Article
Endocrinology & Metabolism
Yuqin Zhang, Meili Cai, Diliqingna Dilimulati, Ziwei Lin, Hang Sun, Ran Cui, Hongxiang Fei, Xinxin Gao, Qiongjing Zeng, Xiaowen Shao, Manna Zhang, Shen Qu
Summary: This study found that a high level of visceral adipose tissue (VAT) mass is associated with an increased risk of hyperuricemia in patients with polycystic ovary syndrome (PCOS). Excessive VAT should be considered in the occurrence and development of PCOS with hyperuricemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Fuensanta Navarro-Lafuente, Julian J. Arense-Gonzalo, Maria L. Sanchez-Ferrer, Maria T. Prieto-Sanchez, Ana Cutillas-Tolin, Jaime Mendiola, Evdochia Adoamnei, Esteban Gazabat-Barbado, Jesus Vioque, Alberto M. Torres-Cantero
Summary: This study suggests that higher intakes of specific fatty acids are related to some PCOS phenotypes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Obstetrics & Gynecology
Sara Shojaei-Zarghani, Maryam Rafraf
Summary: Current studies suggest that resveratrol may benefit patients with PCOS, improving histomorphological features, hormone levels, and glycemic control. However, more mechanistic studies and RCTs are needed to determine its clinical effectiveness in the management of PCOS.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Katherine VanHise, Erica T. Wang, Keith Norris, Ricardo Azziz, Margareta D. Pisarska, Jessica L. Chan
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women worldwide. There are racial and ethnic differences in PCOS phenotypes and metabolic dysfunction. This review summarizes the current literature on disparities in PCOS diagnosis and outcomes in the United States. Future studies should focus on racial and ethnic-specific differences in PCOS and include a diverse population in PCOS research.
FERTILITY AND STERILITY
(2023)
Article
Reproductive Biology
Leandro M. Velez, Marcus Seldin, Alicia B. Motta
Summary: PCOS is a common endocrinopathy affecting 5-10% of women of reproductive age, characterized by ovarian cysts, ovulation disorders, and hyperandrogenism, along with metabolic abnormalities. Chronic inflammation may play a pivotal role in the pathogenesis of PCOS.
BIOLOGY OF REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
Jia Zhu, Anders U. Eliasen, Izzuddin M. Aris, Sara E. Stinson, Jens-Christian Holm, Torben Hansen, Marie-France Hivert, Klaus Bonnelykke, Rany M. Salem, Joel N. Hirschhorn, Yee-Ming Chan
Summary: Genetic risk factors for PCOS are associated with alterations in metabolic, growth, and developmental traits in childhood.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Anju E. Joham, Nadira S. Kakoly, Helena J. Teede, Arul Earnest
Summary: This study found a significantly higher incidence of hypertension among women with PCOS compared to those without, especially among obese women. PCOS was independently associated with an increased risk of hypertension, further exacerbated by obesity. Including PCOS in hypertension risk assessments may help in early identification and management of the disorder.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Malgorzata Kaluzna, Magdalena Czlapka-Matyasik, Aleksandra Bykowska-Derda, Jerzy Moczko, Marek Ruchala, Katarzyna Ziemnicka
Summary: This study compared ten different methods of VAT estimation in PCOS women and found that WHtR, WHT.5R, WC, BMI, and LAP had the highest predictive value. Different age groups of PCOS patients had different cut-off values for VAT identification.
