from protein sequences and using classification tools, MRSA and MSSA were successfully distinguished. MRSA showed high resistance to penicillin and high pathogenic risk. Cross-infection between different types of MRSA was found in Quanzhou, and MRSA in traditional hospitals exhibited increasingly blurred molecular characteristics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Infectious Diseases
Joshua. B. Parsons, Annette. C. Westgeest, Brian. P. B. Conlon, Vance. G. Fowler
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a deadly pathogen that can persist in the bloodstream for days despite appropriate antibiotics. Persistent MRSA bacteremia is common and associated with poor clinical outcomes. This review explores the factors related to host-pathogen interaction and discusses the clinical relevance of each element. Treatment options and diagnostic approaches for managing persistent MRSA bacteremia are also discussed.
Article
Public, Environmental & Occupational Health
Feiteng Zhu, Hemu Zhuang, Shujuan Ji, Er Xu, Lingfang Di, Zhengan Wang, Shengnan Jiang, Haiping Wang, Lu Sun, Ping Shen, Yunsong Yu, Yan Chen
Summary: The study found that in households of CA-MRSA infected patients in China, most MRSA isolates belonged to epidemic CA-MRSA clones, while no MRSA was detected in the control group households. The research revealed that the home environment is an important reservoir for MRSA.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Microbiology
Melissa J. Karau, Suzannah M. Schmidt-Malan, Scott A. Cunningham, Jayawant N. Mandrekar, Bobbi S. Pritt, Tiffany R. Keepers, Alisa W. Serio, Surya Chitra, Robin Patel
Summary: Omadacycline, vancomycin, and rifampin, as well as rifampin combination therapies, were evaluated in an experimental rat model of MRSA osteomyelitis. The results showed that rifampin combination therapy was effective in reducing MRSA recovery without developing resistance. The combination of omadacycline and rifampin yielded negative MRSA detection, suggesting its potential as a treatment for osteomyelitis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Pediatrics
Shaquita Bell, Jason F. Deen, Molly Fuentes, Kelly Moore
Summary: American Indian and Alaska Native populations face significant health disparities, especially starting from childhood. Health care providers specializing in pediatrics have the unique opportunity to address disease rates among AI/AN youth and improve their overall health status through advocacy and policy making.
Article
Public, Environmental & Occupational Health
Zachary Giano, Ricky L. Camplain, Carolyn Camplain, George Pro, Shane Haberstroh, Julie A. Baldwin, Denna L. Wheeler, Randolph D. Hubach
Summary: This study represents the largest empirical investigation of adverse childhood experiences among American Indian and Alaska Native populations to date. American Indians and Alaska Natives had higher average adverse childhood experience scores compared to individuals identifying as White, Black, and Hispanic. Female participants, younger individuals, those with lower incomes, and sexual minorities reported higher average adverse childhood experience scores.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2021)
Article
Infectious Diseases
Jian Peng, Biswajit Mishra, Rajamohammed Khader, LewisOscar Felix, Eleftherios Mylonakis
Summary: In this study, a smaller antimicrobial peptide C18 derived from cecropin 4 showed high antibacterial activity against various bacteria and yeasts, with a remarkable effect on drug-resistant Staphylococcus aureus. C18 also exhibited the capability to eliminate persister cells, reduce biofilm adherence, interact with DNA, and down-regulate virulence factor genes. Moreover, C18 showed promising results in a Galleria mellonella model, highlighting its potential as a therapeutic candidate for severe MRSA infections.
Review
Public, Environmental & Occupational Health
Gina Kruse, Victor A. Lopez-Carmen, Anpotowin Jensen, Lakotah Hardie, Thomas D. Sequist
Summary: The Indian Health Service has made progress in narrowing health disparities between American Indian and Alaska Native populations and other racial and ethnic groups, but still faces challenges such as inadequate funding, limited resources, and the need for culturally sensitive services.
