Article
Biophysics
Nicholas X. Williams, Brittani Carroll, Steven G. Noyce, Hansel Alex Hobbie, Daniel Y. Joh, Joseph G. Rogers, Aaron D. Franklin
Summary: A handheld point-of-care test (POCT) was developed to measure blood coagulation time using low-cost printed sensors, providing a rapid and accurate way to test coagulation time anywhere. The system exhibited good stability and reliability, with consistent measurements for both chicken and human blood under different conditions.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Medical Laboratory Technology
Adil I. Khan, Busadee Pratumvinit, Ellis Jacobs, Gerald J. Kost, Heba Kary, Jan Balla, Julie Shaw, Lara Milevoj Kopcinovic, Michel Vaubourdolle, Paloma Oliver, Paul R. E. Jarvis, Prasad Pamidi, Rajiv T. Erasmus, Ruth O'Kelly, Samarina Musaad, Sverre Sandberg
Summary: The IFCC C-POCT supports the use of POCT outside of hospitals, but emphasizes the importance of managing the associated risks to ensure reliable test results and patient safety. Healthcare professionals, regulatory bodies, laboratories, and manufacturers should all be involved in education and oversight to ensure correct selection, analysis, troubleshooting, and interpretation of POC test results.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Xian Chen, Xuexin Duan, Yunhua Gao
Summary: Point-of-care testing (POCT) has played a crucial role in various fields due to its faster turnaround compared to laboratory testing. The development of micro- and nanotechnology has led to the emergence of acoustofluidics, which utilizes acoustic waves to manipulate fluids and particles, and has been widely applied in POCT research.
Article
Engineering, Biomedical
Meiying Zhang, Xin Cui, Nan Li
Summary: Smartphone-based biosensors have advantages of rapid, accurate, low-cost and multi-analytes analysis capability for metabolite profiling. They are promising for daily and comprehensive metabolite monitoring, transforming clinical diagnostics into non-clinical self-testing, and enabling personalized treatments of metabolic-disorder related diseases.
MATERIALS TODAY BIO
(2022)
Review
Medical Laboratory Technology
Allison A. Venner, Lori A. Beach, Jennifer L. Shea, Michael J. Knauer, Yun Huang, Angela W. S. Fung, James Dalton, Mathieu Provencal, Julie L. Shaw
Summary: Point of Care Testing (POCT) refers to clinical laboratory testing done closer to the patient, often by non-laboratory trained clinical staff like physicians or nurses. Quality assurance practices for POCT are crucial and involve aspects like device selection, verification, ongoing quality assurance, and operator management.
CLINICAL BIOCHEMISTRY
(2021)
Article
Nursing
Suzanne Bench, Sarah Lennox
Summary: This study investigates nurses' perceptions of current POCT practice in critical care pre and post the COVID-19 pandemic. Results show the impact of POCT on nurses' workload, patient care provision, and staff wellbeing.
NURSING IN CRITICAL CARE
(2022)
Review
Chemistry, Analytical
Zhong-Yu Wang, Ming-Hui Sun, Qun Zhang, Pei-Feng Li, Kun Wang, Xin-Min Li
Summary: This article mainly summarizes the research progress in point-of-care testing (POCT) of microRNAs (miRNAs) based on portable instruments and visual readout methods. It emphasizes the importance of this technology in clinical diagnosis and its advantages of high specificity, sensitivity, efficiency, cost-saving, and easy operation.
Article
Materials Science, Multidisciplinary
Jiuchuan Guo, Shuqin Chen, Jinhong Guo, Xing Ma
Summary: Lateral flow immunoassays (LFIAs) have rapidly developed and widely used in point-of-care-testing, offering advantages such as low cost, easy operation, and short time-consumption. To improve sensitivity, novel nanomaterials have been utilized as labels in LFIAs to generate various signals for quantitative or semi-quantitative detection.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Seoyoon Song, Huisoo Jang, Deborah Lee, Woojin Jeong, Eun Hwan Bae, Hoon Kim, Yong Sung Choi, Minhye Shin, Sun Min Kim, Tae-Joon Jeon
Summary: This study introduces a chromatic biosensor composed of poly(diacetylene), alginate, and LB broth (PAL) that can complete antimicrobial susceptibility testing in a short amount of time. The biosensor is portable, stable, and yields comparable results to the gold standard methods.
Review
Chemistry, Analytical
Antareep Sharma, Alfred Iing Yoong Tok, Palaniappan Alagappan, Bo Liedberg
Summary: POCT platforms in sports science are gaining attention for their ability to monitor athlete health, performance, recovery, and doping control. They also assist trainers in optimizing training plans and aid sports committees in enforcing effective doping control measures.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Liule Zhang, Xia Gao, Xiying Chen, Minyang Zhao, Haotian Wu, Yaqing Liu
Summary: In this study, a ratiometric fluorescent system was proposed for point-of-care testing of fluoride ion using a smartphone as an analyzer. The system showed a significant fluorescence color change, eliminating interference and improving detection accuracy. The system demonstrated excellent selectivity, and by integrating a smartphone with a color scan app, it achieved further improvement in detection sensitivity and quantitative analysis.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Biao Zhang, Jingyi Zhang, Yihan Lang, Zicheng Wang, Danfeng Cai, Xiaoping Yu, Xiaodong Lin
Summary: A novel dual-mode nanoplatform based on sea urchin-shaped Pt@Au NPs with high peroxidase-like activity is developed for sensitive detection of histamine. The colorimetric-based UV-vis nanoplatform allows for sensitive detection of histamine with a linear range of 0.5-100 ng/mL and a low limit of detection (LOD) of 0.3 ng/mL. Additionally, a smartphone-loaded color picker APP can intelligently detect histamine based on the R/B ratio in the color channels, achieving a detection range of 0.5-1000 ng/mL and a LOD as low as 0.15 ng/mL, significantly expanding the detection range. This easy-to-use and sensitive detection system shows great potential in ensuring the safety of protein-rich meat food.
Article
Chemistry, Analytical
Xinghui Yu, Yongqiang Ma, Siyuan Liu, Chunchun Qi, Weiqi Zhang, Wen Xiang, Zhaoxian Li, Kai Yang, Shaoxian Duan, Xinrao Du, Jian Yu, Yan Xie, Zicheng Wang, Wentao Jiang, Li Zhang, Xiaodong Lin
Summary: Post-operative pathogenic infections in liver transplantation pose a serious threat to human health. Researchers have developed a chemiluminescence-based method for the rapid and sensitive detection of Staphylococcus aureus. By integrating specific capture and separation techniques, this portable device, integrated with a smartphone, enables specific detection of S. aureus with high antibacterial efficiency. The method is simple to use and cost-effective, demonstrating great potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2023)
Article
Medicine, General & Internal
Bin-Feng Yin, Xin-Hua Wan, Ming-Zhu Yang, Chang-Cheng Qian, A. S. M. Muhtasim Fuad Sohan
Summary: This study developed a wave-shaped microfluidic chip assisted multiplexed detection platform, which enables rapid and sensitive detection of multiple biomarkers including CRP, PCT, and IL-6. The detection process is simple and shows good selectivity and repeatability, making it suitable for point-of-care testing.
MILITARY MEDICAL RESEARCH
(2022)
Article
Psychiatry
Joseph Butler, Simone de Cassan, Phil Turner, Belinda Lennox, Gail Hayward, Margaret Glogowska
Summary: Some clinicians believe that the usability of the technology, positive impact on patient experience, and improved self-efficacy are driving factors for successful implementation of POCT, while issues with device functioning and potential negative effects on the therapeutic relationship with patients are barriers.