Article
Biotechnology & Applied Microbiology
Vaclav Brazda, Otilia Porubiakova, Alessio Cantara, Natalia Bohalova, Jan Coufal, Martin Bartas, Miroslav Fojta, Jean-Louis Mergny
Summary: The study identified multiple potential G-quadruplex forming sequences in the G4-EA-H1N1 genomes, which could serve as potential therapeutic targets.
Article
Immunology
Jiapei Yu, Hui Li, Ju Jia, Zhisheng Huang, Shuai Liu, Ying Zheng, Shengrui Mu, Xiaoyan Deng, Xiaohui Zou, Yeming Wang, Xiao Shang, Dan Cui, Lixue Huang, Xiaoxuan Feng, William J. Liu, Bin Cao
Summary: Despite the use of vaccines and anti-viral drugs, influenza A virus still poses a significant epidemic risk to global public health. Through single-cell transcriptome analyses, we have identified the high heterogeneity of susceptibility to viral infection and biological responses in different subsets of CD4(+) T and CD8(+) T cells. Effector memory CD8(+) T cells (CD8(+) T-EM) were found to be the most susceptible subset to pandemic influenza A virus infection among primary human T cells. Non-productive infection was established in CD8(+) T-EM and naive CD8(+) T cells, indicating the mechanisms of intracellular antiviral activities in human T cells.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Multidisciplinary Sciences
Tingting Li, Junyu Chen, Qingbing Zheng, Wenhui Xue, Limin Zhang, Rui Rong, Sibo Zhang, Qian Wang, Minqing Hong, Yuyun Zhang, Lingyan Cui, Maozhou He, Zhen Lu, Zhenyong Zhang, Xin Chi, Jinjin Li, Yang Huang, Hong Wang, Jixian Tang, Dong Ying, Lizhi Zhou, Yingbin Wang, Hai Yu, Jun Zhang, Ying Gu, Yixin Chen, Shaowei Li, Ningshao Xia
Summary: Influenza A viruses are a significant global threat, and this study has identified a chimeric monoclonal antibody, C12H5, that offers broad neutralization against H1N1 and H5N1 viruses. The antibody targets a specific epitope on the surface glycoprotein of the virus, leading to control of virus entry and egress. This discovery could have implications for the development of antiviral drugs and broad-protection vaccines against influenza.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Kristien Van Reeth, Anna Parys, Jose Carlos Mancera Gracia, Ivan Trus, Koen Chiers, Philip Meade, Sean Liu, Peter Palese, Florian Krammer, Elien Vandoorn
Summary: This study demonstrates that sequential vaccination with diverse H1N1 viruses in pigs induces a broad H1N1 antibody response, providing protection against multiple H1N1 strains in humans and pigs.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Yuchong Wang, Xujun Zhang, Kefan Bi, Hongyan Diao
Summary: MicroRNAs play important roles in regulating virus replication and host antiviral response during H1N1 infection, with some defending against the virus and others promoting viral replication. They are involved in host-viral interactions and have versatile functions in this process.
