Article
Infectious Diseases
Catia Cilloniz, Cristina Dominedo, Albert Gabarrus, Carolina Garcia-Vidal, Jose Becerril, Diego Tovar, Estela Moreno, Juan M. Pericas, Carmen Rosa Vargas, Antoni Torres
Summary: This study aimed to describe the prevalence, risk factors, and outcomes of MSSA community-acquired pneumonia and found that MSSA CAP patients had higher 30-day mortality than pneumococcal CAP patients, with MSSA being an independent factor of mortality.
JOURNAL OF INFECTION
(2021)
Article
Microbiology
Abdeljallil Zeggay, Alban Atchon, Benoit Valot, Didier Hocquet, Xavier Bertrand, Kevin Bouiller
Summary: Using genomic data, the study determined the origin of MRSA ST398 isolates causing invasive infections in patients with no livestock contact. The isolates were sequenced and analyzed for the presence of virulence and resistance genes. Phylogenetic analysis revealed that MSSA isolates were human-associated, while MRSA isolates were livestock-associated. The results suggest that livestock-associated MRSA acquired virulence genes, enabling them to cause invasive infections in humans.
Article
Plant Sciences
Andres Humberto Uc-Cachon, Angel de Jesus Dzul-Beh, Geovani Antonio Palma-Pech, Bertha Jimenez-Delgadillo, Jose Salvador Flores-Guido, Carlos Gracida-Osorno, Gloria Maria Molina-Salinas
Summary: This study evaluated the in-vitro anti-Staphylococcus aureus activities of 15 Mayan medicinal plants, with 8 plant extracts showing significant antibacterial effects against S. aureus and 13 plant extracts affecting the biofilm formation of the bacteria.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biology
Funda Yildirim, Mert Sudagidan, Ali Aydin, Ibrahim Akyazi, Gulay Merve Bayrakal, Orhan Yavuz, Aydin Gurel
Summary: This study demonstrates the pathogenicity of foodborne PVL-positive MSSA strains in vivo, showing that they can cause acute necrotising pneumonia and significantly elevate the expression of important inflammatory factors.
Article
Infectious Diseases
Adham Mohamed, Nicholas Bennett, Jeannette Ploetz, Laura Aragon, Kevin Kennedy, Sarah Boyd
Summary: This study compared the safety and efficacy of ceftriaxone (CRO) and cefazolin (CZO) in the treatment of methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. The results showed no difference in the clinical cure rate between CRO and CZO at 28 days or at discharge. There were also no differences in treatment failure, safety events, and other secondary endpoints between the two groups. The findings suggest that there is no clinical difference between CRO and CZO for the definitive treatment of MSSA bacteremia.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Multidisciplinary Sciences
Sherry Usun Jones, Kek Heng Chua, Ching Hoong Chew, Chew Chieng Yeo, Fatimah Haslina Abdullah, Norlela Othman, Boon Pin Kee, Suat Moi Puah
Summary: This study aimed to investigate the spa types of Malaysian S. aureus isolates from various clinical specimens. The results showed that spa type t032 was the most predominant in MRSA, while t127 and t091 were the most common in MSSA.
Article
Immunology
Matthew P. Cheng, Alexander Lawandi, Guillaume Butler-Laporte, Samuel De L'Etoile-Morel, Katryn Paquette, Todd C. Lee
Summary: The study aimed to determine the efficacy of synergistic treatment with daptomycin when given with either cefazolin or cloxacillin for the treatment of MSSA BSI. Results showed that adjunctive daptomycin therapy did not shorten the duration of bacteremia when added to standard-of-care treatment for MSSA BSIs, and should not be routinely considered.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biology
Low Yi Xin, Toh Hui Min, Puteri Nur Liyana Mohd Zin, Thiruchelvi Pulingam, Jimmy Nelson Appaturi, Thaigarajan Parumasivam
Summary: This study evaluates the antibacterial activities of 61 plant extracts from 49 Malaysian ethnomedicinal plants, with 7 plant extracts showing good efficacy against MSSA strains. When combined with vancomycin and ciprofloxacin, the active plant extracts showed no interaction against MSSA and MRSA strains.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Gi Yong Lee, Soo In Lee, Sun Do Kim, Ji Heon Park, Geun-Bae Kim, Soo-Jin Yang
Summary: This study examined the clonal diversities of livestock-associated Staphylococcus aureus isolates from broiler farms, slaughterhouses, and retail chicken meat. The study found different genotypes of methicillin-resistant S. aureus and methicillin-susceptible S. aureus. Two dominant genetic lineages of methicillin-resistant S. aureus were found in healthy broilers.
