Review
Cell Biology
Xue Wu, Meng Sun, Zhi Yang, Chenxi Lu, Qiang Wang, Haiying Wang, Chao Deng, Yonglin Liu, Yang Yang
Summary: The article discusses the role of chemokines in inflammatory responses and the importance of CCR9 and its ligand CCL25 in regulating diseases, emphasizing their pivotal roles in inflammation-related diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Hematology
Akshay Sharma, Alexis Leonard, Kamille West, Jeffrey M. Gossett, Naoya Uchida, Sandhya Panch, David Stroncek, Leigh Poston, Salem Akel, Jane S. Hankins, Courtney Fitzhugh, Matthew M. Hsieh, Guolian Kang, John F. Tisdale, Mitchell J. Weiss, Yan Zheng
Summary: We adjusted the collection strategy for haematopoietic stem and progenitor cells from patients with sickle cell disease, resulting in improved collection efficiency. However, this modification also led to an increase in red blood cell contamination of the collected cells.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Biophysics
Nina Worel, Andreas Holbro, Hans Vrielink, Claudia Ootjers, Kaatje Le Poole, Ingrid Beer-Wekking, Tuula Rintala, Miquel Lozano, Halvard Bonig
Summary: Autologous CAR-T cells offer significant benefits for refractory malignancies. Hospitals not previously involved in immune effector cell therapy will need to develop capacity and expertise to integrate CAR-T cells. The GoCART Coalition aims to disseminate knowledge and skills, standardize management and documentation, and benchmark clinical results of CAR-T cell recipients. This guide provides initial suggestions for apheresis readiness and starting material collection, but comprehensive training is necessary for compliance with regulations and assessment of cellular composition and safety.
BONE MARROW TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Juan Hernandez, Elodie Rouille, Florian Chocteau, Marie Allard, Karine Haurogne, Florence Lezin, Julie M. Herve, Jean-Marie Bach, Jerome Abadie, Blandine Lieubeau
Summary: The study revealed that dogs with inflammatory bowel disease (IBD) exhibited varying degrees of clinical disease, with no significant histopathological alterations in gut tissues compared to controls except in the colon. Dogs with IBD had decreased CD3(+) T lymphocyte numbers in the ileum and colon, while other cell populations were similar between the two groups. The levels of certain chemokines in the mucosa were affected by the disease to a limited extent.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Medicine, General & Internal
Farah Yasmin, Hala Najeeb, Unaiza Naeem, Abdul Moeed, Thoyaja Koritala, Salim Surani
Summary: Inflammatory Bowel Disease (IBD) is characterized by leukocyte infiltration and the release of cytokines. Current pharmacological therapies have limited efficacy, and new interventions such as selective granulocyte-monocyte-apheresis (GMA) and leukocytapheresis (LCAP) are emerging as non-pharmacological treatment options that reduce mortality.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Immunology
Guojiu Fang, Fanzhi Kong, Haiqing Zhang, Bin Huang, Jifa Zhang, Xueli Zhang
Summary: Mendelian randomization (MR) analysis revealed that IL-16, IL-18, and CXCL10 are positively associated with inflammatory bowel disease (IBD), while IL-12p70 and CCL23 are negatively associated with IBD. IL-16 and IL-18 may increase the risk of ulcerative colitis (UC), and CXCL10 may increase the risk of Crohn's disease (CD). However, there is no evidence to support a causal relationship between IBD and its main subtypes (UC and CD) with the levels of ILs and chemokines. Sensitivity analyses showed robust results without heterogeneity and pleiotropy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wei Gao, Yufen Wang, Jian Bi, Xiuli Chen, Na Li, Yingde Wang, Haiying Tang, Jingwei Mao
Summary: The abnormal crosstalk between gut immune system and liver in nonalcoholic steatohepatitis (NASH) may be related to the changes in the numbers and activity of CD4+ T cells and DC subsets. This imbalance in gut immunity in NASH could be due to impaired gut chemokine receptor 9 (CCR9)/chemokine ligand 25 (CCL25) signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Jingyuan Li, Jamal Muhammad, Tian Xie, Jiaxing Sun, Yufei Lei, Zimeng Wei, Shan Pan, Hong Qin, Liang Shao, Daozi Jiang, Qiuping Zhang
Summary: This study identified a negative correlation between LINC00853 and CCR9 expression in T-ALL, with LINC00853 suppressing cell migration and invasion by regulating the CCR9/CCL25 pathway.
