Article
Pediatrics
Ryan M. Hanson, Amy J. Wagner
Summary: Severe, complicated Clostridium difficile colitis is rare in pediatric patients and little is known about its medical and surgical management in this population. A case report of a 15-year-old female patient with severe, complicated C difficile colitis successfully treated with diverting loop ileostomy and colonic lavage is presented. This approach, instead of subtotal colectomy and end ileostomy, should be considered as an alternative for pediatric patients with severe, complicated C difficile colitis.
Review
Medicine, General & Internal
Ibrahim A. Al-Zahrani
Summary: Clostridioides difficile (C. difficile) infection is a global threat to many healthcare settings. Excessive use of antimicrobials, lack of optimal antibiotic policies, and suboptimal infection control practices have fueled the development of this health issue. Prudent use of antimicrobials and simple infection control measures can significantly reduce infection rates.
SAUDI MEDICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Jianhua Luo, Qi Yang, Xiaofeng Zhang, Yuanyuan Zhang, Li Wan, Xiechao Zhan, Yao Zhou, Liuqing He, Danyang Li, Dazhi Jin, Ying Zhen, Jing Huang, Yanyan Li, Liang Tao
Summary: The study identified tissue factor pathway inhibitor (TFPI) as the receptor for TcdB4, a dominant virulence factor of hypervirulent clade 2 Clostridioides difficile. TFPI is highly expressed in the intestinal glands and protects the colonic epithelium from TcdB2/4. These findings reveal new mechanisms for CDI pathogenesis.
Review
Biochemistry & Molecular Biology
Andrea Piccioni, Federico Rosa, Federica Manca, Giulia Pignataro, Christian Zanza, Gabriele Savioli, Marcello Covino, Veronica Ojetti, Antonio Gasbarrini, Francesco Franceschi, Marcello Candelli
Summary: The composition of the human microbiome plays a crucial role in health, and alterations in the microbiota can lead to Clostridium difficile infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Meng Wang, Zifeng Deng, Yanmei Li, Yi Ma, Jufang Wang
Summary: A novel lytic protein Cw1-CWB2 with high binding specificity and strong lytic activity has been designed in this study for combating C. difficile.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Ashleigh S. Paparella, Briana L. Aboulache, Rajesh K. Harijan, Kathryn S. Potts, Peter C. Tyler, Vern L. Schramm
Summary: Clostridium difficile produces toxins TcdA and TcdB causing diarrhea by affecting host cell functions using UDP-glucose, leading to disease onset. Researchers identified potential therapeutic approach using transition state analogue iminosugars.
NATURE COMMUNICATIONS
(2021)
Article
Rehabilitation
Justin Weppner, Joelle Gabet, Mark Linsenmeyer, Mohamed Yassin, Gary Galang
Summary: The study found the presence of C difficile spores in an acute rehabilitation environment and showed that proper disinfection methods can effectively reduce the risk of infection. It is important to sporicidally disinfect surfaces such as beds and wheelchairs to decrease the rates of C difficile infection.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Infectious Diseases
Papanin Putsathit, Stacey Hong, Narelle George, Christine Hemphill, Peter G. Huntington, Tony M. Korman, Despina Kotsanas, Monica Lahra, Rodney McDougall, Andrew McGlinchey, Casey Moore, Graeme R. Nimmo, Louise Prendergast, Jennifer Robson, Lynette Waring, Michael C. Wehrhahn, Gerhard F. Weldhagen, Richard M. Wilson, Thomas Riley, Daniel R. Knight
Summary: The study found that the majority of C. difficile isolated in Australia showed susceptibility to the recommended antimicrobials for treating CDI, with low resistance to carbapenems and fluoroquinolones, and rare multidrug resistance. However, resistance to clindamycin was common, with one fluoroquinolone-resistant ribotype 027 strain detected.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Surgery
Alexis Hess, Saskya Byerly, Emily Lenart, Cory Evans, Andrew Kerwin, Dina Filiberto
Summary: This study aimed to identify predictors of Clostridium Difficile Infection (CDI) in general surgery patients. Patients who underwent general surgery operations were analyzed, and it was found that older age, emergent operation, increased time to operation, infections at surgical sites, deep organ space infections, steroid use, metastatic cancer, smoking, and decreased body mass index (BMI) were independent predictors of CDI.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Multidisciplinary Sciences
Mao Hagihara, Tadashi Ariyoshi, Yasutoshi Kuroki, Shuhei Eguchi, Seiya Higashi, Takeshi Mori, Tsunemasa Nonogaki, Kenta Iwasaki, Makoto Yamashita, Nobuhiro Asai, Yusuke Koizumi, Kentaro Oka, Motomichi Takahashi, Yuka Yamagishi, Hiroshige Mikamo
Summary: CBM 588 enhances the antibacterial activity against C. difficile, reduces colon epithelial damage, and improves immunity through upregulating pathogen specific immunoglobulin A and enhancing gut epithelial barrier function to protect colon tissue from CDI.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Siqi Wang, Leyang Xiang, Fang li, Wenlin Deng, Pinjing Lv, Ye Chen
Summary: This study found that levels of fecal short-chain fatty acids (SCFAs), particularly butyrate, are reduced, and normal colon structure is damaged in patients with CDI compared with those in healthy individuals. Bile acid (BA) metabolic disorder in patients with CDI is characterized by increased primary BA levels and decreased secondary BAs. Butyrate treatment may serve as a novel therapeutic approach for patients with CDI.
