Article
Nutrition & Dietetics
Lin Li, Zhilei Shan, Zhenzhen Wan, Rui Li, Tingting Geng, Qi Lu, Kai Zhu, Zixin Qiu, Xuena Zhang, Yujie Liu, Liegang Liu, An Pan, Gang Liu
Summary: This study found that healthy scores for low-carbohydrate and low-fat diets were associated with lower all-cause mortality, while unhealthy scores were associated with higher all-cause mortality, especially among individuals with prediabetes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Nutrition & Dietetics
Nazanin Moslehi, Sheida Zeraattalab-Motlagh, Fatemeh Rahimi Sakak, Sakineh Shab-Bidar, Fahimeh Ramezani Tehrani, Parvin Mirmiran
Summary: There is no high-certainty evidence that diets alone improve health or reproductive outcomes in women with PCOS. However, supplementation with vitamin D, probiotics/synbiotics, omega-3, inositol, and curcumin has favorable effects on some metabolic outcomes.
Article
Nutrition & Dietetics
Kaixuan Che, Junqiang Qiu, Longyan Yi, Menghui Zou, Zhihui Li, Amelia Carr, Rhiannon M. J. Snipe, Dan Benardot
Summary: The study found that a short-term FACR diet may improve fat oxidation and submaximal exercise economy, but does not enhance performance in a 5 km running time trial.
Article
Endocrinology & Metabolism
Ye Tian, Jingjing Zhang, Mingyue Li, Jie Shang, Xiaohong Bai, Huijuan Zhang, Yanxia Wang, Haitao Chen, Xueru Song
Summary: The study aimed to determine the distinct serum fatty acids in different subtypes of polycystic ovary syndrome (PCOS) and their association with metabolic risk factors. The results showed that total monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) were lower in the reproductive subtype compared to the metabolic subtype of PCOS. Specific fatty acids such as myristic acid, palmitoleic acid, and oleic acid were strongly associated with metabolic risk factors.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Wing Ting Leung, Zhijing Tang, Yuanyuan Feng, Haiyun Guan, Zengshu Huang, Wei Zhang
Summary: This study conducted a meta-analysis to summarize the available evidence on dietary fiber intake in PCOS patients. The results showed that PCOS women have a significantly lower dietary fiber intake compared to controls, which may be influenced by geographic region and dietary assessment method.
Review
Endocrinology & Metabolism
Mariam Farrag, Djedjiga Ait Eldjoudi, Maria Gonzalez-Rodriguez, Alfonso Cordero-Barreal, Clara Ruiz-Fernandez, Maurizio Capuozzo, Miguel Angel Gonzalez-Gay, Antonio Mera, Francisca Lago, Ahmed Soffar, Amina Essawy, Jesus Pino, Yousof Farrag, Oreste Gualillo
Summary: Adipose tissue malfunction results in altered adipokine secretion, particularly asprosin, which contributes to various metabolic diseases including obesity, diabetes mellitus, and cardiovascular disorders. Asprosin, a novel adipokine, is released from white adipose tissue during fasting and has gluconeogenic and orexigenic effects. Dysregulated levels of asprosin are found in obesity, type 2 diabetes, polycystic ovarian syndrome, non-alcoholic fatty liver, and certain types of cancer. Understanding the role and signaling pathways of asprosin could lead to potential therapeutic targets and diagnostic tools.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nellysha Namela Muhammad Abdul Kadar, Fairus Ahmad, Seong Lin Teoh, Mohamad Fairuz Yahaya
Summary: The supplementation of stingless bee honey (SBH) and pure antioxidant caffeic acid (CA) can reverse the hyperglycemic and hypertensive effects induced by high-carbohydrate high-fructose (HCHF) diet. SBH can significantly reduce brain TNF-alpha levels and increase brain neurotrophic factor BDNF levels.
Article
Endocrinology & Metabolism
Katherine VanHise, Jessica L. Chan, Sahar Wertheimer, Roy G. Handelsman, Ekaterina Clark, Rae Buttle, Erica T. Wang, Ricardo Azziz, Margareta D. Pisarska
Summary: This study compares women with PCOS in Alabama and California and finds geographical differences in hormonal and metabolic parameters. Women with PCOS in Alabama are more likely to have hirsutism and metabolic dysfunction, while women with PCOS in California are more likely to have hyperandrogenemia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Mariell Ryssdal, Eszter Vanky, Live Marie T. Stokkeland, Anders Hagen Jarmund, Bjorg Steinkjer, Tone Shetelig Lovvik, Torfinn Stove Madssen, Ann-Charlotte Iversen, Guro F. Giskeodegard
Summary: A post-hoc analysis of two randomized controlled trials including 615 pregnant women with PCOS showed that metformin treatment can increase levels of various cytokines in the maternal serum, indicating its immunomodulating rather than anti-inflammatory properties.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Harshal Deshmukh, Maria Papageorgiou, Liz Wells, Shahzad Akbar, Thomas Strudwick, Ketki Deshmukh, Salvatore Giovanni Vitale, Alan Rigby, Rebecca V. Vince, Marie Reid, Thozhukat Sathyapalan
Summary: A comparison study found that a very-low-calorie diet (VLCD) resulted in greater weight loss and more pronounced improvements in body composition, hyperandrogenaemia, and metabolic markers in obese women with polycystic ovary syndrome (PCOS) compared to a moderate energy deficit approach.
