期刊
CLINICAL INFECTIOUS DISEASES
卷 47, 期 3, 页码 421-424出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/589867
关键词
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资金
- NCRR NIH HHS [M01 RR000044, RR00046, M01 RR000095, RR00096, M01 RR000046, RR00044, M01 RR000047, RR00047, M01 RR000096, RR00095] Funding Source: Medline
- NIAID NIH HHS [AI25859, U01 AI046370, U01 AI038858, AI25915, AI27670, U01 AI027665, U01 AI032783, U01 AI025859, U01 AI027673, P30 AI027757, AI46381, AI46736, AI27660, U01 AI046381, U01 AI025903, U01 AI027664, U01 AI027660, UM1 AI068634, AI34853, AI46370, U01 AI032782, U01 AI027661, U01 AI046386, R21 AI065288-01A1, U01 AI039156, AI 32782, AI27673, U01 AI027663, AI27666, AI25868, AI68634, AI38858, AI25897, U01 AI025897, AI27661, U01 AI027670, AI27664, AI46386, AI068634, AI46339, AI25903, R21 AI065288, P30 AI050410, U01 AI025868, U01 AI068634, AI50410, AI27757, AI27665, U01 AI046339, AI39156, U01 AI027658, AI27663, U01 AI027666, U01 AI034853, U01 AI025915, AI27658, AI32783] Funding Source: Medline
Using standard and ultrasensitive techniques, we detected nonnucleoside reverse-transcriptase inhibitor-associated resistance mutations in 11 (20%) of 54 subjects who discontinued virologically suppressive nonnucleoside reverse-transcriptase inhibitor-containing antiretroviral therapy. Resistance was detected in 45% and 14% of subjects with a baseline human immunodeficiency virus type 1 RNA level of 51-400 copies/mL and <= 50 copies/mL, respectively. Mutations remained detectable for at least 48 weeks in some subjects.
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