期刊
CLINICAL GENETICS
卷 78, 期 1, 页码 1-7出版社
WILEY
DOI: 10.1111/j.1399-0004.2010.01402.x
关键词
CHEK2; breast cancer
The 1100delC mutation of the CHEK2 gene was found to be a cause of breast cancer in 2002. The lifetime risk of breast cancer among women with a mutation and with a family history of breast cancer is approximately 25%. These women are good candidates for screening with MRI and for chemoprevention with tamoxifen. It is reasonable to test for this single mutation when women undergo testing for BRCA1 and BRCA2.
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