Article
Immunology
Irina Nudelman, Daniil Kudrin, German Nudelman, Raamesh Deshpande, Boris M. M. Hartmann, Steven H. Kleinstein, Chad L. L. Myers, Stuart C. C. Sealfon, Elena Zaslavsky
Summary: The study examined the activation of functional modules in host cells by influenza viruses of varying pathogenicity, revealing a common core response to infection that is temporally shifted for different viruses. Differentially regulated functional modules highlighted unique elements of host responses to different virus strains, providing mechanistic insight into the differences in host response to influenza strains.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Seong Uk Son, Eun-Kyung Lim, Soojin Jang, Jaewoo Lim, Seung Beom Seo, Taejoon Kang, Juyeon Jung, Seo Yeong Oh, Sun-Woo Yoon, Dongeun Yong, Jaejong Lee
Summary: The study developed a conductive thread-based immunosensor to easily detect airborne viruses, which is important in preventing the spread of infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biology
Fei Meng, Yan Chen, Zuchen Song, Qiu Zhong, Yijie Zhang, Chuanling Qiao, Cheng Yan, Huihui Kong, Liling Liu, Chengjun Li, Huanliang Yang, Hualan Chen
Summary: Animal influenza viruses, particularly EA H1N1, pose a continuous threat to human public health. The study reveals the genetic diversity and pandemic potential of EA H1N1 viruses in pigs, indicating the need for careful monitoring and preparedness. Some strains of EA H1N1 have become highly pathogenic and transmissible in animals, raising concerns about potential human infections and the efficacy of current vaccines.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Virology
Min Dou, Wenjun Song, Yongping Lin, Qigao Chen, Chang Lu, Zhongmin Liu
Summary: The study analyzed clinical characteristics and viral genes in patients with severe pneumonia due to H1N1 influenza virus in Guangzhou in 2019. Risk factors for severe disease were identified as chronic lung disease and cardiovascular disease, with a significant rate of secondary infections in critically ill patients. Furthermore, serum IL-8 levels were significantly higher in critically ill patients compared to nonsevere patients and healthy controls.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Min Gu, Kaibiao Chen, Zhichuang Ge, Jun Jiao, Tianyu Cai, Suhan Liu, Xiaoquan Wang, Xinan Jiao, Daxin Peng, Xiufan Liu
Summary: This study investigated the genetic and biologic characteristics of two Eurasian avian-like H1N1 swine influenza viruses from pigs in China. One swine isolate showed high similarity to contemporary human Eurasian avian-like H1N1 isolates, had a preference for binding to human-type receptors, and demonstrated vigorous replication in mice without the need for adaptation.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Immunology
Anna Parys, Elien Vandoorn, Jacqueline King, Annika Graaf, Anne Pohlmann, Martin Beer, Timm Harder, Kristien Van Reeth
Summary: A pig farmer in the Netherlands was infected with a Eurasian avian-like swine influenza A(H1N1) virus that was also found in the farmed pigs. Antigenic and genetic characterization of both viruses was conducted. Continued surveillance of swine influenza A viruses is necessary for assessing risks in humans and pigs.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Hyun-Jong Lee, Gwanghui Ryu, Ki-Il Lee
Summary: This study compared the symptomatic characteristics of influenza A/H3N2 and A/H1N1 subtypes in primary healthcare settings in Korea. The results showed that the H3N2-dominant season had higher average body temperature and more patients with high fever compared to the H1N1-dominant season. On the other hand, symptoms such as myalgia, cough, and sore throat were more common in the H1N1-dominant season. Antiviral drugs were prescribed to the majority of febrile patients in both seasons.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Justin R. Ortiz, David Bernstein, Daniel F. Hoft, Christopher W. Woods, Micah T. McClain, Sharon E. Frey, Rebecca C. Brady, Christopher Bryant, Ashley Wegel, Robert W. Frenck Jr, Emmanuel B. Walter, Getahun Abate, Sarah R. Williams, Robert L. Atmar, Wendy A. Keitel, Nadine Rouphael, Mathew J. Memoli, Mamodikoe K. Makhene, Paul C. Roberts, Kathleen M. Neuzil
Summary: This study evaluated the associations between baseline influenza virus-specific HAI and MN titers and subsequent symptomatic influenza virus infection in a controlled human infection study. The results showed that high baseline HAI and MN were associated with protection from illness.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Pharmacology & Pharmacy
Jangsu Lee, Kyoung Sub Kim, Kun Na
Summary: In this study, a nanocomplex for intranasal administration was developed to directly block and prevent viral infection in the respiratory tract. The nanocomplex demonstrated stability and suitable viscosity for nasal administration, and maintained the antioxidant and antiviral effects of the aronia extract and carrageenan. By intranasal administration, the nanocomplex efficiently prevented influenza A virus infection.
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2022)
Article
Emergency Medicine
B. S. Katherine Burton, Jonathan Mondragon, Clifford Buckley, Nicolas Ong
Summary: This case highlights the challenges of diagnosing thyroid storm in the emergency department and emphasizes the importance of considering it in treatment when more common diagnoses fail to respond. Diagnosis of thyroid storm relies on clinical suspicion, laboratory findings, and response to therapy.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
