Article
Surgery
Shao-Lai Zhou, Hao-Yang Xin, Rong-Qi Sun, Zheng-Jun Zhou, Zhi-Qiang Hu, Chu-Bin Luo, Peng-Cheng Wang, Jia Li, Jia Fan, Jian Zhou
Summary: This cohort study in China characterized the distribution of KRAS variant subtypes in a large group of ICC patients. The presence of G12 KRAS variants, specifically the G12V variant, was associated with worse survival and increased risk of recurrence.
Article
Endocrinology & Metabolism
Yanghua Fan, Yichao Li, Xinjie Bao, Huijuan Zhu, Lin Lu, Yong Yao, Yansheng Li, Mingliang Su, Feng Feng, Shanshan Feng, Ming Feng, Renzhi Wang
Summary: Machine learning models were developed to predict delayed remission in Cushing's disease patients who did not achieve immediate remission postoperatively. Factors such as younger age, lower body mass index, higher Knosp grade, and absence of tumor on pathological examination correlated with lower rates of delayed remission. The Adaboost model, incorporating 18 features including preoperative 24-hour urine free cortisol, postoperative morning serum cortisol, and age, showed superior predictive ability compared to traditional methods.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Oncology
Flore-Anne Pain, Guillaume Beinse, Henri Azais, Marie Auvray-Kuentz, Louis-Marie Garcin, Nicolas Delanoy, Enrica Bentivegna, Louise Benoit, Huyen-Thu Nguyen-Xuan, Helene Blons, Emmanuelle Fabiano, Marie-Aude L. E. Frere Belda, Anne-Sophie Bats, Meriem Koual
Summary: This study retrospectively investigated the patterns of recurrence and prognosis of patients with recurrent TP53 mutated endometrial carcinoma. The results showed that TP53 mutated patients had the worst recurrence free survival and overall survival, with a higher risk of recurrence during the first three years and a higher incidence of peritoneal recurrence. These findings suggest that TP53 status could be useful in defining follow-up strategies.
Article
Health Care Sciences & Services
Natalia Kuritsyna, Uliana A. Tsoy, Vladislav Y. Cherebillo, Artem A. Paltsev, Anton Ryzhkov, Pavel A. Ryazanov, Vladimir K. Ryzhkov, Elena N. Grineva
Summary: This study aimed to find a combination of predictors to forecast Cushing's disease (CD) remission after transsphenoidal endoscopic surgery (TSS). The results showed that adenoma size, high-dose dexamethasone suppression test (HDDST) serum cortisol suppression rate, and morning serum cortisol level 24 hours after surgery were predictors of CD remission one year after TSS.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Emre Yekeduz, Omer Dizdar, Neyran Kertmen, Sercan Aksoy
Summary: This study aimed to assess the clinicopathological factors affecting early and late recurrences in patients with operable breast cancer. The results showed that HER2+ disease, lymph node metastasis, lymphovascular invasion (LVI), and high tumor grade were associated with increased risk of early recurrence, while HER2+ disease and LVI were associated with decreased risk of late recurrence.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
M. G. Davey, E. J. Ryan, P. F. McAnena, M. R. Boland, M. K. Barry, K. J. Sweeney, C. M. Malone, R. J. McLaughlin, A. J. Lowery, M. J. Kerin
Summary: The study analyzed patients diagnosed with estrogen-receptor positive, progesterone-receptor positive, and human epidermal growth factor receptor-2 negative breast cancer between 2005 and 2015, showing excellent survival outcomes after almost a decade of follow-up. However, fatal progression is often imminent once distant recurrence occurs.
SURGICAL ONCOLOGY-OXFORD
(2021)
Article
Oncology
Muriel Heimann, Niklas Schafer, Christian Bode, Valeri Borger, Lars Eichhorn, Frank A. Giordano, Erdem Guresir, Andreas H. Jacobs, Yon-Dschun Ko, Jennifer Landsberg, Felix Lehmann, Alexander Radbruch, Christina Schaub, Katjana S. Schwab, Johannes Weller, Ulrich Herrlinger, Hartmut Vatter, Patrick Schuss, Matthias Schneider
Summary: In geriatric patients with surgically treated brain metastases, pre-operative frailty is associated with poor survival, with multiple intracranial metastases, infratentorial localization, preoperative CRP >5 mg/l, and frailest patients identified as predictors for reduced overall survival.
