Article
Immunology
Rosa De Vincenzo, Nicola Caporale, Valentina Bertoldo, Caterina Ricci, Maria Teresa Evangelista, Nicolo Bizzarri, Luigi Pedone Anchora, Giovanni Scambia, Giovanni Capelli
Summary: This study evaluated the effect of 9-valent HPV vaccination on HPV and cytological test results in adult women. The results showed a significant reduction in clearance time for HPV HR+ and Pap positivity in women who received the third dose of the vaccine.
Article
Health Care Sciences & Services
Leticia Munoz-Hernando, Reyes Oliver-Perez, Victoria Bravo-Violeta, Alejandro Olloqui, Belen Parte-Izquierdo, Cristina Almansa-Gonzalez, Rocio Bermejo-Martinez, Ana Belen Bolivar-De Miguel, Alvaro Diez, Jose Miguel Seoane-Ruiz, Lucia Parrilla-Rubio, Alvaro Tejerizo-Garcia
Summary: This study analyzed the prevalence of anal high-risk HPV infection and abnormal anal cytology in women living with HIV, finding that concomitant HR-HPV cervical infection is the main predictor of HR-HPV anal infection.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Virology
Ye Li, Yebin Feng, Yanlin Chen, Wenyu Lin, Hangjing Gao, Ming Chen, Kelvin Stefan Osafo, Xiaodan Mao, Yafang Kang, Leyi Huang, Dabin Liu, Shuxia Xu, Lixiang Huang, Binhua Dong, Pengming Sun
Summary: The study reveals a close correlation between peripheral blood lymphocyte subsets and HPV infection and clearance. CD4 + T cells are important determinants of HPV infection, and T cells, NK cells, and CD8 + T cells can serve as potential biomarkers for predicting natural HPV clearance, which can aid in patient risk stratification, individualized treatment, and follow-up management.
Article
Public, Environmental & Occupational Health
Yu Zhang, Ya Xu, Ziqin Dian, Guiqian Zhang, Xin Fan, Yuan Zhao, Yi Sun
Summary: This study investigated the prevalence and genotype distribution of HPV infection among outpatient-based populations. The results showed differences in the prevalence and genotype distribution of HPV infection among different outpatient populations, with the highest prevalence in gynecological outpatients. The most common HPV genotypes were HPV-52, 16, and 58. High prevalence of HPV infection was observed among women under 25 years and over 55 years.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Immunology
Zhuochen Li, Rachel L. Winer, Selly Ba, Marie Pierre Sy, John Lin, Qinghua Feng, Geoffrey S. Gottlieb, Papa Salif Sow, Nancy B. Kiviat, Stephen E. Hawes
Summary: In Senegalese women, HIV-positive women had a lower likelihood of clearing incident HPV infections compared to HIV-negative women, while HIV-2-infected or dually infected women were more likely to clear incident HPV infections than HIV-1-infected women.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Meijuan Li, Tingyan Liu, Ganfeng Luo, Xiaoli Sun, Guiying Hu, Ying Lu, Richie H. Xu, Huachun Zou, Xiping Luo
Summary: In women in Guangdong, HPV52, 58, 68, and 39 are more likely to cause infection and be persistent. Incidence and persistence rates of HPV are higher in younger and older women compared to middle-aged women. The period of HPV retesting may impact the detection of HPV incidence, persistence and clearance.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Immunology
Joseph E. Tota, Anna R. Giuliano, Stephen E. Goldstone, Brady Dubin, Alfred Saah, Alain Luxembourg, Christine Velicer, Joel M. Palefsky
Summary: The incidence of human papillomavirus (HPV)-related cancer is rising in men, and this study found that the prevalence of HPV infection and seropositivity is higher in men who have sex with men (MSM) compared to heterosexual men (HM). However, overall prevalence is still low. Catch-up vaccination after sexual debut may be beneficial.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Microbiology
Laura Bergqvist, Ilkka Kalliala, Karoliina Aro, Eeva Auvinen, Maija Jakobsson, Mari Kiviharju, Seppo Virtanen, Joakim Dillner, Pekka Nieminen, Karolina Louvanto
Summary: The study found that behavioral factors such as smoking, age, and sexual debut are associated with genotype-specific HPV prevalence in unvaccinated women. Delaying sexual debut can reduce the risk of HPV16 infection, but has little impact on other genotypes. Contraceptive methods seem to have no effect on HR-HPV positivity.
