Article
Nutrition & Dietetics
Yacong Bo, Huadong Xu, Huanhuan Zhang, Junxi Zhang, Zhongxiao Wan, Xin Zhao, Zengli Yu
Summary: This study found that higher dietary intake of folate and vitamin B6 is significantly associated with lower all-cause and cardiovascular mortality.
Article
Cardiac & Cardiovascular Systems
Jiamin Huang, Pipasha Khatun, Yuqing Xiong, Bingrui Liu, Yisu Zhao, Quanjun Lyu
Summary: This study found that higher dietary intake of vitamin B6 may be associated with a lower prevalence of cardiovascular disease (CVD) in the United States population. Conversely, there was no significant association between dietary intake of folate and vitamin B12 and the odds of CVD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Lijing Wang, Cui Zhou, Huiyan Yu, Ling Hao, Mengwei Ju, Wenjing Feng, Zhiting Guo, Xuejing Sun, Qiushi Fan, Rong Xiao
Summary: This study aimed to investigate the effects of co-supplementation with vitamin D, folic acid, and vitamin B-12 on learning and memory ability in vitamin D-deficient mice. The results showed that the co-supplementation significantly improved the learning and memory impairment caused by vitamin D deficiency, possibly through the regulation of CYP27A1 expression and the metabolism of 27-OHC, 25(OH)D, and SAM.
Review
Chemistry, Applied
A. J. M. Santos, S. Khemiri, S. Simo, C. Prista, I. Sousa, A. Raymundo
Summary: Vitamins are essential organic compounds that are necessary for good health but cannot be synthesized by the human body. Vitamins B6 and B12 are hydrophilic vitamins that play vital roles in cellular operation, growth, and development. This review focuses on the important aspects of vitamins B6 and B12, including their roles, consequences of deficiency, food sources, and chromatographic techniques developed in the last two decades for their determination.
Article
Neurosciences
Lei Zhao, Lili Guan, Jinyan Sun, Xiaoming Li
Summary: This study aimed to investigate the association between B vitamins and depression and cognitive dysfunction. The results showed that patients with depression and cognitive dysfunction had the lowest levels of B vitamins compared with the other two groups, and serum folate, vitamin B6, and vitamin B12 were positively correlated with cognitive dysfunction.
ACTA NEUROPSYCHIATRICA
(2023)
Article
Nutrition & Dietetics
Samuel Berkins, Helgi Birgir Schioth, Gull Rukh
Summary: The study found no significant association between vitamin B6, B12, and folate intakes and both global and subcortical brain volumes among participants with depression. However, vitamin B12 intake was positively associated with right pallidum among non-depressed participants, and a significant interaction between vitamin B12 intake and depression status on the right pallidum was observed. Additionally, a significant interaction between folate intake and depression status on grey matter volume and left thalamus was observed.
Article
Nutrition & Dietetics
Nathalia Cristina Freitas-Costa, Pedro Gomes Andrade, Paula Normando, Keronlainy Silva Salvatte Nunes, Carlos Eduardo Raymundo, Ines Rugani Ribeiro de Castro, Elisa Maria de Aquino Lacerda, Dayana Rodrigues Farias, Gilberto Kac
Summary: This study evaluated the association between vitamins B6, B12, and folate concentrations/status and early childhood development (ECD) and found that vitamin B6 was positively associated with DQ, while vitamin B12 was negatively associated with DQ. There was no significant association between folate status and DQ.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Ziva Lavrisa, Hristo Hristov, Masa Hribar, Katja Zmitek, Anita Kusar, Barbara Korousic Seljak, Matej Gregoric, Urska Blaznik, Nadan Gregoric, Katja Zaletel, Adrijana Oblak, Josko Osredkar, Igor Pravst
Summary: Vitamin B12 deficiency is a common issue in the Slovenian population, especially among the elderly. Lower intake is observed in females, and meat and milk are the main contributors to vitamin B12 intake across all age groups. Serum vitamin B12 levels have a significant impact on the health of the elderly.
Article
Nutrition & Dietetics
Haofeng Hong, Longting Chen, Yiming Zhong, Zihuan Yang, Weishi Li, Chunli Song, Huijie Leng
Summary: This study used a Mendelian randomization approach to investigate the potential causal effects of homocysteine, folate, and vitamin B12 on site- and gender-specific osteoarthritis (OA). The results showed that genetically predicted homocysteine had adverse effects on OA, while genetically predicted folate and vitamin B12 had protective effects on OA.
Article
Geriatrics & Gerontology
Imrich Blasko, Michaela Defrancesco, Herbert Oberacher, Lorin Loacker, Georg Kemmler, Josef Marksteiner, Christian Humpel
Summary: This study investigated the effectiveness of lipid metabolites and vitamin B12 and folate levels as biomarkers for predicting MCI-to-AD conversion. The findings suggest that some plasma lipids significantly change in subjects converting to AD, while folate levels decrease in MCI-AD conversion. Further research is needed to determine if peripheral lipid changes correspond with brain changes during the course of the disease, indicating potential for lipids as prognostic markers.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Oncology
Paramita Khairan, Tomotaka Sobue, Ehab Salah Eshak, Ling Zha, Tetsuhisa Kitamura, Norie Sawada, Motoki Iwasaki, Manami Inoue, Taiki Yamaji, Taichi Shimazu, Hiroyasu Iso, Shoichiro Tsugane
Summary: The dietary intake of vitamin B12 is positively associated with the risk of esophageal cancer in the Japanese population, especially among non-drinkers, according to the Japan Public Health Center-based Prospective Study.
Article
Obstetrics & Gynecology
Pooja Dhiman, Raji Ramachandran Pillai, Anand Babu Wilson, Nancy Premkumar, Balaji Bharadwaj, Veena P. Ranjan, Soundravally Rajendiran
Summary: The study found that women with postpartum depression had significantly lower levels of vitamin B12 and higher levels of MMA and 5-methyl THF in their blood, which were closely associated with the risk of postpartum depression.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Review
Endocrinology & Metabolism
Juan R. Ulloque-Badaracco, Enrique A. Hernandez-Bustamante, Esteban A. Alarcon-Braga, Ali Al-kassab-Cordova, Juan C. Cabrera-Guzman, Percy Herrera-Anazco, Vicente A. Benites-Zapata
Summary: This systematic review and meta-analysis assessed the association of vitamin B12, folic acid, and homocysteine (Hcy) levels with MetS. The results showed that higher vitamin B12 levels were inversely associated with MetS, whereas higher Hcy levels were positively associated with MetS. Folate levels were not associated with MetS.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Zhe Ding, Lihui Luo, Shaohui Guo, Qing Shen, Yueying Zheng, Shengmei Zhu
Summary: The association between folate and vitamin B12 with cognitive performance was studied using cross-sectional data of older adults. The study found an inverse U-shaped relationship between folate/vitamin B12 status and cognitive function. Older adults could be categorized into different status groups based on biochemical examination, and these groups showed significantly different cognitive test outcomes.
Article
Nutrition & Dietetics
Li Li, Qi Huang, Linjian Yang, Rui Zhang, Leili Gao, Xueyao Han, Linong Ji, Xiantong Zou
Summary: There is an association between non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) with levels of vitamin B12 and associated metabolites, while MMA and HCY may be associated with an increased risk for advanced fibrosis.