FRONTIERS IN ONCOLOGY
(2021)
Review
Endocrinology & Metabolism
Juergen Honegger, Isabella Nasi-Kordhishti
Summary: Transsphenoidal surgery (TSS) is the preferred initial treatment for Cushing's disease (CD), with microscopic TSS and endoscopic TSS being the two available surgical techniques. Repeat TSS can achieve remission rates of over 70% for microadenomas. Early postoperative assessment of remission status and a steroid-sparing protocol are recommended for postoperative management. Prophylactic antithrombotic measures can significantly reduce the risk of postoperative thromboembolic events. Prevention or successful treatment of cortisol withdrawal syndrome remains a challenge. The development of functional imaging holds promise for improved preoperative detection of microadenomas. Intraoperative identification of microadenomas using specific fluorescent targeting is a promising future avenue.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Linda Aagaard Rasmussen, Niels Lyhne Christensen, Anne Winther-Larsen, Susanne Oksbjerg Dalton, Line Flytkjaer Virgilsen, Henry Jensen, Peter Vedsted
Summary: This study developed and validated a register-based algorithm to identify patients diagnosed with recurrent lung cancer. The algorithm achieved a sensitivity of 83.3%, a specificity of 93.8%, and a positive predictive value of 87.0%. However, the positive predictive value decreased to 70% when applied in populations with low recurrence rates.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Oncology
Zhou Huang, Mei Shi, Wei-Hu Wang, Liang-Fang Shen, Yu Tang, Qing-Lin Rong, Li Zhu, Xiao-Bo Huang, Jian Tie, Jia-Yi Chen, Jun Zhang, Hong-Fen Wu, Jing Cheng, Min Liu, Chang-Ying Ma, Shu-Lian Wang, Ye-Xiong Li
Summary: This study successfully established a nomogram for predicting locoregional recurrence in breast cancer patients treated with neoadjuvant chemotherapy and mastectomy, which showed better predictive performance compared to traditional staging systems and other models.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Jie Wu, Xiao Wu, Le Yang, ShenHao Xie, Bin Tang, ZhiGao Tong, BoWen Wu, YouQing Yang, Han Ding, YouYuan Bao, Lin Zhou, Tao Hong
Summary: This study aimed to construct a predictive model for postoperative hypopituitarism in craniopharyngioma patients one year after surgery, and found that intact hypothalamus structure is critical in maintaining pituitary function. The study results showed that exclusive hypothalamus injury significantly increased the risk of anterior and posterior pituitary dysfunction, while exclusively sacrificing stalk infiltrated by tumors did not significantly increase the risk of pituitary dysfunction. The predictive models in both the training and validation groups showed high accuracy in predicting anterior and posterior pituitary dysfunction one year after surgery.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Zhihong Yao, Zunxian Tan, Jifei Yang, Yihao Yang, Cao Wang, Jiaxiang Chen, Yanan Zhu, Tiying Wang, Lei Han, Lin Zhu, Zuozhang Yang
Summary: This study aimed to establish a prognostic nomogram for predicting 5-year overall survival in Chinese high-grade osteosarcoma patients under 30 years old. The nomogram included nine important variables based on multivariate analysis, providing valuable clinical insight for personalized risk assessment. The model demonstrated accurate prediction ability and clinical benefit in a Chinese population-based cohort.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Andrew Matsumoto, Jeffery N. Li, Martha Matsumoto, Juliana Pineider, Rajiv I. Nijhawan, Divya Srivastava
Summary: Research on the long-term outcomes of high-risk cutaneous squamous cell carcinomas (hrSCC) treated with Mohs micrographic surgery (MMS) is limited. MMS remains an effective treatment for hrSCC, with factors like perineural invasion, poor differentiation, and immunosuppression associated with poor outcomes. Further study is needed on the effect of adjuvant treatment.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Immunology
Paulette Esperanza Walo-Delgado, Enric Monreal, Silvia Medina, Ester Quintana, Susana Sainz de la Maza, Jose Ignacio Fernandez-Velasco, Paloma Lapuente, Manuel Comabella, Lluis Ramio-Torrenta, Xavier Montalban, Luciana Midaglia, Noelia Villarrubia, Angela Carrasco-Sayalero, Eulalia Rodriguez-Martin, Ernesto Roldan, Jose Meca-Lallana, Roberto Alvarez-Lafuente, Jaime Masjuan, Lucienne Costa-Frossard, Luisa Maria Villar
