期刊
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
卷 52, 期 5, 页码 401-406出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10601325.2015.1018816
关键词
polymer micelle; glioblastoma; RGD; Daunorubicin; target delivery
资金
- National Key Technology RD Program [2012BAI29B05]
- National Natural Science Fund [81150015]
- Jilin Provincial Scientific and Technologic Development Project [20111809]
- Project of Technology Department of Jilin City [201233126, 201233120]
- Doctoral Science Foundation of Beihua University [5210235013081]
Daunorubicin (Dau) has been widely used in the treatment of many solid tumors. However, the side effects of Dau seriously hinder its further application in clinical use. How to increase the drug accumulation in tumors and reduce the damage to normal tissues is an urgent problem to be solved. In this study, we developed c(RGDfK) decorated PEG-PLA micelles for target delivery of Dau to C6 glioblastoma cells. The enhanced uptake of cRGD decorated micelles by C6 cells were observed via CLSM and flow cytometry experiments. Moreover, the cRGD decorated micelles showed more cytotoxicity to C6 cells than undecorated micelles ex vivo. Therefore, cRGD decorated micelles represent a promising approach in improving drug accumulation for treatment of glioblastoma.
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