Review
Oncology
Clara Le Fevre, Jean-Marc Constans, Isabelle Chambrelant, Delphine Antoni, Caroline Bund, Benjamin Leroy-Freschini, Roland Schott, Helene Cebula, Georges Noel
Summary: This review presents various imaging techniques and potential imaging biomarkers to differentiate pseudoprogression from true progression, improving diagnostic accuracy.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Oncology
Ingrid Sidibe, Fatima Tensaouti, Julia Gilhodes, Bastien Cabarrou, Thomas Filleron, Franck Desmoulin, Soleakhena Ken, Georges Noel, Gilles Truc, Marie Pierre Sunyach, Marie Charissoux, Nicolas Magne, Jean -Albert Lotterie, Margaux Roques, Patrice Peran, Elizabeth Cohen-Jonathan Moyal, Anne Laprie
Summary: This study investigates the feasibility of using a multiapproach analysis to distinguish true tumor progression (TP) from pseudoprogression (PSP) in glioblastoma patients. The results suggest that three spectroscopic ratios can differentiate PSP from TP, and tumor volume at relapse is the most predictive factor in the multivariate analysis. Patients with PSP have a higher overall survival compared to TP patients.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Aliya Anil, Ashley M. Stokes, Renee Chao, Leland S. Hu, Lea Alhilali, John P. Karis, Laura C. Bell, C. Chad Quarles
Summary: In this study, the optimal standardized rCBV threshold for the single-dose, dual-echo protocol was determined to generate FTB maps that match those derived from the reference standard, double-dose, single-echo protocol. The results showed a strong correlation between the mean tumor sRCBV values obtained from the two protocols. The study also demonstrated that dual-echo DSC-MRI acquisitions enable robust single-dose sRCBV and FTB mapping, providing pulse sequence parameter flexibility.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Mohammadreza Alizadeh, Nima Broomand Lomer, Mobin Azami, Mohammad Khalafi, Parnian Shobeiri, Melika Arab Bafrani, Houman Sotoudeh
Summary: Radiomics, a promising tool that extracts features from medical images, can help differentiate the progression, recurrence, pseudoprogression, and radionecrosis of glioma and glioblastoma multiforme (GBM). It can significantly impact patient care and post-treatment follow-ups.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dan Liao, Yuan-Cheng Liu, Jiang-Yong Liu, Di Wang, Xin-Feng Liu
Summary: This study aimed to investigate the diagnostic performance of different parameters derived from diffusion-weighted imaging (DWI) models in differentiating tumour progression from pseudoprogression in glioblastoma patients. The results showed that multi-b DWI is a promising method for differentiating tumour progression from pseudoprogression with high diagnostic accuracy. The parameter "a" derived from the stretched-exponential model is the most promising DWI parameter for the prediction of tumour progression in glioblastoma patients.
BMC MEDICAL IMAGING
(2023)
Review
Biochemistry & Molecular Biology
Ingrid Sidibe, Fatima Tensaouti, Margaux Roques, Elizabeth Cohen-Jonathan-Moyal, Anne Laprie
Summary: Glioblastoma is the most frequent malignant primitive brain tumor in adults. Advanced magnetic resonance imaging techniques and radiomics analysis can help differentiate pseudoprogression from true progression, and provide predictive models for diagnosis, prognosis, and therapeutic response.
Article
Oncology
Jing Xi, Bilal Hassan, Ruth G. N. Katumba, Karam Khaddour, Akshay Govindan, Jingqin Luo, Jiayi Huang, Jian L. Campian
Summary: This study suggests that ALC levels before or after treatment do not predict true disease progression or pseudoprogression in GBM patients. Patients with true progression had worse overall survival compared to those with pseudoprogression. A larger sample size including CD4 cell counts may be needed to evaluate the predictive value of peripheral blood biomarkers for pseudoprogression.
Review
Clinical Neurology
Jacob S. Young, Nadeem Al-Adli, Katie Scotford, Soonmee Cha, Mitchel S. Berger
Summary: Managing patients with glioblastoma requires a combination of standard therapies and innovative immunotherapies, but assessment becomes more complex with advanced MRI techniques. Identifying pseudoprogression is critical for successful patient management.