Article
Oncology
Michael H. Chung, Hugo De Vuyst, Sharon A. Greene, Nelly R. Mugo, Troy D. Querec, Evans Nyongesa-Malava, Anthony Cagle, Samah R. Sakr, Stanley Luchters, Marleen Temmerman, Elizabeth R. Unger, Christine J. McGrath
Summary: This study compared the clearance of high-risk HPV in HIV-positive women after cryotherapy or LEEP treatment, and found that the clearance rate was significantly higher in the LEEP treatment group. Persistent hrHPV was significantly associated with recurrent CIN2+, suggesting that LEEP's benefits may be related to its ability to clear hrHPV infection. Screening for hrHPV infection after treatment among HIV-positive women may help rule out recurrent CIN disease due to its high sensitivity and negative predictive value.
Article
Oncology
Marjorie M. A. de Souza, Gunter Hartel, Catherine M. Olsen, David C. Whiteman, Annika Antonsson
Summary: This Australian-based study assessed the prevalence of oral HPV infection in Australian residents and found that the prevalence was 7.2%. The study also found a strong association between oral HPV infection and sexual behaviors, and suggested that HPV vaccination may result in a lower risk of infection with nonavalent HPV types.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Yinhui Jiang, Shu Xu, Jinzhi Lan, Jinjuan Zhang, Tengxiang Chen
Summary: This study observed the association between vitamin K intake and HPV infection, finding a nonlinearity between the two. An increase in log2 vitamin K intake of one unit was associated with a 43% reduction in the risk of HPV infection within the range of 0-3.81. However, the risk of HPV infection did not continue to decline when log2 vitamin K intake exceeded 3.81. There was no association between vitamin K intake and HPV subtype.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2022)
Article
Oncology
Annika Antonsson, Marjorie de Souza, Zoe C. Wood, Angela Carroll, Kim Van, Lachlan Paterson, Nirmala Pandeya, David C. Whiteman
Summary: Oral infection with HPV is likely to contribute to the increasing incidence of oropharyngeal squamous cell carcinoma, and is associated with sexual behaviors. New oral infections with HPV in the sample were not rare, with most infections being cleared but not universally, suggesting a reservoir of infection may predispose to oropharyngeal carcinogenesis.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Infectious Diseases
Li-pei Luo, Ping He, Qiao-tu Liu, Yang-hua Jiang, Yang-nan Zhang, Qing-zhao Li, Qiu Li, Sheng-tao Li, Fan Yang, Hua Ling, Xin-gui Dai, Zhong-yu Li, Hong-liang Chen
Summary: This study found an overall HPV prevalence of 18.71% among females in Southern China from 2012-2018, with varying age-specific prevalence. The top three prevalent high-risk HPV genotypes were HPV52, -16, and -58, suggesting their potential coverage in HPV vaccines for Southern China.
