期刊
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
卷 7, 期 1, 页码 48-53出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cgh.2008.08.032
关键词
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资金
- National Institutes of Health [R21 DK080408-01, R24DK067674]
- Crohn's and Colitis Foundation of America (CCFA)
- GI and Motility Disorders
- Gastrointestinal Biopsychosocial Research Center at the University of North Carolina [R24DK067674]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R24DK067674, R21DK080408] Funding Source: NIH RePORTER
Gastroenterologists often encounter situations when the clinical and pathophysiological features that typically distinguish functional from organic disorders overlap. This blurring of boundaries can occur with post-infectious irritable bowel syndrome (PI-IBS), a subset of IBS and a newly described entity IBD-IBS. The key associating features include pain and usually diarrheal symptoms that are disproportionate to the observed pathology, microscopic inflammation, and often a co-association with psychological distress. A previous initiating gastrointestinal infection is required for PI-IBS and assumed for IBD-IBS. Using this perspective we discuss the clinical and pathophysiological features of PI-IBS and IBD-IBS and the growing evidence for the overlapping features of these two disorders in terms of alteration of gut flora, immune dysregulation, and role of stress. A unifying model of PI-IBS and IBD-IBS is proposed that may have important clinical and research implications. It obligates us to reframe our understanding of illness and disease from the dualistic biomedical model into a more integrated biopsychosocial (BPS) perspective.
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