期刊
CLINICAL INFECTIOUS DISEASES
卷 46, 期 -, 页码 S87-S91出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/523335
关键词
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资金
- NICHD NIH HHS [R37 HD12437] Funding Source: Medline
- NIDDK NIH HHS [P01 DK33506, P30 DK040561-12, R01 DK70260, P30 DK40561, P30 DK040561] Funding Source: Medline
At birth, the newborn leaves the germ-free intrauterine environment and enters a highly contaminated extrauterine world, which requires potent host defenses to prevent disease. Intestinal defenses develop during gestation and have the capacity to respond but first must be exposed to colonizing bacteria. I review the importance of bacterial colonization for the appearance of normal mucosal immune function and the clinical consequences of inadequate colonization with regard to development of disease. For example, we now know that an imbalance in T-helper (Th) cells (e. g., Th2 levels greater than Th1 levels) can predispose to autoimmune disease and gut inflammation or disease, such as necrotizing enterocolitis. As we determine the role of bacterial colonization in the gut (bacterial-epithelial cross talk), we should have more-appropriate ways to modulate the gut immune responses-for example, by use of probiotics to prevent the expression of these gastrointestinal diseases.
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