BMC INFECTIOUS DISEASES
(2021)
Article
Immunology
Mariam El-Zein, Farzin Khosrow-Khavar, Ann N. Burchell, Pierre-Paul Tellier, Shaun Eintracht, Elizabeth McNamara, Francois Coutlee, Eduardo L. Franco
Summary: The study found that baseline serum 25-hydroxyvitamin D levels were not significantly associated with HPV prevalence and incidence, but showed a modest negative association with HPV clearance. Vitamin D levels <30 ng/mL were marginally associated with increased HPV clearance compared to levels >= 30 ng/mL.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Simon Blaine-Sauer, Myeong-Kyun Shin, Kristina A. Matkowskyj, Ella Ward-Shaw, Paul F. Lambert
Summary: This study demonstrates that MmuPV1 infection alone can efficiently mediate high-grade squamous intraepithelial lesions in the anal tract of mice using the NSG immunocompromised strain. We also show that MmuPV1, in combination with the chemical carcinogen DMBA, has carcinogenic potential. Furthermore, MmuPV1 is able to persist for up to 6 months in the anal tract of UVB-irradiated FVB/NJ mice and contributes to high-grade disease and cancer in an immunocompetent strain.
Article
Gastroenterology & Hepatology
Tien S. Dong, Jonathan P. Jacobs, Vatche Agopian, Joseph R. Pisegna, Walid Ayoub, Francisco Durazo, Pedram Enayati, Vinay Sundaram, Jihane N. Benhammou, Mazen Noureddin, Gina Choi, Venu Lagishetty, Oliver Fiehn, Marc T. Goodman, David Elashoff, Shehnaz K. Hussain
Summary: The study found that gut-liver axis biomarkers Alloprevotela and methionine, methionine and taurocholic acid were able to predict future HCC development in patients with liver cirrhosis.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Eileen O. Dareng, Jonathan P. Tyrer, Daniel R. Barnes, Michelle R. Jones, Xin Yang, Katja K. H. Aben, Muriel A. Adank, Simona Agata, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Gerasimos Aravantinos, Banu K. Arun, Annelie Augustinsson, Judith Balmana, Elisa Bandera, Rosa B. Barkardottir, Daniel Barrowdale, Matthias W. Beckmann, Alicia Beeghly-Fadiel, Javier Benitez, Marina Bermisheva, Marcus Q. Bernardini, Line Bjorge, Amanda Black, Natalia Bogdanova, Bernardo Bonanni, Ake Borg, James D. Brenton, Agnieszka Budzilowska, Ralf Butzow, Saundra S. Buys, Hui Cai, Maria A. Caligo, Ian Campbell, Rikki Cannioto, Hayley Cassingham, Jenny Chang-Claude, Stephen J. Chanock, Kexin Chen, Yoke-Eng Chiew, Wendy K. Chung, Kathleen B. M. Claes, Sarah Colonna, Linda S. Cook, Fergus J. Couch, Mary B. Daly, Fanny Dao, Eleanor Davies, Miguel de la Hoya, Robin de Putter, Joe Dennis, Allison DePersia, Peter Devilee, Orland Diez, Yuan Chun Ding, Jennifer A. Doherty, Susan M. Domchek, Thilo Dork, Andreas du Bois, Matthias Durst, Diana M. Eccles, Heather A. Eliassen, Christoph Engel, Gareth D. Evans, Peter A. Fasching, James M. Flanagan, ReneeT Fortner, Eva Machackova, Eitan Friedman, Patricia A. Ganz, Judy Garber, Francesca Gensini, Graham G. Giles, Gord Glendon, Andrew K. Godwin, Marc T. Goodman, Mark H. Greene, Jacek Gronwald, Opal Study Group, AOCSGroup, Eric Hahnen, Christopher A. Haiman, Niclas Hakansson, Ute Hamann, Thomas V. O. Hansen, Holly R. Harris, Mikael Hartman, Florian Heitz, Michelle A. T. Hildebrandt, Estrid Hogdall, Claus K. Hogdall, John