JOURNAL OF NEUROSURGERY
(2023)
Review
Oncology
Clara Le Fevre, Benoit Lhermitte, Guido Ahle, Isabelle Chambrelant, Helene Cebula, Delphine Antoni, Audrey Keller, Roland Schott, Alicia Thiery, Jean-Marc Constans, Georges Noel
Summary: This paper highlights the differentiation of pseudoprogression from true progression in glioblastoma patients through clinical and pathological markers, aiming to help guide appropriate disease management based on accurate diagnosis.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Oncology
Ji Eun Park, Ho Sung Kim, NakYoung Kim, Seo Young Park, Young-Hoon Kim, Jeong Hoon Kim
Summary: Three distinct spatial habitats based on multiparametric physiologic MRIs were identified to predict survival rates in patients with posttreatment glioblastoma. Short-term increases in hypervascular cellular habitat and hypovascular cellular habitat were significantly associated with shorter progression-free survival (PFS) after concurrent chemoradiotherapy (CCRT). Combining with clinical predictors, habitat risk score showed good predictive performance for PFS and overall survival (OS), stratifying patients into different PFS groups.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Riccardo Leone, Hagen Meredig, Martha Foltyn-Dumitru, Felix Sahm, Stefan Hamelmann, Felix Kurz, Tobias Kessler, David Bonekamp, Heinz-Peter Schlemmer, Mikkel Bo Hansen, Wolfgang Wick, Martin Bendszus, Philipp Vollmuth, Gianluca Brugnara
Summary: In this study, machine-learning and deep-learning models were used to differentiate pseudoprogression from true tumor progression by combining clinical data, MGMT methylation status, and radiomic features. The results showed that currently available imaging biomarkers could not reliably differentiate pseudoprogression from true tumor progression, and further collaborative efforts are needed to build more reliable models.
NEURO-ONCOLOGY ADVANCES
(2023)
Article
Oncology
Friederike Hesse, Alan J. Wright, Vencel Somai, Flaviu Bulat, Felix Kreis, Kevin M. Brindle
Summary: The study demonstrates that detecting fumarate metabolism using H-2 MRI can early identify tumor cell death in glioblastoma following chemoradiation, potentially improving the clinical evaluation of treatment response.
Article
Clinical Neurology
F. Kuo, N. N. Ng, S. Nagpal, E. L. Pollom, S. Soltys, M. Hayden-Gephart, G. Li, D. E. Born, M. Iv
Summary: This study aimed to differentiate between tumor and radiation necrosis in brain metastases patients treated with stereotactic radiosurgery using MR perfusion and metabolic metrics. The results showed that relative CBV and high fractional tumor burden were the best indicators for distinguishing between tumor and radiation necrosis.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Oncology
Mana Moassefi, Shahriar Faghani, Gian Marco Conte, Roman O. Kowalchuk, Sanaz Vahdati, David J. Crompton, Carlos Perez-Vega, Ricardo A. Domingo Cabreja, Sujay A. Vora, Alfredo Quinones-Hinojosa, Ian F. Parney, Daniel M. Trifiletti, Bradley J. Erickson
Summary: This study developed a deep learning model that successfully distinguished pseudoprogression (PsP) from true progression (TP) in patients with glioblastoma (GBM). The model achieved high accuracy, AUROCC, sensitivity, and specificity.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Laiz Laura de Godoy, Suyash Mohan, Sumei Wang, MacLean P. Nasrallah, Yu Sakai, Donald M. O'Rourke, Stephen Bagley, Arati Desai, Laurie A. Loevner, Harish Poptani, Sanjeev Chawla
Summary: In this study, the researchers validated a multiparametric MRI model to differentiate pseudoprogression from tumor progression in glioblastoma patients. The model accurately identified pseudoprogression in 95% of cases and had an overall concordance rate of 70% with histopathology/mRANO criteria. The findings suggest that the MRI model may be helpful in clinical management and prognostication of GBM patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Yoshie Umemura, Diane Wang, Kyung K. Peck, Jessica Flynn, Zhigang Zhang, Robin Fatovic, Erik S. Anderson, Kathryn Beal, Alexander N. Shoushtari, Thomas Kaley, Robert J. Young
JOURNAL OF NEURO-ONCOLOGY
(2020)
Review
