Article
Infectious Diseases
Peter Thelma Ngwa Niba, Akindeh Mbuh Nji, Innocent Mbulli Ali, Lawrence Fonyonga Akam, Cedric Hermann Dongmo, Jean Paul Kengne Chedjou, Calvino Tah Fomboh, William Dorian Nana, Ornella Laetitia Ayem Oben, Abdel Aziz Selly-Ngaloumo, Marcel N. Moyeh, Jude Achidi Ngu, Ambassa Jean Ludovic, Pierre Martiniel Aboh, Marie Carine Enyegue Ambani, Pierrette Albertine Mbarga Omgba, Grace Bissohong Kotcholi, Linus Moye Adzemye, Danielle Regine Abenkou Nna, Adele Douanla, Ze Ango, Marie Sophie Ewane, Joel Tewara Ticha, Fritz Mbuh Tatah, Golwa Dinza, Valentine Nchafor Ndikum, Dorothy A. Fosah, Jude D. Bigoga, Michael Alifrangis, Wilfred F. Mbacham
Summary: This study evaluated the effectiveness and safety of AS-AQ and AL for home-based treatment of uncomplicated P. falciparum malaria in Yaounde, Cameroon. The results showed that both AS-AQ and AL were effective and safe for the management of malaria in a home setting.
BMC INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Charles O. Obonyo, Elizabeth A. Juma, Vincent O. Were, Bernhards R. Ogutu
Summary: This study found that a 3-day low dose course of quinine plus clindamycin is not effective in treating uncomplicated falciparum malaria in children under 5 years of age in Kenya, where artemether-lumefantrine remains effective.
Article
Parasitology
Judickaelle Irinantenaina, Gwenaelle Carn, Dina Ny Aina Liantsoa Randriamiarinjatovo, Aina Nirina Harimanana, Seheno Razanatsiorimalala, Nicolas Ralemary, Maurice Randriarison, Celestin Razafinjato, Raphael Hotahiene, Milijaona Randrianarivelojosia
Summary: A study conducted in Madagascar evaluated the efficacy and safety of artemisinin-based combination therapy (ACT) for the treatment of uncomplicated Plasmodium falciparum malaria. The results showed that the combination of artesunate + amodiaquine and artemether + lumefantrine were effective and safe. The study suggests that these therapies can be used for treatment in health facilities, at the community level, and for mass drug administration campaigns. Rating: 8/10.
Article
Public, Environmental & Occupational Health
Vy Bui, Colleen R. Higgins, Sarah Laing, Sachiko Ozawa
Summary: This study examines the impact of substandard and falsified antimalarials on health and economy in Benin, showing the significant cost and death associated with poor-quality antimalarials. Replacing all antimalarials with quality-assured artemisinin combination therapies has the potential to save costs and prevent deaths.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Infectious Diseases
Abel Nhama, Lidia Nhamussua, Eusebio Macete, Quique Bassat, Crizolgo Salvador, Sonia Enosse, Baltazar Candrinho, Eva Carvalho, Arsenio Nhacolo, Arlindo Chidimatembue, Abuchahama Saifodine, Rose Zulliger, Naomi Lucchi, Samaly S. Svigel, Leah F. Moriarty, Eric S. Halsey, Alfredo Mayor, Pedro Aide
Summary: An evaluation of artemisinin-based combination therapy (ACT) for malaria treatment in Mozambique showed that both artemether-lumefantrine (AL) and amodiaquine-artesunate (AS-AQ) have therapeutic efficacies well above the 90% threshold recommended by WHO, and are well-tolerated.
Article
Infectious Diseases
Catherine O. Falade, Adebola E. Orimadegun, Fiyinfoluwa I. Olusola, Obaro S. Michael, Oluwafunmibi E. Anjorin, Roland I. Funwei, Aduragbenro D. Adedapo, Abiola L. Olusanya, Bose E. Orimadegun, Olugbenga A. Mokuolu
Summary: In Nigeria, declining responsiveness to artemether-lumefantrine (AL) has been reported, and the efficacy and safety of pyronaridine-artesunate (PA) in the Nigerian pediatric population is unknown. This study compared the efficacy and safety of PA and AL for the treatment of uncomplicated falciparum malaria in Nigeria.