L. Hopper, Ruea-Yea Huang, Chad Huff, Peter J. Hulick, David G. Huntsman, Evgeny N. Imyanitov, Claudine Isaacs, Anna Jakubowska, Paul A. James, Ramunas Janavicius, Allan Jensen, Oskar Th Johannsson, Esther M. John, Michael E. Jones, Daehee Kang, Beth Y. Karlan, Anthony Karnezis, Linda E. Kelemen, Elza Khusnutdinova, Lambertus A. Kiemeney, Byoung-Gie Kim, Susanne K. Kjaer, Ian Komenaka, Jolanta Kupryjanczyk, Allison W. Kurian, Ava Kwong, Diether Lambrechts, Melissa C. Larson, Conxi Lazaro, Nhu D. Le, Goska Leslie, Jenny Lester, Fabienne Lesueur, Douglas A. Levine, Lian Li, Jingmei Li, Jennifer T. Loud, Karen H. Lu, Phuong L. Mai, Siranoush Manoukian, Jeffrey R. Marks, Rayna KimMatsuno, Keitaro Matsuo, Taymaa May, Lesley McGuffog, John R. McLaughlin, Iain A. McNeish, Noura Mebirouk, Usha Menon, Austin Miller, Roger L. Milne, Albina Minlikeeva, Francesmary Modugno, Marco Montagna, Kirsten B. Moysich, Elizabeth Munro, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Joanne Ngeow Yuen Yie, Henriette Roed Nielsen, Finn C. Nielsen, Liene Nikitina-Zake, Kunle Odunsi, Kenneth Offit, Edith Olah, Siel Olbrecht, Olufunmilayo Olopade, Sara H. Olson, Hakan Olsson, Ana Osorio, Laura Papi, Sue K. Park, Michael T. Parsons, Harsha Pathak, Inge Sokilde Pedersen, Ana Peixoto, Tanja Pejovic, Pedro Perez-Segura, Jennifer B. Permuth, Beth Peshkin, Paolo Peterlongo, Anna Piskorz, Darya Prokofyeva, Paolo Radice, Johanna Rantala, Marjorie J. Riggan, Harvey A. Risch, Cristina Rodriguez-Antona, Eric Ross, Mary Anne Rossing, Ingo Runnebaum, Dale P. Sandler, Marta Santamarina, Penny Soucy, Rita K. Schmutzler, V. Wendy Setiawan, Kang Shan, Weiva Sieh, Jacques Simard, Christian F. Singer, Anna P. Sokolenko, Honglin Song, Melissa C. Southey, Helen Steed, Dominique Stoppa-Lyonnet, Rebecca Sutphen, Anthony J. Swerdlow, Yen Yen Tan, Manuel R. Teixeira, Soo Hwang Teo, Kathryn L. Terry, Mary BethTerry, Mads Thomassen, Pamela J. Thompson, Liv Cecilie Vestrheim Thomsen, Darcy L. Thull, Marc Tischkowitz, Linda Titus, Amanda E. Toland, Diana Torres, Britton Trabert, Ruth Travis, Nadine Tung, Shelley S. Tworoger, Ellen Valen, Anne M. van Altena, Annemieke H. van der Hout, ElsVan Nieuwenhuysen, Elizabeth J. van Rensburg, Ana Vega, Digna Velez Edwards, Robert A. Vierkant, Frances Wang, Barbara Wappenschmidt, Penelope M. Webb, Clarice R. Weinberg, Jeffrey N. Weitzel, Nicolas Wentzensen, Emily White, Alice S. Whittemore, Stacey J. Winham, Alicja Wolk, Yin-Ling Woo, Anna H. Wu, Li Yan, Drakoulis Yannoukakos, Katia M. Zavaglia, Wei Zheng, Argyrios Ziogas, Kristin K. Zorn, Zdenek Kleibl, Douglas Easton, Kate Lawrenson, Anna DeFazio, Thomas A. Sellers, Susan J. Ramus, Celeste L. Pearce, Alvaro N. Monteiro, Julie Cunningham, Ellen L. Goode, Joellen M. Schildkraut, Andrew Berchuck, Georgia Chenevix-Trench, Simon A. Gayther, Antonis C. Antoniou, Paul D. P. Pharoah
Summary: This study developed polygenic risk score models for risk prediction of epithelial non-mucinous ovarian cancer and validated their predictive value in diverse populations and BRCA1/BRCA2 mutation carriers, suggesting potential clinical utility in ovarian cancer prevention programs.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Immunology
