Article
Gastroenterology & Hepatology
Michael B. Wallace, Prateek Sharma, Pradeep Bhandari, James East, Giulio Antonelli, Roberto Lorenzetti, Micheal Vieth, Ilaria Speranza, Marco Spadaccini, Madhav Desai, Frank J. Lukens, Genci Babameto, Daisy Batista, Davinder Singh, William Palmer, Francisco Ramirez, Rebecca Palmer, Tisha Lunsford, Kevin Ruff, Elizabeth Bird-Liebermann, Victor Ciofoaia, Sophie Arndtz, David Cangemi, Kirsty Puddick, Gregory Derfus, Amitpal S. Johal, Mohammed Barawi, Luigi Longo, Luigi Moro, Alessandro Repici, Cesare Hassan
Summary: This study demonstrates that the use of artificial intelligence can significantly reduce the miss rate of colorectal neoplasia, especially for small and subtle lesions. This is of great importance in improving the prevention of colorectal cancer.
Article
Multidisciplinary Sciences
Kertu Liis Krigul, Oliver Aasmets, Kreete Lull, Tonis Org, Elin Org
Summary: Colorectal cancer is a challenging public health problem and successful treatment depends on the stage at diagnosis. This study demonstrates that analyzing microbiome in FIT tubes for CRC screening programs is feasible and may improve the sensitivity of CRC detection.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Uri Ladabaum, John Shepard, Ajitha Mannalithara
Summary: The study analyzed colonoscopy volumes and lesion detection rates before and after the endorsement of colorectal cancer (CRC) screening at 45-49 years of age. It found that lowering the screening initiation age had a modest effect on colonoscopy volume without compromising screening yield, and the detection rates for lesions in the 45-49 age group were similar to those in older age groups. Further national monitoring is needed to fully assess the impact of this change in screening guidelines.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Saloa Unanue-Arza, Isabel Idigoras-Rubio, Maria Jose Fernandez-Landa, Isabel Bilbao-Iturribarria, Luis Bujanda, Isabel Portillo
Summary: This study utilized the algorithm proposed by the World Endoscopy Organization to analyze colorectal cancers detected in the Basque Country screening program. It found that interval type PCCRC is less frequent than non-interval type PCCRC, however, interval type PCCRCs were significantly more often diagnosed in advanced stages compared to non-interval type PCCRCs.
Article
Gastroenterology & Hepatology
Jesper Clausen Nielsen, Magnus Ploug, Gunnar Baatrup, Rasmus Kroijer
Summary: The study found no significant difference in post colonoscopy colorectal cancer occurrence between individuals with either no or low-risk adenomas in the Danish faecal occult blood test screening program. Instead, advancing age and higher faecal test value were associated with an increased risk of post colonoscopy colorectal cancer.
COLORECTAL DISEASE
(2021)
Letter
Gastroenterology & Hepatology
Henriette C. Jodal, Magnus Loberg
Summary: This article is linked to papers by Jodal et al. To view these articles, please visit the provided link.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Erica K. Barnell, Elizabeth M. Wurtzler, Julie La Rocca, Thomas Fitzgerald, Jessica Petrone, Yansheng Hao, Yiming Kang, Faith L. Holmes, David A. Lieberman
Summary: This study evaluated the sensitivity and specificity of a noninvasive multitarget stool RNA test for colorectal cancer and precancerous lesions. The results showed that the test had a sensitivity of 94% for detecting colorectal cancer and 46% for detecting advanced adenomas, with a specificity of 88%.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Gastroenterology & Hepatology
Keming Yang, Yin Cao, Carino Gurjao, Yang Liu, Chuan-Guo Guo, Chun-Han Lo, Xiaoyu Zong, David Drew, Connor Geraghty, Elizabeth Prezioso, Matt Moore, Craig Williams, Tom Riley, Melissa Saul, Shuji Ogino, Marios Giannakis, Adam Bass, Robert E. Schoen, Andrew T. Chan
Summary: This study compared the characteristics of interval colorectal cancers (CRCs) and screen-detected CRCs. The results showed that interval CRCs had a higher risk of death compared to screen-detected CRCs, and this increased risk couldn't be explained by clinical prognostic factors. However, no significant differences in mutational features were found between interval and screen-detected CRCs.
