Review
Gastroenterology & Hepatology
Baha Moshiree, Douglas Drossman, Aasma Shaukat
Summary: Belching, bloating, and abdominal distention are common gastrointestinal symptoms that significantly affect patients' quality of life. This article provides best practice advice for clinicians on how to differentiate, diagnose, and manage these symptoms using dietary, behavioral, and drug therapies. The importance of proper evaluation and testing to rule out other potential diseases is also emphasized.
Article
Gastroenterology & Hepatology
David Deutsch, Michel Bouchoucha, Julien Uzan, Jean-Jacques Raynaud, Jean-Marc Sabate, Robert Benamouzig
Summary: The severity of abdominal pain is associated with bloating severity in patients with functional bowel disorders, with differences in associations based on gender and specific phenotype. In female patients, severity of abdominal pain is negatively associated with age and positively associated with depression, constipation severity, and diarrhea severity. In male patients, severity of abdominal pain is associated with state anxiety, constipation severity, and diarrhea severity.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Nutrition & Dietetics
Seyedeh-Zeynab Hosseinian, Fahimeh Haghighatdoost, Parisa Hajihashemi, Peyman Adibi
Summary: The effects of gluten on dyspeptic symptoms were assessed through a systematic review and meta-analysis. The results showed that gluten challenge significantly worsened symptoms of bloating, early satiety, and epigastric pain, but had no effect on nausea. These findings indicate that restricting gluten intake may be effective in reducing dyspeptic symptoms.
Article
Gastroenterology & Hepatology
Christopher Ma, Siddharth Singh, Vipul Jairath, Gabriela Radulescu, Stephanie K. M. Ho, May Y. Choi
Summary: Food insecurity is prevalent among patients with celiac disease (CeD), negatively impacting the adoption of a gluten-free diet (GFD) and nutritional intake. Food insecure CeD patients tend to be younger, less educated, nonwhite, living in poverty, and less likely to adhere to a GFD.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Review
Nutrition & Dietetics
Tommaso Pessarelli, Andrea Sorge, Luca Elli, Andrea Costantino
Summary: This review summarizes the role of low-FODMAP diet and gluten-free diet in functional abdominal bloating and distension. Ingested food plays a key role in the pathophysiology of these disorders, and potential mechanisms of food-related symptoms are discussed. The review analyzes current literature on the efficacy of these diets and suggests that low-FODMAP diet may be effective for bloating, while more research is needed on the gluten-free diet.
FRONTIERS IN NUTRITION
(2022)
Review
Nutrition & Dietetics
Andrea Costantino, Gloria Maria Aversano, Giovanni Lasagni, Veronica Smania, Luisa Doneda, Maurizio Vecchi, Leda Roncoroni, Elide Anna Pastorello, Luca Elli
Summary: Many patients experience symptoms after wheat ingestion, which could be due to celiac disease, wheat allergy, or non-celiac wheat sensitivity. This review provides an algorithm for diagnosing the cause of symptoms and emphasizes the importance of a personalized approach and regular follow-up.
FRONTIERS IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Daniel R. Monaco, Brandon M. Sie, Thomas R. Nirschl, Audrey C. Knight, Hugh A. Sampson, Anna Nowak-Wegrzyn, Robert A. Wood, Robert G. Hamilton, Pamela A. Frischmeyer-Guerrerio, H. Benjamin Larman
Summary: Allergic reactions occur when IgE molecules are crosslinked by antigens. The AllerScan system identifies differences between wheat allergy and sensitivity, as well as a key wheat epitope that triggers dominant IgE responses in allergic patients.