Article
Endocrinology & Metabolism
Stine Gry Kristensen, Ajay Kumar, Linn Salto Mamsen, Bhanu Kalra, Susanne Elisabeth Pors, Jane Alro Botkjaer, Kirsten Tryde Macklon, Jens Fedder, Erik Ernst, Kate Hardy, Stephen Franks, Claus Yding Andersen
Summary: This study investigated the differences in concentrations of GDF9, BMP15, and the GDF9/BMP15 heterodimer in follicle fluids from women with and without polycystic ovaries (PCO). The results showed that GDF9 levels were significantly higher in women with PCO, while BMP15 levels were significantly lower, resulting in an increased GDF9/BMP15 ratio. This aberrant endocrine environment may serve as a new biomarker for PCO.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Tansel Sapmaz, Kubra Sevgin, Sude Topkaraoglu, Muhammetnur Tekayev, Fatma Gumuskaya, Fatima Efendic, Mahmud Esad Pence, Selman Aktas, Gulam Hekimoglu, Oktay Irkorucu
Summary: This study examined the effects of propolis on ovarian folliculogenesis, p53 expression, and serum LH and P levels in PCOS modeled rats. Treatment with 50 mg/kg of propolis ameliorated cystic and primary follicles, while 150 mg/kg increased LH levels. Low concentrations of propolis cannot completely improve the hormone profile and p53 expression associated with PCOS.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Endocrinology & Metabolism
Yiming Gao, Caihong Xin, Huaying Fan, Xin Sun, Hongli Wang
Summary: In this meta-analysis, it was found that the levels of chemerin, a newly identified adipokine, were significantly higher in patients with PCOS compared to healthy controls. However, there was no significant difference in the levels of apelin, another adipokine, between the two groups.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maya Barsky, Jamie Merkison, Pardis Hosseinzadeh, Liubin Yang, Janet Bruno-Gaston, Jay Dunn, William Gibbons, Chellakkan Selvanesan Blesson
Summary: Polycystic ovary syndrome (PCOS) is a common form of anovulatory infertility with a strong hereditary component. Research indicates that excessive prenatal androgens can affect ovarian development by altering gene expression and mitochondrial function. This programming may begin at birth and is influenced by androgens in utero.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Emma Oberg, Liselotte Blomberg, Torbjorn Akerstedt, Angelica Linden Hirschberg
Summary: This study compared sleep variables in women with PCOS and controls, and assessed the impact of behavioral modification intervention on sleep. The results showed that women with PCOS had shorter sleep duration and worse sleep efficiency, but their total sleep time at night was within the normal range. Behavioral modification intervention reduced daytime sleep duration and improved sleep behavior.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jia Zhu, Natalia Pujol-Gualdo, Laura B. L. Wittemans, Cecilia M. Lindgren, Triin Laisk, Joel N. Hirschhorn, Yee-Ming Chan
Summary: Genetic risk factors for PCOS have phenotypic consequences in men, indicating that they can act independently of ovarian function. Thus, PCOS in women may not always be a primary disorder of the ovaries.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Anuradhaa Subramanian, Siang Ing Lee, Katherine Phillips, Konstantinos A. Toulis, Punith Kempegowda, Michael W. O'Reilly, Nicola J. Adderley, Shakila Thangaratinam, Wiebke Arlt, Krishnarajah Nirantharakumar
Summary: The study found that pregnant women with PCOS have a higher risk of preterm birth and cesarean delivery compared to those without PCOS, but there is no significant association with low birthweight, high birthweight, or stillbirth.
Review
Food Science & Technology
Luigi Barrea, Matteo Megna, Sara Cacciapuoti, Evelyn Frias-Toral, Gabriella Fabbrocini, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: Psoriasis is a chronic immune-mediated skin disease influenced by genetic and lifestyle factors. Nutrition and obesity are significant contributors to its pathogenesis and severity. Certain diets with anti-inflammatory properties, such as the very-low-calorie ketogenic diet (VLCKD), may improve clinical severity by reducing weight and systemic inflammation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Luigi Barrea, Massimiliano Caprio, Dario Tuccinardi, Eleonora Moriconi, Laura Di Renzo, Giovanna Muscogiuri, Annamaria Colao, Silvia Savastano
Summary: Cancer cells predominantly utilize aerobic glycolysis for metabolism. This characteristic has led to the hypothesis that dietary manipulation, such as a ketogenic diet, can influence tumor treatment and prognosis. The effectiveness of the ketogenic diet in cancer management may be attributed to various mechanisms, beyond the originally proposed glucose/insulin signaling inhibition. A qualified nutritionist is essential in managing the potential complications of this dietary therapy.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Giovanna Muscogiuri, Luigi Barrea, Massimiliano Caprio, Florencia Ceriani, Alberto O. Chavez, Marwan El Ghoch, Evelyn Frias-Toral, Rucha J. Mehta, Verna Mendez, Stavroula A. Paschou, Agnieszka Pazderska, Silvia Savastano, Annamaria Colao
