Article
Biochemistry & Molecular Biology
Esteban Alejandro Gomez-Gaitan, Yessica Eleanet Garcia-Ortega, Ana Miriam Saldana-Cruz, Betsabe Contreras-Haro, Jorge Ivan Gamez-Nava, Emilio Edsaul Perez-Guerrero, Cesar Arturo Nava-Valdivia, Sergio Gallardo-Moya, Alejandra Martinez-Hernandez, Laura Gonzalez Lopez, Blanca Esthela Rios-Gonzalez, Jazmin Marquez-Pedroza, Miriam Mendez-del Villar, Yussef Esparza-Guerrero, Alejandra Villagomez-Vega, Miguel Angel Macias Islas
Summary: This study investigated the association between the HLA-DRB1 * 0403 genetic variant and therapeutic response to disease-modifying therapies (DMTs) in patients with multiple sclerosis (MS). The results of the study showed that the genetic variant was not associated with therapeutic response in Mexican MS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Federica Murgia, Florianna Giagnoni, Lorena Lorefice, Paola Caria, Tinuccia Dettori, Maurizio N. N. D'Alterio, Stefano Angioni, Aran J. J. Hendren, Pierluigi Caboni, Monica Pibiri, Giovanni Monni, Eleonora Cocco, Luigi Atzori
Summary: Sex hormones are correlated with the clinical activity of multiple sclerosis. Estrogens and progesterone may have a neuroprotective effect in MS, supporting further research on their therapeutic uses.
Article
Clinical Neurology
Richard L. Yates, Jonathan Pansieri, Qizhu Li, Jack S. Bell, Sydney A. Yee, Jacqueline Palace, Margaret M. Esiri, Gabriele C. DeLuca
Summary: The study found that the HLA-DRB1*15 genotype is associated with the relationship between cortical inflammation and neuronal density in multiple sclerosis, suggesting a potential modulation effect of HLA-DRB1*15 on these factors.
Article
Clinical Neurology
Melinda Magyari, Nils Koch-Henriksen
Summary: There are sex differences in the activity and severity of multiple sclerosis, with women experiencing more inflammatory disease activity and men being more susceptible to the neurodegenerative component.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Wallace J. Brownlee, Carmen Tur, Andreea Manole, Arman Eshaghi, Ferran Prados, Katherine A. Miszkiel, Claudia A. M. Gandini Wheeler-Kingshott, Henry Houlden, Olga Ciccarelli
Summary: This study found that HLA-DRB1*1501 is associated with the severity of multiple sclerosis (MS), as indicated by long-term disability worsening and greater extent of inflammatory disease activity and tissue loss. HLA-DRB1*1501 may provide useful information for prognosis and treatment decisions in early relapse-onset MS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Immunology
Fan Yang, Leyu Zhou, Yi Shen, Shenglan Zhao, Yanyi Zheng, Ruoting Men, Xiaoli Fan, Li Yang
Summary: HLA-DRB1*04:05 is linked to the clinical features and prognosis of AIH in Chinese patients. Metabolomics analysis identified inosine as a highly altered metabolite. Inosine treatment attenuated hepatocyte apoptosis, enhanced antioxidant ability and inhibited the activation and glycolysis of CD4(+) T cell.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Shani Gilron, Rinat Gabbay-Benziv, Rasha Khoury
Summary: Male-sex is an independent risk factor for adverse perinatal outcomes, such as gestational diabetes mellitus (GDM) and large gestational age neonates. This study aimed to explore whether the impact of GDM on neonatal birth weight varies according to fetal sex.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Immunology
Seik-Soon Khor, Yosuke Omae, Nao Nishida, Masaya Sugiyama, Noriko Kinoshita, Tetsuya Suzuki, Michiyo Suzuki, Satoshi Suzuki, Shinyu Izumi, Masayuki Hojo, Norio Ohmagari, Masashi Mizokami, Katsushi Tokunaga
Summary: This study identified specific HLA alleles associated with the severity of COVID-19, which can be used for early identification of potential severe cases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Psychology, Multidisciplinary
Antje B. M. Gerdes, Laura-Ashley Fraunfelter, Melissa Braband, Georg W. Alpers
Summary: One of the most robust findings in psychopathology is that specific phobias are more common in women than in men. The prevalence of specific phobias in women is supported by limited empirical data, and there are various theoretical explanations for the biological and social contributions to this gender difference. Interestingly, individuals with stereotypical feminine characteristics tend to be more fearful than those with stereotypical masculine characteristics, suggesting that gender roles beyond biological sex play a role in fearfulness. This study aimed to examine the relationship between maternal gender stereotypes and children's fear, and the results showed that maternal fear of snakes and gender stereotypes were correlated with their daughters' fear of snakes and self-reported fear. The findings suggest that parental gender stereotypes may play a potential role in the development and maintenance of fear in their children.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Deena M. Walker, Xianxiao Zhou, Ashley M. Cunningham, Aarthi Ramakrishnan, Hannah M. Cates, Casey K. Lardner, Catherine J. Pena, Rosemary C. Bagot, Orna Issler, Yentl van der Zee, Andrew P. Lipschultz, Arthur Godino, Caleb J. Browne, Georgia E. Hodes, Eric M. Parise, Angelica Torres-Berrio, Pamela J. Kennedy, Li Shen, Bin Zhang, Eric J. Nestler