Clinical Neurology
Alipi V. Bonm, Reed Ritterbusch, Patrick Throckmorton, Jerome J. Graber
JOURNAL OF NEUROIMAGING
(2020)
Letter
Oncology
Jerome J. Graber, Benjamin Plato, Raya Mawad, Daniel J. Moore
LEUKEMIA & LYMPHOMA
(2020)
Article
Clinical Neurology
Nathaniel Swinburne, Eve LoCastro, Ramesh Paudyal, Jung Hun Oh, Neil K. Taunk, Akash Shah, Kathryn Beal, Behroze Vachha, Robert J. Young, Andrei Holodny, Amita Shukla-Dave, Vaios Hatzoglou
FRONTIERS IN NEUROLOGY
(2020)
Article
Otorhinolaryngology
Stephanie Flukes, Shivangi Lohia, Christopher A. Barker, Jennifer R. Cracchiolo, Ian Ganly, Snehal G. Patel, Benjamin R. Roman, Jatin P. Shah, Alexander N. Shoushtari, Viviane Tabar, Akash Shah, Marc A. Cohen
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2020)
Review
Clinical Neurology
Boryana M. Eastman, Vyshak A. Venur, Simon S. Lo, Jerome J. Graber
JOURNAL OF NEUROSURGICAL SCIENCES
(2020)
Article
Clinical Neurology
Mehrnaz Jenabi, Robert J. Young, Raquel Moreno, Madeleine Gene, Nicholas Cho, Ricardo Otazo, Andrei I. Holodny, Kyung K. Peck
Summary: This study demonstrated the clinical potential and significant advantages of preoperative mb-DTI in brain tumor patients, with improved fiber FA and lower MD in whole brain and tumor regions, as well as slightly better tractography results compared to s-DTI.
JOURNAL OF NEUROIMAGING
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Simone Krebs, Christian Grommes, Michael R. McDevitt, Sean D. Carlin, Joseph A. O'Donoghue, Maya S. Graham, Robert J. Young, Heiko Schoder, Philip H. Gutin, Neil H. Bander, Joseph R. Osborne
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Correction
Radiology, Nuclear Medicine & Medical Imaging
Simone Krebs, Christian Grommes, Michael R. McDevitt, Sean D. Carlin, Joseph A. O'Donoghue, Maya S. Graham, Robert J. Young, Heiko Schoeder, Philip H. Gutin, Neil H. Bander, Joseph R. Osborne
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Oncology
Jonathan T. Yang, N. Ari Wijetunga, Elena Pentsova, Suzanne Wolden, Robert J. Young, Denise Correa, Zhigang Zhang, Junting Zheng, Alexa Steckler, Weronika Bucwinska, Ashley Bernstein, Allison Betof Warner, Helena Yu, Mark G. Kris, Andrew D. Seidman, Jessica A. Wilcox, Rachna Malani, Andrew Lin, Lisa M. DeAngelis, Nancy Y. Lee, Simon N. Powell, Adrienne Boire
Summary: Compared with photon IFRT, proton craniospinal irradiation (pCSI) improved CNS progression-free survival (PFS) and overall survival (OS) for patients with non-small-cell lung cancer and breast cancer with leptomeningeal metastasis (LM), with no increase in serious treatment-related adverse events (TAEs).
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Brandon S. Imber, Robert J. Young, Kathryn Beal, Anne S. Reiner, Alexandra M. Giantini-Larsen, Jonathan T. Yang, David Aramburu-Nunez, Gil'ad N. Cohen, Cameron Brennan, Viviane Tabar, Nelson S. Moss
Summary: Salvage resection plus Cs131 brachytherapy may be a potential option for recurrent previously irradiated brain metastases, offering improved local control and toxicity profiles.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Correction
Oncology
Brandon S. Imber, Robert J. Young, Kathryn Beal, Anne S. Reiner, Alexandra M. Giantini-Larsen, Simone Krebs, Jonathan T. Yang, David Aramburu-Nunez, Gil'ad N. Cohen, Cameron Brennan, Viviane Tabar, Nelson S. Moss
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nathaniel Swinburne, Vivek Yadav, Krishna Nand Keshava Murthy, Pierre Elnajjar, Hao-Hsin Shih, Prashanth Kumar Panyam, Alice Santilli, David Gutman, Luke Pike, Nelson Moss, Jacqueline Stone, Vaios Hatzoglou, Akash Shah, Krishna Juluru, Sohrab Shah, Andrei Holodny, Robert Young
Summary: This study investigates the development of brain MRI tumor segmentation models using data mined line annotations. The results show that training models with pseudo-masks generated from line annotations and unsupervised segmentation, combined with semi-supervised learning for self-refinement, can produce accurate tumor segmentation models. The hybrid inference method combining full-image segmentation with detection plus image patch segmentation outperforms full image segmentation alone.
