Article
Cell Biology
Rui Xu, Ming Wu, Shuna Liu, Wenwen Shang, Rong Li, Juan Xu, Lei Huang, Fang Wang
Summary: Immunotherapy is expected to be a promising treatment for ovarian cancer due to its immunogenicity. However, immunosuppression in the tumor microenvironment poses challenges. Studies have shown that the metabolism pathways of Tregs in the cancer environment may contribute to immunosuppression, and TLR8 can reverse the inhibitory function of Tregs. Activation of TLR8 signaling results in decreased glucose metabolism in Tregs and promotes proliferation of naive T cells in the ovarian cancer microenvironment.
CELL DEATH & DISEASE
(2021)
Article
Biology
Severine Menoret, Laurent Tesson, Severine Remy, Victor Gourain, Celine Serazin, Claire Usal, Aude Guiffes, Vanessa Chenouard, Laure-Helene Ouisse, Malika Gantier, Jean-Marie Heslan, Cynthia Fourgeux, Jeremie Poschmann, Carole Guillonneau, Ignacio Anegon
Summary: In this study, a Foxp3-EGFP rat transgenic line was created to genetically tag CD4(+) and CD8(+) FOXP3(+) regulatory T cells. CD4(+)EGFP(+) Treg were found to be 5-10 times more frequent than CD8(+)EGFP(+) Treg. RNAseq analysis provided insights into the transcriptome of CD8(+) Treg, allowing for a better understanding of their phenotype and function.
Article
Immunology
Jin-ya Wang, Xiaoyan Dong, Zhiwei Yu, Lei Ge, Lu Lu, Ling Ding, Weihua Gan
Summary: The study demonstrated that borneol alleviated asthma in mice by downregulating miR-26a and miR-142-3p, which reduced CD4+ T cells infiltration, thereby attenuating disease progression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Kevin Bassler, Lisa Schmidleithner, Mehrnoush Hadaddzadeh Shakiba, Tarek Elmzzahi, Maren Koehne, Stefan Floess, Rebekka Scholz, Naganari Ohkura, Timothy Sadlon, Kathrin Klee, Anna Neubauer, Shimon Sakaguchi, Simon C. Barry, Jochen Huehn, Lorenzo Bonaguro, Thomas Ulas, Marc Beyer
Summary: Through the analysis of a large transcriptomic dataset of various human CD4(+) T cell conditions, researchers identified six common denominators of CD4(+) T cell functionality. They also discovered that MEOX1, a transcription factor, has a similar expression pattern to FOXP3 in T-reg cells and can be upregulated by IL-2. Knockdown of MEOX1 in T-reg cells significantly affected downstream gene expression programs and T-reg cell suppressive capacity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jessica G. Lee, Kathleen E. Jaeger, Yoichi Seki, Yi Wei Lim, Christina Cunha, Aleksandra Vuchkovska, Alexander J. Nelson, Anya Nikolai, Dan Kim, Michael Nishimura, Katherine L. Knight, Paula White, Makio Iwashima
Summary: The study reveals that a subset of CD14(+) monocytes can generate regulatory Foxp3(+) T-bet(+) T cells from umbilical cord blood, which suppress T-cell proliferation and ameliorate graft-versus-host disease. Additionally, adult peripheral blood monocytes are capable of inducing Foxp3(+) T cells, but their induction is inhibited by lymphoid cells from adult peripheral blood in neonates. This suggests a novel immunoregulatory role of monocytes in generating regulatory T cells with implications for both neonates and adults.