Summary: Obesity and its related comorbidities, such as type 2 diabetes, are significant global public health issues. Insulin resistance in muscle and liver is the underlying pathophysiologic defect leading to obesity and predicting the onset of type 2 diabetes. Despite the well-recognized role of insulin resistance in metabolic diseases, there are currently no specific nutritional recommendations for managing this condition. An international panel of experts reviewed the literature on this topic and aimed to provide nutritional advice for managing insulin resistance, hyperinsulinemia, and reactive hypoglycemia to prevent the progression or worsening of insulin resistance and, ultimately, type 2 diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Luigi Barrea, Gabriella Pugliese, Evelyn Frias-Toral, Marwan El Ghoche, Bianca Castellucci, Sebastian Pablo Chapela, Maria de los Angeles Carignano, Daniela Laudisio, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This review provides an update on the benefits of coffee consumption on health outcomes, highlighting its potential for preventing inflammatory and oxidative stress-related diseases, reducing the incidence of certain cancers, and lowering the risk of all-cause mortality. However, more randomized controlled studies are needed to establish a causal link between coffee intake and health outcomes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Luigi Barrea, Claudia Vetrani, Massimiliano Caprio, Marwan El Ghoch, Evelyn Frias-Toral, Rucha J. Mehta, Verna Mendez, Eleonora Moriconi, Stavroula A. Paschou, Agnieszka Pazderska, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This article reviews the evidence and uncertainties surrounding nutritional therapy for patients with type 2 diabetes and obesity, providing guidance for clinical practice.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Immunology
Giorgio Bogani, Luca Lalli, Francesco Sopracordevole, Andrea Ciavattini, Alessandro Ghelardi, Tommaso Simoncini, Francesco Plotti, Jvan Casarin, Maurizio Serati, Ciro Pinelli, Alice Bergamini, Barbara Gardella, Andrea Dell'Acqua, Ermelinda Monti, Paolo Vercellini, Innocenza Palaia, Giorgia Perniola, Margherita Fischetti, Giusi Santangelo, Alice Fracassi, Giovanni D'Ippolito, Lorenzo Aguzzoli, Vincenzo Dario Mandato, Luca Giannella, Cono Scaffa, Francesca Falcone, Chiara Borghi, Mario Malzoni, Andrea Giannini, Maria Giovanna Salerno, Viola Liberale, Biagio Contino, Cristina Donfrancesco, Michele Desiato, Anna Myriam Perrone, Giulia Dondi, Pierandrea De Iaco, Simone Ferrero, Giuseppe Sarpietro, Maria G. Matarazzo, Antonio Cianci, Stefano Cianci, Sara Bosio, Simona Ruisi, Lavinia Mosca, Raffaele Tinelli, Rosa De Vincenzo, Gian Franco Zannoni, Gabriella Ferrandina, Marco Petrillo, Giampiero Capobianco, Salvatore Dessiole, Annunziata Carlea, Fulvio Zullo, Barbara Muschiato, Stefano Palomba, Stefano Greggi, Arsenio Spinillo, Fabio Ghezzi, Nicola Colacurci, Roberto Angioli, Pierluigi Benedetti Panici, Ludovico Muzii, Giovanni Scambia, Francesco Raspagliesi, Violante Di Donato
Summary: In this study, a prognostic nomogram was developed to assess the risk of cervical dysplasia persistence/recurrence after primary conization. Variables such as diagnosis of CIN3, presence of high-risk HPV types, positive endocervical margins, HPV persistence, and omission of HPV vaccination after conization were found to significantly increase the risk of cervical dysplasia persistence/recurrence. The nomogram can be a useful tool for counseling women about their risk and the importance of HPV vaccination after conization.
Review
Obstetrics & Gynecology
Stefano Palomba, Amerigo Vitagliano, Roberto Marci, Donatella Caserta
Summary: Endometrial scratching is a controversial procedure aimed at improving reproductive outcomes for infertile women. Recommendations regarding its use vary, with some authors advising against it and others supporting its application in certain patient populations. This article provides a critical analysis of existing evidence and offers insights for future research.
REPRODUCTIVE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ludovica Verde, Maria Dalamaga, Xavier Capo, Giuseppe Annunziata, Maria Hassapidou, Annamaria Docimo, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri, Luigi Barrea
Summary: High adherence to the Mediterranean diet (MD) leads to better results in the very low-calorie ketogenic diet (VLCKD), possibly due to the antioxidant and anti-inflammatory properties of the MD, which create a metabolic state favorable for more effective ketosis.
Review
Biochemistry & Molecular Biology
Luigi Barrea, Claudia Vetrani, Ludovica Verde, Evelyn Frias-Toral, Florencia Ceriani, Simona Cernea, Annamaria Docimo, Chiara Graziadio, Devjit Tripathy, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: Diet is crucial in the pathogenesis of T2DM. Individualized medical nutritional therapy has been shown to improve outcomes, and various eating patterns have proven benefits for T2DM patients. Personalized meal plans should be considered, with reduced carbohydrate intake and replacement of high GI foods. The quality of fats is important, and supplementation with antioxidants or micronutrients is not recommended.