MOLECULAR IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Liang Ding, Wenjing Zhou, Jian Zhang, Qingsong Tang, Weizhang Xiao, Ming Chen, Zhenya Shen, Weiqian Chen
Summary: Uncontrolled inflammation can cause sepsis-associated immune disorders, and EVs can be used as drug carriers to target inflammatory monocytes for treatment, showing potential clinical significance.
Review
Gastroenterology & Hepatology
Giorgos Bamias, Evanthia Zampeli, Eugeni Domenech
Summary: Inflammatory bowel disease (IBD) is a chronic immune-mediated disease that includes Crohn's disease (CD) and ulcerative colitis (UC). This article provides an overview of the immunological aspects, pharmacological management, and biomarkers of IBD. Adsorptive granulocyte and monocyte apheresis (GMA) with Adacolumn can effectively treat UC and has secondary immune effects. Fecal calprotectin concentrations, neutrophil counts in histological samples, and the neutrophil/lymphocyte ratio in peripheral blood may serve as useful biomarkers for predicting GMA effectiveness in the future.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Rocio Rivera Rodriguez, Jeremy James Johnson
Summary: Inflammatory Bowel Disease (IBD) is a chronic autoimmune disease characterized by intestinal inflammation. The incidence of IBD is rapidly increasing in newly developed countries, making it a global concern. Two major types of IBD, ulcerative colitis (UC) and Crohn's disease (CD), have different manifestations and locations of inflammation in the digestive tract. Current FDA-approved treatments for IBD are only effective for 50% of patients and come with serious side effects, highlighting the need for safer and more effective therapies. Plant-based diets, such as the Mediterranean diet rich in anti-inflammatory phytochemicals, have shown benefits in preventing and improving symptoms of IBD. Terpenes, a class of phytochemicals abundant in Mediterranean herbs and citrus fruits, have been studied for their potential to modulate inflammatory signaling in IBD. However, there is still conflicting and inconclusive evidence regarding their effectiveness. This review evaluates preclinical studies on terpenes and their impact on basic inflammatory signaling in IBD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
Songling Chai, Zhihao Wen, Rongxin Zhang, Yuwen Bai, Jing Liu, Juanjuan Li, Wenyao Kongling, Weixian Chen, Fu Wang, Lu Gao
Summary: The interaction between CCR9 and its ligand CCL25 promotes tumor growth and metastasis in salivary adenoid cystic carcinoma (SACC) through activating the PI3K/AKT signaling pathway.
Article
Oncology
Hang Yu, Ying Mei, Yang Dong, Chao Chen, Xianke Lin, Hailong Jin, Jiren Yu, Xiaosun Liu
Summary: The study aimed to investigate the role of CCR9-CCL25 interaction in the pDC-mediated immunosuppressive microenvironment of gastric cancer. The results showed that the expression of CCR9+CCL25 increased in gastric cancer tissue, and more CCR9+ pDCs were found in metastatic lymph nodes and carcinoma tissue, which were associated with advanced T staging and lymph node metastasis and conferred a poor prognosis. Therefore, CCR9-CCL25 interaction may play an important role in guiding pDCs to metastatic lymph nodes and carcinoma tissue, contributing to the formation of tumor immunosuppressive microenvironment and leading to a worse prognosis.