Feixue Wei, Ningshao Xia, Rebeca Ocampo, Marc T. Goodman, Nancy A. Hessol, Beatriz Grinsztejn, Ana P. Ortiz, Fanghui Zhao, Erna M. Kojic, Rupert Kaul, Isabelle Heard, Imran O. Morhason-Bello, Anna-Barbara Moscicki, Alexandra de Pokomandy, Joel M. Palefsky, Luana L. S. Rodrigues, Racheal S. Dube Mandishora, Reshmie A. Ramautarsing, Silvia Franceschi, Sheela Godbole, Fernanda K. Tso, Lynette J. Menezes, Chunqing Lin, Gary M. Clifford
Summary: Age-specific shifts in HPV16 prevalence from cervix to anus suggest that HPV infections may persist longer, or occur later in life, in the anus than cervix. This has important implications for using cervical screening results to direct anal cancer prevention.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Feixue Wei, Marc T. Goodman, Ningshao Xia, Jun Zhang, Anna R. Giuliano, Gypsyamber D'Souza, Nancy A. Hessol, Maarten F. Schim van der Loeff, Jianghong Dai, Karin Neukam, Alexandra de Pokomandy, I. Mary Poynten, Ronald B. Geskus, Joaquin Burgos, Isabelle Etienney, Anna Barbara Moscicki, Maria Gabriella Dona, Maura L. Gillison, Alan G. Nyitray, Rebecca G. Nowak, Evy Yunihastuti, Huachun Zou, Carmen Hidalgo-Tenorio, Nittaya Phanuphak, Jean Michel Molina, Alice M. Schofield, Stephen Kerr, Song Fan, Yong Lu, Jason J. Ong, Admire T. Chikandiwa, Sirinya Teeraananchai, Nicola Squillace, Dorothy J. Wiley, Joel M. Palefsky, Damien Georges, Catharina J. Alberts, Gary M. Clifford
Summary: This study provides a comprehensive analysis of the natural history of anal high-risk HPV infection and identifies differences among different risk groups. These findings are crucial for designing effective anal cancer prevention programs.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Oncology
Ashley Weir, Eun-Young Kang, Nicola S. Meagher, Gregg S. Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J. Riggan, Aleksandra Gentry-Maharaj, Andy Ryan, Naveena Singh, Martin Widschwendter, Jennifer Alsop, Michael S. Anglesio, Matthias W. Beckmann, Jessica Berger, Christiani Bisinotto, Jessica Boros, Alison H. Brand, James D. Brenton, Angela Brooks-Wilson, Michael E. Carney, Julie M. Cunningham, Kara L. Cushing-Haugen, Cezary Cybulski, Esther Elishaev, Ramona Erber, Sian Fereday, Anna Fischer, Luis Paz-Ares, Javier Gayarre, Blake C. Gilks, Marcel Grube, Paul R. Harnett, Holly R. Harris, Arndt Hartmann, Alexander Hein, Joy Hendley, Brenda Y. Hernandez, Sabine Heublein, Yajue Huang, Tomasz Huzarski, Anna Jakubowska, Mercedes Jimenez-Linan, Catherine J. Kennedy, Felix K. F. Kommoss, Jennifer M. Koziak, Bernhard Kraemer, Nhu D. Le, Jaime Lesnock, Jenny Lester, Jan Lubinski, Janusz Menkiszak, Britta Ney, Alexander Olawaiye, Sandra Orsulic, Ana Osorio, Luis Robles-Diaz, Matthias Ruebner, Mitul Shah, Raghwa Sharma, Yurii B. Shvetsov, Helen Steed, Aline Talhouk, Sarah E. Taylor, Nadia Traficante, Robert A. Vierkant, Chen Wang, Lynne R. Wilkens, Stacey J. Winham, Javier Benitez, Andrew Berchuck, David D. Bowtell, Francisco J. Candido dos Reis, Linda S. Cook, Anna DeFazio, Jennifer A. Doherty, Peter A. Fasching, Maria J. Garcia, Ellen L. Goode, Marc T. Goodman, Jacek Gronwald, David G. Huntsman, Beth Y. Karlan, Stefan Kommoss, Francesmary Modugno, Joellen M. Schildkraut, Hans-Peter Sinn, Annette Staebler, Linda E. Kelemen, Caroline E. Ford, Usha Menon, Paul D. P. Pharoah, Martin Koebel, Susan J. Ramus, D. Bowtell, A. DeFazio, N. Traficante, S. Fereday, A. Brand, P. Harnett, R. Sharma
