期刊
CLINICAL EEG AND NEUROSCIENCE
卷 46, 期 3, 页码 183-191出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1550059414523959
关键词
ADHD; EEG; graph theory; small-world networks; Multi-Source Interference Task
资金
- National Natural Science Foundation of China [81071150]
- Produce-Study-Research program, Guangdong Province, Ministry of Education of China [2008B09050023]
We investigated the topologic properties of human brain attention-related functional networks associated with Multi-Source Interference Task (MSIT) performance using electroencephalography (EEG). Data were obtained from 13 children diagnosed with attention-deficit/hyperactivity disorder (ADHD) and 13 normal control children. Functional connectivity between all pairwise combinations of EEG channels was established by calculating synchronization likelihood (SL). The cluster coefficients and path lengths were computed as a function of degree K. The results showed that brain attention functional networks of normal control subjects had efficient small-world topologic properties, whereas these topologic properties were altered in ADHD. In particular, increased local characteristics combined with decreased global characteristics in ADHD led to a disorder-related shift of the network topologic structure toward ordered networks. These findings are consistent with a hypothesis of dysfunctional segregation and integration of the brain in ADHD, and enhance our understanding of the underlying pathophysiologic mechanism of this illness.
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