期刊
CLINICAL GENITOURINARY CANCER
卷 7, 期 1, 页码 39-42出版社
CIG MEDIA GROUP, LP
DOI: 10.3816/CGC.2009.n.007
关键词
c-Met pathway inhibitors; Leukopenia; Neutropenia; Non-clear-cell carcinoma
Background: Cytotoxic chemotherapy has not been well investigated in non-clear-cell renal cell carcinoma (RCC). A phase II study was thus conducted to assess the efficacy of carboplatin and paclitaxel in such patients. Patients and Methods: Patients were treated with carboplatin (area under the curve of 6) and paclitaxel 225 mg/m(2) every 21 days and assessed for measurable disease response every 2 cycles. An initial 20 patients were planned to be enrolled to rule out a null hypothesized 15% response rate. Results: Seventeen patients were enrolled, of which 16 patients had papillary and 1 had collecting duct histology. The patient with collecting duct histology had a complete response, but no responses were observed in patients with papillary histology and the trial was thus terminated early. Toxicities were as expected for the carboplatin and paclitaxel regimen. Conclusion: Carboplatin and paclitaxel is not an active regimen in patients with metastatic papillary RCC. Future studies should explore the role of this or similar regimens in collecting duct carcinoma.
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