Article
Immunology
Richard E. Nelson, Kelly M. Hatfield, Hannah Wolford, Matthew H. Samore, R. Douglas Scott, Sujan C. Reddy, Babatunde Olubajo, Prabasaj Paul, John A. Jernigan, James Baggs
Summary: This study estimated the healthcare costs associated with infections due to multidrug-resistant bacteria in the United States, revealing that these infections resulted in substantial healthcare costs.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Richard E. Nelson, David Hynn, Amanda Jezek, Matthew H. Samore
Summary: This study analyzed data from the Department of Veterans Affairs in the United States and found that infections due to multidrug-resistant bacteria were associated with high healthcare costs and mortality rates. Efforts to prevent these infections could save a significant number of lives and healthcare resources.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Health Care Sciences & Services
Teresa M. Wozniak, Amalie Dyda, Greg Merlo, Lisa Hall
Summary: This study estimated the health and economic impact of five hospital-associated AMR pathogens in Australia in 2020. It found that there were 1,031 AMR-associated deaths from these infections, with respiratory infections and bloodstream infections having the highest odds of dying and resulting in high hospital costs. The study highlights the need for country-level estimates of AMR impact to inform programs and policies to reduce morbidity and mortality.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Article
Immunology
Ian D. Plumb, Allison C. Brown, Erin K. Stokes, Jessica C. Chen, Heather Carleton, Beth Tolar, Preethi Sundararaman, Amy Saupe, Daniel C. Payne, Hazel J. Shah, Jason P. Folster, Cindy R. Friedman
Summary: Reports show an increasing trend of Salmonella enterica I serotype 4,[5],12:i:- infections resistant to multiple antibiotics. Analyzing data from national surveillance systems, we found that the proportion of ASSuT-resistant Salmonella 4,[5],12:i:- increased from 1.1% to 2.6% during 2009-2013 and 2014-2018 respectively. Genetic analysis revealed a phylogenetic clade with 69% of isolates, among which 77% had genetic determinants of ASSuT resistance and 16% had genetic determinants of decreased susceptibility to other antibiotics. Outbreaks associated with the multidrug-resistant clade were mainly linked to pork consumption or contact with swine. Preventing Salmonella 4,[5],12:i:- carriage in swine could be key in preventing human infections with this strain.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Louise K. Francois Watkins, Mark E. Laughlin, Lavin A. Joseph, Jessica C. Chen, Megin Nichols, Colin Basler, Robert Breazu, Christy Bennett, Lia Koski, Martha P. Montgomery, Michael J. Hughes, Scott Robertson, Charlotte G. Lane, Amber J. Singh, Danielle Stanek, Ellen Salehi, Eric Brandt, Glen McGillivary, Jade Mowery, Jamie DeMent, Rachael D. Aubert, Aimee L. Geissler, Sietske de Fijter, Ian T. Williams, Cindy R. Friedman
Summary: The study found that extensively drug-resistant C jejuni strains have been circulating among the population since at least 2011, associated with illnesses among individuals who have had contact with pet store puppies. Practitioners should inquire about puppy exposure when treating patients with Campylobacter infection, especially when routine antibiotics are ineffective. The commercial dog industry should take action to prevent the spread of extensively drug-resistant C jejuni from pet store puppies to humans.
Article
Microbiology
Kaitlin Benedict, Ian Hennessee, Jeremy A. W. Gold, Dallas J. Smith, Samantha Williams, Mitsuru Toda
Summary: This study analyzed blastomycosis-associated hospitalizations in the United States from 2010 to 2020. The results showed a relatively low hospitalization rate with no apparent temporal trend, but higher rates among individuals aged 65 and older and males. The in-hospital death rate increased during this period and was associated with age, chronic obstructive pulmonary disease, and malignancy.
Article
Public, Environmental & Occupational Health
Weichun Huang, Xiaoshu Wei, Guifeng Xu, Xingyu Zhang, Xing Wang
Summary: This study aimed to determine the epidemiology, risk factors, and clinical outcomes of carbapenem-resistant Pseudomonas aeruginosa (CRPA) infections among critically ill pediatric patients in a large tertiary pediatric hospital in China. The study found that risk factors for CRPA infection included a hospitalization length of >28 days, invasive operations, and blood transfusion. Conversely, a birth weight >= 2,500 g and breast nursing were protective factors against CRPA infections. Platelet < 100 x 10(9)/L and serum urea <3.2 mmol/L were independent predictors of mortality due to P. aeruginosa infection.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Infectious Diseases
Paula Soza-Ossandon, Dacil Rivera, Kasim Allel, Gerardo Gonzalez-Rocha, Mario Quezada-Aguiluz, Ivan San Martin, Patricia Garcia, Andrea Moreno-Switt
Summary: Healthcare-associated infections caused by Staphylococcus, particularly Staphylococcus aureus, pose a high risk to human and animal health. The study identified methicillin resistant staphylococci in equine patients and hospital environments, showing the presence of multidrug resistance genes and potential transmission risks. Tackling antimicrobial resistance within equine hospitals should involve wider control over antimicrobial consumption and reducing exposure to AMR reservoirs in animals to prevent cross-transmission of drug-resistant Staphylococcus.