NATURE COMMUNICATIONS
(2021)
Review
Food Science & Technology
Laryssa Rosa de Sousa Franckilin, Anna Clara Paiva Menezes Dos Santos, Flavio Eduardo Dias Araujo Freitas, Isabela Garbazza Vieira, Carlos Eduardo de Freitas Jorge, Daniela Godoy Neri, Maria Vitoria Cota de Abreu, Janaina Koenen Fonseca, Renato Guimaraes Loffi, Giselle Foureaux
Summary: Gluten, the most common protein in wheat, is associated with celiac disease, wheat allergy, and non-celiac gluten sensitivity. These disorders have similar clinical manifestations but differ in development pathways and diagnostic criteria. A gluten-free diet is the most effective treatment for celiac disease and may also lead to improvements in neuropathologies and the gut microbiome.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Immunology
Wenhui Fu, Chen Chen, Qiang Xie, Shimin Gu, Sha Tao, Wentong Xue
Summary: This study investigated the effects of Pediococcus acidilactici XZ31 on wheat-induced allergy. The results showed that P. acidilactici XZ31 attenuated allergic responses, regulated immune balance, and reduced gluten-specific IgE production. It also modulated gut microbiota and increased the abundance of beneficial bacteria. This research provides a new strategy for treating wheat allergy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Noe Ontiveros, Raul Emilio Real-Delor, Jose Antonio Mora-Melgem, Carlos Eduardo Beltran-Cardenas, Oscar Gerardo Figueroa-Salcido, Marcela de Jesus Vergara-Jimenez, Feliznando Isidro Cardenas-Torres, Lilian Karem Flores-Mendoza, Jesus Gilberto Aramburo-Galvez, Francisco Cabrera-Chavez
Summary: The study found that a significant number of Paraguayan adults suffer from gluten-related disorders, with a higher prevalence among women than men. Most individuals adhering to a gluten-free diet do so based on recommendations from healthcare professionals.
Review
Nutrition & Dietetics
Craig Friesen, Jennifer Colombo, Jennifer Schurman
Summary: Functional abdominal pain disorders (FAPDs) and food allergies are relatively common in children and adolescents, and share pathophysiologic processes including immune and psychological processes. Food antigens may trigger mast cell activation, while in FAPDs, aeroallergens appear to be more likely to cause symptoms.
Article
Medicine, General & Internal
Jessica Sjolund, Inger Kull, Anna Bergstrom, Jacob Jaras, Jonas F. Ludvigsson, Hans Tornblom, Magnus Simren, Ola Olen
Summary: The study found positive associations between childhood allergy-related diseases and adolescent AP-FGIDs, including IBS, suggesting shared pathophysiology among these disorders.
Review
Food Science & Technology
Kalekristos Yohannes Woldemariam, Juanli Yuan, Zhen Wan, Qinglin Yu, Yating Cao, Huijia Mao, Yingli Liu, Jing Wang, Hongyan Li, Baoguo Sun
Summary: Wheat mainly consists of gluten with 30% gliadin and 50% glutenin, which are associated with celiac disease. The challenge lies in discovering new gluten-based peptides with high affinity toward T-cells. The highly immunogenic 33-mer gliadin peptide is considered the main cause, so consistent data on different gluten peptides and their immunogenicity is urgently needed.
FOOD REVIEWS INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Fernando Fernandez-Banares, Beatriz Arau, Agnes Raga, Montserrat Aceituno, Eva Tristan, Anna Carrasco, Laura Ruiz, Albert Martin-Cardona, Pablo Ruiz-Ramirez, Maria Esteve
Summary: This study showed that a gluten-free diet is effective in treating patients with FBD, especially in those with a positive low-grade coeliac score and coeliac lymphogram.
Review
Gastroenterology & Hepatology
Vivek C. Goodoory, Mais Khasawneh, Christopher J. Black, Eamonn M. M. Quigley, Paul Moayyedi, Alexander C. Ford
Summary: This article conducted a meta-analysis to study the efficacy of probiotics in the treatment of irritable bowel syndrome (IBS). The study found that certain combinations of probiotics or strains may be beneficial for IBS, but the certainty of the evidence was low.
Review
Gastroenterology & Hepatology
Brigida Barberio, David J. Gracie, Christopher J. Black, Alexander C. Ford
Summary: This study conducted a network meta-analysis to compare the relative efficacy of various biological therapies and small molecules in the treatment of luminal Crohn's disease. The results showed differences in the effectiveness of different drugs in inducing and maintaining clinical remission, and previous exposure to biologics also had an impact on treatment outcomes.