Summary: Recently, a study found a positive correlation between protein expression of FOXJ1 and the 5-year survival rate of patients with tubo-ovarian high-grade serous carcinoma (HGSC). However, protein expression of GMNN was not significantly associated with patient survival. This study provides preliminary evidence for the prognostic value of FOXJ1 in HGSC and validates the prior mRNA-based prognostic association through immunohistochemistry.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Theodore M. Brasky, Erinn M. Hade, David E. Cohn, Alison M. Newton, Stacey Petruzella, Kelli O'Connell, Kimberly A. Bertrand, Linda S. Cook, Immaculata De Vivo, Mengmeng Du, Jo L. Freudenheim, Christine M. Friedenreich, Marc T. Goodman, Jessica Gorzelitz, Torukiri I. Ibiebele, Vittorio Krogh, Linda M. Liao, Loren Lipworth, Lingeng Lu, Susan McCann, Tracy A. O'Mara, Julie R. Palmer, Jeanette Ponte, Anna Prizment, Harvey Risch, Sven Sandin, Leo J. Schouten, Veronica Wendy Setiawan, Xiao-ou Shu, Britton Trabert, Piet A. van den Brandt, Penelope M. Webb, Nicolas Wentzensen, Lynne R. Wilkens, Alicja Wolk, Herbert Yu, Marian L. Neuhouser
Summary: This study analyzed data from 12 prospective cohort studies and found that higher dietary intake of long-chain omega-3 polyunsaturated fatty acids (LCn3PUFA) may increase the risk of endometrial cancer, especially among specific subgroups characterized by body weight and tumor pathology.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Amber A. DeVries, Joe Dennis, Jonathan P. Tyrer, Pei-Chen Peng, Simon G. Coetzee, Alberto L. Reyes, Jasmine T. Plummer, Brian D. Davis, Stephanie S. Chen, Felipe Segato Dezem, Katja K. H. Aben, Hoda Anton-Culver, Natalia N. Antonenkova, Matthias W. Beckmann, Alicia Beeghly-Fadiel, Andrew Berchuck, Natalia Bogdanova, Nadja Bogdanova-Markov, James D. Brenton, Ralf Butzow, Ian Campbell, Jenny Chang-Claude, Georgia Chenevix-Trench, Linda S. Cook, Anna DeFazio, Jennifer A. Doherty, Thilo Dork, Diana M. Eccles, A. Heather Eliassen, Peter A. Fasching, Renee T. Fortner, Graham G. Giles, Ellen L. Goode, Marc T. Goodman, Jacek Gronwald, Niclas Hakansson, Michelle A. T. Hildebrandt, Chad Huff, David G. Huntsman, Allan Jensen, Siddhartha Kar, Beth Y. Karlan, Elza K. Khusnutdinova, Lambertus A. Kiemeney, Susanne K. Kjaer, Jolanta Kupryjanczyk, Marilyne Labrie, Diether Lambrechts, Nhu D. Le, Jan Lubinski, Taymaa May, Usha Menon, Roger L. Milne, Francesmary Modugno, Alvaro N. Monteiro, Kirsten B. Moysich, Kunle Odunsi, Hakan Olsson, Celeste L. Pearce, Tanja Pejovic, Susan J. Ramus, Elio Riboli, Marjorie J. Riggan, Isabelle Romieu, Dale P. Sandler, Joellen M. Schildkraut, V. Wendy Setiawan, Weiva Sieh, Honglin Song, Rebecca Sutphen, Kathryn L. Terry, Pamela J. Thompson, Linda Titus, Shelley S. Tworoger, Els Van Nieuwenhuysen, Digna Velez Edwards, Penelope M. Webb, Nicolas Wentzensen, Alice S. Whittemore, Alicja Wolk, Anna H. Wu, Argyrios Ziogas, Matthew L. Freedman, Kate Lawrenson, Paul D. P. Pharoah, Douglas F. Easton, Simon A. Gayther, Michelle R. Jones
