☆ 4.7 Editorial Material

Bacteremic complications of intravascular catheters colonized with Staphylococcus aureus

CLINICAL INFECTIOUS DISEASES (2008)

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CLINICAL INFECTIOUS DISEASES

卷 46, 期 1, 页码 114-118

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UNIV CHICAGO PRESS

DOI: 10.1086/524077

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Immunology Infectious Diseases Microbiology

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Patients with Staphylococcus aureus colonization of an intravascular catheter but without demonstrated bacteremia within 24 h after intravascular catheter removal had a 24% (12 of 49 patients) chance of subsequent S. aureus bacteremia if they did not receive immediate antistaphylococcal antibiotics. Treatment within 24 h after intravascular catheter removal led to a 83% reduction in the incidence of subsequent bacteremia.

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JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2022)

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Article Immunology

Spatio-temporal changes in pre-exposure prophylaxis uptake among MSM in mainland France between 2016 and 2021: a Bayesian small area approach with MSM population estimation

Haoyi Wang, Jean-Michel Molina, Rosemary Dray-Spira, Axel J. Schmidt, Ford Hickson, David van de Vijver, Kai J. Jonas

Summary: This study used national pharmaco-epidemiology surveillance data and regional MSM population estimations to model the spatio-temporal distribution of PrEP uptake among MSM in France 2016-2021 to identify marginalized MSM at risk for HIV and increase their PrEP uptake.

JOURNAL OF THE INTERNATIONAL AIDS SOCIETY (2023)

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Article Multidisciplinary Sciences

The BAF complex inhibitor pyrimethamine reverses HIV-1 latency in people with HIV-1 on antiretroviral therapy

Henrieke A. B. Prins, Raquel Crespo, Cynthia Lungu, Shringar Rao, Letao Li, Ronald J. Overmars, Grigorius Papageorgiou, Yvonne M. Mueller, Mateusz Stoszko, Tanvir Hossain, Tsung Wai Kan, Bart J. A. Rijnders, Hannelore I. Bax, Eric C. M. van Gorp, Jan L. Nouwen, Theodora E. M. S. de, Carolina A. M. Schurink, Mariana de Mendonca Melo, Els van Nood, Angela Colbers, David Burger, Robert-Jan Palstra, Jeroen J. A. van Kampen, David A. M. C. van de Vijver, Thibault Mesplede, Peter D. Katsikis, Rob A. Gruters, Birgit C. P. Koch, Annelies Verbon, Tokameh Mahmoudi, Casper Rokx

Summary: The BAF complex inhibitor pyrimethamine can reactivate the latent HIV-1 reservoir in people living with HIV-1 (PLWH) on suppressive antiretroviral therapy, but does not lead to a reduction in the size of the inducible reservoir.

SCIENCE ADVANCES (2023)

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Article Immunology

Population-level impact of expanding PrEP coverage by offering long-acting injectable PrEP to MSM in three high-resource settings: a model comparison analysis

Sarah E. Stansfield, Jesse Heitner, Kate M. Mitchell, Carla M. Doyle, Rachael M. Milwid, Mia Moore, Deborah J. Donnell, Brett Hanscom, Yiqing Xia, Mathieu Maheu-Giroux, David van de Vijver, Haoyi Wang, Ruanne Barnabas, Marie-Claude Boily, Dobromir T. Dimitrov

Summary: Long-acting injectable cabotegravir (CAB-LA) demonstrated superiority to daily tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) for HIV pre-exposure prophylaxis (PrEP) in the HPTN 083/084 trials. The potential impact of expanding PrEP coverage by offering CAB-LA to men who have sex with men (MSM) in different countries (US, Canada, and the Netherlands) was compared using three risk-stratified HIV transmission models.

JOURNAL OF THE INTERNATIONAL AIDS SOCIETY (2023)

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Article Multidisciplinary Sciences

Characteristics and short- and long-term direct medical costs among adults with timely and delayed presentation for HIV care in the Netherlands

Stephanie Popping, Lisbeth E. Versteegh, Brooke Nichols, David A. M. C. van de Vijver, Ard van Sighem, Peter Reiss, Suzanne Geerlings, Charles A. B. Boucher, Annelies Verbon

Summary: In Europe, many people living with HIV (PLWH) are diagnosed and start treatment late, leading to worse health outcomes. This study analyzed data from the ATHENA cohort in the Netherlands to assess the costs of HIV-care based on time of presentation and identify factors contributing to higher costs in the first and fifth year of antiretroviral therapy (ART) initiation. The study found that very late presentation was associated with substantial costs, particularly non-ART medication costs, which were nearly seven times higher compared to timely presentation.

PLOS ONE (2023)

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