Review
Medicine, General & Internal
Marco Spadaccini, Davide Massimi, Yuichi Mori, Ludovico Alfarone, Alessandro Fugazza, Roberta Maselli, Prateek Sharma, Antonio Facciorusso, Cesare Hassan, Alessandro Repici
Summary: Colorectal cancer is the third most common cancer worldwide, with the highest incidence in high-income countries. A well-designed endoscopic screening program can significantly reduce colorectal cancer incidence and mortality. Artificial intelligence (AI) applications in endoscopy, specifically machine and deep learning, have the potential to automatically extract specific features from endoscopic images/videos, assisting endoscopists in various aspects of their practice. This review aims to summarize the current knowledge on AI-aided endoscopy and its potential role in colorectal cancer prevention.
Review
Medicine, General & Internal
R. Hultcrantz
Summary: Colorectal cancer is one of the most common cancers globally and suitable for screening, with varying incidence rates worldwide. Women have a lower incidence of CRC, requiring tailored strategies for screening. Introducing colorectal cancer screening is crucial for reducing mortality rates.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Aasma Shaukat, Charles J. Kahi, Carol A. Burke, Linda Rabeneck, Bryan G. Sauer, Douglas K. Rex
Summary: This article provides an update on the 2009 American College of Gastroenterology CRC screening guidelines and discusses detailed recommendations for CRC screening in average-risk individuals and those with a family history of CRC, as well as the role of aspirin for chemoprevention, quality indicators for colonoscopy, organized CRC screening approaches, and improving adherence to CRC screening. The optimization of CRC screening is essential to effectively reduce CRC incidence and mortality, which can be achieved through high rates of adherence, quality monitoring, evidence-based guidelines, and the removal of barriers throughout the care spectrum. Developing cost-effective, highly accurate, noninvasive modalities to improve overall adherence to the screening process is also a desirable goal.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anu E. Obaro, Andrew A. Plumb, Steve Halligan, Susan Mallett, Paul Bassett, Paul McCoubrie, Rachel Baldwin-Cleland, Carmen Ugarte-Cano, Phillip Lung, Janice Muckian, Rajapandian Ilangovan, Arun Gupta, Charlotte Robinson, Antony Higginson, Ingrid Britton, Rebecca Greenhalgh, Uday Patel, Evgenia Mainta, Anmol Gangi, Stuart A. Taylor, David Burling
Summary: This study aimed to investigate the impact of a one-day individualized training program on the diagnostic sensitivity of experienced radiologists in detecting 6-mm or larger lesions in CT colonography (CTC) scans, as well as the durability of the improvement and any associated factors. The results showed that the training intervention led to a significant improvement in sensitivity, and this improvement was maintained at 6 and 12 months after the intervention.
Review
Oncology
Enea Ferlizza, Rossella Solmi, Michela Sgarzi, Luigi Ricciardiello, Mattia Lauriola
Summary: Colorectal cancer (CRC) ranks as the third most common cancer worldwide, emphasizing the significance of early detection. Screening through fecal occult blood tests has shown to reduce CRC incidence and mortality, however, low participation rates and false positives are key challenges. Recent research has focused on new fecal tests, biomarkers, and liquid biopsy methods to enhance accuracy and participation in CRC screening.
Article
Medicine, General & Internal
Zainab Aziz, Sophie Wagner, Alice Agyekum, Yoanna S. Pumpalova, Matthew Prest, Francesca Lim, Sheila Rustgi, Fay Kastrinos, William M. Grady, Chin Hur
Summary: Despite recommendations for universal screening, adherence to colorectal cancer screening in the US is low. This study evaluated the cost-effectiveness of liquid biopsy for colorectal cancer screening and found that colonoscopy was the most cost-effective strategy, while liquid biopsy was not cost-effective at its current cost and screening performance.
Article
Gastroenterology & Hepatology
Samiksha Pandey, Susan S. Fish, Hemant K. Roy
Summary: The study found that the incidence rate of colorectal cancer is increasing in the younger population, with rectum being the most prevalent site. Hispanics are usually diagnosed with colorectal cancer at a younger age. Lower BMI is associated with a higher risk of mortality. There was no significant difference in survival between younger and older populations.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)