Summary: This study identified risk associations between copy number variants (CNVs) and epithelial ovarian cancer (EOC), particularly for the BRCA1, BRCA2, and RAD51C genes. The study also found enrichment of CNVs at known EOC risk loci and functional biofeatures in EOC-related cell types. These findings suggest that CNVs may play a potentially pathogenic role in the development of EOC.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Minh Tung Phung, Penelope M. Webb, Anna DeFazio, Sian Fereday, Alice W. Lee, David D. L. Bowtell, Peter A. Fasching, Ellen L. Goode, Marc T. Goodman, Beth Y. Karlan, Jenny Lester, Keitaro Matsuo, Francesmary Modugno, James D. Brenton, Toon Van Gorp, Paul D. P. Pharoah, Joellen M. Schildkraut, Karen McLean, Rafael Meza, Bhramar Mukherjee, Jean Richardson, Bronwyn Grout, Anne Chase, Cindy McKinnon Deurloo, Kathryn L. Terry, Gillian E. Hanley, Malcolm C. Pike, Andrew Berchuck, Susan J. Ramus, Celeste Leigh Pearce, Ovarian Canc Assoc Consortium
Summary: This study analyzed the association between 12 lifestyle and personal exposures and having residual disease after surgery in patients with high-grade serous ovarian cancer (HGSC). The use of menopausal estrogen-only therapy (ET) was associated with a lower likelihood of having macroscopic residual disease, while parous women who did not breastfeed also had a lower likelihood of residual disease. These factors could potentially be included in risk stratification models for HGSC patients.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Kate Gersekowski, Torukiri I. Ibiebele, Jennifer A. Doherty, Holly R. Harris, Marc T. Goodman, Kathryn L. Terry, Anna H. Wu, Elisa V. Bandera, Bo Qin, Jue-Sheng Ong, Jonathan P. Tyrer, Suzanne C. Dixon-Suen, Francesmary Modugno, Harvey A. Risch, Penelope M. Webb
Summary: A pooled analysis of case-control studies suggests that high dietary folate intake may increase the risk of ovarian cancer in women with endometriosis. Further research is needed to explore the potential cancer-promoting effects of folate in this population.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Anil K. Chaturvedi, Eric A. Engels, Ruth M. Pfeiffer, Nicolas Wentzensen, William F. Anderson, Philip S. Rosenberg
Summary: Increases in the incidence and survival of oropharyngeal cancers in the United States since 1984 are attributed to HPV infection. This study examined 271 oropharyngeal cancer patients and found that HPV-positive patients had a significantly longer survival period. The incidence of HPV-positive oropharyngeal cancers is expected to exceed that of cervical cancers by 2020.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Lauren M. Hurwitz, Penelope M. Webb, Susan J. Jordan, Jennifer A. Doherty, Holly R. Harris, Marc T. Goodman, Yurii B. Shvetsov, Francesmary Modugno, Kirsten B. Moysich, Joellen M. Schildkraut, Andrew Berchuck, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Susan J. Ramus, Anna H. Wu, Celeste Leigh Pearce, Nicolas Wentzensen, Shelley S. Tworoger, Paul D. P. Pharoah, Britton Trabert
Summary: Frequent aspirin use is associated with reduced ovarian cancer risk, and genetic factors do not appear to modify this association according to a study. The findings suggest that aspirin use may be effective in preventing ovarian cancer regardless of genetic susceptibility.