Article
Biochemistry & Molecular Biology
Sung Won Lee, Hyun Jung Park, Luc Van Kaer, Seokmann Hong
Summary: In this study, the deficiency of CD1d-restricted iNKT cells was found to lead to the expansion of Foxp3(-)CD25(+)CD4(+) T cells in colitis. The MLN dendritic cells in DSS-treated Yeti/CD1d KO mice were shown to promote the differentiation of these cells. Furthermore, Foxp3(-)CD25(+)CD4(+) T cells were found to be pathogenic in DSS-treated Yeti/CD1d KO mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Chun-Ling Liang, Weihui Lu, Feifei Qiu, Dan Li, Huazhen Liu, Fang Zheng, Qunfang Zhang, Yuchao Chen, Chuanjian Lu, Bin Li, Zhenhua Dai
Summary: PF can ameliorate lupus nephritis by reducing proteinuria, serum creatinine, anti-dsDNA levels, and renal cellular infiltration, as well as by improving renal immunopathology. It also has the potential to promote Treg differentiation and proliferation mediated by M2 macrophages, suggesting it may be used as a possible treatment for lupus nephritis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Immunology
Shaokui Chen, Zibei Lin, Tianzhen He, Md Sahidul Islam, Long Xi, Ping Liao, Yang Yang, Ying Zheng, Xin Chen
Summary: There is evidence that topical administration of TET nanoemulsion can stimulate the expansion of Tregs through the TNF-TNFR2 pathway and inhibit the development of psoriasis-like disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Julie Weidner, Carina Malmhall, Vahid Arabkari, Aidan Barrett, Emma Boberg, Linda Ekerljung, Madeleine Radinger
Summary: The polarization of CD4+ T cells into different T helper subsets is a crucial process in many diseases, including asthma. miR-19a has been identified as a regulator in T cell polarization by negatively controlling the expression of the SGK1 gene, therefore affecting T cell development. Thus, miR-19a plays an important role in the binding and regulation of SGK1 transcript levels during T cell development.
Article
Cell Biology
Yiyang Chen, Zeyu Li, Jianfeng Liang, Jiayu Liu, Jiansuo Hao, Quan Wan, Jiameng Liu, Chongdai Luo, Zhiyuan Lu
Summary: In this study, it was discovered that circRNA has_circ_0069313 is upregulated in oral squamous cancer cells (OSCC) and is associated with poor prognosis. The mechanism of has_circ_0069313's function involves inhibiting miR-325-3p-induced degradation of Foxp3, resulting in immunity escape. Furthermore, has_circ_0069313 acts as an exosomal circRNA and promotes the function of Treg cells by maintaining Foxp3 levels.
Article
Immunology
Eros Di Giorgio, Liqing Wang, Yan Xiong, Lanette M. Christensen, Tatiana Akimova, Rongxiang Han, Arabinda Samanta, Matteo Trevisanut, Claudio Brancolini, Ulf H. Beier, Wayne W. Hancock
Summary: The Mads/Mef2 family of transcription factors regulate differentiation in various cell types and are involved in physiological feedback loops. Disruption of their interaction with Hdac9 can lead to the development of pathologic states, including cancer. These transcription factors also indirectly control tumor progression by regulating antitumor immunity, particularly in Treg cells, adding complexity to the study of Treg biology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Disha Rao, Johanna A. A. Stunnenberg, Ruben Lacroix, Petros Dimitriadis, Joanna Kaplon, Fabienne Verburg, Paula T. T. van van Royen, Esmee P. Hoefsmit, Kathrin Renner, Christian U. U. Blank, Daniel S. S. Peeper
Summary: Glucose limitation and increased lactic acid levels due to elevated glycolytic activity of tumor cells create a metabolic barrier for tumor infiltrating immune cells. Regulatory T cells (Tregs) are not inhibited in lactic acid-rich environments, and lactic acid enhances the induction of Tregs. Acidicity in the tumor microenvironment can be targeted therapeutically to reduce Treg-mediated immune suppression within tumors.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Pawan K. Gupta, Jennifer B. Allocco, Jane M. Fraipont, Michelle L. McKeague, Peter Wang, Michael S. Andrade, Christine McIntosh, Luqiu Chen, Ying Wang, Yan Li, Jorge Andrade, Jose R. Conejo-Garcia, Anita S. Chong, Maria-Luisa Alegre
Summary: This study investigates the susceptibility of Tconvs to Treg suppression during tolerance induction in transplantation. The findings suggest that transplantation tolerance is associated with an increased sensitivity of alloreactive Tconvs to Treg suppression, which is regulated by the expression of the transcription factor Satb1. Targeting Satb1 could potentially be a strategy to improve transplant outcomes by modulating Treg-sparing immunosuppressive therapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Biaolong Deng, Weiqi Zhang, Yicheng Zhu, Yangyang Li, Dan Li, Bin Li
Summary: Regulatory T (Treg) cells play a critical role in maintaining immune homeostasis and their dysfunction in aged patients may contribute to age-related diseases. Immune therapies targeting Treg cells show promising results in treating cancers and autoimmune diseases. Understanding Treg cell function better may help in developing new immune therapies against aging.