Summary: The study demonstrates that social isolation during adolescence enhances preference for cocaine in male but not female mice and alters cocaine-induced protein and transcriptional profiles in the medial amygdala (meA) particularly in males. The results show that the meA is essential for modulating the sex-specific effects of social experience on drug reward and establish Crym as a critical mediator of sex-specific behavioral and transcriptional plasticity.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Navia Vinoy, Neethu Sheeja, Suresh Kumar, Lalitha Biswas
Summary: The study identified HLA-DRB1 * 15:01, 15:02, and DQB1 * 06:02 as predisposing alleles for MS in our population, while HLA-DRB1 * 14:04 was found to be a protective allele. Significant associations were also observed between HLA-DRB1 alleles and IL7R (rs6897932) genotypes in MS patients.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Clinical Neurology
Marijne Vandebergh, Nicolas Degryse, Benedicte Dubois, An Goris
Summary: Multiple sclerosis (MS) is a complex disease involving genetic variants and environmental factors, including obesity, vitamin D deficiency, Epstein-Barr virus infection, and smoking. Leveraging genetics through the Mendelian randomization paradigm helps inform prevention strategies for MS by studying the impact of environmental factors on susceptibility. This approach draws parallels with observational studies and randomized controlled trials, highlighting the challenges and opportunities for future research in this area.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Fardowsa L. A. Yusuf, Jose M. A. Wijnands, Mohammad Ehsanul Karim, Elaine Kingwell, Feng Zhu, Charity Evans, John D. Fisk, Yinshan Zhao, Ruth Ann Marrie, Helen Tremlett
Summary: Sex and age differences in healthcare utilization were observed during the prodromal phase of multiple sclerosis. Males and older individuals had higher rates of healthcare utilization and were more likely to visit general practitioners, while younger individuals were more likely to visit ophthalmologists. However, no significant sex and age differences were found in the smaller clinical cohort.
FRONTIERS IN NEUROLOGY
(2022)
Article
Health Care Sciences & Services
Patricia K. Coyle
Summary: Multiple sclerosis is a major central nervous system disease that predominantly affects young adults, with females being more susceptible than males. Research has shown that sex-based differences influence various aspects of multiple sclerosis, leading to new insights in understanding, management, and treatment of the disease.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Valery Fuh-Ngwa, Yuan Zhou, Phillip E. Melton, Ingrid van der Mei, Jac C. Charlesworth, Xin Lin, Amin Zarghami, Simon A. Broadley, Anne-Louise Ponsonby, Steve Simpson-Yap, Jeannette Lechner-Scott, Bruce Taylor
Summary: Limited studies have been conducted to identify and validate genetic loci associated with disability progression in multiple sclerosis (MS). This study aimed to identify MS genetic loci associated with worsening of disability and develop ensemble genetic learning models to predict future worsening. The researchers found 7 genetic loci associated with risk of disability worsening, most of which were related to peptide hormones and steroids biosynthesis pathways. The derived ensembles provided additional prognostic values and incorporated genetic information into clinical decision making for MS patients.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Cecily Q. Bernales, Mary Encarnacion, Maria G. Criscuoli, Irene M. Yee, Anthony L. Traboulsee, A. Dessa Sadovnick, Carles Vilarino-Gueell
Article
Clinical Neurology
Anthony L. Traboulsee, Lindsay Machan, J. Marc Girard, Jean Raymond, Reza Vosoughi, Brian W. Hardy, Francois Emond, Jean-Luc Gariepy, Jeffrey N. Bone, Gary Siskin, Darren Klass, Saul Isserow, Judy Illes, A. Dessa Sadovnick, David K. Li
Article
Radiology, Nuclear Medicine & Medical Imaging