Article
Biochemistry & Molecular Biology
Giulia de Alteriis, Gabriella Pugliese, Antonella Di Sarno, Giovanna Muscogiuri, Luigi Barrea, Valentina Cossiga, Giuseppe Perruolo, Michele Francesco Di Tolla, Francesca Zumbolo, Pietro Formisano, Filomena Morisco, Silvia Savastano
Summary: Visceral obesity is associated with the progression of NASH. CK18 epitopes M30 and M65 are accurate markers for detecting NASH. This study found that CK18M30 and CK18M65 levels were significantly correlated with anthropometric and metabolic characteristics, liver stiffness, and indices of steatosis and fibrosis in subjects with visceral obesity. These levels could serve as good biomarkers for early identification of NASH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Stefano Palomba, Flavia Costanzi, Scott M. Nelson, Donatella Caserta, Peter Humaidan
Summary: This study reviewed and analyzed different interventions for preventing and reducing OHSS in IVF patients. The most effective interventions were found to be GnRH-ant co-treatment and GnRH agonist triggering, with moderate evidence. Mild ovarian stimulation and dopaminergic agonists were also effective and safe interventions.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Editorial Material
Nutrition & Dietetics
Mikiko Watanabe, Silvia Savastano, Carla Lubrano, Giovanni Spera
Article
Public, Environmental & Occupational Health
Stefano Palomba, Domenico Carone, Amerigo Vitagliano, Flavia Costanzi, Alice Fracassi, Tiziana Russo, Serena Del Negro, Altiero Biello, Aldo Di Filippo, Antonio Mangiacasale, Antonio Monaco, Antonio Ranieri, Beatrice Ermini, Bruno Francesco Barba, Claudio Castello, Federica Di Guardo, Francesco Pastorella, Elena Bernasconi, Ezio Michele Tricarico, Francesca Filippi, Francesco Polsinelli, Giuseppe Lo M. Monte, Loredana Sosa Fernandez, Marco Galletta, Paolo Giardina, Pasquale Totaro, Roberto Laganara, Roberto Liguori, Matteo Buccheri, Mario Montanino Oliva, Rosita Piscopo, Assunta Iuliano, Nicola Innantuoni, Irene Romanello, Francesco Sinatra, Annalisa Liprino, Roberto Thiella, Alessandra Tiezzi, Tiziana Bartolotti, Alessandra Tomasi, Valeria Finocchiaro, Mario Thiella, Giuseppa Fuggetta, Sebastiano Messineo, Francesco Isabella, Marcello Tripodi, Stefania Iaccarino, Giovanni Battista La Sala, Enrico Papaleo, Donatella Caserta, Roberto Marci, Edgardo Somigliana, Antonino Guglielmino, talian Soc Human Reprod SIRU
Summary: This study aimed to assess the views and behaviors towards endometrial scratching (ES) among fertility specialists in Italy and the relationship between these views and the attitudes towards the use of ES as an add-on in their commercial setting. The results showed that ES is still performed by fertility specialists in Italy to improve the implantation rate in IVF patients, but they have a poor attitude towards proposing ES as an add-on in the commercial setting.
Review
Biochemistry & Molecular Biology
Stefano Palomba, Flavia Costanzi, Scott M. Nelson, Aris Besharat, Donatella Caserta, Peter Humaidan
Summary: The aim of this study was to evaluate and grade interventions for the prevention and reduction of OHSS in IVF patients. The results showed that follitropin delta may reduce the incidence of early OHSS in low-risk IVF patients, while in high-risk patients, inositol pretreatment, low-dose urinary hCG for ovulation triggering, and luteal phase administration of a GnRH antagonist may reduce the risk of OHSS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Barbara Altieri, Luigi Barrea, Roberta Modica, Filomena Bottiglieri, Federica de Cicco, Giovanna Muscogiuri, Luisa Circelli, Giovanni Savarese, Carolina Di Somma, Silvia Savastano, Annamaria Colao, Antongiulio Faggiano
Summary: Vitamin D deficiency is common among GEP-NET patients and may be associated with high tumor grade and disease progression. Monitoring of 25(OH)D levels is essential in these patients, and vitamin D supplementation should be considered in the management of GEP-NET patients with vitamin D deficiency or insufficiency.