Article
Medicine, General & Internal
Maria-Elina Mosorin, Terhi Piltonen, Anni S. Rantala, Marika Kangasniemi, Elisa Korhonen, Risto Bloigu, Juha S. Tapanainen, Laure Morin-Papunen
Summary: This clinical trial compares hormonal and metabolic changes in women with PCOS after 9 weeks of continuous use of oral or vaginal CHCs. Blood samples and OGTT were collected at baseline and after treatment. Both oral and vaginal CHCs decreased androgenicity and tended to promote insulin resistance in PCOS women. Larger and longer studies are needed to compare the metabolic effects of different administration routes of CHCs in PCOS women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
G. Jean Campbell, Sophie G. Lucic Fisher, Amanda E. Brandon, M. M. Alistair Senior, Kim S. Bell-Anderson
Summary: In utero glycemia is an important determinant of fetal growth. Women with gestational diabetes are more likely to deliver large-for-gestational age babies that are at increased risk for obesity. The maternal nutritional state modulates the development of offspring biological systems during the critical periods of gestation and lactation.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Asieh Mansour, Majid Samadi, Milad Sanginabadi, Hadis Gerami, Sara Karimi, Saeed Hosseini, Nooshin Shirzad, Azita Hekmatdoost, Armita Mahdavi-Gorabi, Mohammad Reza Mohajeri-Tehrani, Mostafa Qorbani
Summary: Resveratrol was found to improve menstrual function and reduce hair loss in women with PCOS, while showing no significant effects on androgens, insulin, and lipid levels.
CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
I. R. Cincione, C. Graziadio, F. Marino, C. Vetrani, F. Losavio, S. Savastano, A. Colao, D. Laudisio
Summary: Our study aimed to evaluate the association between PCOS and KD in overweight and/or obese women with PCOS, and to assess the potential beneficial effects on metabolic and endocrine parameters compared to a standard, balanced hypocaloric diet like Mediterranean diet (MD).
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Food Science & Technology
Iqra Masood, Sana Noreen, Komal Raza, Waseem Khalid, Muhammad Abdul Rahim, Khalid Abdelsamea Mohamedahmed
Summary: PCOS is a common endocrine disorder in women, characterized by various symptoms including polycystic ovaries, hyperandrogenism, and anovulation. This study compared the effects of a ketogenic diet and a hypocaloric Mediterranean diet in women with PCOS and found that the ketogenic diet led to significant weight loss and improvements in cholesterol, blood glucose, and hormone levels.
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2023)
Article
Endocrinology & Metabolism
Sarah E. Hoover, Barbara A. Gower, Yenni E. Cedillo, Paula C. Chandler-Laney, Sarah E. Deemer, Amy M. Goss
Summary: The study suggests that in women with PCOS who have adapted to a low GL diet, a low GL meal can reduce ghrelin and increase glucagon. Further research is needed to determine the influence of diet composition on ad libitum intake in women with PCOS.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Valene Garr Barry, Mariah Stewart, Taraneh Soleymani, Renee A. Desmond, Amy M. Goss, Barbara A. Gower
Summary: The study concludes that prescribing a LCHF diet to middle-aged adults may be an optimal strategy for reducing disease risk, particularly for those with insulin resistance.