Summary: Baseline blood lymphocyte profile can help identify relapsing remitting multiple sclerosis (RRMS) patients at higher risk of developing secondary autoimmune adverse events (AIAEs) after alemtuzumab treatment. Patients with higher B-cell percentages and lower CD4+ T cell percentages at baseline were more likely to develop AIAEs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Beata Baranska, Dariusz Bazalinski, Grzegorz Guzik, Maria Kozka, Robert Slusarz, Pawel Wiech
Summary: Spinal metastases are a common manifestation of advanced neoplastic disease, causing severe pain and neurological disorders. Spine stabilisation surgery and spinal cord decompression surgery can relieve the pressure associated with the disease and improve the quality of life of patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Chiara Sabbadin, Francesca Beggiao, Carlotta Keiko Vedolin, Gloria Orlando, Eugenio Ragazzi, Filippo Ceccato, Mattia Barbot, Luciana Bordin, Gabriella Dona, Alessandra Andrisani, Anna Belloni Fortina, Carla Scaroni, Decio Armanini
Summary: This study demonstrates that spironolactone is a safe and effective treatment for hyperandrogenic skin disorders, particularly in patients with polycystic ovary syndrome. The medication can provide long-lasting improvement in symptoms, even after discontinuation for several months.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Article
Endocrinology & Metabolism
Mitsuhide Naruse, Masanori Murakami, Takuyuki Katabami, Tomaz Kocjan, Mirko Parasiliti-Caprino, Marcus Quinkler, Matthieu St-Jean, Sam O'Toole, Filippo Ceccato, Ivana Kraljevic, Darko Kastelan, Mika Tsuiki, Jaap Deinum, Edelmiro Menendez Torre, Troy Puar, Athina Markou, George Piaditis, Kate Laycock, Norio Wada, Marianne Aardal Grytaas, Hiroki Kobayashi, Akiyo Tanabe, Chin Voon Tong, Nuria Valdes Gallego, Sven Gruber, Felix Beuschlein, Lydia Kuerzinger, Norlela Sukor, Elena A. B. Aisha Azizan, Oskar Ragnarsson, Michiel F. Nijhoff, Giuseppe Maiolino, Guido Di Dalmazi, Valentina Kalugina, Andre Lacroix, Raluca Maria Furnica, Tomoko Suzuki
Summary: This study investigated the diversity of approaches utilized for each diagnostic step in different expert centers regarding primary aldosteronism (PA). The results showed significant variations in blood sampling conditions, assay methods, screening and confirmatory tests among centers. This diversity may lead to inconsistent diagnosis of PA and limit comparison of evidence between centers. Standardization of the diagnostic process and revisiting the concept of mild PA are necessary.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Filippo Ceccato, Mattia Barbot, Alessandro Mondin, Marco Boscaro, Maria Fleseriu, Carla Scaroni
Summary: This study aimed to evaluate the diagnostic accuracy of the CRH test, desmopressin test, and HDDST for the differential diagnosis of CD and EAS. The CRH test showed the highest sensitivity for detecting CD and the highest specificity for detecting EAS, while the diagnostic accuracy of HDDST and desmopressin test was lower.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
F. Ceccato, C. K. Vedolin, G. Voltan, G. Antonelli, M. Barbot, D. Basso, D. Regazzo, C. Scaroni, G. Occhi
Summary: This study aims to evaluate the growth hormone (GH) response in patients with and without acromegaly. It was found that a paradoxical increase in GH levels was observed after glucose intake. The study also revealed a higher prevalence of GH response in acromegalic patients, which was associated with an increased occurrence of glucose metabolism abnormalities.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
A. Mondin, M. Barbot, G. Voltan, I. Tizianel, C. K. Vedolin, P. Mazzeo, M. Lazzara, M. Boscaro, C. Scaroni, F. Ceccato
Summary: The study aimed to provide an overview of available dynamic tests for discriminating between neoplastic and non-neoplastic hypercortisolism and to quantify their diagnostic performance. The combined Dex-CRH test showed the highest sensitivity, while the CRH test demonstrated excellent specificity. Further research is needed, particularly in mild Cushing's Disease and well-characterized non-neoplastic hypercortisolism patients.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Oncology
Francesca Torresan, Arianna Beber, Donatella Schiavone, Stefania Zovato, Francesca Galuppini, Filippo Crimi, Filippo Ceccato, Maurizio Iacobone
Summary: The study analyzed the long-term outcomes in 170 patients who underwent surgery for pheochromocytoma and sympathetic paraganglioma (PHEO/sPGL). It was found that even apparently benign and sporadic variants had a risk of long-term recurrence, highlighting the importance of lifelong follow-up.
