Review
Infectious Diseases
Hiroki Namikawa, Ken-Ichi Oinuma, Koichi Yamada, Yukihiro Kaneko, Hiroshi Kakeya, Taichi Shuto
Summary: This systematic review and meta-analysis suggests that hypermucoviscous Klebsiella pneumoniae strains are associated with an increased risk of abscess formation in bacteremia cases, but not with a significant increase in mortality rate. The string test is reaffirmed as an important tool for detecting hypermucoviscous K. pneumoniae.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Infectious Diseases
James S. Molton, I. Russel Lee, Denis Bertrand, Ying Ding, Shirin Kalimuddin, David C. Lye, Niranjan Nagarajan, Yunn-Hwen Gan, Sophia Archuleta
Summary: The study found that hypermucoviscous Klebsiella pneumoniae could potentially be shared among household members, indicating a potential transmission risk of hypermucoviscous strains within households.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Emergency Medicine
Genevieve S. Pentecost, Jacob Kesterson
Summary: Invasive Liver Abscess Syndrome, caused by Klebsiella pneumoniae, is a manifestation of systemic infection. Although common in Southeast Asia, it is uncommon in the United States. This article presents a case of pyogenic liver abscess and associated endogenous endophthalmitis in a patient presenting to the emergency department.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Immunology
Zhijie Zhang, Hairui Wang, Yawen Guo, Zhaoyu Liu, Zhihui Chang
Summary: This study found significant differences in bacterial characteristics between IKPLA and KPLA, including microbiological changes, activation of related metabolic pathways, and expression of pathogenic genes. These differences provide clues for exploring the mechanism of invasiveness in KPLA.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Public, Environmental & Occupational Health
H. Namikawa, K. -I. Oinuma, K. Yamada, Y. Kaneko, H. Kakeya, T. Shuto
Summary: This study identified diabetes mellitus and liver abscess as predictors of hypervirulent Klebsiella pneumoniae infections through a systematic review and meta-analysis. Prudent management, including the search for multiple sites of infection and/or metastatic spread and the enforcement of an early and appropriate source control procedure, should be initiated for patients with these predictors.
JOURNAL OF HOSPITAL INFECTION
(2023)
Article
Infectious Diseases
Shixiao Li, Sufei Yu, Minfei Peng, Jiajia Qin, Chunyan Xu, Jiao Qian, Minmin He, Peng Zhou
Summary: This study analyzed 135 patients with Klebsiella pneumoniae-caused liver abscesses and found that patients with sepsis had higher rates of complications and metastatic infections. Patients with sepsis exhibited different clinical features compared to those without sepsis.
BMC INFECTIOUS DISEASES
(2021)
Article
Immunology
Dakang Hu, Wenjie Chen, Weiwen Wang, Dongxing Tian, Pan Fu, Ping Ren, Qing Mu, Gang Li, Xiaofei Jiang
Summary: This study aims to investigate the mechanisms of Klebsiella pneumoniae-induced pyogenic liver abscess (PLA). Differences were found between K. pneumoniae strains from PLA and non-PLA samples for virulence genes and factors. Hypercapsule production is the cornerstone of hypervirulence, regardless of exopolysaccharides. K. pneumoniae-induced PLA may decrease core inflammatory cytokines rather than increase anti-inflammatory cytokines. Exopolysaccharides could also attenuate the inflammatory response to aid in the immune escape of K. pneumoniae.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Jihui Chen, Yu Yang, Huimin Yao, Shuhong Bu, Lixia Li, Fang Wang, Feng Chen, Huijuan Yao
Summary: This study analyzed the clinical information of adult patients with carbapenem-resistant Klebsiella pneumoniae (CRKP) infection, established a nomogram for predicting mortality risk, and determined the effectiveness of different antimicrobial regimens. The results can help clinicians identify high-risk adult patients with CRKP infection, improve treatment outcomes, and reduce mortality.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Microbiology
Jorge Cardenas-Alvarez, Galit Balayla, Abel Triana, Rodrigo Lankenau, Carlos Franco-Paredes, Andres F. Henao-Martinez, Gabriel Motoa
Summary: This scoping review provides an overview of the characteristics and clinical presentations of cryptogenic Klebsiella pneumoniae liver abscess in the Americas. The majority of cases involve males with diabetes who have traveled from Southeast or East Asia. Extrahepatic involvement and bacteremia are common, with the lungs, ocular structures, and central nervous system being commonly affected. Treatment includes percutaneous drainage and the use of third generation cephalosporins, but the pooled fatality rate remains at 9%.