ANNUAL REVIEW OF PUBLIC HEALTH
(2022)
Article
Food Science & Technology
Martina Florianova, Kristyna Korena, Helena Juricova
Summary: This study evaluated the prevalence of Staphylococcus aureus in dry-fermented salami and found multidrug-resistant and virulent strains. The source of contamination was identified as raw pork and human carriers. Therefore, maintaining high standards of hygiene and manufacturing practices in food processing is crucial.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Kathy K. Byrd, Jason M. Mehal, Sarah F. Schillie, Robert C. Holman, Dana Haberling, Trudy Murphy
PUBLIC HEALTH REPORTS
(2015)
Article
Public, Environmental & Occupational Health
Kathy K. Byrd, Melissa Furtado, Tim Bush, Lytt Gardner
AIDS PATIENT CARE AND STDS
(2016)
Article
Medicine, General & Internal
Philip J. Peters, Pamela Pontones, Karen W. Hoover, Monita R. Patel, Romeo R. Galang, Jessica Shields, Sara J. Blosser, Michael W. Spiller, Brittany Combs, William M. Switzer, Caitlin Conrad, Jessica Gentry, Yury Khudyakov, Dorothy Waterhouse, S. Michele Owen, Erika Chapman, Jeremy C. Roseberry, Veronica McCants, Paul J. Weidle, Dita Broz, Taraz Samandari, Jonathan Mermin, Jennifer Walthall, John T. Brooks, Joan M. Duwve
NEW ENGLAND JOURNAL OF MEDICINE
(2016)
Article
Public, Environmental & Occupational Health
Anil Suryaprasad, Kathy K. Byrd, John T. Redd, David G. Perdue, Michele Manos, Brian J. McMahon
AMERICAN JOURNAL OF PUBLIC HEALTH
(2014)
Article
Public, Environmental & Occupational Health
Brigg Reilley, Emily Bloss, Kathy K. Byrd, Jonathan Iralu, Lisa Neel, James Cheek
AMERICAN JOURNAL OF PUBLIC HEALTH
(2014)
Article
Infectious Diseases
Carrie Reed, Dana Bruden, Kathy K. Byrd, Vic Veguilla, Michael Bruce, Debby Hurlburt, David Wang, Crystal Holiday, Kathy Hancock, Justin R. Ortiz, Joe Klejka, Jacqueline M. Katz, Timothy M. Uyeki
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2014)
Article
Immunology
Gregory A. Raczniak, Lisa R. Bulkow, Michael G. Bruce, Carolyn L. Zanis, Richard L. Baum, Mary M. Snowball, Kathy K. Byrd, Umid M. Sharapov, Thomas W. Hennessy, Brian J. McMahon
JOURNAL OF INFECTIOUS DISEASES
(2013)
Article
Public, Environmental & Occupational Health
Kathy K. Byrd, Felicia Hardnett, Patrick G. Clay, Ambrose Delpino, Ron Hazen, Michael D. Shankle, Nasima M. Camp, Sumihiro Suzuki, Paul J. Weidle
AIDS PATIENT CARE AND STDS
(2019)
Article
Immunology
Kathy K. Byrd, John G. Hou, Tim Bush, Ron Hazen, Heather Kirkham, Ambrose Delpino, Paul J. Weidle, Michael D. Shankle, Nasima M. Camp, Sumihiro Suzuki, Patrick G. Clay
CLINICAL INFECTIOUS DISEASES
(2020)
Article
Immunology
Kathy K. Byrd, John G. Hou, Ron Hazen, Heather Kirkham, Sumihiro Suzuki, Patrick G. Clay, Tim Bush, Nasima M. Camp, Paul J. Weidle, Ambrose Delpino
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2019)
Article
Immunology
Kathy K. Byrd, Nasima M. Camp, Kashif Iqbal, Paul J. Weidle
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2019)
Article
Public, Environmental & Occupational Health
Kathy K. Byrd, Felicia Hardnett, John G. Hou, Patrick G. Clay, Sumihiro Suzuki, Nasima M. Camp, Michael D. Shankle, Paul J. Weidle, Michael S. Taitel
Article
Public, Environmental & Occupational Health
Kiren Mitruka, Clelia Pezzi, Brittney Baack, Heather Burke, Jennifer Cochran, Jasmine Matheson, Kailey Urban, Marisa Ramos, Kathy Byrd
JOURNAL OF IMMIGRANT AND MINORITY HEALTH
(2019)
Article
Public, Environmental & Occupational Health
Mary R. Tanner, Tim Bush, Steven R. Nesheim, Paul J. Weidle, Kathy K. Byrd
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2017)
Article
Health Policy & Services
Kathy K. Byrd, Melissa Furtado, Tim Bush, Lytt Gardner
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2015)