Letter
Gastroenterology & Hepatology
Conchubhair Winters, Alexander Charles Ford
Review
Gastroenterology & Hepatology
Brigida Barberio, Pierfrancesco Visaggi, Edoardo Savarino, Nicola de Bortoli, Christopher J. Black, Alexander C. Ford
Summary: This study conducted a network meta-analysis to evaluate the efficacy and safety of different medical therapies for endoscopy-negative reflux disease. The results showed that proton pump inhibitors (PPIs) are superior to other drugs in treating this condition. Future research should focus on better patient classification and investigating the efficacy of other drugs.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Vivek C. Goodoory, Cho Ee Ng, Christopher J. Black, Alexander C. Ford
Summary: This study examined willingness to pay for medications among individuals with irritable bowel syndrome (IBS). The results showed that women and individuals with an annual income of 30,000 pounds or more were more likely to be willing to pay for medication. In addition, individuals with lower IBS-related quality of life were more willing to pay for a medication that could improve their symptoms.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Shahida Din, Christian P. Selinger, Christopher J. Black, Alexander C. Ford
Summary: A network meta-analysis was conducted to examine the risk of Herpes zoster infection associated with biologics and small molecules used to treat inflammatory bowel disease (IBD). The results showed that Janus kinase inhibitors, particularly tofacitinib, were most likely to increase the risk of Herpes zoster infection, and the risk increased with higher doses.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Vivek C. C. Goodoory, Elspeth A. A. Guthrie, Cho E. E. Ng, Christopher J. J. Black, Alexander C. C. Ford
Summary: Irritable bowel syndrome (IBS) has a substantial impact on the quality of life of affected individuals, and the negative impact is worse than observed in some severe chronic organic conditions.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Gastroenterology & Hepatology
Maria Rosa Ingrosso, Michael Camilleri, Jan Tack, Gianluca Ianiro, Christopher J. Black, Alexander C. Ford
Summary: This study evaluated the efficacy and safety of drugs for gastroparesis through a network meta-analysis. The results showed that oral dopamine antagonists and tachykinin-1 antagonists were more effective than placebo. For individual symptoms, oral metoclopramide showed good efficacy for nausea, fullness, and bloating. However, the confidence in the evidence for most comparisons was low to moderate, indicating a need for more effective therapies for gastroparesis.
Editorial Material
Gastroenterology & Hepatology
Vivek C. Goodoory, Elspeth A. Guthrie, Cho Ee Ng, Christopher J. Black, Alexander C. Ford
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Maria rosa Ingrosso, Christopher j. Black, Alexander c. Ford
Article
Gastroenterology & Hepatology
Christy Riggott, Keeley M. Fairbrass, Christopher J. Black, David J. Gracie, Alexander C. Ford
Summary: Using latent class analysis, this study identified novel clusters of patients with inflammatory bowel disease (IBD) and found that patients with higher gastrointestinal and psychological symptoms were at a higher risk of adverse disease outcomes and were also high-volume users of healthcare.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Gastroenterology & Hepatology
Kee-Huat Chuah, Christopher J. Black, Vincent Tee, Sze-Zee Lim, Wen-Xuan Hian, Nur-Fazimah Sahran, Yeong-Yeh Lee, Sanjiv Mahadeva, Alexander C. Ford
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Gastroenterology & Hepatology
Vivek C. Goodoory, Mais Khasawneh, Christopher J. Black, Eamonn M. M. Quigley, Paul Moayyedi, Alexander C. Ford
Summary: This article conducted a meta-analysis to study the efficacy of probiotics in the treatment of irritable bowel syndrome (IBS). The study found that certain combinations of probiotics or strains may be beneficial for IBS, but the certainty of the evidence was low.
Review
Gastroenterology & Hepatology
Pierfrancesco Visaggi, Brigida Barberio, Giulio Del Corso, Nicola de Bortoli, Christopher J. Black, Alexander C. Ford, Edoardo Savarino
Summary: A network meta-analysis was conducted to compare the efficacy of different drugs for active eosinophilic esophagitis (EoE). The results showed that most available drugs were more effective than placebo in treating EoE. However, significant heterogeneity among the trials hindered the establishment of a solid therapeutic hierarchy.
Article
Gastroenterology & Hepatology
Christy Riggott, Keeley M. Fairbrass, Christian P. Selinger, David J. Gracie, Alexander C. Ford
Summary: The use of opioids in patients with inflammatory bowel disease (IBD) is associated with psychological comorbidity and an increased risk of intestinal resection, particularly with stronger formulations. Future studies should classify the risks of different opioids to develop reliable prescribing algorithms, and evaluate the effectiveness of addressing psychological factors as an opioid avoidance strategy in routine IBD care.
INFLAMMATORY BOWEL DISEASES
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Mais Khasawneh, Orla F. Craig, David J. Gracie, Christopher J. Black, Alexander C. Ford