Enedino Hernandez-Torres, Vanessa Wiggermann, Lindsay Machan, A. Dessa Sadovnick, David K. B. Li, Anthony Traboulsee, Simon Hametner, Alexander Rauscher
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2019)
Letter
Clinical Neurology
Carles Vilarino-Gueell, Mary Encarnacion, Cecily Q. Bernales, A. Dessa Sadovnick
MULTIPLE SCLEROSIS JOURNAL
(2019)
Article
Genetics & Heredity
Carles Vilarino-Guell, Alexander Zimprich, Filippo Martinelli-Boneschi, Bruno Herculano, Zhe Wang, Fuencisla Matesanz, Elena Urcelay, Koen Vandenbroeck, Laura Leyva, Denis Gris, Charbel Massaad, Jacqueline A. Quandt, Anthony L. Traboulsee, Mary Encarnacion, Cecily Q. Bernales, Jordan Follett, Irene M. Yee, Maria G. Criscuoli, Angela Deutschlander, Eva M. Reinthaler, Tobias Zrzavy, Elisabetta Mascia, Andrea Zauli, Federica Esposito, Antonio Alcina, Guillermo Izquierdo, Laura Espino-Paisan, Jorge Mena, Alfredo Antiguedad, Patricia Urbaneja-Romero, Jesus Ortega-Pinazo, Weihong Song, A. Dessa Sadovnick
Article
Biochemistry & Molecular Biology
Marjan Gharagozloo, Shaimaa Mahmoud, Camille Simard, Kenzo Yamamoto, Diwakar Bobbala, Subburaj Ilangumaran, Matthew D. Smith, Albert Lamontagne, Samir Jarjoura, Jean-Bernard Denault, Veronique Blais, Louis Gendron, Caries Vilarino-Guell, A. Dessa Sadovnick, Jenny P. Ting, Peter A. Calabresi, Abdelaziz Amrani, Denis Gris
Article
Clinical Neurology
A. Dessa Sadovnick, Robert Carruthers, Maria Houtchens, Alice Schabas, Penelope Smyth
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2020)
Editorial Material
Genetics & Heredity
Mary Encarnacion, Cecily Q. Bernales, Anthony L. Traboulsee, A. Dessa Sadovnick, Carles Vilarino-Guell
PHARMACOGENOMICS JOURNAL
(2019)
Article
Health Care Sciences & Services
M. Ploughman, M. B. Downer, R. W. Pretty, E. M. Wallack, S. Amirkhanian, M. C. Kirkland
QUALITY OF LIFE RESEARCH
(2020)
Article
Genetics & Heredity
Lisa F. Popplewell, Mary Encarnacion, Cecily Q. Bernales, A. Dessa Sadovnick, Anthony L. Traboulsee, Jacqueline A. Quandt, Carles Vilarino-Guell
Article
Clinical Neurology
A. Dessa Sadovnick, Irene M. Yee, Maria Criscuoli, Gabriele C. DeLuca
Summary: The study evaluated the impact of temporal increase of female to male sex ratio on the familial risk for individuals with multiple sclerosis. Genetic sharing and environmental factors were found to both play important roles in determining familial risk. An increase in MS risk due to environmental factors was observed over time, particularly for sisters/brothers of female probands.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Kristen M. Krysko, Annika Anderson, Jessica Singh, Kira McPolin, Alice Rutatangwa, William Rowles, A. Dessa Sadovnick, Maria K. Houtchens, Riley Bove
Summary: The prevalence of peripartum depression in women with multiple sclerosis appears to be similar to the general population, with factors such as older age, primiparity, pre-pregnancy depression, sleep disturbance, and breastfeeding difficulty associated with higher risk. Prospective studies are needed to further explore the impact of peripartum depression on self-management in multiple sclerosis and offspring development.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Dessa Sadovnick, Maria Criscuoli, Irene Yee, Robert Carruthers, Alice Schabas, Virginia Devonshire, Penelope Smyth
Summary: This study found that women with multiple sclerosis (MS) do not have a higher risk of first-trimester miscarriages compared to the general population.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Bridget LaMonica Ostrem, Annika Anderson, Sarah Conway, Brian C. Healy, Jiwon Oh, Dina Jacobs, Ruth Dobson, Edith Larmon Graham, A. Dessa Sadovnick, Vanessa Zimmerman, Yanqing Liu, Riley Bove, Maria Houtchens
Summary: Moderately to severely disabled women with MS have a lower risk of relapse during pregnancy, but a significant increase postpartum. Women with higher preconception EDSS have a greater risk of relapses and disability worsening postpartum.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2022)
Article
Clinical Neurology
Dessa Sadovnick, Maria Criscuoli, Irene Yee, Robert Carruthers, Alice Schabas, Penelope Smyth
Summary: This prospective real world study aims to gain insight into the various paths to conception that women with MS take, including the use of assisted reproductive technologies and decisions regarding disease modifying therapy. The study highlights the lack of international consensus on managing these women and the importance of providing real world data through studies like CANPREG-MS.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2021)