EUROPEAN RADIOLOGY
(2023)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
F. Tixier, P. Klages, S. Riyahi, J. Jiang, H. Um, N. Tyagi, R. Young, H. Veeraraghavan
Article
Oncology
Robin Guo, Mark Schreyer, Jason C. Chang, S. Michael Rothenberg, Dahlia Henry, Paolo Cotzia, Mark G. Kris, Natasha Rekhtman, Robert J. Young, David M. Hyman, Alexander Drilon
JCO PRECISION ONCOLOGY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Apurva A. Bonde, Mayur Virarkar, Mohd Zahid, Sriram Jaganathan, Manuel J. Menendez, Luis Calimano, Bryan R. Foster, Danielle Fritze, Courtney L. Thomas, Pankaj Gupta
Summary: This article describes the common and uncommon appearances of gallbladder adenomyomatosis on multimodality imaging, helping differentiate it from non-benign gallbladder abnormalities, and providing important clinical and surgical management information.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Dheeman Futela, Suryansh Bajaj, Mihir Khunte, Xiao Wu, Seyedmehdi Payabvash, Dheeraj Gandhi, Ajay Malhotra
Article
Radiology, Nuclear Medicine & Medical Imaging
Renhui Cai, Juan Xu, Chaoqun Yan, Jie Wang, L. I. Wang, Leizhi Ku, Di Zhou, L. I. Zhu, Chunli He, Xinxiang Zhao, Xiaojing Ma
Summary: This paper analyzes the correlation between imaging features and ECG features in patients with coronary artery fistula (CAF). The study finds significant differences in ECG characteristics between coronary-cameral fistula (CCF) and coronary-pulmonary artery fistula (CPAF). Surgical treatment can improve ECG findings in some patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jordan Bozer, Kevin Peng, Melissa Magyer, Marilyn Niedermeier, Mina S. Makary
Summary: This study aimed to examine the impact of an educational website on patient understanding of Interventional Radiology (IR). The results showed that the use of an educational website can effectively improve patients' understanding of IR and familiarity with common interventional procedures.
Article
Radiology, Nuclear Medicine & Medical Imaging
Siavash Zamirpour, Marko T. Boskovski, James P. Pirruccello, William A. Pace, Alan E. Hubbard, Joseph R. Leach, Liang Ge, Elaine E. Tseng
Summary: This study evaluated sex-specific temporal changes in aortic size and sex differences in aortic reporting. The results showed that women had significantly higher aortic growth rates compared to men, and aortic dimensions were much less frequently reported in women than men.
Article
Radiology, Nuclear Medicine & Medical Imaging
Monica Miranda-Schaeubinger, Hermon Miliard Derbew, Alexandra Ramirez, Maretta Smith, Mohammad Jalloul, Savvas Andronikou, Hansel J. Otero
Summary: The prevalence of abnormal chest radiographs in patients with positive purified protein derivative (PPD) test was very low in a tertiary pediatric center in the United States. No cases of severe disease were identified, and patients with abnormal findings did not require a change in treatment according to current WHO guidelines.
Article
Radiology, Nuclear Medicine & Medical Imaging
A. Sailer, K. Fitzgerald, J. F. B. Chick, D. S. Shin, E. J. Monroe
Summary: This manuscript describes an approach to successful common femoral arterial access and arteriography in infants, highlighting common pearls and pitfalls.
Article
Radiology, Nuclear Medicine & Medical Imaging
Apurva Bonde, Alice W. Fung, Skye C. Mayo, Peter Li, Brett S. Walker, Sriram Jaganathan, Nadine Mallak, Elena K. Korngold
Summary: Hepatic arterial infusion pumps allow selective administration of chemotherapy to the liver, maximizing its effects while minimizing systemic toxicity. Radiologists play a crucial role in pre-operative planning, treatment response assessment, and evaluation of potential complications. This article aims to familiarize radiologists with various aspects of HAI pumps.
Article
Radiology, Nuclear Medicine & Medical Imaging
Huseyin Bilgin, Ercan Ayaz
Summary: By examining radiographs of children with mucopolysaccharidosis, early diagnosis can be achieved before clinical symptoms become prominent. Therefore, X-ray screening of children in endemic regions of mucopolysaccharidosis is feasible.