Review
Obstetrics & Gynecology
Maryam Kazemi, Joy Y. Kim, Cynthia Wan, Julia D. Xiong, Stephen A. Parry, Ricardo Azziz, Marla E. Lujan
Summary: This study compared the cardiometabolic and reproductive health risk between Hispanic and White women with polycystic ovary syndrome in the United States. It found that Hispanic women had greater impairments in glucoregulatory status but no significant differences in reproductive risks could be concluded.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Endocrinology & Metabolism
Carrie Riestenberg, Anika Jagasia, Daniela Markovic, Richard P. Buyalos, Ricardo Azziz
Summary: The study estimated the excess prevalence and economic burden of pregnancy-related and long-term health morbidities attributable to PCOS, showing an additional total healthcare-related economic burden of $4.3 billion annually in the United States. Together with prior analysis, the economic burden of PCOS is estimated at $8 billion annually in 2020 USD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Daniel L. Smith, Rebecca L. Hanson, Stephanie L. Dickinson, Xiwei Chen, Amy M. Goss, John B. Cleek, W. Timothy Garvey, David B. Allison
Summary: The study found no significant differences in body weight, fat mass, or glucoregulatory biomarkers after 30 days of increased potato consumption compared to almond consumption. The results do not support a causal relationship between increased French fried potato consumption and negative health outcomes studied.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Endocrinology & Metabolism
Sylvia Kiconco, Chau T. Tay, Kate L. Rassie, Ricardo Azziz, Helena J. Teede, Anju E. Joham
Summary: A systematic review of 31 longitudinal cohort studies involving 28,316 participants from four continents found that women with PCOS had a higher risk of Type 2 diabetes compared to those without PCOS, but evidence for other cardiometabolic outcomes was inconsistent. Longitudinal studies in unselected populations are needed for more high-quality data in this area.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
U. Ezeh, M. D. Pisarska, R. Azziz
Summary: In women with hyperandrogenic polycystic ovary syndrome (PCOS), the severity of menstrual cyclicity is related to the risk of hyperinsulinemia and dysglycemia. Women with amenorrhea have a higher risk of post-challenge hyperinsulinemia and dysglycemia compared to those with oligomenorrhea or eumenorrhea.
HUMAN REPRODUCTION
(2022)
Editorial Material
Endocrinology & Metabolism
Ricardo Azziz
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Obstetrics & Gynecology
Sylvia Kiconco, Chau Thien Tay, Kate Louise Rassie, Ricardo Azziz, Helena J. Teede, Anju E. Joham
Summary: Limited evidence suggests that levels of total testosterone and dehydroepiandrosterone sulphate decline significantly in women with PCOS, with a higher risk of gestational diabetes. However, understanding the changes in reproductive, psychological, and oncological features of PCOS throughout the lifespan remains unclear.
HUMAN REPRODUCTION
(2022)
Article
Nutrition & Dietetics
Moriah P. Bellissimo, Candace C. Fleischer, David A. Reiter, Amy M. Goss, Lei Zhou, Matthew Ryan Smith, Jacob Kohlmeier, Rabindra Tirouvanziam, Phong H. Tran, Li Hao, Benjamin H. Crain, Greg D. Wells, Dean P. Jones, Thomas R. Ziegler, Jessica A. Alvarez
Summary: This study found distinct sex-dependent associations between monocyte and skeletal muscle mitochondrial metabolism with body composition. These findings may provide insights for sex-specific interventions to improve mitochondrial function and metabolic health.
NUTRITION & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Katherine VanHise, Jessica L. Chan, Sahar Wertheimer, Roy G. Handelsman, Ekaterina Clark, Rae Buttle, Erica T. Wang, Ricardo Azziz, Margareta D. Pisarska
Summary: This study compares women with PCOS in Alabama and California and finds geographical differences in hormonal and metabolic parameters. Women with PCOS in Alabama are more likely to have hirsutism and metabolic dysfunction, while women with PCOS in California are more likely to have hyperandrogenemia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Fernando Bril, Uche Ezeh, Mina Amiri, Sana Hatoum, Lauren Pace, Yen-Hao Chen, Fred Bertrand, Barbara Gower, Ricardo Azziz
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting 5% to 15% of reproductive-aged women globally, characterized by dysfunction in adipose tissue (AT), leading to metabolic and inflammation abnormalities. Dysregulation in storage capacity, impaired adipogenesis, insulin signaling dysfunction, dysregulated lipolysis, epigenetic dysregulation, and mitochondrial dysfunction are identified mechanisms of AT dysfunction in PCOS. Additional research is urgently needed to further understand and address this important aspect of PCOS.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Selma F. F. Witchel, Ricardo Azziz, Sharon E. E. Oberfield
Summary: Descriptions of probable PCOS can be found in ancient Roman writings and in Renaissance art. Attention to domesticated animal reproduction led ancient observers to understand the role of the testes in male phenotypes, proven experimentally by testicular transplantation (in chickens) in 1849. Testosterone was isolated and its structure determined in the 1930s, but the multiple pathways of androgen synthesis have only been delineated recently. PCOS is now recognized as a complex disorder characterized by irregular menses and hyperandrogenism often associated with infertility; its prevalence may be as high as 20% of reproductive age women. Premature exaggerated adrenarche, obesity, and insulin resistance have been associated with PCOS, but the mechanistic link between these factors and hyperandrogenism remains unclear.
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Meeting Abstract
Endocrinology & Metabolism
Sarah Hoover, Barbara Gower, Amy Goss
Meeting Abstract
Endocrinology & Metabolism
Lauren Fowler, Amy Goss, Catharine Couch, Jose Fernandez, W. Timothy Garvey, Barbara Gower