Article
Infectious Diseases
Guoming Li, Yueming Yuan, Shaoqin Zheng, Chenguang Lu, Mingqiang Li, Ruixiang Tan, Hongying Zhang, Rahamatou Silai, Ruimei Liu, Kamal Said Abdallah, Affane Bacar, Qin Xu, Jianping Song, Wanting Wu, Changsheng Deng
Summary: The study found that artemisinin-piperaquine and artemether-lumefantrine maintained high efficacy and tolerance in treating uncomplicated falciparum malaria in the Comoros. However, asymptomatic malaria infections may pose new challenges to malaria control.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Public, Environmental & Occupational Health
Mateusz M. Plucinski, Joel L. N. Barratt
Summary: This study introduces a novel method for nonparametric statistical testing of relatedness for P. falciparum parasites. The approach showed high sensitivity and reliability in identifying related genotypes.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Infectious Diseases
Yves Daniel Compaore, Issaka Zongo, Anyirekun F. Some, Nouhoun Barry, Frederick Nikiema, Talato N. Kabore, Aminata Ouattara, Zachari Kabre, Kadidiatou Wermi, Moussa Zongo, Rakiswende S. Yerbanga, Issaka Sagara, Abdoulaye Djimde, Jean Bosco Ouedraogo
Summary: The study found that Pyronaridine-artesunate and artemether-lumefantrine showed similar hepatic safety when used repeatedly in patients with uncomplicated malaria. Pyronaridine-artesunate is considered a suitable alternative to the current first-line anti-malarial drugs in endemic areas.
Article
Public, Environmental & Occupational Health
Gabriel Kishoyian, Eliud N. M. Njagi, George O. Orinda, Francis T. Kimani, Kevin Thiongo, Damaris Matoke-Muhia
Summary: After a decade of use, artemether-lumefantrine remains highly effective in clearing Plasmodium falciparum parasites in children aged between 6 and 60 months in Kenya. Continued monitoring is essential to prevent potential resistance to the drug in all target users.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Medicine, General & Internal
Catherine Segbefia, Seth Kwabena Amponsah, Adwoa K. A. Afrane, Mame Yaa Nyarko, Yvonne Brew, Nihad Salifu, Samuel Yao Ahorhorlu, Abdul Malik Sulley, Lars Hviid, Michael Fokuo Ofori, George Obeng Adjei
Summary: In this study, interactions between hydroxyurea (HU) and antimalarials in sickle cell disease (SCD) were explored. The study found that parasite clearance and adverse event occurrence were similar in SCD children treated with artemether-lumefantrine (AL) regardless of HU status. However, distinct patterns of changes in laboratory indices suggest the potential need for larger, more focused studies in the future.
FRONTIERS IN MEDICINE
(2023)
Article
Infectious Diseases
Youssouf Diarra, Oumar Kone, Lansana Sangare, Lassina Doumbia, Dade Bouye Ben Haidara, Mouctar Diallo, Ababacar Maiga, Hamadoun A. Sango, Halidou Sidibe, Jules Mihigo, Douglas Nace, Dragan Ljolje, Eldin Talundzic, Venkatachalam Udhayakumar, Erin Eckert, Celia J. Woodfill, Leah F. Moriarty, Pharath Lim, Donald J. Krogstad, Eric S. Halsey, Naomi W. Lucchi, Ousmane A. Koita
Summary: The study in Selingue, Mali showed that both artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) remain effective for the treatment of uncomplicated malaria. ASAQ demonstrated significantly better efficacy compared to AL.
