期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 8, 页码 2487-2491出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201409659
关键词
alkene difunctionalization; aryl migration; dibenzocycloheptadienes; indanes; radical cascades
资金
- European Research Council (ERC) [307948]
- University of Granada
- Swiss National Science Foundation
Two highly stereoselective radical-mediated syntheses of densely functionalized indanes and dibenzocycloheptadienes from ortho-vinyl- and ortho-vinylaryl-substituted N-(arylsulfonyl)-acrylamides, respectively, are presented here. The chemoselective addition of insitu generated radicals (X-.) onto the styrene moieties triggers an unprecedented reaction cascade, resulting in the formation of one new CX bond and two new CC bonds, a formal 1,4-aryl migration, and the extrusion of SO2 to generate an amidyl radical intermediate. This intermediate, upon Habstraction, leads to the observed 5- and 7-membered ring carbocyclic products, respectively, in a highly efficient manner.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据