Article
Immunology
X. J. Lee, A. J. Stewardson, L. J. Worth, N. Graves, T. M. Wozniak
Summary: The study found that Escherichia coli urinary tract infections had the most significant impact on hospital length of stay among the 5 studied pathogens, and that antimicrobial-resistant infections resulted in higher healthcare costs for patients infected with third-generation cephalosporin or methicillin-resistant strains.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Nicolas Francisco Fernandez-Martinez, Mario Rivera-Izquierdo, Rocio Ortiz-Gonzalez-Serna, Virginia Martinez-Ruiz, Pablo Lardelli-Claret, Adrian Hugo Aginagalde-Llorente, Maria del Carmen Valero-Ubierna, Maria Auxiliadora Vergara-Diaz, Nicola Lorusso
Summary: This study indicates that social factors should be considered when investigating healthcare-associated infections caused by multidrug-resistant bacteria. The heterogeneity in the incidence of cases between municipalities in Andalusia may be explained by social determinants of health, as well as under-notification.
Article
Infectious Diseases
Steven I. Aronin, Vikas Gupta, Michael W. Dunne, Janet A. Watts, Kalvin C. Yu
Summary: Antimicrobial resistance (AMR) can complicate the management of urinary tract infections. This retrospective study evaluated the regional differences in AMR among Enterobacterales urine isolates from hospitalized and ambulatory adult patients. The study found a high prevalence of resistance to beta-lactams and other antibiotics, as well as the presence of extended-spectrum beta-lactamase-producing isolates and multidrug resistance. Significant geographic variations in AMR were observed, but the resistance rates remained above recommended thresholds for empirical treatment of urinary tract infections.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Critical Care Medicine
Tetsu Ohnuma, Shingo Chihara, Blair Costin, Miriam Treggiari, Raquel R. Bartz, Karthik Raghunathan, Vijay Krishnamoorthy
Summary: In patients with community-onset sepsis, the prevalence of blood culture-positive sepsis was 14%, and resistant organisms were infrequent. Blood culture-positive sepsis and nonblood culture-positive sepsis were associated with lower in-hospital mortality compared to culture-negative sepsis.
CRITICAL CARE MEDICINE
(2023)
Article
Immunology
Felicita Medalla, Weidong Gu, Cindy R. Friedman, Michael Judd, Jason Folster, Patricia M. Griffin, Robert M. Hoekstra
Summary: Research using Bayesian hierarchical models on Salmonella infections in the United States from 2004 to 2016 found an increasing incidence of antimicrobial-resistant strains. The rise in resistance varied by serotype, with some types showing a faster increase. These estimates can help set targets and priorities for prevention efforts.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Michael J. Loftus, Tracey E. M. W. Young-Sharma, Sue J. Lee, Shitanjni Wati, Gnei Z. Badoordeen, Luke V. Blakeway, Sally M. H. Byers, Allen C. Cheng, Ben S. Cooper, Hugh Cottingham, Adam W. J. Jenney, Jane Hawkey, Nenad Macesic, Ravi Naidu, Amitesh Prasad, Vinita Prasad, Litia Tudravu, Timoci Vakatawa, Elke Van Gorp, Jessica A. Wisniewski, Eric Rafai, Anton Y. Peleg, Andrew J. Stewardson
Summary: In Fiji, patients with Enterobacterales bloodstream infections have high mortality rates, with a high occurrence of 3GC-R associated with increased length of hospital stay but not with in-hospital mortality.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Chemistry, Multidisciplinary
Maochao Zheng, Xiaolei Wu, Chao Lu, Wancong Zhang, Shijie Tang, Ying Luo, Daojun Liu
Summary: The development of alternative antimicrobial therapeutics is needed due to the emergence of antibiotic resistance in bacterial pathogens. Polypept(o)ide-based bactericides, which mimic antimicrobial host defense peptides, have shown promise in the treatment of antibiotic-resistant and recurring infections. This review summarizes recent advances in membrane-active polypept(o)ide-based bactericides, focusing on their ability to disrupt bacterial cell walls/membranes and combat acquired antibiotic resistance and biofilm formation.
MATERIALS TODAY CHEMISTRY
(2023)
