Review
Chemistry, Analytical
Yuqiao Liu, Junmin Li, Shenghao Xiao, Yanhui Liu, Mingxia Bai, Lixiu Gong, Jiaqian Zhao, Dajing Chen
Summary: Precision medicine is essential for optimizing drug dosage and minimizing toxicity. Wearable sensors offer real-time and continuous drug monitoring, enabling personalized medicine and reducing healthcare costs.
Review
Biochemistry & Molecular Biology
Ethan Hau Yin Lam, Fengqing Yu, Sabrina Zhu, Zongjie Wang
Summary: In the past decade, personalized medicine has made significant progress in addressing patient-specific disease complexities and developing individualized treatment strategies. The emergence of 3D bioprinting has provided novel opportunities for personalized medicine, although current bioprinted constructs have limitations in achieving anatomically realistic organs with mature biological functions. This review discusses the principles and realizations of bioprinting, focusing on techniques such as extrusion printing and digital light processing (DLP). It also explores the applications of bioprinted constructs in regenerative medicine and drug discovery. Despite the challenges, bioprinting shows promise as an empowering technology to overcome critical obstacles in personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Nathalia O. O. Gomes, Paulo A. A. Raymundo-Pereira
Summary: Paracetamol is recommended by WHO as the main non-opioid analgesic for mild pain, but high levels of its use can cause hepatotoxicity and nephrotoxicity. This study developed a sensor on a polyester substrate to detect paracetamol levels in human saliva, showing interference-free results. The sensor can be used as a disposable device to quickly detect paracetamol in untreated raw saliva, enabling personalized therapy by tracking the active substance and preventing overdoses and side effects.
Article
Engineering, Environmental
Paulo A. Raymundo-Pereira, Nathalia O. Gomes, Sergio A. S. Machado, Osvaldo N. Oliveira Jr
Summary: This paper reports on wearable glove-embedded sensors for non-invasive and selective determination of therapeutic drugs and biomarkers in sweat samples. The sensors showed high sensitivity and selectivity, as well as robustness against multiple flexion cycles.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Rannissa Puspita Jayanti, Nguyen Phuoc Long, Nguyen Ky Phat, Yong-Soon Cho, Jae-Gook Shin
Summary: To control the growing number of drug-resistant TB cases, innovative approaches like precision dosing and TDM play a crucial role in adjusting drug doses for improved treatment outcomes. These tools are particularly important for patients with complex comorbidities and high risk of treatment failure.
Review
Oncology
Pattanaik Smita, Patil Amol Narayan, J. Kumaravel, Prakash Gaurav
Summary: Cytotoxic drugs are highly effective but have low therapeutic index. Therapeutic drug monitoring (TDM) research has been conducted to understand the relationship between drug concentration and therapeutic efficacy and toxicity for these drugs. TDM can provide valuable insights, but its implementation needs to be justified by demonstrating improved patient outcomes. This article compiles evidence and best practices for TDM of three cytotoxic drugs and highlights the shift towards model informed precision dosing.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Zhichao Li, Haibo Xu, Lei Yu, Jia Wang, Qian Meng, Hongbing Mei, Zhiming Cai, Wei Chen, Weiren Huang
Summary: This research established an effective three-dimensional culture system for generating kidney cancer organoids and successfully generated 33 organoid lines from different subtypes of kidney cancer. These organoids preserved the histological architecture, mutational landscape, and transcriptional profile of the parental tumor tissues, and revealed inter- and intra-tumoral heterogeneity. Additionally, the organoids can be used for drug screening and evaluating the efficacy of immunotherapy.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Noor A. A. Nahid, Julie A. A. Johnson
Summary: CYP2D6 pharmacogenetics and phenoconversion are crucial for ensuring drug safety and efficacy, but their implementation in clinical practice faces challenges.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2022)
Article
Oncology
Raquel Pineiro-Perez, Miguel Abal, Laura Muinelo-Romay
Summary: This review provides a global perspective on the evaluation of circulating biomarkers in endometrial tumors, highlighting the key areas where these markers can be developed into a real clinical tool.
Review
Oncology
Axel Bengtsson, Roland Andersson, Jonas Rahm, Karthik Ganganna, Bodil Andersson, Daniel Ansari
Summary: This review outlines the most important challenges in exploiting organoid platforms for drug discovery and clinical applications. Some of these challenges may be overcome by novel methods under investigation, such as 3D bioprinting systems, microfluidic systems, optical metabolic imaging, and liquid handling robotics. An optimized organoid workflow inspired by all technical solutions presented in the article is also proposed.