MICROBIOLOGY SPECTRUM
(2023)
Article
Pharmacology & Pharmacy
Xi-Wang Liu, Ya-Jun Yang, Zhe Qin, Shi-Hong Li, Li-Xia Bai, Wen-Bo Ge, Jian-Yong Li
Summary: This study investigated the antibacterial activity of the active component IBCL from traditional Chinese herb medicine Cullen corylifolium against Clostridium difficile. Results showed that IBCL effectively killed the bacteria by disrupting the cell membrane integrity, reducing weight loss associated with CDI infections.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Dongxuan Li, Yi Song, Zhanfeng Bai, Xin Xi, Feng Liu, Yang Zhang, Chunmeng Qin, Dan Du, Qian Du, Songqing Liu
Summary: Antibacterial drug exposure is a potential risk factor for Clostridium difficile infection, and this study reviewed CDI reports related to antibacterial drug exposure in the FDA Adverse Event Reporting System database. Metronidazole had the highest number of reports and the highest positive adverse reaction signal strength for CDI. The study also revealed risk characteristics for different antibacterial drugs and suggested that the CDI risk of metronidazole and vancomycin may be underestimated.
Article
Plant Sciences
Young-Jin Son, Young-Rok Kim, Sang-Hun Oh, Sungji Jung, Marco A. Ciufolini, Hee-Jong Hwang, Jin-Hwan Kwak, Hyunjoo Pai
Summary: Clostridioides difficile infection is a global health threat and micrococcin P2 (MP2) has shown promising results as an effective antimicrobial agent against the hypervirulent C. difficile strain through in vitro and in vivo studies.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Gastroenterology & Hepatology
Anqi Jin, Tony Chien, Qiwen Huang, Pragati Kenkare, Mai Vu, Sandra Wilson, Edward S. Huang
Summary: The study found that cholecystectomy is associated with a slightly increased risk of incident CDI, but this effect is not influenced by the use of proton pump inhibitors, antibiotics, or hospitalization.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Alex Carignan, Sebastien Poulin, Philippe Martin, Annie-Claude labbe, Louis Valiquette, Hamed Al-Bachari, Louis-Philippe Montpetit, Jacques Pepin
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2016)
Article
Public, Environmental & Occupational Health
Dominik Mertz, Richard Whitlock, Alicia Y. Kokoszka, Stephanie W. Smith, Alex Carignan, Muhammad Rehan, Iqbal H. Jaffer, Ali Alsagheir, Mark Loeb
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Denis Lane, Isabelle Matte, ClauDe laplante, Perrine Garde-Granger, Alex Carignan, Paul Bessette, Claudine Rancourt, Alain Piche
Article
Immunology
Karina A. Top, Marie-Noelle Billard, Marie-Claude Gariepy, Isabelle Rouleau, Jeffrey M. Pernica, Anne Pham-Huy, Caroline Quach, Dat Tran, Wendy Vaudry, Simon Dobson, Francois D. Boucher, Alex Carignan, Taj Jadavji, Athena McConnell, Shelly A. McNeil, Scott A. Halperin, Gaston De Serres
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2016)
Article
Biotechnology & Applied Microbiology
Antoine Couture-Cossette, Alex Carignan, Subburaj Ilangumaran, Louis Valiquette
EXPERT OPINION ON BIOLOGICAL THERAPY
(2017)
Article
Mycology
Jessica St-Pierre, Philippe J. Dufresne, Alex Carignan, Emilie Levesque, Francis Bernard, Jean Longtin, Louiselle LeBlanc
Editorial Material
Medicine, Research & Experimental
Alex Carignan, Louis-Charles Fortier
M S-MEDECINE SCIENCES
(2018)
Article
Medicine, Research & Experimental
Nick Daneman, Asgar H. Rishu, Ruxandra Pinto, Pierre Aslanian, Sean M. Bagshaw, Alex Carignan, Emmanuel Charbonney, Bryan Coburn, Deborah J. Cook, Michael E. Detsky, Peter Dodek, Richard Hall, Anand Kumar, Francois Lamontagne, Francois Lauzier, John C. Marshall, Claudio M. Martin, Lauralyn McIntyre, John Muscedere, Steven Reynolds, Wendy Sligl, Henry T. Stelfox, M. Elizabeth Wilcox, Robert A. Fowler
Review
Public, Environmental & Occupational Health
Iman Fakih, Elise Fortin, Marc-Andre Smith, Alex Carignan, Claude Tremblay, Jasmin Villeneuve, Danielle Moisan, Charles Frenette, Caroline Quach
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2018)
Article
Multidisciplinary Sciences
Antoine Couture-Cossette, Alex Carignan, Adam Mercier, Claudine Desruisseaux, Louis Valiquette, Jacques Pepin
Article
Medicine, Research & Experimental
Rachel B. van Oostveen, Alberto Romero-Palacios, Richard Whitlock, Shun Fu Lee, Stuart Connolly, Alex Carignan, C. David Mazer, Mark Loeb, Dominik Mertz
Article
Infectious Diseases
Alex Carignan, Robert Sabbagh, Vincent Masse, Nicolas Gagnon, Louis-Philippe Montpetit, Marc-Andre Smith, Mathieu Raymond, Catherine Allard, Cybele Bergeron, Jacques Pepin
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2019)
Article
Public, Environmental & Occupational Health
Iman Fakih, Elise Fortin, Marc-Andre Smith, Alex Carignan, Claude Tremblay, Jasmin Villeneuve, Danielle Moisan, Charles Frenette, Caroline Quach, Alexandra M. Schmidt, Lise-Andree Galarneau, Sylvie Latreille, Muleka Ngenda-Muadi, Noemie Savard, Melissa Trudeau
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2019)
Article
Infectious Diseases
C. Asselin, N. Ekindi, A. Carignan, P. O. Richard
Article
Public, Environmental & Occupational Health
Caroline Sheitoyan-Pesant, Isabelle Alarie, Christian Iorio-Morin, David Mathieu, Alex Carignan
AMERICAN JOURNAL OF INFECTION CONTROL
(2017)