期刊
CLINICAL IMMUNOLOGY
卷 139, 期 2, 页码 177-184出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2011.01.014
关键词
Behcet's disease; Vogt-Koyanagi-Harada disease; HLA-B27; Uveitis; Cytokines
类别
资金
- FWO-Vlaanderen, Brussels, Belgium
- Regional Government of Flanders
We assayed aqueous humor (AH) samples from patients with Behcet's disease (BD), Vogt Koyanagi Harada (VKH) disease, and HLA-B27-associated uveitis and control patients for the proinflammatory cytokines IL-15, IL-17, interferon-gamma and tumor necrosis factor-alpha and the immunosuppressive cytokine IL-10. Cytokine levels were significantly higher in the three disease groups than in controls. In patients with similar disease activity, levels of IL-15 and IFN-gamma were significantly higher in BD patients than in VKH and HLA-B27-associated uveitis groups. Logistic regression identified a significant negative correlation between BD and high levels of IL-10 and a significant positive correlation between VKH disease and high levels of IL-10. The proinflammatory cytokines versus IL-10 ratios were significantly higher in BD compared with other groups. These data suggest that both T helper (Th) 1 and Th17 cells are involved in endogenous uveitis immunopathogenesis. BD is characterized by extensive Th1 polarization, severe proinflammatory conditions and a low immunosuppressive status. (C) 2011 Elsevier Inc. All rights reserved.
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