Article
Infectious Diseases
Cindy Lau, Deborah Marriott, Jessica Bui, Melanie Figtree, Michael Gould, Adriana Chubaty, Yuen Su, Suman Adhikari, Pam Konecny, Kristi Kozierowski, Taylor Holland, Eliza Milliken, Ayesha Akram, Alexander Mcnamara, Yihui Sun, Sebastiaan Van Hal, Asad E. Patanwala, Aryan Shahabi-Sirjani, Timothy Gray, Chin Yen Yeo, Angela Netluch, Stephanie Halena, Marcelle Appay, Rozanna Alameddine, Fiona Yin, Quoc Nguyen, Mei-Yi So, Indy Sandaradura, Hannah Yejin Kim, Semun Galimam, Nicole Cerruto, Tony Lai, Timothy Gilbey, Kathryn Daveson, Stephanie E. Reuter, Jonathan Penm, Jan-Willem Alffenaar
Summary: This study aimed to evaluate linezolid toxicity in a large multicentre cohort and found that linezolid treatment-limiting toxicity remains a problem. TDM-guided dose optimisation significantly reduced the risk of toxicity and a treatment duration beyond 28 days was no longer significantly associated with toxicity.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Chemistry, Multidisciplinary
Jia Heng Teoh, Sook Muay Tay, Jerry Fuh, Chi-Hwa Wang
Summary: This study investigates the application of 3D printing to fabricate hydrogel wound dressings with customizable architectures and drug dosages. Results show that 3D printing has the ability to customize drug dosages and drug release rates through co-loading different drugs at various positions and varying the thickness of drug-free layers over drug-loaded layers in the wound dressing.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Microbiology
Gouxin Huang, Raees Khan, Yilin Zheng, Ping-Chin Lee, Qingnan Li, Imran Khan
Summary: Research in the field of gut microbiota has shown that these microbes play a crucial role in human health, affecting drug efficacy and toxicity. Intra-individual variability of gut microbiota can result in biased drug responses. Various methods, such as prebiotic and probiotic interventions, can be used to treat diseases by altering gut microbiota composition.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Oncology
Amy de Haar-Holleman, Lisa M. C. van Hoogstraten, Maarten C. C. M. Hulshof, Metin Tascilar, Katharin Bruck, Richard P. Meijer, J. Alfred Witjes, Lambertus A. Kiemeney, Katja K. H. Aben
Summary: This study compared the toxicity, overall survival (OS), and disease-free survival (DFS) between oral capecitabine and intravenous 5-fluorouracil (5-FU) in chemoradiotherapy for muscle-invasive bladder cancer (MIBC) patients. There was no significant difference in adverse events, 2-year OS, and 2-year DFS between the two regimens. Capecitabine-based CRT may be considered as an alternative to a 5-FU-based regimen.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sabarinath Prasad, Mauro Farella
Summary: Wearable devices worn on or near the human body are increasingly being used in orofacial applications, including diagnosis, treatment progress tracking, patient compliance monitoring, and understanding parafunctional behaviors. This communication highlights the role of wearable devices in advancing personalized dental medicine, specifically focusing on monitoring masticatory muscle activity in naturalistic settings. Challenges, opportunities, and future research areas for successful use of wearable devices for precise, personalized care of muscle disorders are also discussed.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Pharmacology & Pharmacy
Jerome Rollin, Audrey Payance, Valerie Gouilleux-Gruart, Michelle Boisdron-Celle, Nicolas Azzopardi, Alain Morel, Yves Gruel, Gilles Paintaud, Erick Gamelin, Herve Watier, Thierry Lecomte
Article
Gastroenterology & Hepatology
Yann Touchefeu, Marie Provost-Dewitte, Thierry Lecomte, Alain Morel, Isabelle Valo, Jean-Francois Mosnier, Celine Bossard, Juliette Eugene, Emilie Duchalais, Jerome Chetritt, Serge Guyetant, Stephane Bezieau, Helene Senellart, Morgane Caulet, Estelle Cauchin, Tamara Matysiak-Budnik
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2016)
Article
Medicine, General & Internal
