期刊
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
卷 11, 期 4, 页码 444-447出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cgh.2012.10.020
关键词
ADA; IBD; Crohn's Disease; Ulcerative Colitis
资金
- Sheba Medical Center
- Legacy heritage foundation from the Rambam Health Care Center
- Janssen
There are few therapeutic options for patients with inflammatory bowel disease who lose response to infliximab because they produced antibodies against the drug. We performed a retrospective analysis to investigate whether administration of immune modulators to 5 patients who developed antibodies to infliximab (ATI) restored response to this drug; 3 patients were given azathioprine/6-mercaptopurine and 2 patients were given methotrexate. Concentrations of infliximab and ATIs, and antitumor necrosis factor (TNF) activity, were analyzed using enzyme-linked immunosorbent assay-based competition assays of serum samples collected before and after patients were given the immunomodulator. In all patients, levels of ATIs gradually decreased and trough levels of infliximab increased; clinical responses were restored to all patients. In competition assays, immunomodulator-induced elimination of ATIs was associated with increased anti-TNF activity in serum. The addition of immunomodulators to therapy might be helpful to patients who have lost response to anti-TNF agents owing to formation of antidrug antibodies.
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