Article
Immunology
Yahong Zheng, Yuting Ding, Mengran Xu, Haoran Chen, Hui Zhang, Yanyan Liu, Weihua Shen, Jiabin Li
Summary: The study identified the gut microbiota as a protective factor against K. pneumoniae infection, and found that FMT could improve inflammatory levels and liver damage in KLA patients, increasing survival rates.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Microbiology
Changrui Qian, Siqin Zhang, Mengxin Xu, Weiliang Zeng, Lijiang Chen, Yining Zhao, Cui Zhou, Ying Zhang, Jianming Cao, Tieli Zhou
Summary: This study investigated the phenotypic and genotypic characteristics of multidrug resistant liver abscess-causing Klebsiella pneumoniae (MDR LAKp) strains from 2016 to 2020. The majority of these strains exhibited resistance to cephalosporins, quinolones, and chloramphenicol, but only half displayed higher virulence than classical MDR strain. Three hypervirulent carbapenem-resistant strains carrying bla(KPC-2) and one colistin-resistant strain carrying mcr-1 were identified. Phylogenetic analysis showed that most MDR LAKp strains belonged to clade 1. This study provides insights into MDR LAKp and highlights the need for prevention measures to control their spread.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Kuan-Jen Chen, Yen-Po Chen, Yi-Hsing Chen, Laura Liu, Nan-Kai Wang, An-Ning Chao, Wei-Chi Wu, Yih-Shiou Hwang, Hung-Da Chou, Eugene Yu-Chuan Kang, Yen-Ting Chen, Ming-Hui Sun, Chi-Chun Lai
Summary: This study investigates the infection sources and antibiotic susceptibilities of Klebsiella pneumoniae in patients with endogenous K. pneumoniae endophthalmitis in Northern Taiwan. Pyogenic liver abscess was identified as the major infection source, and K. pneumoniae showed high susceptibility to ceftazidime and amikacin.
Review
Microbiology
Kai Siang Chan, Christopher Tze Wei Chia, Vishal G. Shelat
Summary: KPPLA patients are younger with a lower prevalence of hepatobiliary disease and malignancy. KPPLA is associated with a lower incidence of multiple and bilobar abscesses, but higher overall metastatic complications. In terms of mortality, KPPLA has a lower rate compared to N-KPPLA.
Article
Medicine, General & Internal
Joo-Hee Hwang, Jeong-Hwan Hwang, Seung Yeob Lee, Jaehyeon Lee
Summary: This study investigated the clinical and microbiological characteristics of prostatic abscesses caused by Klebsiella pneumoniae. The results showed that a particular hypervirulent strain of K. pneumoniae, associated with the K1 capsular type and the presence of the rmpA and iutA genes, was an important pathogen in prostatic abscesses.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Lin Gan, Chao Yan, Jinghua Cui, Guanhua Xue, Hanyu Fu, Bing Du, Hanqing Zhao, Junxia Feng, Yanling Feng, Zheng Fan, Pan Mao, Tongtong Fu, Ziying Xu, Shuheng Du, Shiyu Liu, Rui Zhang, Qun Zhang, Nannan Li, Xiaohu Cui, Xiaoran Li, Yao Zhou, Lei Huang, Jing Yuan
Summary: Klebsiella pneumoniae, a common cause of nosocomial and community-acquired infections, including pneumonia and pyogenic liver abscess, has little known about its population structure. This study investigated the prevalence and characteristics of K. pneumoniae isolates from carriers, pyogenic liver abscess patients, and pneumonia patients. The isolates from different sources had their own sequence types and genomic features. The isolates from liver abscess patients carried more virulence factors, while those from pneumonia patients harbored more resistance genes and replicons. The isolates from liver abscesses also showed higher virulence. The findings suggest that isolates from different sources have distinct genomic features and may infect different patients via different sources.
MICROBIOLOGY SPECTRUM
(2022)