Fabrice Barlesi, Julien Mazieres, Jean-Philippe Merlio, Didier Debieuvre, Jean Mosser, Herve Lena, L'Houcine Ouafik, Benjamin Besse, Isabelle Rouquette, Virginie Westeel, Fabienne Escande, Isabelle Monnet, Antoinette Lemoine, Remi Veillon, Helene Blons, Clarisse Audigier-Valette, Pierre-Paul Bringuier, Regine Lamy, Michele Beau-Faller, Jean-Louis Pujol, Jean-Christophe Sabourin, Frederique Penault-Llorca, Marc G. Denis, Sylvie Lantuejoul, Franck Morin, Quan Tran, Pascale Missy, Alexandra Langlais, Bernard Milleron, Jacques Cadranel, Jean-Charles Soria, Gerard Zalcman
Review
Oncology
Michele Boisdron-Celle, Jean Philippe Metges, Olivier Capitain, Antoine Adenis, Jean Luc Raoul, Thierry Lecomte, You Heng Lam, Roger Faroux, Claude Masliah, Anne Lise Poirier, Virginie Berger, Alain Morel, Erick Gamelin
SEMINARS IN ONCOLOGY
(2017)
Review
Oncology
Michele Boisdron-Celle, Olivier Capitain, Roger Faroux, Christophe Borg, Jean Philippe Metges, Marie Pierre Galais, Mehdi Kaassis, Jaafar Bennouna, Karine Bouhier-Leporrier, Eric Francois, Isabelle Baumgaertner, Veronique Guerin-Meyer, Oana Cojocarasu, Celia Roemer-Becuwe, Claire Stampfli, Ludovic Rosenfeld, Thierry Lecompte, Virginie Berger, Alain Morel, Erick Gamelin
SEMINARS IN ONCOLOGY
(2017)
Letter
Oncology
Michele Boisdron-Celle, Alain Morel, Erick Gamelin, Olivier Capitain, Roger Faroux, Christophe Borg, Jean Philippe Metges, Marie Pierre Galais, Mehdi Kaassis, Jaafar Bennouna, Karine Bouhier-Leporrier, Eric Francois, Isabelle Baumgaertner, Veronique Guerin-Meyer, Oana Cojocarasu, Claire Stampfli, Ludovic Rosenfeld, Thierry Lecomte, Virginie Berger
SEMINARS IN ONCOLOGY
(2017)
Article
Oncology
Dan Rosmarin, Claire Palles, David Church, Enric Domingo, Angela Jones, Elaine Johnstone, Haitao Wang, Sharon Love, Patrick Julier, Claire Scudder, George Nicholson, Anna Gonzalez-Neira, Miguel Martin, Daniel Sargent, Erin Green, Howard McLeod, Ulrich M. Zanger, Matthias Schwab, Michael Braun, Matthew Seymour, Lindsay Thompson, Benjamin Lacas, Valerie Boige, Nuria Ribelles, Shoaib Afzal, Henrik Enghusen, Soren Astrup Jensen, Marie-Christine Etienne-Grimaldi, Gerard Milano, Mia Wadelius, Bengt Glimelius, Hans Garmo, Milena Gusella, Thierry Lecomte, Pierre Laurent-Puig, Eva Martinez-Balibrea, Rohini Sharma, Jesus Garcia-Foncillas, Zdenek Kleibl, Alain Morel, Jean-Pierre Pignon, Rachel Midgley, David Kerr, Ian Tomlinson
JOURNAL OF CLINICAL ONCOLOGY
(2014)
Article
Oncology
Laure Sorber, Karen Zwaenepoel, Koen De Winne, Kaat Van Casteren, Elien Augustus, Julie Jacobs, Xiang Hua Zhang, Daniella Galdermans, Els De Droogh, Anneke Lefebure, Ann-Marie Morel, Erika Saenen, Frederique Bustin, Ingel Demedts, Ulrike Himpe, Thierry Pieters, Paul Germonpre, Sofie Derijcke, Koen Deschepper, Jan P. Van Meerbeeck, Christian Rolfo, Patrick Pauwels
Article
Multidisciplinary Sciences
Ichrak Riahi-Chebbi, Soumaya Souid, Houcemeddine Othman, Meriam Haoues, Habib Karoui, Alain Morel, Najet Srairi-Abid, Makram Essafi, Khadija Essafi-Benkhadir
SCIENTIFIC REPORTS
(2019)
Article
Oncology
Sebastien Couraud, Fabrice Barlesi, Clara Fontaine-Deraluelle, Didier Debieuvre, Jean-Philippe Merlio, Lionel Moreau, Michele Beau-Faller, Remi Veillon, Jean Mosser, Faraj Al Freijat, Pierre-Paul Bringuier, Herve Lena, L'Houcine Ouafik, Virginie Westeel, Alain Morel, Clarisse Audigier-Valette, Pascale Missy, Alexandra Langlais, Franck Morin, Pierre-Jean Souquet, David Planchard
EUROPEAN JOURNAL OF CANCER
(2019)
Article
Pathology
Louise-Marie Chevalier, Amandine Billaud, Christophe Passot, Adelaide Renoult, Frederic Bigot, Veronique Verriele, Alain Morel
ANNALES DE PATHOLOGIE
(2020)
Article
Genetics & Heredity
Louise-Marie Chevalier, Amandine Billaud, Sabrina Fronteau, Jonathan Dauve, Anne Patsouris, Veronique Verriele, Alain Morel
MOLECULAR DIAGNOSIS & THERAPY
(2020)
Article
Oncology
Lea Paolini, Clement Adam, Celine Beauvillain, Laurence Preisser, Simon Blanchard, Pascale Pignon, Valerie Seegers, Louise-Marie Chevalier, Mario Campone, Romuald Wernert, Veronique Verrielle, Pedro Raro, Norbert Ifrah, Vincent Lavoue, Philippe Descamps, Alain Morel, Veronique Catros, Guillaume Tcherkez, Guy Lenaers, Cinzia Bocca, Judith Kouassi Nzoughet, Vincent Procaccio, Yves Delneste, Pascale Jeannin
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Medicine, General & Internal
Amandine Billaud, Veronique Verriele, Jonathan Dauve, Louise-Marie Chevalier, Alain Morel
Review
Oncology
Amandine Billaud, Louise-Marie Chevalier, Mario Campone, Alain Morel, Frederic Bigot
BULLETIN DU CANCER
(2020)