Article
Infectious Diseases
Sri Krishna, Sweta Mishra, Prakash Tiwari, Anup K. Vishwakarma, Sushrikanta Khandai, Suyesh Shrivastava, Anil K. Verma, Shashikant Tiwari, Hari Barman, Surendra Jhariya, Pradeep Tiwari, Anup S. Tidgam, Brij M. Varun, Sunil Singh, Naresh Yerane, Chintaman R. Tembhurne, Prem L. Mandavi, Shyam S. Tekam, Manas Malik, Kali P. Behera, Himanshu Jayswar, Khemraj Sonwani, Mukund S. Diggikar, Madan M. Pradhan, Sher S. Khasotiya, Avdhesh Kumar, Neeraj Dhingra, Maria Dorina G. Bustos, Eva-Maria Christophel, Pascal Ringwald, Roop Kumari, Man M. Shukla, Neeru Singh, Aparup Das, Praveen K. Bharti
Summary: Malaria is a major public health issue in India, with artemether-lumefantrine being shown to be highly effective in treating uncomplicated Plasmodium falciparum malaria. The study findings demonstrate the efficacy of AL across all age groups and the absence of functional k13 gene mutations in the study area.
Article
Microbiology
Nelli Westercamp, Mary Owidhi, Kephas Otieno, Winnie Chebore, Ann M. Buff, Meghna Desai, Simon Kariuki, Aaron M. Samuels
Summary: The study compared the efficacy of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) in the treatment of uncomplicated malaria. The results showed that both AL and DP were efficacious and well tolerated, but the efficacy of AL appeared to be waning.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Kale Gubae, Hussein Mohammed, Heven Sime, Henok Hailgiorgis, Anteneh Kassahun Mare, Bokretsion Gidey, Mebrahtom Haile, Gudissa Assefa, Worku Bekele, Geremew Tasew, Solomon Mequanente Abay, Ashenafi Assefa
Summary: This study aimed to assess the therapeutic efficacy of AL in the treatment of uncomplicated P. falciparum infection. The results showed that AL demonstrated high therapeutic efficacy and good safety profile, suggesting its continuation as the first-line drug for the treatment of uncomplicated P. falciparum malaria in Ethiopia.
Editorial Material
Medicine, General & Internal
Christopher J. M. Whitty
Article
Medicine, General & Internal
Marcel Tanner, Brian Greenwood, Christopher J. M. Whitty, Evelyn K. Ansah, Ric N. Price, Arjen M. Dondorp, Lorenz von Seidlein, J. Kevin Baird, James G. Beeson, Freya J. I. Fowkes, Janet Hemingway, Kevin Marsh, Faith Osier
Article
Public, Environmental & Occupational Health
Helena Hildenwall, Ben Amos, George Mtove, Florida Muro, Kerstin Cederlund, Hugh Reyburn
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2016)
Article
Public, Environmental & Occupational Health
Camilla H. Drabe, Lasse S. Vestergaard, Marie Helleberg, Nyagonde Nyagonde, Michala V. Rose, Filbert Francis, Ola P. Theilgaard, Jens Asbjorn, Ben Amos, Ib Christian Bygbjerg, Morten Ruhwald, Pernille Ravn
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2016)
Article
Medicine, General & Internal
Robert A. Lever, Christopher J. M. Whitty
BRITISH MEDICAL BULLETIN
(2016)
Article
Infectious Diseases
David G. Lalloo, Delane Shingadia, David J. Bell, Nicholas J. Beeching, Christopher J. M. Whitty, Peter L. Chiodini
JOURNAL OF INFECTION
(2016)
Article
Infectious Diseases
Evelyn K. Ansah, Margaret Gyapong, Solomon Narh-Bana, Constance Bart-Plange, Christopher J. M. Whitty
Article
Public, Environmental & Occupational Health