Article
Food Science & Technology
Francesca Fanelli, Daniele Chieffi, Gyu-Sung Cho, Justyna Schubert, Omar Amine Mekhloufi, Jacek Bania, Charles M. A. P. Franz, Vincenzina Fusco
Summary: This study characterized genetically diverse Staphylococcus aureus strains isolated from ready-to-eat foods in Algiers, Algeria, and investigated their ability to produce enterotoxins. The strains showed a wide range of enterotoxin and antibiotic resistance genes, as well as virulence-related genes. A phylogenomic analysis revealed clustering based on sequence type and geographical origin rather than the source of isolation.
Article
Microbiology
Ryota Miyazawa, So Shimoda, Keiichi Matsuda, Ryuta Tobe, Tasuke Ando, Hiroshi Yoneyama
Summary: Staphylococcus aureus is a major pathogen in humans and livestock, causing serious issues such as bovine mastitis. This study monitored cases of intramammary infection caused by S. aureus in the Miyagi Prefecture, Japan, and analyzed the strains obtained from dairy farms. The study found recurrent cases of infection and identified a Methicillin-Sensitive SA (MSSA) ST398 strain isolated from mastitis-containing cows, which is the first confirmed case in Japan. The results highlight the importance of nationwide surveillance to manage the distribution of ST398 strains in dairy farms for human and animal health.
Article
Microbiology
Cristina Tello-Diaz, Marta Palau, Estela Munoz, Xavier Gomis, Joan Gavalda, Nuria Fernandez-Hidalgo, Sergi Bellmunt-Montoya
Summary: The aim of this study was to quantify in vitro biofilm formation by methicillin-susceptible Staphylococcus aureus (MSSA) on the surfaces of different types of commonly used vascular grafts. The Dacron silver-triclosan and Omniflow II vascular grafts showed the greatest resistance to in vitro methicillin-susceptible Staphylococcus aureus biofilm formation compared to other vascular grafts.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
A. J. Heffernan, F. B. Sime, S. Mohd Sazlly Lim, S. Adiraju, S. C. Wallis, J. Lipman, G. D. Grant, J. A. Roberts
Summary: This study investigated the pharmacodynamics of ceftriaxone against methicillin-susceptible Staphylococcus aureus (MSSA) and determined the optimal dosage. The results showed that only a high ceftriaxone dose of 2 g twice daily achieved bacterial killing and sustained inhibition of bacterial growth.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Microbiology
Tanis C. Dingle, Dulini Gamage, Sara Gomez-Villegas, Blake M. Hanson, Jinnethe Reyes, April Abbott, Carey-Ann D. Burnham, Jennifer Dien Bard, Stephanie Fritz, William R. Miller, Lars F. Westblade, Barbara Zimmer, Cesar A. Arias, Susan Butler-Wu
Summary: This multicenter study evaluated the prevalence of the cefazolin inoculum effect (CzIE) in North American methicillin-susceptible Staphylococcus aureus (MSSA) isolates. The study found that the CzIE was present in 18.6% of MSSA isolates, with varying prevalence across different study sites. Furthermore, more CzIE-positive isolates had a cefazolin MIC of 1.0 μg/mL, while more CzIE-negative isolates had a MIC of 0.25 μg/mL.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Infectious Diseases
Luzia Renggli, Michael Gasser, Niccolo Buetti, Andreas Kronenberg
Summary: The study aimed to analyze the recent trends of MRSA and MSSA bloodstream infections (BSI) in Switzerland and its different linguistic regions. The findings showed that the incidence of S. aureus BSI increased by 30% over the study period, with a significant increase in MSSA and a decrease in MRSA, particularly in the French-speaking region.