Article
Pathology
Martin Kobel, Eun-Young Kang, Ashley Weir, Peter F. Rambau, Cheng-Han Lee, Gregg S. Nelson, Prafull Ghatage, Nicola S. Meagher, Marjorie J. Riggan, Jennifer Alsop, Michael S. Anglesio, Matthias W. Beckmann, Christiani Bisinotto, Michelle Boisen, Jessica Boros, Alison H. Brand, Angela Brooks-Wilson, Michael E. Carney, Penny Coulson, Madeleine Courtney-Brooks, Kara L. Cushing-Haugen, Cezary Cybulski, Suha Deen, Mona A. El-Bahrawy, Esther Elishaev, Ramona Erber, Sian Fereday, Anna Fischer, Simon A. Gayther, Arantzazu Barquin-Garcia, Aleksandra Gentry-Maharaj, C. Blake Gilks, Helena Gronwald, Marcel Grube, Paul R. Harnett, Holly R. Harris, Andreas D. Hartkopf, Arndt Hartmann, Alexander Hein, Joy Hendley, Brenda Y. Hernandez, Yajue Huang, Anna Jakubowska, Mercedes Jimenez-Linan, Michael E. Jones, Catherine J. Kennedy, Tomasz Kluz, Jennifer M. Koziak, Jaime Lesnock, Jenny Lester, Jan Lubinski, Teri A. Longacre, Maria Lycke, Constantina Mateoiu, Bryan M. McCauley, Valerie McGuire, Britta Ney, Alexander Olawaiye, Sandra Orsulic, Ana Osorio, Luis Paz-Ares, Teresa Ramon Y Cajal, Joseph H. Rothstein, Matthias Ruebner, Minouk J. Schoemaker, Mitul Shah, Raghwa Sharma, Mark E. Sherman, Yurii B. Shvetsov, Naveena Singh, Helen Steed, Sarah J. Storr, Aline Talhouk, Nadia Traficante, Chen Wang, Alice S. Whittemore, Martin Widschwendter, Lynne R. Wilkens, Stacey J. Winham, Javier Benitez, Andrew Berchuck, David D. Bowtell, Francisco J. Candido dos Reis, Ian Campbell, Linda S. Cook, Anna DeFazio, Jennifer A. Doherty, Peter A. Fasching, Renee T. Fortner, Maria J. Garcia, Marc T. Goodman, Ellen L. Goode, Jacek Gronwald, David G. Huntsman, Beth Y. Karlan, Linda E. Kelemen, Stefan Kommoss, Nhu D. Le, Stewart G. Martin, Usha Menon, Francesmary Modugno, Paul D. P. Pharoah, Joellen M. Schildkraut, Weiva Sieh, Annette Staebler, Karin Sundfeldt, Anthony J. Swerdlow, Susan J. Ramus, James D. Brenton
Summary: This study aimed to investigate the association between p53 expression status and survival in women with common ovarian carcinoma histotypes. Abnormal p53 expression was found to be associated with an increased risk of death in endometrioid carcinoma (EC) and clear cell carcinoma (CCC) patients. Furthermore, abnormal p53 expression was also associated with shorter overall survival in patients with EC and CCC.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2023)
Article
Oncology
Zachary S. Zumsteg, Michael Luu, Philip S. Rosenberg, Julia K. Elrod, Freddie Bray, Salvatore Vaccarella, Christopher Gay, Diana J. Lu, Michelle M. Chen, Anil K. Chaturvedi, Marc T. Goodman
Summary: The incidence of oropharyngeal cancer is increasing worldwide, with a shift towards older age groups in men and diverse patterns in women.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)