TRANSLATIONAL ONCOLOGY
(2023)
Review
Chemistry, Medicinal
Dandan Liu, Varma Saikam, Katie A. Skrada, Didier Merlin, Suri S. Iyer
Summary: Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract, which can be diagnosed through endoscopy and biopsy. However, these methods are expensive and invasive, so alternative noninvasive biomarkers are being explored for disease management and prognosis.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Gastroenterology & Hepatology
Anna M. Buchner, Yecheskel Schneider, Gary R. Lichtenstein
Summary: Biological therapy targeting tumor necrosis factor-alpha has become crucial in treating patients with inflammatory bowel disease, but high costs limit accessibility. Biosimilars offer the potential to reduce expenditures and increase availability, providing more options for patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Ciputra Adijaya Hartana, Emma Ahlen Bergman, A. Ali Zirakzadeh, David Krantz, Malin E. Winerdal, Max Winerdal, Markus Johansson, Farhood Alamdari, Tomasz Jakubczyk, Hans Glise, Katrine Riklund, Amir Sherif, Ola Winqvist
Article
Oncology
Malin E. Winerdal, David Krantz, Ciputra A. Hartana, Ali A. Zirakzadeh, Ludvig Linton, Emma A. Bergman, Robert Rosenblatt, Janos Vasko, Farhood Alamdari, Johan Hansson, Benny Holmstrom, Markus Johansson, Max Winerdal, Per Marits, Amir Sherif, Ola Winqvist
CANCER IMMUNOLOGY RESEARCH
(2018)
Article
Oncology
Emma Ahlen Bergman, Ciputra Adijaya Hartana, Markus Johansson, Ludvig B. Linton, Sofia Berglund, Martin Hyllienmark, Christian Lundgren, Benny Holmstrom, Karin Palmqvist, Johan Hansson, Farhood Alamdari, Ylva Huge, Firas Aljabery, Katrine Riklund, Malin E. Winerdal, David Krantz, A. Ali Zirakzadeh, Per Marits, Louise K. Sjoholm, Amir Sherif, Ola Winqvist
CLINICAL EPIGENETICS
(2018)
Article
Allergy
Sandra Hellberg, Ratnesh B. Mehta, Anna Forsberg, Goran Berg, Jan Brynhildsen, Ola Winqvist, Maria C. Jenmalm, Jan Ernerudh
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Immunology
Kurt Arkestal, Michael Mints, Anders Enocson, Ludvig Linton, Per Marits, Hans Glise, John Andersson, Ola Winqvist
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2018)
Article
Urology & Nephrology
Lu Zhang, Jin Hu, A. Ali Zirakzadeh, Jesper Rosvall, Mats Hedlund, Ping Sheng Hu, Robert P. A. Wallin, Amir Sherif, Ola Winqvist
Article
Allergy
Julia Arebro, Cecilia Drakskog, Ola Winqvist, Claus Bachert, Susanna Kumlien Georen, Lars-Olaf Cardell
Article
Hematology
Julien Record, Anton Sendel, Joanna S. Kritikou, Nikolai Kuznetsov, Hanna Brauner, Minghui He, Noemi Nagy, Mariana M. S. Oliveira, Elena Griseti, Christoph B. Haase, Jenny Dahlstrom, Sanjaykumar Boddul, Fredrik Wermeling, Adrian J. Thrasher, Chaohong Liu, John Andersson, Hans-Erik Claesson, Ola Winqvist, Siobhan O. Burns, Magnus Bjorkholm, Lisa S. Westerberg
Article
Urology & Nephrology
Julia Alvaeus, Robert Rosenblatt, Markus Johansson, Farhood Alamdari, Tomasz Jakubczyk, Benny Holmstrom, Tammer Hemdan, Ylva Huge, Firas Aljabery, Susanne Gabrielsson, Katrine Riklund, Ola Winqvist, Amir Sherif
WORLD JOURNAL OF UROLOGY
(2020)
Article
Immunology
Zenib Aljadi, Frida Kalm, Caroline Nilsson, Ola Winqvist, Aman Russom, Joachim Lundahl, Anna Nopp
CLINICAL IMMUNOLOGY
(2019)
Article
Immunology
A. Ali Zirakzadeh, Amir Sherif, Robert Rosenblatt, Emma Ahlen Bergman, Max Winerdal, David Yang, Johanna Cederwall, Vivianne Jakobsson, Martin Hyllienmark, Ola Winqvist, Per Marits
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Urology & Nephrology
Robert Rosenblatt, Gabriella Lorentzi, Maryam Bahar, Danna Asad, Ramona Forsman, Markus Johansson, Marwan Shareef, Farhood Alamdari, Anders Bergh, Ola Winqvist, Amir Sherif
SCANDINAVIAN JOURNAL OF UROLOGY
(2020)
Article
Multidisciplinary Sciences
Stefanie Hiltbrunner, Michael Mints, Maria Eldh, Robert Rosenblatt, Benny Holmstrom, Farhood Alamdari, Markus Johansson, Rosanne E. Veerman, Ola Winqvist, Amir Sherif, Susanne Gabrielsson
SCIENTIFIC REPORTS
(2020)
Article
Immunology
A. Oras, B. Quirant-Sanchez, D. Popadic, S. Thunberg, O. Winqvist, S. Heck, M. Cwikowski, D. Riemann, B. Seliger, E. Martinez Caceres, R. Uibo, T. Giese
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2020)
Article
Immunology
David Krantz, Michael Mints, Malin Winerdal, Katrine Riklund, Dorothea Rutishauser, Roman Zubarev, Amir Ali Zirakhzadeh, Farhood Alamdari, Markus Johansson, Amir Sherif, Ola Winqvist
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2020)