Article
Infectious Diseases
Ryan L. Mork, Patrick G. Hogan, Carol E. Muenks, Mary G. Boyle, Ryley M. Thompson, Melanie L. Sullivan, John J. Morelli, Jennifer Seigel, Rachel C. Orscheln, Juliane Bubeck Wardenburg, Sarah J. Gehlert, Carey-Ann D. Burnham, Andrey Rzhetsky, Stephanie A. Fritz
LANCET INFECTIOUS DISEASES
(2020)
Review
Pediatrics
Clayton D. Albracht, Teri N. Hreha, David A. Hunstad
Summary: Urinary tract infections (UTIs) are not only a disease that affects women, but also certain male populations such as infants and elderly men. High-grade vesicoureteral reflux is a primary risk factor for upper-tract UTI in children. Recent studies indicate that there are sex and hormone-specific effects on UTI pathogenesis and immune responses.
PEDIATRIC NEPHROLOGY
(2021)
Article
Oncology
Stephanie S. Cabler, Patrick G. Hogan, Stephanie A. Fritz, Jeffrey J. Bednarski, David A. Hunstad
PEDIATRIC BLOOD & CANCER
(2020)
Editorial Material
Pediatrics
Rachel C. Orscheln, Jason G. Newland, David A. Rosen
JOURNAL OF PEDIATRICS
(2021)
Article
Public, Environmental & Occupational Health
Patrick Dawson, Mary Claire Worrell, Sara Malone, Sarah C. Tinker, Stephanie Fritz, Brett Maricque, Sadaf Junaidi, Gemille Purnell, Albert M. Lai, Julie A. Neidich, Justin S. Lee, Rachel C. Orscheln, Rachel Charney, Terri Rebmann, Jon Mooney, Nancy Yoon, Machelle Petit, Spring Schmidt, Jean Grabeel, Lee Ann Neill, Lisa C. Barrios, Snigdha Vallabhaneni, Randall W. Williams, Clay Goddard, Jason G. Newland, John C. Neatherlin, Johanna S. Salzer
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2021)
Letter
Immunology
Tarin M. Bigley, Zhimin Song, Rachel C. Orscheln, David B. Wilson, Baddr A. Shakhsheer, Mai He, Stuart C. Sweet, Mary C. Dinauer, Maleewan Kitcharoensakkul
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Review
Immunology
Hunter W. Kuhn, Teri N. Hreha, David A. Hunstad
Summary: Recent advances in preclinical modeling of urinary tract infections have provided new insights into the host response and tissue damage. The roles of neutrophils, macrophages, antimicrobial peptides, and renal epithelial cells in controlling uropathogens and tissue injury have been explored. Epigenetic modifications during bacterial cystitis have also been linked to bladder remodeling and increased susceptibility to recurrent UTI. This research could inform the development of preventive and therapeutic approaches for UTI.
TRENDS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Kevin J. Downes, Victoria A. Statler, Rachel C. Orscheln, Melissa K. Cousino, Michael Green, Marian G. Michaels, William J. Muller, Tanvi S. Sharma, Lara A. Danziger-Isakov, Monica Ardura
Summary: The COVID-19 pandemic poses challenges for pediatric solid organ transplant recipients and their families, particularly regarding school re-entry and COVID-19 vaccines. A team of specialists in various fields assembled to address these concerns and provide expert statements specific to pediatric SOT recipients attending school in the United States in 2021.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Article
Immunology
Lisa K. McLellan, Allyssa L. Daugherty, David A. Hunstad
Summary: Uropathogenic Escherichia coli (UPEC) encounters a bottleneck in the female bladder during cystitis, but males show a less restrictive bottleneck during successful renal infection. The study also found that kidney bacterial communities (KBCs) are clonal in origin despite the influx of infected bladder urine into the renal pelvis.