Helena Hildenwall, Florida Muro, Jaqueline Jansson, George Mtove, Hugh Reyburn, Ben Amos
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2017)
Article
Multidisciplinary Sciences
Vanessa K. Wong, Stephen Baker, Thomas R. Connor, Derek Pickard, Andrew J. Page, Jayshree Dave, Niamh Murphy, Richard Holliman, Armine Sefton, Michael Millar, Zoe A. Dyson, Gordon Dougan, Kathryn E. Holt
NATURE COMMUNICATIONS
(2016)
Article
Infectious Diseases
Vanessa K. Wong, Kathryn E. Holt, Chinyere Okoro, Stephen Baker, Derek J. Pickard, Florian Marks, Andrew J. Page, Grace Olanipekun, Huda Munir, Roxanne Alter, Paul D. Fey, Nicholas A. Feasey, Francois-Xavier Weill, Simon Le Hello, Peter J. Hart, Samuel Kariuki, Robert F. Breiman, Melita A. Gordon, Robert S. Heyderman, Jan Jacobs, Octavie Lunguya, Chisomo Msefula, Calman A. MacLennan, Karen H. Keddy, Anthony M. Smith, Robert S. Onsare, Elizabeth De Pinna, Satheesh Nair, Ben Amos, Gordon Dougan, Stephen Obaro
PLOS NEGLECTED TROPICAL DISEASES
(2016)
Meeting Abstract
Infectious Diseases
N. Gordon, B. Amos, E. Azore, G. Bastiaens, C. Buhler, S. Issah, P. Jorakate, S. Raghu, T. Leslie
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Meeting Abstract
Infectious Diseases
N. Gordon, V. Aggarwal, B. Amos, C. Buhler, A. Huszar, J. McKenzie, J. Mitchell, N. Moyen, P. Mubangizi, T. Leslie
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Immunology
Geofrey Makenga, George Mtove, J. Kevin Yin, Abubakary Mziray, Veneranda M. Bwana, William Kisinza, Julius Mjema, Ben Amos, Laura Antony, Delane Shingadia, Shahin Oftadeh, Robert Booy
Summary: This study investigated the antibody response and vaccine efficacy of PCV13 in HIV-infected children. The results showed a reduction in acquisition of new vaccine serotypes of S. pneumoniae in the PCV13 group compared to the Hib vaccine group.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Tamalee Roberts, Arjun Chandna, Wanitda Watthanaworawit, Areerat Thaiprakong, Sona Soeng, Manivone Simmalavong, Phonelavanh Phoumin, Weerawut Saengchun, Nongyao Khatta, Pattaraporn Hinfonthong, Napaporn Kaewpundoem, Sue J. Lee, Carlo Perrone, Ben Amos, Paul Turner, Elizabeth A. Ashley, Clare L. Ling
Summary: This study evaluated the impact of delay and temperature on the viability of organisms in blood culture bottles that have flagged positive in automated systems. The results showed that the viability of most organisms was not affected by the delay and temperature conditions. Storing the positive blood culture bottles at lower temperatures and using bacterial transport swabs helped preserve the viability of Streptococcus pneumoniae.
BMC INFECTIOUS DISEASES
(2022)
Article
Health Policy & Services
Clare I. R. Chandler, Helen Burchett, Louise Boyle, Olivia Achonduh, Anthony Mbonye, Deborah DiLiberto, Hugh Reyburn, Obinna Onwujekwe, Ane Haaland, Arantxa Roca-Feltrer, Frank Baiden, Wilfred F. Mbacham, Richard Ndyomugyenyi, Florence Nankya, Lindsay Mangham-Jefferies, Sian Clarke, Hilda Mbakilwa, Joanna Reynolds, Sham Lal, Toby Leslie, Catherine Maiteki-Sebuguzi, Jayne Webster, Pascal Magnussen, Evelyn Ansah, Kristian S. Hansen, Eleanor Hutchinson, Bonnie Cundill, Shunmay Yeung, David Schellenberg, Sarah G. Staedke, Virginia Wiseman, David G. Lalloo, Christopher J. M. Whitty
HEALTH SYSTEMS & REFORM
(2016)