Review
Health Care Sciences & Services
Irene Tizianel, Chiara Sabbadin, Simona Censi, Cristina Clausi, Anna Colpo, Anca Irina Leahu, Maurizio Iacobone, Caterina Mian, Carla Scaroni, Filippo Ceccato
Summary: Primary hyperthyroidism is an endocrine disorder characterized by excessive thyroid hormone synthesis and secretion. Treatment options include medical therapy, radioactive iodine, total thyroidectomy, and in severe cases, therapeutic plasma exchange. Two cases of thyrotoxicosis, one caused by amiodarone treatment and the other by methimazole-induced agranulocytosis, were described as examples of therapeutic plasma exchange applications in clinical practice.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Endocrinology & Metabolism
Marta Padovan, Giulia Cerretti, Mario Caccese, Mattia Barbot, Eleonora Bergo, Gianluca Occhi, Carla Scaroni, Giuseppe Lombardi, Filippo Ceccato
Summary: Despite multimodal treatment, pituitary adenomas can still show a tendency to grow. Temozolomide (TMZ) has been used for the treatment of aggressive pituitary tumors in the past 15 years. The use of TMZ requires a careful balance of different expertise, especially in terms of selection criteria.
EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Alessandro Mondin, Filippo Ceccato, Giacomo Voltan, Pierluigi Mazzeo, Renzo Manara, Luca Denaro, Carla Scaroni, Mattia Barbot
Summary: This study evaluated the prevalence of cortisol-related complications and mortality rates in a large cohort of Cushing’s disease (CD) patients referred to a single center. It was found that patients in remission showed a significant improvement in cardiovascular comorbidities, while those with active CD had poor survival outcomes.
Review
Genetics & Heredity
Giacomo Voltan, Michele Cannito, Michela Ferrarese, Filippo Ceccato, Valentina Camozzi
Summary: Vitamin D plays a crucial role in calcium and phosphate metabolism, bone health, and various extra-skeletal functions. It binds to vitamin D receptors (VDRs) in different tissues, modulating the expression of numerous target genes. Gene polymorphisms in VDRs may influence gene expression, leading to the development of chronic diseases and metabolic complications.
Article
Endocrinology & Metabolism
Ilaria Piva, Simona Censi, Jacopo Manso, Susi Barollo, Loris Bertazza, Carla Scaroni, Caterina Mian, Mattia Barbot
Summary: In this case report, we present a novel loss-of-function gene mutation in the TSH receptor gene associated with a TSH resistance phenotype.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Article
Endocrinology & Metabolism
Beatrice Righi, Salma R. Ali, Jillian Bryce, Jeremy W. Tomlinson, Walter Bonfig, Federico Baronio, Eduardo C. Costa, Guilherme Guaragna-Filho, Guy T'Sjoen, Martine Cools, Renata Markosyan, Tania A. S. S. Bachega, Mirela C. Miranda, Violeta Iotova, Henrik Falhammar, Filippo Ceccato, Marianna R. Stancampiano, Gianni Russo, Eleni Daniel, Richard J. Auchus, Richard J. Ross, S. Faisal Ahmed
Summary: This study aims to investigate the prevalence of comorbidity in adults with 21-hydroxylase CAH and the current practice for assessing comorbidity. A questionnaire was sent to 46 expert centres managing adults with CAH, collecting information on therapy and surveillance practice for osteoporosis/osteopaenia, hyperlipidaemia, type 2 diabetes/hyperinsulinaemia, hypertension, CV disease, and obesity. The results indicate that cardiometabolic and bone morbidities are not uncommon in adults with CAH. Standardized screening and collection of data are needed to explore optimal therapy.
Article
Oncology
Filippo Crimi, Elena Agostini, Alessandro Toniolo, Francesca Torresan, Maurizio Iacobone, Irene Tizianel, Carla Scaroni, Emilio Quaia, Cristina Campi, Filippo Ceccato
Summary: Radiomics is a promising research field that combines big data analysis from tissue texture analysis with clinical questions. We studied the application of CT texture analysis in adrenal pheochromocytomas to define the correlation between the extracted features and the secretory pattern, histopathological data, and natural history of the disease.