INFECTION AND IMMUNITY
(2021)
Article
Infectious Diseases
Joshua Wolf, Mark J. Abzug, Rachel L. Wattier, Paul K. Sue, Surabhi B. Vora, Philip Zachariah, Daniel E. Dulek, Alpana Waghmare, Rosemary Olivero, Kevin J. Downes, Scott H. James, Swetha G. Pinninti, April Yarbrough, Margaret L. Aldrich, Christine E. MacBrayne, Vijaya L. Soma, Steven P. Grapentine, Carlos R. Oliveira, Molly Hayes, David W. Kimberlin, Sarah B. Jones, Laura L. Bio, Theodore H. Morton, Jane S. Hankins, Gabriela M. Maron, Kathryn Timberlake, Jennifer L. Young, Rachel C. Orscheln, Hayden T. Schwenk, David L. Goldman, Helen E. Groves, W. Charles Huskins, Nipunie S. Rajapakse, Gabriella S. Lamb, Alison C. Tribble, Elizabeth C. Lloyd, Adam L. Hersh, Emily A. Thorell, Adam J. Ratner, Kathleen Chiotos, Mari M. Nakamura
Summary: This study suggests that there is currently no evidence supporting the use of monoclonal antibody therapy for treating COVID-19 in children or adolescents, despite the typically mild course of the disease in this population. Limited evidence of modest benefit in adults is available, but there is a risk of potential harm associated with infusion reactions or anaphylaxis.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2021)
Article
Infectious Diseases
Katelyn L. Parrish, Noble K. Salwan, Ryley M. Thompson, Patrick G. Hogan, Rachel C. Orscheln, Jason G. Newland, Stephanie A. Fritz
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2020)
Article
Infectious Diseases
Kevin J. Downes, Lara A. Danziger-Isakov, Melissa K. Cousino, Michael Green, Marian G. Michaels, William J. Muller, Rachel C. Orscheln, Tanvi S. Sharma, Victoria A. Statler, Rachel L. Wattier, Monica Ardura
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2020)
Article
Infectious Diseases
Kathleen Chiotos, Molly Hayes, David W. Kimberlin, Sarah B. Jones, Scott H. James, Swetha G. Pinninti, April Yarbrough, Mark J. Abzug, Christine E. MacBrayne, Vijaya L. Soma, Daniel E. Dulek, Surabhi B. Vora, Alpana Waghmare, Joshua Wolf, Rosemary Olivero, Steven Grapentine, Rachel L. Wattier, Laura Bio, Shane J. Cross, Nicholas O. Dillman, Kevin J. Downes, Kathryn Timberlake, Jennifer Young, Rachel C. Orscheln, Pranita D. Tamma, Hayden T. Schwenk, Philip Zachariah, Margaret Aldrich, David L. Goldman, Helen E. Groves, Gabriella S. Lamb, Alison C. Tribble, Adam L. Hersh, Emily A. Thorell, Mark R. Denison, Adam J. Ratner, Jason G. Newland, Mari M. Nakamura
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2020)
Article
Physiology
Teri N. Hreha, Christina A. Collins, Allyssa L. Daugherty, Joy Twentyman, Nitin Paluri, David A. Hunstad
PHYSIOLOGICAL REPORTS
(2020)
Review
Infectious Diseases
Kathleen Chiotos, Molly Hayes, David W. Kimberlin, Sarah B. Jones, Scott H. James, Swetha G. Pinninti, April Yarbrough, Mark J. Abzug, Christine E. MacBrayne, Vijaya L. Soma, Daniel E. Dulek, Surabhi B. Vora, Alpana Waghmare, Joshua Wolf, Rosemary Olivero, Steven Grapentine, Rachel L. Wattier, Laura Bio, Shane J. Cross, Nicholas O. Dillman, Kevin J. Downes, Carlos R. Oliveira, Kathryn Timberlake, Jennifer Young, Rachel C. Orscheln, Pranita D. Tamma, Hayden T. Schwenk, Philip Zachariah, Margaret L. Aldrich, David L. Goldman, Helen E. Groves, Nipunie S. Rajapakse, Gabriella S. Lamb, Alison C. Tribble, Adam L. Hersh, Emily A. Thorell, Mark R. Denison, Adam J. Ratner, Jason G. Newland, Mari M. Nakamura
Summary: Although COVID-19 is usually mild in children, some may develop severe or critical illness. Supportive care is typically enough for most cases, but for severe cases, remdesivir is suggested, with a duration of 5 days. It is not recommended to use hydroxychloroquine or other protease inhibitors for COVID-19 in children.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2021)